Cross-Talk between NOK and EGFR: Juxtamembrane and Kinase domain interactions enhancing STAT3/5 signaling in breast cancer tumorigenesis by Yinyin Wang, Bingdong Zhang, Chunhua He, Bo Tian, Sihan Liu, Jianghua Li, Jiayu Wang, Shigao Yang, Bingtao Zhu, Xiaoguang Wang, Zhijie Chang, Chenxi Cao

“…We demonstrated that co-expression of NOK and EGFR correlated with tumor malignant stages in breast cancer patients. Our finding introduces a new cross interaction manner of EGFR-NOK via juxtamembrane (JM) domains and kinase domains, uncovers a mechanism by which NOK coordinates EGFR to enhance EGF-STAT3/5 signaling during tumorigenesis and metastasis, and proposes a potential strategy for targeting NOK-EGFR in breast cancer treatment.…”
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The passport database of VIR’s bean collection as a tool for systemizing bean genetic diversity, studying the collection’s history, and monitoring the crop’s worldwide breeding (an... by T. V. Buravtseva, G. P. Egorova, M. A. Vishnyakova

“…For the bean collection, the history of its systemization has had several stages. In 1923, systemic recording of bean accessions that entered the collection started with their registration in special journals, called catalogues. …”
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Acceptance of Mass Drug Administration for Prophylaxis against Lymphatic Filariasis in a Tribal Endemic Area: A Descriptive Cross-sectional Study by Asmit Agarwal, Vikas Maharshi

“…Background: India is at a critical stage to eliminate filariasis. Uncovering the factors governing may help taking appropriate measures to achieve the goal. …”
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Upregulation of GSTP1 mediated by chimeric TFE3 promotes TFE3-tRCC progression by targeting JNK signaling pathway by Weixu Chen, Mengtong Wu, Lin Du, Changhua Fang, Hao Wang, Wendi Wang, Chengwei Zhang, Hongqian Guo, Gutian Zhang

“…Abstract Background TFE3-translocation renal cell carcinoma (TFE3-tRCC), a distinct subtype of kidney cancer characterized by Xp11.2 translocations, involving TFE3 fusion with various partner genes, lacks effective treatments and prognostic biomarkers for advanced stages. This study aimed to unravel the pathogenic mechanisms and uncover novel therapeutic targets. …”
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FINANCIAL PERFORMANCE ANALYSIS OF THE COMPANY THROUGH PROFITABILITY RATIOS by Mihaela SUDACEVSCHI, Viorica Mirela ŞTEFAN-DUICU

“…The strengths and weaknesses of the company are identified in the performance evaluation stage specific to financial management, resulting in an analysis of behavior and identifying methods to improve activities.…”
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Study on a Large-Scale Persistent Strong Dense Fog Event in Central and Eastern China by Hongbin Wang, Zhiwei Zhang, Duanyang Liu, Yuying Zhu, Xuerong Zhang, Chengsong Yuan

“…The characteristic of radiation fog is that the central and eastern part of China was controlled by “L” type high pressure. In the stage of advection radiation fog, the combined effect of weak cold advection and radiation cooling leads to the occurrence of SDF. (3) Regarding the duration of the fog event, the inversion structure is continuously maintained at night and in the morning near the stratum, and when the fog intensity is strong, the inversion intensity is correspondingly large, the fog top is lower than the inversion layer top, and the top of the SDF is between 80 and 400 meters.…”
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Global research trends in the application of artificial intelligence in oncology care: a bibliometric study by Mianmian Xu, Yafang Chen, Tianen Wu, Yuyan Chen, Wanling Zhuang, Yinhui Huang, Chuanzhen Chen

“…AI in oncology nursing is entering a stage of rapid development, providing valuable reference for scholars and professionals in the field.…”
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Outcomes of Congenital Nasolacrimal Duct Obstruction Surgery Converted into Balloon Dilation and Silicone Intubation due to Probing Difficulty by Oren Yaakov Sagiv, Achia Nemet, Asaf Achiron, Doron Neumann, Raimo Tuuminen, Oriel Spierer

“…The surgical team may prepare to proceed with secondary surgery under the same anesthesia after the initial attempt of probing and irrigation. This stepwise two-stage approach in patients with congenital NLDO failing primary surgery resulted in a high success rate with minimal interventions, avoiding repeated general anesthesia.…”
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THE EFFECT OF DELAY IN TEMPERATURE VARIATIONS ON RESULTS OF GLUCOSE TEST IN DM PATIENTS WITH HYPERCHOLESTEROLEMIA by Chori Khotul Ula, Edy Haryanto Edy Haryanto, Syamsul Arifin Syamsul Arifin, Wisnu Istanto

“…Background: The pre-analytic stage has the most significant contribution to error, which is 60% to 70%. …”
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Multimodal Opera Performance Form Based on Human-Computer Interaction Technology by Lin Wu

