A Novel Rat Infant Model of Medial Temporal Lobe Epilepsy Reveals New Insight into the Molecular Biology and Epileptogenesis in the Developing Brain by Carola Wormuth, Anna Papazoglou, Christina Henseler, Dan Ehninger, Karl Broich, Britta Haenisch, Jürgen Hescheler, Rüdiger Köhling, Marco Weiergräber

“…The model had a survival rate of >80% and exhibited characteristic spontaneous recurrent electrographic seizures (SRES) in both the hippocampus and cortex that persisted into adulthood. Using implantable video-EEG radiotelemetry, we quantified a complex set of seizure parameters that demonstrated the induction of chronic electroencephalographic seizure activity in our InfRPil-mTLE model, which predominated during the dark cycle. …”
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Transcranial Direct Current Stimulation Modulates Neurogenesis and Microglia Activation in the Mouse Brain by Anton Pikhovych, Nina Paloma Stolberg, Lea Jessica Flitsch, Helene Luise Walter, Rudolf Graf, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger

“…Activated microglia in the cerebral cortex and neuroblasts generated in the subventricular zone as the major neural stem cell niche were assessed immunohistochemically. …”
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Capacity Enhancement in 60 GHz Based D2D Networks by Relay Selection and Scheduling by Waheed ur Rehman, Tabinda Salam, Jin Xu, Xiaofeng Tao

“…Using vertex multicoloring, we allow transmitter-receiver (Tx-Rx) communication pairs to span over more colors, enabling better time slot utilization. …”
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Brain-Specific SNAP-25 Deletion Leads to Elevated Extracellular Glutamate Level and Schizophrenia-Like Behavior in Mice by Hua Yang, Mengjie Zhang, Jiahao Shi, Yunhe Zhou, Zhipeng Wan, Yicheng Wang, Yinghan Wan, Jun Li, Zhugang Wang, Jian Fei

“…A significantly elevated extracellular glutamate level was detected in the cerebral cortex of the mouse model. Compared with Ctrls, SNAP-25 was dramatically reduced by about 60% both in cytoplasm and in membrane fractions of cerebral cortex of cKOs, while the other two core members of SNARE complex: Syntaxin-1 (increased ~80%) and Vamp2 (increased ~96%) were significantly increased in cell membrane part. …”
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Cortical areas associated to higher cognition drove primate brain evolution by Marina Melchionna, Silvia Castiglione, Giorgia Girardi, Antonio Profico, Alessandro Mondanaro, Gabriele Sansalone, Narimane Chatar, Alejandro Pérez Ramos, Marcos Fernández-Monescillo, Carmela Serio, Luca Pandolfi, Jacob Dembitzer, Mirko Di Febbraro, Marta Michelle Caliendo, Alessia Di Costanzo, Linda Morvillo, Antonella Esposito, Pasquale Raia

“…By developing statistical tools to study the evolution of the brain cortex at the fine scale, we found that rapid cortical expansion in the prefrontal region took place early on during the evolution of primates. …”
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Phenotypic Characterization, Evaluation, and Classification of Cassava (Manihot esculenta Crantz) Accessions in Ethiopia by Berhanu Bilate Daemo, Derbew Belew Yohannes, Tewodros Mulualem Beyene, Wosene Gebreselassie Abtew

“…Furthermore, the study identified the desirable accessions for desired storage root characteristics such as root constrictions, the external color of the storage root, the color of root pulp, the color of the root cortex, and cortex peeling tendency. In conclusion, the various analyses performed indicated the existence of sufficient genetic variability for the characteristics evaluated, which could be attributed to the dissimilar genetic backgrounds of the evaluated accessions. …”
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Effects of treadmill running on anxiety- and craniofacial pain-like behaviors with histone H3 acetylation in the brain of mice subjected to social defeat stress. by Kajita Piriyaprasath, Mana Hasegawa, Yuya Iwamoto, Rantaro Kamimura, Andi Sitti Hajrah Yusuf, Noritaka Fujii, Kensuke Yamamura, Keiichiro Okamoto

“…Behavioral and immunohistochemical experiments were conducted to evaluate the impact of TR regimens on SDS-related those behaviors, as well as epigenetic and neural activity markers in the anterior cingulate cortex (ACC), insular cortex (IC), rostral ventromedial medulla (RVM), and cervical spinal dorsal horn (C2). …”
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Modulation of High-Frequency rTMS on Reward Circuitry in Individuals with Nicotine Dependence: A Preliminary fMRI Study by Tao Wang, Ruiyang Li, Dongyan Chen, Mei Xie, Zhiqiang Li, Huan Mao, Yuting Ling, Xiaoyun Liang, Guojun Xu, Jianjun Zhang

“…This study aimed to investigate the effect of high-frequency rTMS with the left dorsolateral prefrontal cortex (L-DLPFC) as a target region on smoking addiction in nicotine-dependent individuals by detecting the change of spontaneous brain activity in the reward circuitry. …”
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Sufentanil enhances the cortical neurogenesis of rats with traumatic brain injury via PI3K/AKT signal pathway by Wei Gu, Mimi Wu, Ruocui Zhang, Peiyu Liu, Yang Jiao, Hui Rong

“…The oxidative stress, inflammation, nerve cell damage, melatonin, brain-derived neurotrophic factor (BDNF), neuron regeneration and p-AKT protein level in the cortex were detected with ELISA, TUNEL, qRT-PCR, immunofluorescence and Western blot. …”
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Correlation of precisely fabricated geometric characteristics of DNA-origami nanostructures with their cellular entry in human lens epithelial cells by Yexuan Guo, Tianze Xiong, Hong Yan, Rui Xue Zhang

