Combination Blockade of the IL6R/STAT-3 Axis with TIGIT and Its Impact on the Functional Activity of NK Cells against Prostate Cancer Cells by S. González-Ochoa, M. C. Tellez-Bañuelos, A. S. Méndez-Clemente, A. Bravo-Cuellar, G. Hernández Flores, L. A. Palafox-Mariscal, J. Haramati, E. J. Pedraza-Brindis, K. Sánchez-Reyes, P. C. Ortiz-Lazareno

“…Prostate cancer (PCa) is one of the neoplasms with the highest incidence and mortality rate in men worldwide. Advanced stages of the disease are usually very aggressive, and most are treated with chemotherapeutic drugs that generally cause side effects in these patients. …”
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From Dickens’s Theatrical Performance to Contemporary post Dickensian Narrative and Artistic Performance (Acker, Ackroyd, Waters and Rushdie) by Georges Letissier

“…With Dickens, who in this respect is very much in the Sternean-Shandian vein, theatrical performance is both inside the text (e.g. the parodic staging of Hamlet in Great Expectations) and outside the text, when dramatized versions of his novels are specially written to be acted out. …”
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Assist-linked brief intervention to reduce risky pattern of substance use in male workers employed at a tertiary care hospital in India: A randomized controlled trial by Sambhu Prasad, Debasish Basu, Surendra K. Mattoo, B. N Subodh

“…More participants receiving ALBI were ready to change to RCQ action stage (p values for tobacco, alcohol, and cannabis <0.001, <0.001 and 0.007, respectively). …”
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Differentially expressed microRNAs in pre-transplant lung biopsies target immune checkpoint proteins and can predict primary graft dysfunction in lung transplantation by Vitale Miceli, Pia Ferrigno, Claudio Centi, Claudia Carcione, Gioacchin Iannolo, Valentina Agnese, Giovanna Lo Iacono, Rosa Liotta, Pier Giulio Conaldi, Massimo Pinzani, Lavinia De Monte, Alessandro Bertani

“…Lung transplantation (LTx) significantly improves outcomes for patients with end-stage respiratory failure. However, primary graft dysfunction (PGD) remains one of the most relevant hurdles. …”
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Most diverse, most neglected: weevils (Coleoptera: Curculionoidea) are ubiquitous specialized brood-site pollinators of tropical flora by Haran, Julien, Kergoat, Gael J., de Medeiros, Bruno A. S.

“…Plants engaged in weevil-mediated pollination are generally of typical cantharophilous type exhibiting large, white and fragrant flowers or inflorescences and they also show specific structures to host the larval stages of their specialist pollinators. Another characteristic feature is that flowers often perform thermogenesis and exhibit a range of strategies to separate sexual phases, either spatially or temporally. …”
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Blood coagulation system in patients with chronic kidney disease: a prospective observational study by Xi Yang, Yang Wang, Ri-bao Wei, Ting-yu Su, Meng-jie Huang, Ping Li, Xiang-mei Chen, Ping Di, Qing-ping Li

“…During the 1-year of follow-up, one cardiovascular event occurred in patients with CKD 5 stage, whereas no thromboembolic event occurred in the CKD 3 and 4 and control groups.Conclusions Patients with CKD are characterised by endothelial dysfunction and increased coagulation, especially FVIII activity. …”
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Effectiveness of the User-Centered “Healthcare CEO” App for Patients With Type 1 Diabetes Transitioning From Adolescence to Early Adulthood: Protocol for a Randomized Controlled Tr... by Yueh-Tao Chiang, Hsing-Yi Yu, Pei-Kwei Tsay, Chi-Wen Chen, Chi-Wen Chang, Chien-Lung Hsu, Fu-Sung Lo, Philip Moons

