TUBA1B as a novel prognostic biomarker correlated with immunosuppressive tumor microenvironment and immunotherapy response by Juntao Qi, Juntao Qi, Mingming Zhou, Na Yang, Huiyun Ma, Min He, Gujie Wu, Chang Ge, Liuyin Jin, Lin Cheng, Wei Liao, Hefei Ren, Caiyun Lei

“…We also conducted in vitro functional assays to assess TUBA1B’s functional role in tumor cells, allowing for a detailed examination of its relationship with cancer prognosis and immune modulation.Results: Our findings indicate that TUBA1B expression is dysregulated across multiple cancers, correlating strongly with poor survival outcomes and advanced pathological stages. Functional enrichment analyses further revealed that TUBA1B regulates key cell cycle processes, driving tumor proliferation, migration, and invasion. …”
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Diagnostic utility of translabial ultrasound in pelvic organ prolapse: a prospective observational study by Milosz Pietrus, Kazimierz Pityński, Iwona Gawron, Maciej W. Socha, Krzysztof Nowosielski, Robert Biskupski-Brawura-Samaha, Marcin Waligóra

“…This study explored the diagnostic utility of translabial ultrasound for POP, emphasising its correlation with clinical assessments based on International Continence Society (ICS) criteria.Methods Seventy-one patients with POP Quantification System (POP-Q) stage 0-IV with or without UI were prospectively enrolled at Jagiellonian University Medical College between 2014 and 2016. …”
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Archived Cytogenetic Cell Pellets Used to Detect a BCR::ABL1 Driver Mutation Eight Years before Disease Presentation by Ramakrishnan Sasi, Michelle Spruill, Peter L. Perrotta

“…By identifying individuals who are at increased risk, it may be possible to initiate preventive measures or begin treatment at an earlier stage before disease progression.…”
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Online sales funnel as an analytical tool for business efficiency management by E. Vasilieva, V. Loseva

“…A scenarios matrix for promoting information about a product, a brand, or a service using various communication channels has been compiled.Among various strategies of a sales funnel management the following three main strategies have been highlighted: the strategy of a proportional expansion (when increasing a traffic at the entrance of a funnel, which gives a large conversion, the funnel expands at all next stages, and the output result is increased); the strategy of stretching (increasing of a conversion at each level results in the output increasing), and the strategy of a key level (this strategy demands to determine the level of the funnel, which limits the entire system, and to apply efforts to improve conversion indicators at this special level). …”
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Stiffness of a fire-damaged reinforced concrete column during unloading after high-intensity horizontal impact by A. G. Tamrazyan, V. I. Chernik

“…In determining the unloading stiffness, a method based on direct consideration of the stress and strain distribution in the stress-strain stage corresponding to full unloading is used. The model takes into account different levels of axial loading, indirect reinforcement by transverse clamps, longitudinal bending and non-uniform stress distribution in the compressed zone of concrete.Results. …”
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Accelerating discoveries at DIII-D with the Integrated Research Infrastructure by T. Bechtel Amara, S. P. Smith, Z. A. Xing, S. S. Denk, A. Deshpande, A. O. Nelson, C. Simpson, E. W. DeShazer, T. F. Neiser, O. Antepara, C. M. Clark, J. Lestz, J. Colmenares, N. Tyler, P. Ding, M. Kostuk, E. D. Dart, R. Nazikian, T. Osborne, S. Williams, T. Uram, D. Schissel

“…The workflows developed for this project are intended to serve as prototypes that can be replicated on other experiments and can be run to provide timely and essential information for ITER, as well as next stage fusion power plants.…”
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Investigation of the Large-Scale Pallet by Recycled Polypropylene and the Sequential Valve Gate System during the Injection Molding by Chun-Der Cheng, Hsi-Hsun Tsai, Yi-Ling Liao

“…The PTC Creo software is used to construct plastic pallets (1100 mm×1100 mm×140 mm), filled by twelve gates using a baffle cooling system. During the four-stage filling of the sequential valve gate system, the flow front spreads from the central gate to the four corners of the pallet, decreasing the number of welding lines, with an average filling pressure of 19.23 MPa by a sequential valve gate scheme which is approximately 65% of the concurrent valve gate opening scheme. …”
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Tracking Deep Meteoric Fluid Circulation Along a Regional Detachment Fault Using Field Infrared Spectroscopy by Tom Brikowski, Chinomso Madubuike, Jeremy McDowell, Greg Greywall

