Oridonin ameliorates renal fibrosis in diabetic nephropathy by inhibiting the Wnt/β-catenin signaling pathway by Jushuang Li, Lan Shu, Qianqian Jiang, Baohong Feng, Zhimin Bi, Geli Zhu, Yanxia Zhang, Xiangyou Li, Jun Wu

“…Diabetic nephropathy (DN) is one of the most serious and frequent complications among diabetes patients and presently constitutes vast the cases of end-stage renal disease worldwide. Tubulointerstitial fibrosis is a crucial factor related to the occurrence and progression of DN. …”
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Genetic control of scald resistance in barley landraces by O. N. Soboleva, G. S. Konovalova, E. E. Radchenko

“…The resistance genes of these forms are manifested during all the stages of plant ontogenesis.…”
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University proceedings. Volga region. Social sciences by N.V. Prokazina, Ya.A. Yukhnevich

“…The conducted analysis allows us to con-sider ageism as a social phenomenon that includes behavioral and emotional components based on the age stages of a person's life. It is argued that ageism manifests itself both in relation to representatives of the older and younger generations. …”

Possible Threats of IgA Vasculitis in Children: One Center Experience by Eglė Lanzbergaitė-Manuilova, Skirmantė Rusonienė, Augustina Jankauskienė

“…Easy obtained laboratory parameters such as NLP, PLR could help to predict GI involvement in early disease stage, but had no value for predicting kidney involvement. …”
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Deciphering sepsis: transforming diagnosis and treatment through systems immunology by Robert E. W. Hancock, Andy An, Claudia C. dos Santos, Amy H. Y. Lee

“…Longitudinal within-patient analyses can also reveal mechanisms (including epigenetics) that drive differential sepsis trajectories over time, enabling the prospect of disease stage-specific therapy during and after hospitalization, including for post-sepsis and long COVID syndromes. …”
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Behavior of soil aggregates in reclaimed farmland with different restoration durations: Mediating factors and mechanisms by Zhaoxinyu Liu, Junying Li, Lina Gao, Xinju Li, Wen Song, Luofan Li, Yulong Zang, Gengdi Zhang

“…Soil aggregates, particularly macroaggregates, served as mediators within the RMS system. In the early stages of reclamation, inorganic cementing agents were crucial for maintaining RMS aggregation and SOC sequestration. …”
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Linking the Historical Sample of the Netherlands with the USA Censuses, 1850–1940 by Diogo Paiva, Francisco Anguita, Kees Mandemakers

“…For this purpose, a linking process was designed, comprising of three stages: harmonization, matching and validation. The different nature of the two datasets (HSN and the USA Censuses) asked for some harmonization prior to the matching. …”
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Quantitative Analysis of COVID-19 Pandemic Responses Based on an Improved SEIR-SD Model by Yang Liu, Bingrui Liu, Yi Deng, Jia Liu

“…The results show that both the medical and administrative efforts, especially in the early stage of the epidemic, are significant in reducing the number of infections and shortening the epidemic period. …”
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Why and how to create training sessions in the form of a game at a university? by Mariia I. Sharko

“…The algorithm includes: targeting based on the formed competence and type of occupation; Definition of activity content; development of a system of training assignments; identification of the features of the group affecting educational and gaming activities; determining a gaming base and a gaming task; selection of methods of influencing the emotional state of students; preparation of educational means. …”
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Government Responses to COVID-19: A Comparative Analysis of Visegrad Countries by Zafer Koca

“…Originality/Value: The study aims to contribute a detailed and comparative analysis of government responses and challenges of V4 countries in the fight against Covid-19 in the initial stage of the outbreak. …”
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Religious Fatwā and Human Security: Managing Public Health through the Lens of Islamic Jurisprudence in Indonesia and Saudi Arabia by Khairul Hamim, Lalu Supriadi Bin Mujib, Ahmad Muhasim

“…This fatwā is especially pertinent given the roles of MUI and CSS, which, from the early stages of the COVID-19 pandemic, have contributed to supporting government policies through the fatwā they issued. …”
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Microglial Nrf2-mediated lipid and iron metabolism reprogramming promotes remyelination during white matter ischemia by Hang Zhang, Sheng Yang, Yi-Lin Lu, Luo-Qi Zhou, Ming-Hao Dong, Yun-Hui Chu, Xiao-Wei Pang, Lian Chen, Lu-Lu Xu, Lu-Yang Zhang, Li-Fang Zhu, Ting Xu, Wei Wang, Ke Shang, Dai-Shi Tian, Chuan Qin