“…This innovative app has the potential to improve the quality of care for adolescents with T1D during this critical stage and may serve as valuable evidence in support of app-based intervention strategies. …”
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Individualized diagnosis of Parkinson’s disease based on multivariate magnetic resonance imaging radiomics and clinical indexes by Qianqian Ye, Chenhui Lin, Fangyi Xiao, Tao Jiang, Jialong Hou, Yi Zheng, Jiaxue Xu, Jiani Huang, Keke Chen, Jinlai Cai, Jingjing Qian, Weiwei Quan, Yanyan Chen

“…The clinical-radiomics model was constructed by integrating clinical variables, including UPDRS, Hoehn-Yahr stage, age, sex, and MMSE scores. Receiver operating characteristic (ROC) curves were generated to evaluate the performance of the models. …”
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Cloning and expression analysis of the glucocorticoid receptors and the effects of cortisol in sex differentiation in protogynous hermaphroditic swamp eel, Monopterus albus by Jialin Su, Lei Sun, Jiaqi Yang, Weizhi Yao, Hongyan Xu, Ke Feng

“…During female-to-male sex reversal, the expression levels of gr1a and gr1b decreased significantly at the stage of ovotestis III, and gr2 showed a trend of increase, and increased significantly in the testis. …”
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Problems in the formation and implementation of the methodology for investigating homicides related to domestic violence by R. L. Stepaniuk, V. O. Husieva, V. V. Kikinchuk

“…This significantly affects the specification of typical investigative situations of the initial and subsequent stages of the investigation, as well as determines the specific tactics of certain procedural actions, including inspection of the scene, interrogation, involvement of experts, etc.…”
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The Consequences of Mining Damage and their Impact on the Natural Environment – a Case Study of Trzebinia by Krzysztof Cygańczuk, Jacek Roguski

“…Land reclamation is the necessity of degrading the natural environment and restoring it to its original state. Introduction: Europe is giving up fossil fuels to reduce CO2 emissions into the atmosphere. …”
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On the Role of the Institute of Headmen of Academic Groups in Russian Universities by Yu. S. Ezrokh

“…The given recommendations can be used in Russia and abroad at the state and local levels in order to improve the quality of the educational process in higher education institutions.…”
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First-Line Chemo-Immunotherapy in SCLC: Outcomes of a Binational Real-World Study by Laura Moliner, MD, Núria Zellweger, MSc, Sabine Schmid, MD, Martina Bertschinger, MD, Christine Waibel, MD, Ferdinando Cerciello, MD, PhD, Patrizia Froesch, MD, Michael Mark, MD, Adrienne Bettini, MD, Pirmin Häuptle, MD, Veronika Blum, MD, Lisa Holer, MSc, Stefanie Hayoz, PhD, Martin Früh, MD, Samreen Ahmed, FRCP, MD, MBBS, MSc, Shradha Bhagani, MD, Nicola Steele, MD, Hannah-Leigh Gray, BSc, Stephen D. Robinson, MD, Michael Davidson, MD (Res), Samantha Cox, MD, MSc, MBBCh, Taha Khalid, MD, Tom R. Geldart, MD, Luke Nolan, FRCS, PhD, Deborah C. Scott, MBChB (MRCP), Lindsay Hennah, MD, Tom Newsom-Davis, MD, PhD, Emma Rathbone, MD, PhD, Catherine Handforth, MD, Arshi Denton, MD, Shairoz Merchant, PhD, Fiona Blackhall, MD, PhD, Laetitia A. Mauti, MD, Raffaele Califano, MD, Sacha I. Rothschild, MD, PhD

“…Introduction: SCLC is characterized by aggressiveness and limited treatment options, especially in extensive-stage SCLC (ES-SCLC). Immunotherapy added to the platinum-etoposide combination has recently become standard in this setting. …”
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Assessment of the impact of HIV infection on the hypothalamic-pituitary-ovarian axis and pubertal development among adolescent girls at a tertiary centre in Zimbabwe: a cross-secti... by Bothwell Takaingofa Guzha, Bismark Mateveke, Hamish Mubata, Tapiwa Chapupu, Vongai Dondo, Maxwell Chirehwa, Rendani Tshikosi, Tsungai Chipato, Zvavahera Mike Chirenje

