Creation of a recombinant Komagataella phaffii strain, a producer of proteinase K from Tritirachium album by A. B. Beklemishev, M. B. Pykhtina, Ya. M. Kulikov, T. N. Goryachkovskaya, D. V. Bochkov, S. V. Sergeeva, A. R. Vasileva, V. P. Romanov, D. S. Novikova, S. E. Peltek

“…The proteinase K gene was inserted into pPICZα-A in such a way that – at a subsequent stage of transfection into yeast cells – it was efficiently expressed under the control of the promoter and terminator of the AOX1 gene, and the product of the exogenous gene contained the signal peptide of the Saccharomyces cerevisiae a-factor to ensure the protein’s secretion into the culture medium. …”
Get full text

Omnidiversity Consolidation of Conservation Assessment: A Case Study of Tasmanian Coastal Geoconservation Sites by Jake Crisp, Joanna Ellison, Andrew Fischer

“…The exclusivity of biodiversity and geodiversity assessment hinders conservation outcomes, evidenced by the prioritization of biodiversity in conservation literature, and lagging developmental state in geodiversity assessment approaches, geoconservation strategies and outcomes. …”
Get full text

Effects of Selenium-Enriched Rape Returning Amount on Available Selenium Content in Paddy Soil and Selenium Accumulation in Rice by Wei Huang, Qingguo Xu, Ning Wu

“…Over time, soil available selenium showed a significant increasing trend, and the content of soil available selenium reached the maximum at tillering stage, and then decreased. (2) For selenium-rich varieties, when the amount of selenium-rich rapeseed returned to the field was less than 15 t/hm2, the selenium content in rice grains increased significantly with the increase of the amount of selenium-rich rapeseed returned to the field, then remained basically stable. …”
Get full text

Students' mathematical reasoning ability with visual, auditorial and kinesthetic learning styles in solving HOTS problems by Nadirotus Sholihah, Afifah Nur Aini

“…The instrument consists of a questionnaire, a mathematical reasoning test, and an interview guide. In the early stages, the researcher gave a questionnaire to 37 students to find out their learning styles, then chose two people from each learning style to take a mathematical reasoning test and interviews. …”
Get full text

Impact of HIF-1α, LOX and ITGA5 Synergistic Interaction in the Tumor Microenvironment on Colorectal Cancer Prognosis by Hayriye Tatlı Doğan, Mehmet Doğan, Seda Kahraman, Doğukan Çanakçı, Mehmet Ali Nahit Şendur, Mustafa Tahtacı, Fazlı Erdoğan

“…In patients with KRAS, NRAS or BRAF mutation and the moderate to strong expression of all three of these proteins in the tumor microenvironment, the number of metastatic lymph nodes was higher than in other patients. Stage IV patients with the moderate to strong expression of HIF-1α, ITGA5 or LOX in the microenvironment had lower progression-free survival than those with weak expression (<i>p</i> < 0.05). …”
Get full text

A novel perspective on survival prediction for AML patients: Integration of machine learning in SEER database applications by Zheng-yi Jia, Maierbiya Abulimiti, Yun Wu, Li-na Ma, Xiao-yu Li, Jie Wang

“…In addition, both the XGBoost classifier and the neural network classifier showed high accuracy and reliability at each prediction stage. Conclusion: Through in-depth analysis, this study provides a deeper understanding of the epidemiological characteristics of AML and successfully establishes a prediction model based on machine learning, which demonstrates good accuracy and reliability in predicting the prognosis of AML patients.…”
Get full text

Early release of circulating tumor cells after transarterial chemoembolization hinders therapeutic response in patients with hepatocellular carcinoma by María L. Espejo-Cruz, Sandra González-Rubio, Juan J. Espejo, Javier M. Zamora-Olaya, María Prieto-Torre, Clara I. Linares, Álvaro Ruiz-Ramas, Álvaro Jiménez-Arranz, Marta Guerrero-Misas, Pilar Barrera-Baena, Antonio Poyato-González, José L. Montero, Marina Sánchez-Frías, María D. Ayllón, Manuel L. Rodríguez-Perálvarez, Manuel de la Mata, Gustavo Ferrín

“…Abstract Background Transarterial chemoembolization (TACE) is the first-line therapeutic option for patients with intermediate-stage hepatocellular carcinoma (HCC). Tumor neovascularization allows tumor growth and may facilitate the release of circulating tumor cells (CTCs) to the bloodstream after TACE. …”
Get full text

Cost-Effective Autonomous Drone Navigation Using Reinforcement Learning: Simulation and Real-World Validation by Tomasz Czarnecki, Marek Stawowy, Adam Kadłubowski

“…A vital component of this approach is creating a multi-stage training environment that accurately replicates actual flight conditions and progressively increases the complexity of scenarios, ensuring a robust evaluation of algorithm performance. …”
Get full text

Technical progress of construction and safe operation of underground gas storage under complex geological conditions by Qiqi WANYAN, Yun WANG, Dongxu LI, Hongcheng XU, Chun LI, Kang LI, Jingcui LI, Lifeng LI

“…Thus, four challenges will be posed to the efficient construction and operation of gas storage, such as (1) the urgent need to perfect the theory and technology for dynamic sealing evaluation of gas storage geological bodies, (2) the capacity design technology for new gas storage types still in the initial stage, (3) inadequate utilization of gas well productivity and great demands for innovative supporting technologies, and (4) inadequate risk warning and safety control capabilities to meet the requirements of the safe operation of gas storage. …”
Get full text