“…That history begins with Mesozoic regional burial metamorphism of Paleozoic sediments, minor late Mesozoic contact metamorphism by silicic intrusives, followed by upwelling of hot metamorphic fluids after detachment initiation (11 MYA), later circulation of moderate-temperature meteoric-geothermal fluids, and young (< 5 MYA) hot epithermal fluids upwelling along detachment-cutting normal faults. Each of these stages is characterized by distinct changes in sheet silicate mineral crystallinity and hydration. …”
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The Emerging Role of Implementing Machine Learning in Food Recommendation for Chronic Kidney Diseases Using Correlation Analysis by Sachin Gupta, Neeraj Garg, Divyanshu Sinha, Babita Yadav, Bhoomi Gupta, Shahajan Miah

“…The results have proved that the ML algorithm detects the risk of CKD occurrence accurately in each stage via analyzing blood sugar, creatinine, and potassium levels. …”
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Developing a Label-Free Infrared Spectroscopic Analysis with Chemometrics and Computational Enhancement for Assessing Lupus Nephritis Activity by Mei-Ching Yu, Xiang-Di Huang, Chin-Wei Kuo, Kai-Fu Zhang, Ping-Chung Liang, U-Ser Jeng, Pei-Yu Huang, Frederick Wai Keung Tam, Yao-Chang Lee

“…The RAD gap (Ψ), defined as the difference in the RAD values between the initial and final stages of serum dehydration, enables the measurement of serum levels of IgG glycosylation (ν₁ (1030 cm⁻¹), ν₂ (1171 cm⁻¹)), serum lactate (ν₁ (1021 cm⁻¹), ν₂ (1171 cm⁻¹)), serum hydrophobicity (ν₁ (2930 cm⁻¹), ν₂ (2960 cm⁻¹)), serum hydrophilicity (ν₁ (1550 cm⁻¹), ν₂ (1650 cm⁻¹)), and albumin (ν₁ (1400 cm⁻¹), ν₂ (1450 cm⁻¹)). …”
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PROTON RADIATION THERAPY: CLINICAL APPLICATION OPPORTUNITIES AND RESEARCH PROSPECTS by M. V. Zabelin, V. A. Klimanov, J. J. Galyautdinova, A. S. Samoilov, A. O. Lebedev, E. V. Shelyhina

“…The data obtained from experience of use of proton radiation therapy with passively scattered fascicle for cancer therapy of a prostate at an early stage showed the admixed results in comparison with modern methods of radiation therapy with the modulated intensity. …”
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SALIVARY FUNCTION AND BIOMARKER PROFILES IN RELATION TO ORAL HEALTH IN PATIENTS WITH PRE-DIALYSIS CHRONIC KIDNEY DISEASE by Georgiana Florentina Gheorghe, Laura Iosif, Oana Elena Amza, Bogdan Dimitriu, Liliana Gârneaţâ, Alexandra Ripszky Totan, Ana Maria Cristina Ţâncu

“…Renal function was compromised, with median eGFR placing 90.2% (n=46) in CKD stages 3–5. Significant associations included filled teeth and stimulated saliva (p<0.01), missing teeth and salivary calcium (p<0.05), filled teeth and IL-6 (p<0.05), and lower creatinine levels correlating with higher DMFT (p<0.01). …”
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Experience in setting up non-robotic minimally invasive direct coronary artery bypass grafting in a non-routine off-pump coronary artery bypass center by Yukiharu Sugimura, Tomoyuki Suzuki, Sebastian Johannes Bauer, Friederike Irmgard Schoettler, Moritz Benjamin Immohr, Michael André Maliwa, Arash Mehdiani, Lachmandath Tewarie, Gereon Schaelte, Ajay Moza, Payam Akhyari

“…MACCE occurs more frequently in the early stages when adopting this surgical technique.…”
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Plant Disease Classifier: Detection of Dual-Crop Diseases Using Lightweight 2D CNN Architecture by Hasibul Islam Peyal, Md. Nahiduzzaman, Md. Abu Hanif Pramanik, Md. Khalid Syfullah, Saleh Mohammed Shahriar, Abida Sultana, Mominul Ahsan, Julfikar Haider, Amith Khandakar, Muhammad E. H. Chowdhury