“…Pubertal milestones were assessed using the age of menarche and Tanner stage for breast and pubic hair development. Growth was assessed using World Health Organisation growth charts. …”
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Various endurance training intensities improve GFR and Up-regulate AQP2/GSK3β in lithium-induced nephropathic rats by Shadan Saberi, Mohammad Amin Rajizadeh, Mohammad Khaksari, Azadeh Saber, Mohammad Akhbari, Soheil Aminizadeh, Forouzan Rafie

“…Abstract Background Lithium is extensively used for mood stabilization in bipolar disorder, but its long-term use can lead to nephrotoxicity, characterized by a reduction in glomerular filtration rate (GFR) and potential progression to end-stage renal disease (ESRD). Exercise has been shown to have protective effects on renal function, yet the impact of varying exercise intensities on lithium-induced nephropathy is not well understood. …”
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Designing the Requirements of the Digital Health Literacy System Focusing on Cancer by Fatemeh Mirshekari, Elham Maserat

“…Materials and Methods: The present study was conducted in two phases of literature review and validity and reliability of requirements in 2023. In the first stage, a literature review was conducted with the keywords of digital health literacy, cancer, requirements, system and application in databases such as PubMed, Scopus, Google Scholar, academic Jihad scientific database and specialized websites. …”
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Advances in Stem Cell Therapy for Huntington’s Disease: A Comprehensive Literature Review by Siddharth Shah, Hadeel M. Mansour, Brandon Lucke-Wold

“…There is strong evidence supporting the transplantation of stem cells or their derivatives in HD animal models, even if stem-cell-based preclinical and clinical trials are still in their early stages. Current treatment only aims at relieving the symptoms rather than treating the pathogenesis of the disease. …”
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Integrative Omics Analysis Reveals Mechanisms of Anthocyanin Biosynthesis in Djulis Spikes by Chunmei Zheng, Wenxuan Ge, Xueying Li, Xiuzhang Wang, Yanxia Sun, Xiaoyong Wu

“…This research initially detected the anthocyanin content at different developmental stages of the spike and subsequently utilized an integrative approach, combining targeted metabolomics, transcriptomics, and untargeted metabolomics analyses, to elucidate the mechanisms of anthocyanin biosynthesis in the spikes of djulis. …”
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Energy intake insufficiency due to underestimated energy requirement by common predictive formulas can be identified by urinary amino acid levels in advanced heart failure by Yoko Sakamoto, Tomohito Ohtani, Kei Nakamoto, Fusako Sera, Shungo Hikoso, Yasushi Sakata

“…However, adequate assessment of energy balance is challenging because of unvalidated common prediction methods and unestablished determinants of REE, resulting in a lack of biomarkers for predicting insufficient energy intake.ObjectiveThis cross-sectional study aimed to evaluate REE in patients with advanced HF and explore biomarkers for insufficient energy intake.MethodsWe measured REE by indirect calorimetry and calculated the total energy expenditure (TEE) of 72 hospitalized patients with advanced-stage HF. We compared these values with commonly-used formulas and analyzed the associations between REE per body weight (REEBW) and parameters related to hemodynamics and HF severity. …”
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The impact of depression and anxiety disorders on postoperative outcomes for patients having total hip or knee arthroplasty: Protocol of a meta-analytic study from cohort studies. by Liang Lin, Qing Zhang, Min Xu, Zhihong Xiao, Guosong Xu, Zubing Mei

“…<h4>Background and purpose</h4>Total hip arthroplasty (THA) and total knee arthroplasty (TKA) are widely performed surgeries for end-stage joint disease, yet the influence of depression and anxiety on postoperative outcomes remains unclear. …”
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