Circulating Isthmin-1 Levels and Their Relationship with Diabetes and Metabolic Diseases in Kuwaiti Adults by Eman Alshawaf, Sulaiman K. Marafie, Mohamed Abu-Farha, Ahmed N. Albatineh, Tahani Alramah, Aldana Albuhairi, Yafa Al Qassar, Reem Zinoun, Rawan Shalabi, Sarah Behbehani, Dalal Mohammed, Fahad Alajmi, Mohammed A. Abdalla, Ebaa Al-Ozairi, Mohammad Shehab, Muhammad Abdul-Ghani, Fahd Al-Mulla, Jehad Abubaker

“…Finally, the adjusted multinomial analysis suggested that higher levels of Ism1 may play a protective role against pre-diabetes (AOR = 0.88, 95% CI = 0.838, 0.925) and T2D (AOR = 0.87, 95% CI = 0.814, 0.934); Conclusions: This study suggests that reduced Ism1 levels are linked to increased insulin resistance, MAFLD, and T2D in obese individuals. …”
Get full text

Epidemiology of community-acquired pneumonia among hospitalised children in Indonesia: a multicentre, prospective study by Rina Triasih, Yan Mardian, Dewi Lokida, Helmia Farida, Herman Kosasih, Adhella Menur Naysilla, Arif Budiman, Chakrawati Hayuningsih, Moh Syarofil Anam, Dwi Wastoro, Mujahidah Mujahidah, Setya Dipayana, Amalia Setyati, Abu Tholib Aman, Nurhayati Lukman, Muhammad Karyana, Ahnika Kline, Aaron Neal, Chuen-Yen Lau, Clifford Lane

Get full text

Author Correction: Epidemiological drivers of transmissibility and severity of SARS-CoV-2 in England by Pablo N. Perez-Guzman, Edward Knock, Natsuko Imai, Thomas Rawson, Cosmo Nazzareno Santoni, Joana Alcada, Lilith K. Whittles, Divya Thekke Kanapram, Raphael Sonabend, Katy A. M. Gaythorpe, Wes Hinsley, Richard G. FitzJohn, Erik Volz, Robert Verity, Neil M. Ferguson, Anne Cori, Marc Baguelin

Get full text

Crinum jagus (J. Thomps. Dandy): Antioxidant and protective properties as a medicinal plant on toluene-induced oxidative stress damages in liver and kidney of rats by Mariama, Salihu, Gaber, El-Saber Batiha, Keneth Iceland, Kasozi, George D., Zouganelis, Souty M.Z., Sharkawi, Eman, Ibrahim Ahmed, Ibe Michael, Usman, Halima, Nalugo, Juma J., Ochieng, Ibrahim, Ssengendo, Olatayo Segun, Okeniran, Theophilus, Pius, Kyobe Ronald, Kimanje, Eric Simidi, Kegoye, Ritah, Kenganzi, Fred Ssempijja

Get full text

An Outbreak of Human Coronavirus OC43 Infection and Serological Cross-Reactivity with SARS Coronavirus by David M Patrick, Martin Petric, Danuta M Skowronski, Roland Guasparini, Timothy F Booth, Mel Krajden, Patrick McGeer, Nathalie Bastien, Larry Gustafson, Janet Dubord, Diane MacDonald, Samara T David, Leila F Srour, Robert Parker, Anton Andonov, Judith Isaac-Renton, Nadine Loewen, Gail McNabb, Alan McNabb, Swee-Han Goh, Scott Henwick, Caroline Astell, Jian Ping Guo, Michael Drebot, Raymond Tellier, Francis Plummer, Robert C Brunham

Get full text

Adherence to a digital therapeutic mediates the relationship between momentary self-regulation and health risk behaviors by Enzo G. Plaitano, Enzo G. Plaitano, Daniel McNeish, Sophia M. Bartels, Sophia M. Bartels, Kathleen Bell, Jesse Dallery, Michael Grabinski, Michaela Kiernan, Hannah A. Lavoie, Hannah A. Lavoie, Shea M. Lemley, Michael R. Lowe, David P. MacKinnon, Stephen A. Metcalf, Stephen A. Metcalf, Lisa Onken, Judith J. Prochaska, Cady Lauren Sand, Cady Lauren Sand, Emily A. Scherer, Luke E. Stoeckel, Haiyi Xie, Lisa A. Marsch

“…Self-regulation is one fundamental behavior change mechanism often incorporated within digital therapeutics as it varies momentarily across time and contexts and may play a causal role in improving these health behaviors. …”
Get full text

APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology by Kristine M. Tran, Nellie E. Kwang, Claire A. Butler, Angela Gomez-Arboledas, Shimako Kawauchi, Cassandra Mar, Donna Chao, Rocio A. Barahona, Celia Da Cunha, Kate I. Tsourmas, Zechuan Shi, Shuling Wang, Sherilyn Collins, Amber Walker, Kai-Xuan Shi, Joshua A. Alcantara, Jonathan Neumann, Duc M. Duong, Nicholas T. Seyfried, Andrea J. Tenner, Frank M. LaFerla, Lindsay A. Hohsfield, Vivek Swarup, Grant R. MacGregor, Kim N. Green

“…We used immunohistochemical and biochemical analysis along with single-cell spatial omics and bulk proteomics to explore the impact of the ApoeCh variant on AD pathological development and the brain’s response to plaques and tau. …”
Get full text

Low-dose trimethoprim-sulfamethoxazole for the treatment of Pneumocystis jirovecii pneumonia (LOW-TMP): protocol for a phase III randomised, placebo-controlled, dose-comparison tri... by Andrea Benedetti, Cecilia T Costiniuk, Kosar Khwaja, Andrew Johnson, Barret Rush, Darrell Tan, Ranjani Somayaji, Salman Qureshi, Michaeline McGuinty, Nicole Ezer, Sara Belga, Emily G. McDonald, Zahra N. Sohani, Guillaume Butler-Laporte, Andrew Aw, Alex Carignan, Matthew P. Cheng, Bryan Coburn, Dan Gregson, Alexander Lawandi, Victor Leung, Sylvain Lother, Derek MacFadden, Leighanne Parkes, Valerie Roy, Ilan Schwartz, Miranda So, Emilie Trinh, Todd C. Lee

“…Primary and secondary outcomes will be compared using logistic regression adjusting for stratification and presented with 95% CI.Ethics and dissemination This study has been conditionally approved by the McGill University Health Centre; Ethics approval will be obtained from all participating centres. …”
Get full text

Frameworks for the design and reporting of anaesthesia interventions in perioperative clinical trials by Karen D. Coulman, Lucy Elliott, Natalie S. Blencowe, Joyce Yeung, Leila Rooshenas, Robert J. Hinchliffe, Ronelle Mouton, Eric Albrecht, David Bosanquet, Kariem El-Boghdadly, Gudrun Kunst, Mandeep Phull, Helen Galley, Ben Gibbison, Suzanne Harrogate, Anna Simpson, Jasmeet Soar, Michael Gillies, Mr James Glasbey, Sina Grape, David Hewson, Simon Howell, Louise Savic, Alan MacFarlane, Brendan McGrath, Ciara O'Donnell, Jon Silversides, Katrina Pirie, Andrew Toner

“…Final frameworks are available at: https://anaesthesiaframeworks.blogs.bristol.ac.uk/. Conclusions: We provide novel frameworks to be used during the design of perioperative trials to facilitate the design, delivery, and reporting of anaesthesia interventions.…”
Get full text

Anxiety, Anger and Depression Amongst Low-Income Earners in Southwestern Uganda During the COVID-19 Total Lockdown by Archibong, Victor, Usman, Ibe Michael, Keneth Iceland, Kasozi, Osamudiamwen, Eric Aigbogun Jr., Josiah, Ifie, Monima, Ann Lemuel, Ssebuufu, Robinson, Chekwech, Gaudencia, Terkimbi, Swase Dominic, Owoisinke, Okon, Mbiydzenyuy, Ngala Elvis, Adeoye, Azeez, Aruwa, oshua Ojodale, Afodun, Adam Moyosore, Odoma, Saidi, Ssempijja, Fred, Ayikobua, Emmanuel Tiyo, Ayuba, John Tabakwot, Nankya, Viola, Onongha, Comfort, Sussan, Henry, Matama, Kevin, Yusuf, Helen, Nalugo, Halima, MacLeod, Ewan, Welburn, Susan Christina

Get full text

Out-of-Wedlock Pregnancy Among Single Mothers in Khartoum, Sudan: Sociodemographic Characteristics, Causes, and Consequences by Amal Abdelgadir Ali Mohamed, Elshafee Ahmed Apaker Babiker, Sohair Mohmoud Godat, Salma Mohammed Gomaa Doalbet, Aida AF Ahmed, Maha Hamed Mohamed Ali, Abdalkhaliq Ahmed Obadi, Amna Mohammed Ali Mustafa, Amani Awad Elkarim Taha, Amira Elnour Eltayeb Elbashir, Ragaa Gasim Ahmed, Fahad A Alghamdi, Waled AM Ahmed

“…Methods: This descriptive, cross-sectional study was conducted at the Mygoma Orphanage Center (MOC) and Shamaa Rehabilitation Center (SRC) using convenience sampling among 200 participants. …”
Get full text