“…It is critical to detect these disorders at an early stage of diagnosis. The purpose of this work is to categorize 14 classes for both cotton and tomato crops, with 12 diseased classes and two healthy classes using a deep learning-based lightweight 2D CNN architecture and to implement the model in an android application named &#x201C;Plant Disease Classifier&#x201D; for smartphone-assisted plant disease diagnosis system, the results of the experiments reveal that the proposed model outperforms the pre-trained models VGG16, VGG19 and InceptionV3 despite having fewer parameters. …”
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Medical complexity in emergency and urgent care settings: a scoping review protocol by Diane Lorenzetti, Tanvir C Turin, Sumedh Bele, Eddy Lang, Doreen Rabi, Naomi Popeski, Marie-Claire Uwamahoro, Conne Lategan, Kate Yakubets, Cassandra Chisholm

“…The Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews checklist will be used to report the selection of studies at different stages.Ethics and dissemination Scoping review methodology uses and reviews publicly available studies and data, so ethics approval is not required. …”
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Physical activity and exercise recommendations for people receiving dialysis: A scoping review. by Kelly Lambert, Courtney J Lightfoot, Dev K Jegatheesan, Iwona Gabrys, Paul N Bennett

“…Key search terms included "kidney disease" OR "kidney failure" OR "chronic kidney disease" OR "end stage kidney disease" AND guideline* OR consensus OR "position statement" OR prescription OR statement AND exercise OR "physical activity". …”
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Effect of music therapy on behavioral and physiological neonatal outcomes: A systematic review and dose-response meta-analysis. by Fatemeh Shahbazi, Marzieh Fattahi-Darghlou, Samad Moslehi, Minoo Dabiri-Golchin, Marjan Shahbazi

“…Ultimately, we employed a two-stage random effects model using the "drmeta" package in Stata software to perform this dose-response meta-analysis.…”
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Uncertainty-aware diabetic retinopathy detection using deep learning enhanced by Bayesian approaches by Mohsin Akram, Muhammad Adnan, Syed Farooq Ali, Jameel Ahmad, Amr Yousef, Tagrid Abdullah N. Alshalali, Zaffar Ahmed Shaikh

“…Abstract Deep learning-based medical image analysis has shown strong potential in disease categorization, segmentation, detection, and even prediction. However, in high-stakes and complex domains like healthcare, the opaque nature of these models makes it challenging to trust predictions, particularly in uncertain cases. …”
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Risk of bias and confounding of observational studies of Zika virus infection: A scoping review of research protocols. by Ludovic Reveiz, Michelle M Haby, Ruth Martínez-Vega, Carlos E Pinzón-Flores, Vanessa Elias, Emma Smith, Mariona Pinart, Nathalie Broutet, Francisco Becerra-Posada, Sylvain Aldighieri, Maria D Van Kerkhove

“…Utilization of the standardized research protocols developed by the WHO, PAHO, Institut Pasteur, and CONSISE will harmonize the key methodological aspects of each study design to minimize bias at different stages of the study. Biases need to be considered by researchers implementing the standardized protocols as well as by users of observational epidemiological studies of ZIKV.…”
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Detection of Circulating Tumor DNA in Patients with Thyroid Nodules by Krupal B. Patel, Nicholas Cormier, James Fowler, Allison Partridge, Julie Theurer, Morgan Black, Nicole Pinto, John Yoo, Kevin Fung, Danielle MacNeil, William Stecho, Christopher Howlett, Muriel Brackstone, John W. Barrett, Anthony Nichols

“…On final pathology, 38 (32.8%) patients had benign thyroid nodules, 45 (38.8%) had classical papillary thyroid cancer (PTC), 23 (19.8%) had nonclassical PTC, and 3 (2.6%) had follicular thyroid cancer. 15/109 patients had detectable BRAF (V600E) ctDNA in their preoperative samples—all of them having classical PTC. Higher T-stage and extrathyroidal extension in PTC were associated with positive BRAF (V600E) ctDNA (p<0.05). …”
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