“…The expression of critical molecule in microglia was regulated using Cx3cr1CreER mice and clinical-stage drugs to assess its effect on white matter injury and cognitive function. …”
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Guarding the Borders of Japan: Occupation, Korean War and Frontier Controls by Tessa Morris-Suzuki

“…In the last months of the Pacific War the center of the nearest big city, Matsuyama, had been reduced to a burnt-out wasteland by allied fire-bombing.2 The villages had been spared the worst of the air-raids, but during the final stages of the war their fishing boats had been requisitioned by the military or lain idle, unable to venture out into the dangerous waters of war. …”
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Changes in the structure and properties of road bitumen during its thermal stabilization by N. I. Shestakov, N. V. Khokhlova, Yu. E. Vasiliev, U. O. Menkina

“…Bitumen undergoes serious changes during technological processes, during the transition from the bulk to the film state under the influence of high temperatures. Thus, thermal stability of bitumen is an important condition for preserving its quality at all stages of its life cycle. …”
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A meta-analysis of the effects of nitrogen fertilizer application on maize (Zea mays L.) yield in Northwest China by Yuanbo Jiang, Haiyan Li, Wenqiong Ma, Wenjing Yu, Junxian Chen, Yalin Gao, Guangping Qi, Minhua Yin, Yanxia Kang, Yanlin Ma, Jinghai Wang, Liting Xu

“…Among the field management factors, the increase in maize yield was better with the variety Qiangsheng 51, topdressing at the jointing and tasseling stages (JS, TS), nitrogen application rate of 175–225 kg·ha-1, and controlled release of nitrogen fertilizer and urea (CRNFU) or the application of a combination of organic and inorganic nitrogen (OIF). …”
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Clinical Characteristics and Outcomes of COVID-19 in Children in Northern Iran by Leila Shahbaznejad, Hamed Rouhanizadeh, Mohammad Reza Navaeifar, Fatemeh Hosseinzadeh, Faeze Sadat Movahedi, Mohammad Sadegh Rezai

“…COVID-19 can cause symptoms in children in two stages. In the first week, upper and lower respiratory symptoms can occur which has lower severity and prevalence compared to adults. …”
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Localized propranolol delivery from a copper-loaded hydrogel for enhancing infected burn wound healing via adrenergic β-receptor blockade by Wenzhe Sun, Hongwei Lu, Pengqin Zhang, Lian Zeng, Bing Ye, Yi Xu, Jianan Chen, Peiran Xue, Jialin Yu, Kaifang Chen, Bin Wu, Xiao Lv, Xiaodong Guo, Yanzhen Qu

“…Meanwhile, propranolol can counteract the inhibitory effects of NE simulated chronic stress microenvironment on angiogenesis and mitigate sympathetic nerve innervation during the early stages of wound healing. Finally, the PNL@GA-Cu hydrogel significantly promoted the repair of third-degree full-thickness burns in SD rats. …”
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Therapeutic strategies for fungating and ulcerating breast cancers: A systematic review and narrative synthesis by Valentina Zagardo, Mandara Harikar, Gianluca Ferini

“…Owing to high heterogeneity, a narrative synthesis was performed, categorizing treatment by year, molecular subtype, histology, and staging. We found that treatment modalities increased, from an average of two in luminal-B cancers to three in HER2-positive cases, with over half achieving complete response. …”
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The association of cigarette smoking with the development and progression of diabetic retinopathy: based on cross-sectional survey and mendelian randomization by Bin Wang, Hui Li, Huafeng Ma, ZaiHong Chen

“…Conclusions Our findings suggest a protective association between smoking and DR development in specific subgroups across different DR stages, while showing no association with DR progression.…”
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Apropiación del Plan de Estudio para la educación básica 2022: un estudio de caso by Fernando Iván Ceballos Escobar

“…It is concluded that appropriation occurs in stages where the different positioning influences the discourses and actions carried out during the process. …”
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