Penalized landmark supermodels (penLM) for dynamic prediction for time-to-event outcomes in high-dimensional data by Anya H. Fries, Eunji Choi, Summer S. Han

“…Using penLM, the key features to predict lung cancer mortality included long-term lung cancer treatments, minority races, regions with low education attainment or racial segregation, and various patient-reported outcomes beyond cancer staging and tumor characteristics. When evaluated using the proposed metrics, the penLM model developed using multi-source data ( $$\:\overline{AUC}_{w}\:$$ of 0.77 [95% confidence interval: 0.74–0.79]) outperformed those developed using single-source data ( $$\:\overline{AUC}_{w}\:$$ range: 0.50–0.74). …”
Get full text

The System of Sociocultural Adaptation of Foreign Students at Leading Russian Universities (On the Example of Azerbaijani and Chinese Students) by V. Yu. Ledеneva, R. Abdullaev, L. Guseynova

“…The substantial role in this process falls to the share of universities and their educational system, which in the initial stages is aimed at accelerating the adaptation of foreign students to everyday life in Russia, also to provide high-quality and promising education.The article presents the results of a study conducted in order to investigate the features of sociocultural adaptation, the difficulties, which are faced by students during their education period and their expectations, coverage of the place and role of universities, therefore, and scientific and pedagogical staff. …”
Get full text

Multimedia: multimodal mediation analysis of microbiome data by Hanying Jiang, Xinran Miao, Margaret W. Thairu, Mara Beebe, Dan W. Grupe, Richard J. Davidson, Jo Handelsman, Kris Sankaran

“…Multimedia is a modular R package with close ties to the wider microbiome software ecosystem that makes statistically rigorous, flexible mediation analysis easily accessible, setting the stage for precise and causally informed microbiome engineering.…”
Get full text

Developing an indicator system and assessing China's progress on climate change adaptation in 2010–2022 from dual-dimension by Yang Song, Xiu Yang, Huimin Li, Mingyu Liu

“…Based on relevant theories, practices, and domestic and international strategic arrangements, we have developed an assessment indicator system from dual-dimension, encompassing both the adaptive stage and the adaptive sector, to assess China's progress in adapting to climate change over the period from 2010 to 2022. …”
Get full text

Use of approved cefazolin based intramammary dry goat treatment and its effects on the milk microbiota by Delower Hossain, Filippo Biscarini, Valentina Monistero, Paola Cremonesi, Bianca Castiglioni, Anoar Jamai Masroure, Alessandro Marinoni, Sara Fusar Poli, Matteo Mezzetti, Maria Filippa Addis, Valerio Bronzo, Erminio Trevisi, Paolo Moroni

“…On the other hand, shifts in microbial composition, including fluctuations in Firmicutes, Proteobacteria, and Actinobacteria, were primarily due to the lactation stage rather than the treatment. Differential abundance analyses identified non-pathogenic genera, such as Acinetobacter, Bacteroides, and Paracoccus, that varied between groups at different timepoints. …”
Get full text

Evaluation of S100A8/A9 and neutrophils as prognostic markers in metastatic melanoma patients under immune-checkpoint inhibition by Yasmin F Melzer, Nadine L Fergen, Christian Mess, Julia-Christina Stadler, Glenn Geidel, Ysabel A Schwietzer, Julian Kött, Klaus Pantel, Stefan W Schneider, Jochen Utikal, Ewa Wladykowski, Sabine Vidal-y-Sy, Alexander T Bauer, Christoffer Gebhardt

“…In 43 metastatic unresected stage III/IV melanoma patients, elevated serum levels of S100A8/A9 and neutrophils before and during ICI treatment correlated with worse outcomes. …”
Get full text

Topsoil Compaction Risk Based on the Different Responses of Soil Structure to Compaction Stress by Huiqing Zhang, Tingfeng He

“…We suggest that the response of the soil structure to compaction stress proceeds along three stages, elastic deformation, plastic deformation without structure failure, and soil structure failure, within which soil structure failure stress and precompression stress are the two key threshold stresses. …”
Get full text

A Self-Emulsifying Nanococktail of Pomegranate and Cannabidiol Reduces Cognitive Decline in Mice by Shoseyov O, Palatnik A, Dadon-Freiberg M, Dagan O, Shaltiel Karyo R

“…., Suite 570, Encino, CA, 91436, USA, Email ronitsh80@gmail.comIntroduction: Stress and inflammation in the early stages of cognitive decline has spurred interest in the use of antioxidants as prophylactic and therapeutic agents. …”
Get full text

Optimization extraction process of Shenghua Decoction and evaluation of its analgesic effects by Zhonghui Pu, Lijuan Chen, Huaidan Liu, Jingzhu Deng, Li Li, Liang Xiong, Liuying Li

“…The optimum conditions led to maximal combined content of ferulic acid and senkyunolide I at 1.2336 mg/g averaged from three validation tests (RSD = 1.84 %, n = 3), 0.9347 mg/g for ferulic acid and 0.2989 mg/g for senkyunolide I, and the bias ratio was 1.82 % compared with the predicted value of 1.251 mg/g, indicating the experimental values obtained from the BBD model agreed with that of the predicted values.Analgesic activity results indicated that SHD at all doses significantly reduced the number of twists induced by glacial acetic acid dose-dependently, and prolonged latency of foot licking to varying degrees at every stage of mice hot-plate test. This study not only developed a rapid and sensitive process that was successfully utilized for extracting SHD, but also discovered SHD with analgesic activity, which provided helpful information for further study.…”
Get full text

