improving Pain mAnagement for childreN and young people attendeD by Ambulance (PANDA): protocol for a realist review. [version 3; peer review: 2 approved, 1 approved with reservati... by Paul Leighton, Georgette Eaton, Georgie Nicholls, Kacper Sumera, Marishona Ortega, Jessica Hodgson, Michael Baliousis, Aloysius Niroshan Siriwardena, Despina Laparidou, Bill Lord, Sarah Redsell, Gregory Adam Whitley, Tatiana Bujor

“…Methods A realist review will be conducted in accordance with the Realist And Meta-narrative Evidence Syntheses: Evolving Standards (RAMESES) guidance. A five-stage approach will be adopted; 1) Developing an Initial Programme Theory (IPT): develop an IPT with key stakeholder input and evidence from informal searching; 2) Searching and screening: conduct a thorough search of relevant research databases and other literature sources and perform screening in duplicate; 3) Relevance and rigour assessment: assess documents for relevance and rigour in duplicate; 4) Extracting and organising data: code relevant data into conceptual “buckets” using qualitative data analysis software; and 5) Synthesis and Programme Theory (PT) refinement: utilise a realist logic of analysis to generate context-mechanism-outcome configurations (CMOCs) within and across conceptual “buckets”, test and refine the IPT into a realist PT. …”
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On the human nature (following in the steps of Belyaev) by A. L. Markel

“…The vital importance of the new possibilities for social communication in human populations disposes to the fixation of genetic features that facilitate such communication. At the early stages of human evolution, the areas of the cerebral cortex that were responsible for the development of speech expanded and reorganized. …”
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Steroids In caRdiac Surgery (SIRS) trial: acute kidney injury substudy protocol of an international randomised controlled trial by Michael Walsh, Salim Yusuf, Chirag Parikh, Jessica Vincent, P J Devereaux, Francois Lamontagne, Matthew T V Chan, Richard Whitlock, Meaghan Cuerden, Amit X Garg, Andre Lamy, Daniel I Sessler, Kevin Teoh, Ainslie Hildebrand, Yunxia Zuo, Pallav Shah, Seyed Hesameddin Abbasi, Mackenzie Quantz, Jean-Pierre Yared, Nicolas Noiseux, Georgios Tagarakis, Antoine Rochon, Janice Pogue, Abbas Salehiomran

“…The authors will use a logistic regression to estimate the adjusted OR of methylprednisolone versus placebo on the primary outcome of AKI in the 14 days following surgery (a postoperative increase in serum creatinine of ≥50%, or ≥26.5 μmol/L, from the preoperative value). The stage of AKI will also be considered, as will the outcome of AKI in those with and without preoperative chronic kidney disease. …”
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A Simple Machine Learning-Based Quantitative Structure–Activity Relationship Model for Predicting pIC₅₀ Inhibition Values of FLT3 Tyrosine Kinase by Jackson J. Alcázar, Ignacio Sánchez, Cristian Merino, Bruno Monasterio, Gaspar Sajuria, Diego Miranda, Felipe Díaz, Paola R. Campodónico

“…<b>Conclusions:</b> These results represent a significant advancement in the field of FLT3 inhibitor discovery, offering a reliable, practical, and efficient approach for early-stage drug development, potentially accelerating the creation of targeted therapies for AML.…”
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Early referral to nephrological care improves long-term survival and hospitalization after dialysis initiation, independent of optimal dialysis start – a call for harmonization of... by Mathias Haarhaus, Lavinia O. Bratescu, Nicolae Pana, Emanuela M. Gemene, Eliana M. Silva, Carla Alexandra R. Santos Araujo, Fernando Macario

“…Early treatment of kidney disease can slow disease progression and reduce the increased risk of mortality associated with end-stage kidney disease. However, uncertainty exists whether early referral (ER) to nephrological care per se or an optimal dialysis start impacts patient outcome after dialysis initiation. …”
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Supporting Smart Manufacturing in the Space Industry: A Case Study by Ala Arman, Andrea Lombardo, Flavia Monti, Massimo Mecella

“…ABSTRACT In the era of Industry 4.0, the New Space Economy, often called Space 4.0, has taken center stage in the satellite industry. The advent of mega‐constellations, which entails mass satellite production, necessitates state‐of‐the‐art manufacturing methods. …”
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The Management of the Aortic Arch in Type A Aortic Dissection: Replace, Repair with the AMDS, or Leave for Another Day? by Ryaan EL-Andari, Michael C. Moon

“…TAR allows for single or staged repair of extensive pathologies and can address distal entry tears, the aneurysmal arch, and head vessel pathologies. …”
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Strategies to mitigate the impact of the COVID-19 pandemic on child and youth well-being: a scoping review protocol by Jeanna Parsons Leigh, Henry T Stelfox, Perri R Tutelman, Diane L Lorenzetti, Melanie C Anglin, Kirsten M Fiest, Stephana Julia Moss, Emily A FitzGerald, Stacie Smith, Micaela Harley, Kathryn Birnie, Sara J Mizen

“…This scoping review will identify, describe and categorise strategies taken to mitigate potentially deleterious impacts of the COVID-19 pandemic on children, youth and their families.Methods and analysis We will conduct a scoping review following the Arksey-O’Malley five-stage scoping review method and the Scoping Review Methods Manual by the Joanna Briggs Institute. …”
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Optical Coherence Tomography by Pier Alberto Testoni

“…The technique may therefore be used to identify preneoplastic conditions of the gastrointestinal tract, such as Barrett's epithelium and dysplasia, and evaluate the depth of penetration of early-stage neoplastic lesions. OCT imaging of the pancreatic and biliary ductal system could improve the diagnostic accuracy for ductal epithelial changes, and the differential diagnosis between neoplastic and non-neoplastic lesions.…”
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Detection of Cannabinoid Receptor Expression by Endometriotic Lesions in Women with Endometriosis as an Alternative to Opioid-Based Pain Medication by Sarah Allam, Elizabeth Paris, Itzel Lazcano, Pincas Bitterman, Sanjib Basu, James O’Donnell, Animesh Barua

