PTPN2 Downregulation Is Associated with Albuminuria and Vitamin D Receptor Deficiency in Type 2 Diabetes Mellitus by Li Zheng, Wei Zhang, Aimei Li, Yan Liu, Bin Yi, Farid Nakhoul, Hao Zhang

“…PTPN2, an anti-inflammatory factor regulated by VDR, was reduced in T2DM CKD stages 1-2. Taken together, our results suggest that therapeutic strategies that enhance PTPN2 may be beneficial for controlling inflammation in T2DM.…”
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Identification and validation of the important role of KIF11 in the development and progression of endometrial cancer by Biying Wang, Lunmin Bao, Xiaoduo Li, Guang Sun, Wu Yang, Nanzi Xie, Ling Lei, Wei Chen, Hailong Zhang, Man Chen, Xing Zhao, Xiufang Wan, Rui Yuan, Hongmei Jiang

“…An analysis of TCGA data revealed that KIF11 is highly expressed in EC and is associated with tumor grade, stage, and a low survival rate. The overexpression of KIF11 in tumor tissues was further confirmed in EC patient samples. …”
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The neighborhood walk: introducing first-year medical students to social determinants of health in underserved neighborhoods by Tien C. Nguyen, Lilly W. Tang, Emma Bryant, Awa S. Jobe, Amy J. Yu, Yui Sugiura, Thuy Bui

“…Given the limited research on the feasibility and educational effects of SDoH experiences implemented at the early stages of medical education, this study presents a unique perspective on an interactive learning opportunity during the preclinical curriculum. …”
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Personnel Policy Strategy of the National Police of Ukraine in the Context of Updating Administrative and Legal Principles of Protecting Human Rights and Freedoms by A. V. Tanko

“…The modern challenges and directions of the personnel policy of the National Police of Ukraine in the conditions of social conflicts escalation are determined. It is stated that the improvement of the personnel policy of the National Police in all stages of its hierarchical structure and all its units has recently influenced, first of all, on the administrative and legal status of this state structure, focusing its activities on human rights and freedoms protection as a general state priority. …”
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CAREER GUIDANCE EXPERIENCE ABROAD by Sergey N. Tolstoguzov

“…The politics in the developed countries is based on interests of the individual: children’s acquaintance with the world of professions begins already at younger school and the moment of definitive selfdetermination is postponed till the end of their senior stage of education; the possibility of direction change of professional preparation in case of detection of discrepancy of qualities of the pupil to originally selected profile is provided. …”
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Prevalence and associated factors of healthy aging among community-dwelling older adults in Lishui city, China: a cross-sectional study by Jian-Hua Chen, Norhasmah Mohd Zain, Azlina Yusuf, Bi-He Ying

“…Participants were recruited by a multi-stage stratified cluster-sampling procedure from a mountainous region in Lishui City, Zhejiang Province, China. …”
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A Novel Immune-Related lncRNA-Based Model for Survival Prediction in Clear Cell Renal Cell Carcinoma by Zedan Zhang, Yanlin Tang, Yanjun Liu, Hongkai Zhuang, Enyu Lin, Lu Xie, Xiaoqiang Feng, Kaiwen Tian, Jiayi Zeng, Jiumin Liu, Yuming Yu

“…Its wide diagnostic capacity was revealed in different subgroups of clinical parameters. Then AJCC-stage, Fuhrman-grade, pharmaceutical, age, and risk score regarded as independent prognostic factors were integrated to construct a nomogram, whose good performance in predicting 3-, 5-, and 7-year overall survival of ccRCC patients was revealed by time-dependent ROC curves and verified by the testing sets and ICGC dataset. …”
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Can system dynamics explain long-term hydrological behaviors? The role of endogenous linking structure by X. Zhou, Z. Sheng, K. Manevski, K. Manevski, K. Manevski, R. Zhao, R. Zhao, Q. Zhang, Y. Yang, S. Han, J. Liu, J. Liu, Y. Yang, Y. Yang, Y. Yang

“…The system dynamics model is in its early stage with applications primarily confined to water-stressed regions and long-term scales. …”
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Determinants of children ever born among ever-married women in Bangladesh: evidence from the Demographic and Health Survey 2017–2018 by Atikur Rahman, Zakir Hossain, Mohammad Lutfor Rahman, Enamul Kabir

“…Objective To investigate the prevalence of the number of children ever born (CEB) and its associated determinants among women aged 15–49 years in Bangladesh.Study design and setting We used clustered data extracted from the last two Bangladesh Demographic and Health Surveys (BDHS 2014 and BDHS 2017–2018). A two-stage stratified sampling was used in both surveys. …”
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Predicting recurrence of non-muscle invasive bladder urothelial carcinoma: predictive value of the optimal cut-off value of Ki67 by Rende Peng, Yaoyu Zhang, Mingzhu Jia, Xinping Yi, Xiaoyao Yi, Shadan Li, Jiangchuan Pi, Wenjun Meng