Perioperative tislelizumab plus chemotherapy for locally advanced gastroesophageal junction adenocarcinoma (NEOSUMMIT-03): a prospective, nonrandomized, open-label, phase 2 trial by Run-Cong Nie, Shu-Qiang Yuan, Ya Ding, Yong-Ming Chen, Yuan-Fang Li, Cheng-Cai Liang, Mu-Yan Cai, Guo-Ming Chen, Wei Wang, Xiao-Wei Sun, De-Sheng Weng, Dan-Dan Li, Jing-Jing Zhao, Xiao-Jiang Chen, Yuan-Xiang Guan, Zhi-Min Liu, Yao Liang, Ma Luo, Jun Chi, Hai-Bo Qiu, Zhi-Wei Zhou, Xiao-Shi Zhang, Ying-Bo Chen

“…This study enrolled patients with GEJA clinically staged as cT3-4aNanyM0 or cT1-2N+M0 from October 2022 to June 2023. …”
Get full text

Russian-Japanese Relations: Long-Term Development Factors by D. V. Streltsov

“…On the one hand, the anti-Russian component in Tokyo's foreign policy is shaped by its membership in the Security Treaty with the United States and its solidarity with the sanctions policy of the Group of Seven towards Russia. …”
Get full text

A Series of Novel Alleles of <i>Ehd2</i> Modulating Heading and Salt Tolerance in Rice by Peng Xu, Shulei Hao, Xiaoxia Wen, Guifang Ma, Qinqin Yang, Ling Liu, Galal Bakr Anis, Yingxin Zhang, Lianping Sun, Xihong Shen, Qunen Liu, Daibo Chen, Yongbo Hong, Yuyu Chen, Xiaodeng Zhan, Shihua Cheng, Liyong Cao, Weixun Wu

“…Transcriptomic analysis of <i>elh10</i> and ZH8015 seedlings exposed to salt stress for 24 h identified 5150 differentially expressed genes (DEGs) at the seedling stage, predominantly linked to stress response pathways. …”
Get full text

Depression, Substance Use, and Demographic Correlates among University Students: A Cross- Sectional Study among Students in Higher Educational Institution by Bala Ganesh Pichamuthu, Kalpana Kosalram, Sathya Thennavan, Sharmila Govardhanan

“…Students studying in higher education institutions are in an important life stage. It is usually the time when many students face pressures, which may lead to substance use disorders and mental health issues. …”
Get full text

Random forest model that incorporates solar-induced chlorophyll fluorescence data can accurately track crop yield variations under drought conditions by Guangpo Geng, Qian Gu, Hongkui Zhou, Bao Zhang, Zuxin He, Ruolin Zheng

“…However, these model types possess limitations, particularly in accounting for specific extreme climate events that occur during the growth stage. In this study, remote sensing data, climate data, and soil moisture data from the winter wheat growth period in northern China from 2003 to 2017 were used to construct a crop yield simulation model based on the Random Forest (RF) algorithm. …”
Get full text

High-Stability and Fast Calibration-Free Temperature Measurement Based on Light-Induced Thermoelastic Spectroscopy by Xiaonan Liu, Shunda Qiao, Ying He, Yufei Ma

“…These techniques utilize the steady-state and transient response characteristics of the quartz tuning fork (QTF), namely, the calibration-free LITES (CF-LITES) and calibration-free heterodyne LITES (CF-H-LITES) methods. …”
Get full text

Prevalence of chronic kidney disease in Saudi Arabia: an epidemiological population-based study by Mohammed A. Alshehri, Husain Y. Alkhlady, Zuhier A. Awan, Mohammed Ridha Algethami, Hadiah B. Al Mahdi, Hussam Daghistani, Khalid Orayj

“…The overall prevalence of CKD was 4.76%, with most having CKD in stage 3 (3.5%). The prevalence of CKD was higher among males compared to females (5.83% vs. 3.88%) and increased significantly with age, being 0.45% among participants aged 18–29 years and reaching 50.94% among participants aged 90 years or older. …”
Get full text

Hybridize Machine Learning Methods and Optimization Techniques to Analyze and Repair Welding Defects via Digital Twin of Jidoka Simulator by Ahmed M. Abed, Tamer S. Gaafar

“…The RRF is superior to Apriori, ECLAT, and FP Growth by 23.98%, 7.44%, and 8.38%, respectively, while CatBAS is superior to XG-boost by 94.62% in response time with a 1.04175% error that activates the treating stage-V quickly. The SQ(R/I/E) increased parcel rescues by 38.2% and reduced financial losses. …”
Get full text

Enhancing water use efficiency and fruit quality in jujube cultivation: A review of advanced irrigation techniques and precision management strategies by Yingying Xing, Mengru Chen, Xiukang Wang

“…The review systematically examines precise irrigation management practices tailored to the critical growth stages of jujube trees. Key findings indicate that the adoption of precise irrigation strategies, such as drip and micro-irrigation, minimizes water waste and effectively meets the specific water requirements of jujube trees. …”
Get full text

The role of the estimated glomerular filtration rate and body roundness index in the risk assessment of uric acid-lowering therapy-resistant gout in U.S. adults: evidence from the... by Mengyuan Zhu, Xingqiang Wang, Zining Peng, Weitian Yan, Qian Deng, Meihui Li, Nian Liu, Ling Zhang

“…It is necessary to monitor serum urate levels more closely and conduct early multidisciplinary comanagement when gout is comorbid with visceral obesity and chronic kidney disease stages 3–5.…”
Get full text

Long-Term Anatomic and Functional Outcomes after Macular Hole Surgery by Karolina Kaźmierczak, Joanna Stafiej, Joanna Stachura, Paweł Żuchowski, Grażyna Malukiewicz

“…These conditions, as well as probably early stage of diabetes mellitus, influenced functional outcomes of studied eyes. …”
Get full text