Proteomics profiling of inflammatory responses to elexacaftor/tezacaftor/ivacaftor in cystic fibrosis by Hazel Ozuna, Hazel Ozuna, Dinesh Bojja, Santiago Partida-Sanchez, Luanne Hall-Stoodley, Amal Amer, Rodney D. Britt, Rodney D. Britt, Shahid Sheikh, David A. Frank, Weiyuan Wang, Bum-Yong Kang, Bum-Yong Kang, Irina Miralda, Irina Miralda, Samantha L. Durfey, Samantha L. Durfey, Benjamin T. Kopp, Benjamin T. Kopp

Get full text

Enhancing the understanding of safety and the quality of patient care among medical and health sciences students in interprofessional climate: an interventional study by Salman Yousuf Guraya, Nabil Sulaiman, Ahmed Hasswan, Vida Abdolhamid Salmanpour, Feras Jassim Jirjees, Mohamed Hassan Taha, Jennat Alamara, Sausan A.L. Kawas, Manal Awad, Jacqueline Maria Dias, Leena R. David, Mohamed Aly Haider, Shaista Salman Guraya, Nihar Ranjan Dash, Amal Al-Qallaf, Sarra Shorbagi, Ibrahim Eltayeb Mahmoud

“…BMC Health Services Research…”
Get full text

Representation of Hispanic Patients in Clinical Trials for Respiratory Failure: A Systematic Review by Emily A. Harlan, MD, MA, MSc, Kaitlin Malley, BS, Grecia Quiroga, MD, Eman Mubarak, MD, Pema Lama, BS, Amanda Schutz, PhD, Adolfo Cuevas, PhD, Catherine L. Hough, MD MSc, Theodore J. Iwashyna, MD PhD, Mari Armstrong-Hough, PhD, Thomas S. Valley, MD, MSc

“…Exclusion of participants who do not speak English may represent a barrier to trial enrollment.…”
Get full text

Practice patterns among early-career primary care (ECPC) physicians and workforce planning implications: protocol for a mixed methods study by Richard J Gibson, Tara Sampalli, Tara Kiran, Richard H Glazier, Agnes Grudniewicz, Kimberlyn McGrail, David Snadden, Ian Scott, M Ruth Lavergne, Laurie J Goldsmith, David Rudoler, Emily Gard Marshall, Megan Ahuja, Doug Blackie, Fred Burge, Steve Hawrylyshyn, Lindsay Hedden, Jacalynne Hernandez-Lee, Kathleen Horrey, Mike Joyce, Adrian MacKenzie, Maria Mathews, Rita McCracken, Madeleine McKay, Charmaine McPherson, Goldis Mitra, Gail Tomblin Murphy, Sabrina T Wong

“…There is speculation that PCPs, especially those early in their careers, may now be working less and/or choosing to practice in focused clinical areas rather than comprehensive family medicine, but little evidence to support or refute this. …”
Get full text

Gestational diabetes mellitus and offspring’s carotid intima–media thickness at birth: MySweetHeart Cohort study by Umberto Simeoni, Antje Horsch, Arnaud Chiolero, Yvan Vial, Nicole Sekarski, Jardena J Puder, Pascal Bovet, Stefano Di Bernardo, Yvan Mivelaz, Adina Mihaela Epure, Sandrine Estoppey Younes, Bobby Stuijfzand, Leah Gilbert, Stefano Lanzi, Justine Gross, Stefano Di Bernardo, Dan Quansah, Jean-Benoît Rossel, Amar Arhab, Sandrine Estoppey Younes, Seyda Mayerat

“…A longer-term follow-up that includes additional vascular measures, such as endothelial function or arterial stiffness, may shed further light on the cardiovascular health trajectories in children born to mothers with GDM.Trial registration number NCT02872974; Pre-results.…”
Get full text

Molecular Detection of Staphylococcal Enterotoxins and mecA Genes Products in Selected Food Samples Collected from Different Areas in Khartoum State by Mohammed Yahya Ahmed, Hashim Abdalbagi Ali, Babbiker Mohammed Taher Gorish, Sara Omer Ali, Eman Saif Aldein Abdalrhim, Mawada Hamza Mergani, Asmaa Abass Abd Elgadir, Somaya Khalid Mohammed, Salma Omer Ahmed, Naglaa Alsaeid Musa, Alaa Saeed Ahmed, Wafaa Mohammed Abdalla, Yousif Fadlallah Hamedelnil, Ahmed Ibrahim Hashim, Hisham N. Altayb

“…The PCR assay showed that the mecA gene was detected in 15 of 84 (17%) S. aureus isolates. …”
Get full text