“…“Audience Engagement (AE)” describes how a stage performance affects the audience’s thoughts, provokes a bodily response, and spurs cognitive growth. …”
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Designing a Model of Effective Factors on Creative Cultural Industries in Iran by Abbas Ghaedamini Harouni, Mehrdad Sadeghi Deh Cheshmeh, Sadegh Sadeghi Deh Cheshmeh, Narjes Mohsenifar

“…Both validity questionnaires were confirmed, and Cronbach's alpha coefficient measured its reliability above 0.70.Findings: The Delphi identification test was used to identify the influential factors and was screened in two stages. Finally, the experts identified the criteria gathered in the research background in 6 criteria and 16 sub-criteria affecting the creative cultural industries in 7 main criteria, and 17 sub-criteria were agreed upon. …”
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The eradication of Asian longhorned beetle at Paddock Wood, UK by Dominic Eyre, Jane Barbrook

“…This method was more effective for detecting trees with A. glabripennis exit holes than trees at an early stage of infestation. A further 42 infested trees were detected when the infested trees and host trees within 100 m of them were felled and the felled material was inspected. …”
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China’s Perceptions of Russia during the Ukraine Conflict by Srikanth Kondapalli

“…The conflict in Ukraine has also caused internal divisions within China and has had an impact on its relations with the West, which are crucial for China's rise on the global stage. This article aims to examine China's interests and positions regarding the ongoing Ukrainian conflict, the implications for its relations with Russia, and the opportunities and challenges that China faces in the current situation. …”
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The scoping, design, and plasma physics optimization of the Eos neutron source stellarator by C.P.S. Swanson, D.A. Gates, S.T.A. Kumar, M.F. Martin, T.G. Kruger, D.W. Dudt, P.J. Bonofiglo, the Thea Energy team

“…In this paper, a set of 1D plasma physics models are coupled and used to design the operating point of the facility and predict performance. At this foundational stage of the design, analytic and approximate models are sufficient to capture the leading-order effects, and fast enough to run in the inner loop of an optimizer. …”
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Dynamic heat transfer mechanisms of internal thermal mass: Effects of thermal conductivity and diffusivity under varied temperature conditions by Ru Yang, Liting Yuan, Dong Zhang, Taiquan Wu, Yihang Lu

“…These findings provide a quantitative basis for estimating the impact of internal thermal mass on indoor air temperature and heat exchange in the early stages of building design.…”
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Evaluation of Type III Adhesive Mortar (ACIII) and Gypsum as Precipitating Agents of Copper and Lead by Jefferson Luiz Alves Marinho, Henrique Douglas Melo Coutinho, Raimundo Nonato Pereira Teixeira, Jorge Marcell Coelho Menezes, Francisco José de Paula Filho, Francisco Assis Bezerra da Cunha

“…Moreover, the precipitation stages by these materials also impact in decreasing the toxicity of metal ions to the evaluated model organism.…”
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Challenges in Designing Blended Learning: the Experience of the “Schools of Instructional Design” by E. A. Drugova, I. I. Zhuravleva, M. G. Aiusheeva

“…The results of the study showed that the respondents’ professional deficits in the design of blended courses were associated with the development of new ways of designing and teaching, growth of the course quality and student-centeredness, and more efficient allocation of time resources and use of online tools. The development stage, which involves the creation or updating of digital learning resources, turned out to be the most challenging for designing. …”
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Optimizing Secure AI Lifecycle Model Management With Innovative Generative AI Strategies by Alaa Omran Almagrabi, Rafiq Ahmad Khan

“…Considering the current weaknesses and threats related to GAI we provide a systematic approach to how safety concerns that are currently relevant can be integrated with every stage of Artificial Intelligence (AI) lifecycle management: from continuous monitoring to the application of cybersecurity trends and practices, etc. …”
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Effects of Lactobacillus plantarum on Physicochemical Properties and Volatile Flavor Substances of Blueberry Juice during Fermentation and Storage by Maowen LIAO, Chen HAN, Wei LIU, Yanlin LI, Changlin CHEN, Huaiyu YUAN, Yan ZHOU, Ke LI, Huajia LI

“…In order to understand the effects of Lactobacillus plantarum on physicochemical properties and volatile flavor substances of blueberry juice during fermentation and storage stages. Fresh Baldwin was used as raw material and Lactobacillus plantarum b-1 was used as starter culture, the changes of physicochemical properties and viable bacterial counts during the fermentation and storage were detected. …”
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Sexual Dysfunction in Asian Males with Type 2 Diabetes Mellitus by Vurmila Venggadasamy, Loon Shin Ho, Badariah Ahmad, Khalid Abdul Kadir

“…In Asia, diabetes affects a younger age group resulting in more people suffering from the complications of diabetes at an earlier stage in life. One of the most serious diabetes mellitus (DM) complications is sexual dysfunction (SD). …”
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