“…More importantly, the vertex number among other geometric parameters was positively correlated with cellular entry. …”
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Brain Activation and Psychomotor Speed in Middle-Aged Patients with Type 1 Diabetes: Relationships with Hyperglycemia and Brain Small Vessel Disease by Misun Hwang, Dana L. Tudorascu, Karen Nunley, Helmet Karim, Howard J. Aizenstein, Trevor J. Orchard, Caterina Rosano

“…Exposure to hyperglycemia, measured as glycosylated hemoglobin A1c, was associated with longer response time and with higher activation in the inferior frontal gyrus and primary sensorimotor and dorsal cingulate cortex. Higher activation in inferior frontal gyrus, primary sensorimotor cortex, thalamus, and cuneus was related to longer response times; in contrast, higher activation in the superior parietal lobe was associated with shorter response times. …”
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Long-Term Treatment with Atypical Antipsychotic Iloperidone Modulates Cytochrome P450 2D (CYP2D) Expression and Activity in the Liver and Brain via Different Mechanisms by Przemysław J. Danek, Władysława A. Daniel

“…Like in the liver, iloperidone reduced CYP2D activity and protein levels in the frontal cortex and cerebellum but enhanced these levels in the nucleus accumbens, striatum and substantia nigra. …”
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Construction of an lncRNA-mediated ceRNA network to investigate the inflammatory regulatory mechanisms of ischemic stroke. by Meimei Xu, Shan Yuan, Xing Luo, Mengsi Xu, Guangze Hu, Zhe He, Xinyuan Yang, Rui Gao

“…Among the 31,183 lncRNAs detected in the rat cerebral cortex, 551 were differentially expressed between the MCAO and sham-operated groups in the ipsilateral cortex (fold change ≥2.0, P < 0.05). …”
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The Impact of Visual Perturbation Neuromuscular Training on Landing Mechanics and Neural Activity: A Pilot Study by Timothy R Wohl, Cody R Criss, Adam L Haggerty, Justin L Rush, Janet E Simon, Dustin R Grooms

“… # Results Following VPNT, LESS scores decreased by 1.5 ± 1.69 errors with a large effect size (0.78), indicating improved mechanics, and reductions in BOLD signal were observed in two clusters: 1) left supramarginal gyrus, inferior parietal lobule, secondary somatosensory cortex (p=.012, z=4.5); 2) right superior frontal gyrus, supplementary motor cortex (p<.01, z=5.3). …”
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Detection of Neuroinflammation in a Rat Model of Subarachnoid Hemorrhage Using [F]DPA-714 PET Imaging by Clément Thomas MD, Johnny Vercouillie PhD, Aurélie Doméné, Clovis Tauber PhD, Michael Kassiou PhD, Denis Guilloteau PhD, Christophe Destrieux MD, PhD, Sophie Sérrière PhD, Sylvie Chalon PhD

“…High SAH grades were strongly and positively correlated with in vivo PET imaging of TSPO in the cortex and striatum. In addition, a positive correlation was found in the cortex in TSPO, with densities determined by imaging and autoradiographic approaches. …”
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Single-cell transcriptomes reveal spatiotemporal heat stress response in maize roots by Ting Wang, Fanhua Wang, Shuhan Deng, Kailai Wang, Dan Feng, Fan Xu, Weijun Guo, Jia Yu, Yue Wu, Hada Wuriyanghan, Shang-Tong Li, Xiaofeng Gu, Liang Le, Li Pu

“…We characterize 15 cell clusters corresponding to 9 major cell types and identify cortex as the main root cell type responsive to HS with the most differentially expressed genes and its trajectory being preferentially affected upon HS. …”
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Distinct role of primate DLPFC and LIP in hierarchical control of learned saccade sequences by Qingjun Wang, Binchao Shi, Jing Jia, Jingyu Hu, Haoran Li, Xin Jin, Aihua Chen

“…By training monkeys to perform heterogeneous saccade sequences, we investigated the role of the dorsolateral prefrontal cortex (DLPFC) and the lateral intraparietal cortex (LIP) in sequence planning and execution. …”
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Phase-Amplitude Coupling of Neural Oscillations Can Be Effectively Probed with Concurrent TMS-EEG by Sarah Glim, Yuka O. Okazaki, Yumi Nakagawa, Yuji Mizuno, Takashi Hanakawa, Keiichi Kitajo

“…In a concurrent TMS-electroencephalography study, we therefore examined the technique’s influence on theta-gamma, alpha-gamma, and beta-gamma phase-amplitude coupling by delivering single-pulse TMS (sTMS) and repetitive TMS (rTMS) over the left motor cortex and right visual cortex of healthy participants. …”
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Insula Volume and Salience Network Are Associated with Memory Decline in Parkinson Disease: Complementary Analyses of Voxel-Based Morphometry versus Volume of Interest by Yan-Ting Lu, Wen-Neng Chang, Chiung-Chih Chang, Cheng-Hsien Lu, Nai-Ching Chen, Chi-Wei Huang, Wei-Che Lin, Ya-Ting Chang

“…VBM uncovered the notion that memory scores were positively correlated with the gray matter (GM) density in the insular cortex and a significant positive correlation between overall cognitive performance and concentration of GM within the lateral temporal cortex. …”
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Étudier les circuits courts par les traces numériques de leurs réseaux by Raphaël Stephens

“…A graph analysis method mobilizing tools from the CorText Platform helps identify exploratory results characterized by unequal relations within the network. …”
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