Experimental Study on the Characteristics of Adsorbed Gas and Gas Production in Shale Formations by Zhiming Hu, Xianggang Duan, Nan Shao, Yingying Xu, Jin Chang, Rui Shen, Xueke Chen

“…Research indicated the following: (1) The gas occurrence state is the main factor that causes the difference of the pressure drop rate and gas production law of shale, coal, and tight sandstone. …”
Get full text

The impact of prolonged blockade of the releasing hormone on alterations in cardiac macrophage polarisation subsequent to quercetin administration in rats by T.A. Voroshylova, V.I. Shepitko, Ye.V. Stetsuk, N.V. Boruta, O.V. Vilkhova, M.V. Rud, G.S. Puzyryov, O.V. Sych, А.A. Miahkokhlib

“…The study employed a series of experimental periods, with the introduction of triptorelin and quercetin at varying stages. Materials and methods. The study was conducted on 60 sexually mature male rats. …”
Get full text

Assessing Glioblastoma Treatment Response Using Machine Learning Approach Based on Magnetic Resonance Images Radiomics: An Exploratory Study by Amirreza Sadeghinasab, Jafar Fatahiasl, Marziyeh Tahmasbi, Sasan Razmjoo, Mohammad Yousefipour

“…Methods MR images from 77 GBM patients were acquired at two post‐surgery stages and preprocessed. From these images, 107 radiomics were extracted from the segmented tumoral cavities. …”
Get full text

The Clinical Impact of Tumor Grade Heterogeneity in Nonmuscle- invasive Urothelial Carcinoma of the Bladder by Meftun Culpan, Ferhat Keser, Ayberk İplikci, Gözde Kır, Gökhan Atış, Asif Yıldırım

“…Patients with mixed-grade tumors had lower rates of pT1 stage diseases than those with high-grade tumors (42.5% vs. 64.0%, respectively) and higher rates than those with low-grade tumors (14.7% vs. 42.5%, respectively) (p=0.001). …”
Get full text

RUSSIAN–JAPANESE TRADE AND ECONOMIC RELATIONS: IS THERE A NEW FULCRUM? by D. V. Streltsov

“…However, given the political, juridical, organizational, technical and other problems, these projects are difficult for implementation at the present stage. In this situation, the allocation of a certain share for Japan in the strategic energy deposits of Siberia and the Far East and the admission of Japanese capital to the exploration and development of these deposits seem to be a realistic choice for Russian strategic planning towards Japan, as such a cooperation would not be a subject of Western sanctions against Russia. …”
Get full text

Theoretical and Methodological Framework of Typologization of Digital Identity by O.A. Persidskaya

“…</strong>The digital environment is becoming such a significant sphere of modern man&rsquo;s existence, that it determines the peculiarity of the social situation of the development of a modern man at different age stages, and determining the cultural and historical specifics of the development of higher mental functions and processes. …”
Get full text

Genomic characterization of three marine fungi, including Emericellopsis atlantica sp. nov. with signatures of a generalist lifestyle and marine biomass degradation by Ole Christian Hagestad, Lingwei Hou, Jeanette H. Andersen, Espen H. Hansen, Bjørn Altermark, Chun Li, Eric Kuhnert, Russell J. Cox, Pedro W. Crous, Joseph W. Spatafora, Kathleen Lail, Mojgan Amirebrahimi, Anna Lipzen, Jasmyn Pangilinan, William Andreopoulos, Richard D. Hayes, Vivian Ng, Igor V. Grigoriev, Stephen A. Jackson, Thomas D. S. Sutton, Alan D. W. Dobson, Teppo Rämä

“…The presence of unknown BGCs sets and large CAZyme repertoire set stage for further investigations of E. atlantica. …”
Get full text

Microbiological Quality of Meat and Swabs from Contact Surface in Butcher Shops in Debre Berhan, Ethiopia by Tefera Atlabachew, Jermen Mamo

“…Hence, adequate sanitary measures should be taken from production to consumption stages.…”
Get full text

Application of Polypyrrole Cellulose Nanocrystalline Composite Conductive Material in Garment Design by Si Su, Shaoying Hu, Qi Liu

“…The experimental results in this paper show that when the reaction time is 2 min, the reaction rate at this time is zero, indicating that this time is in the initial stage of the reaction. After 4 minutes, as the reaction time increases, the reaction rate shows an increasing trend; when the reaction time is longer than 10 minutes, the reaction rate increases slowly and has a downward trend, which indicates the end of the reaction. …”
Get full text

Life cycle assessment for calcination process of flue gas desulfurization gypsum and transformation into β-CaSO4·0.5H2O by Payal Bakshi, Asokan Pappu, Dhiraj Kumar Bharti

“…System boundary covers stages of procedure with cradle-to-gate approach. …”
Get full text

Liver Fibrosis Scores and Hospitalization, Mechanical Ventilation, Severity, and Death in Patients with COVID-19: A Systematic Review and Dose-Response Meta-Analysis by Menglu Liu, Kaibo Mei, Ziqi Tan, Shan Huang, Fuwei Liu, Chao Deng, Jianyong Ma, Peng Yu, Xiao Liu

“…The potential dose-response effect was performed using a stage robust error meta-regression. Results. Sixteen studies with 8,736 hospitalized patients with COVID-19 were included. …”
Get full text