“…Endometriosis is a disease of women of reproductive age associated with infertility and reproductive failure as well as chronic pain of varying degrees depending on the stage of the disease. Currently, opioids are being preferred over nonsteroidal anti-inflammatory drugs (NSAID) due to the latter’s side effects. …”
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Performance Evaluation of Lablab Genotypes across Various Locations of Ethiopia by Melkam Aleme

“…The data were collected on the establishment, days to different physiological stages, forage yields, soil properties, and other related parameters. …”
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Influence of Dry Beach on the Dynamic Stability of Ash Storage Field: A Numerical Analysis by Fangtao She, Chang Liu, Xiangang Zhou, Changjun Qi, Jiulong Ding

“…In this study, an in situ standard penetration test was carried out on a constructed ash storage site in Northwest China to evaluate the potential for liquefaction of alluvial fly ash within the site, and the results show that dynamic liquefaction can occur within a newly constructed three-stage subdam. A numerical analysis of the influence of dry beach length on the dynamic response of the primary dams and subdams and an assessment of the extent of dynamic liquefaction in the ash storage field were carried out using the Wenchuan seismic waves as input ground motion. …”
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PATIENTS' CHRONOTYPE INFLUENCE IN TREATMENT EFFICIENCY OF PLACENTA CRYERXTRACT CHANGES IN MAXILLOFACIAL PHLEGMONS by K. Lokes, M. Pérez Sayáns, V. Lychman, D. Steblovskyi, I. Boiko, D. Avetikov

“…In the control group, significant changes were noted only in the late stages of treatment. The dependence of lipid peroxidation markers on the timing of surgical intervention on the patient's circadian rhythm was established, which is most clearly observed in the 2nd clinical group. …”
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TLR7 Polymorphism (rs179008 and rs179009) in HIV-Infected Individual Naïve to ART by HariOm Singh, Dharmesh Samani, Sumit Aggarwal

“…TLR7 rs179009AG genotype was significantly underrepresented in the intermediate HIV disease stage compared with healthy controls (OR=0.03, P=0.04). …”
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Association of early aspirin use with 90-day mortality in patients with sepsis: an PSM analysis of the MIMIC-IV database by Chunsheng Huang, Qiaoling Tong, Wenyuan Zhang, Zhihao Pan

“…This study aimed to examine the correlation between the administration of aspirin at an early stage and the 90-day mortality rate among sepsis patients.MethodsIn order to distinguish between septic patients who received early aspirin treatment and those who did not, queries were conducted on the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. …”
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Physiological characteristics of IRR 400 series rubber clones (Hevea brasiliensis Muell. Arg.) under drought stress [version 4; peer review: 1 approved, 2 approved with reservation... by Mohammad Basyuni, Yaya Hasanah, Syarifah Aini Pasaribu, Edison Purba

“…The present study aimed to identify drought tolerant traits in order to select or identify drought-tolerant clones at juvenile stage. Methods The first factor examined for this work was clones (IRR 425, IRR 428, IRR 429, IRR 434, IRR 440, RRIC 100, and BPM 24) and the second factor was water content (30%, 60%, and 90%). …”
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Prevalence of Fabry Disease among Patients with Parkinson’s Disease by Alexandra Lackova, Christian Beetz, Sebastian Oppermann, Peter Bauer, Petra Pavelekova, Tatiana Lorincova, Miriam Ostrozovicova, Kristina Kulcsarova, Jana Cobejova, Martin Cobej, Petra Levicka, Simona Liesenerova, Daniela Sendekova, Viktoria Sukovska, Zuzana Gdovinova, Vladimir Han, Mie Rizig, Henry Houlden, Matej Skorvanek

“…Clinical and sociodemographic data, including the MDS-UPDRS-III scores and HY stage (the Hoehn and Yahr scale), were collected, and in-depth phenotyping was performed in subjects with identified GLA variants. …”
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TRANSREGIONAL PARTNERSHIP OF BRICS IN RUSSIAN STUDIES by A. A. Konkin

“…This is the primarily due to the economic aspect: the creation of the New Development Bank completes the first stage of the creation BRICS how the formalized association. …”
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Effectiveness of Voytik-Harbin Protocol in Fabrication of Ram’s Testicular-Derived Hydrogel and Its Impact on Mouse In Vitro Spermatogenesis by Leila Rashki Ghaleno, Tohid Rezaei Topraggaleh, Leila Montazeri, Abdolhossein Shahverdi, Mojtaba Rezazadeh Valojerdi

“…Subsequently, mouse testicular cells were cultivated on collagen hydrogel as the control and the moreeffective testicular-derived hydrogel (TDH) to evaluate the early stages of in vitro spermatogenesis.Results: While the Freytes protocol produced a homogeneous pre-gel solution with both HCl concentrations; elevatingthe pH to 7.4 loosened the hydrogel and made gelation problematic. …”
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Understanding the use of co-design methods for research involving older adults living with HIV: A scoping review protocol. by Paige Brown, Hardeep Singh, Esther Su, Luxey Sirisegaram, Sarah E P Munce, Andrew D Eaton, Alice Zhabokritsky, Stuart McKinlay, Kristina M Kokorelias

“…The methodology encompasses six stages: 1) developing research questions, 2) creating a search strategy, 3) screening and selecting evidence, 4) data extraction, 5) data analysis using content analysis, and 6) consultation with key stakeholders, including community partners and individuals with lived experience. …”
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