“…High Ki67 expression (Ki67>18%) was significantly correlated with tumor stage (P=0.001), tumor grade (P=0.014), immediate postoperative instillation (P=0.001), the expression of P53 (P=0.019) and CK20 (P=0.001). …”
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Detection of Dengue Virus-Specific IgM and IgG Antibodies through Peptide Sequences of Envelope and NS1 Proteins for Serological Identification by Pradeep Kumar Nagar, Deepali Savargaonkar, Anupkumar R. Anvikar

“…Thus, precise diagnosis of dengue at the early stage is very essential for disease control and effective therapy in order to treat or prevent severe complications. …”
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Peculiarities of the special knowledge application in the investigation of taking a government official or law enforcement officer as hostage by O. Yu. Prokopenko

“…As a result of the study, the special knowledge has been classified, namely: by the procedural position of the person who uses it, by the form of expression, by the need to use special knowledge at a certain stage of investigation, by the form of the final result, by the field of knowledge, by the degree of secrecy, by the purpose of use, by the significance of the results obtained. …”
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Association between Growth Hormone and Insulin-like Growth Factor-1 (IGF-1) Levels, Liver Function and Short-Term Survival of Paediatric Liver Recipients by R. M. Kurabekova, O. M. Tsiroulnikova, I. E. Pashkova, L. V. Makarova, N. P. Mozheiko, A. R. Monakhov, O. P. Shevchenko

“…We examined 143 children with end-stage liver disease (ESLD) aged 3 to 73 (median 8) months after related LT. …”
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Unlocking the Potential of Receptor-Based Approaches in Diabetes Treatment by Mohsina Patwekar, Faheem Patwekar, J. Pavan Kumar, P. Dharani Prasad, Nazia Malik, A. Venkata Badarinath, Prashanth Parupathi, Konatham Teja Kumar Reddy, Selvaraja Elumalai, Zainul Abedeen Ab Samad

“…Despite being in early research stages, bile acid receptor agonists and mitochondrial uncouplers have promising potential for modifying lipid and glucose metabolism. …”
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The Impact of Migraine on the Whole Life Course of Patients: Results from the OVERCOME (Japan) 2nd Study by Daisuke Danno, Shiho Suzuki, Tsubasa Takizawa, Ryotaro Ishii, Masayuki Hamakawa, Yoshinori Tanizawa, Satoshi Osaga, Mika Komori

“…Conclusion Migraine affected many individuals from an early stage, but timely support and medical intervention were insufficient. …”
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Variability of the photoperiod response in guar (Cyamopsis tetragonoloba (L.) Taub.) genotypes of different geographic origin by S. B. Teplyakova, V. A. Volkov, E. А. Dzyubenko, E. К. Potokina

“…The observed fact confirms the hypothesis reported earlier about a two-stage launch of the flowering program in guar, according to which budding and flowering itself are controlled by independent gene  systems. …”
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Conflits armés et environnement by Al–Hamandou Dorsouma, Michel-André Bouchard

“…This paper discusses the applicability and usefulness of well established environmental assessment processes in various phases of conflict with emphasis on prevention, anticipation and attenuation of possible impacts.The analysis shows that environmental assessment may play a great role in situation of conflict, both at the pre- and post-conflict stage, and in some degree during the syn-conflict phases. …”
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Understanding the experiences of birthing care during COVID-19: A qualitative systematic review by Danielle Macdonald, Kristen Bigelow-Talbert, Amanda Ross-White, Erna Snelgrove-Clarke, Leah Sookhoo

“…Birth experiences must be respected and supported to ensure that health and wellness outcomes are optimized for families at all stages of the intrapartum, postpartum and early parenting journeys. …”
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Prevalence of malocclusion and orthodontic treatment need in a sample of 12-15-year-old kurdish schoolchildren in Ranyia district by Zana Qadir Omer, Hashem Omer Karim

“…Background and objectives: In recent years, much attention has been focused on measuring the severity and prevalence of malocclusion and orthodontic treatment need worldwide,in particular, the aetiological importance of genetic factors has been reduced, considering that many malocclusions recognize a post-natal origin related to habits at early stages of life and trauma.This study aimed to determine the prevalence of malocclusion and to evaluate the need for orthodontic treatment in school going children in Ranyia district in Kurdistan region of Iraq. …”
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Modified Endothelial Activation and Stress Index: A New Predictor for Survival Outcomes in Classical Hodgkin Lymphoma Treated with Doxorubicin-Bleomycin-Vinblastine-Dacarbazine-Bas... by Fazıl Çağrı Hunutlu, Hikmet Öztop, Vildan Gürsoy, Tuba Ersal, Ezel Elgün, Şeyma Yavuz, Selin İldemir Ekizoğlu, Azim Ali Ekizoğlu, Vildan Özkocaman, Fahir Özkalemkaş

“…<b>Results:</b> The median age at diagnosis was 33 years, and the rate of patients in the advanced stage was 67%. ROC analysis determined an optimal mEASIX score cut-off of 17.28, categorizing patients into mEASIX^high (47%) and mEASIX^low (53%) groups. …”
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