An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode by Xiaoying Jia, Xuping Jing, Ming Li, Minli Gao, Yao Zhong, Entao Li, Yang Liu, Rui Li, Guoqiang Yao, Qiaojie Liu, Minmin Zhou, Yuxia Hou, Linfeng An, Yibao Hong, Shanshan Li, Jiancun Zhang, Wei Wang, Kaiming Zhang, Peng Gong, Sandra Chiu

“…Enzymology data demonstrate that HNC-1664 inhibits RNA synthesis mainly at the pre-catalysis stage. The cryo-EM structures of HNC-1664-bound RdRP-RNA complexes from both SARS-CoV-2 and LASV reveal an unusual base pairing mode of HNC-1664 in part due to its base modification, thus revealing its great potency in binding but not catalysis. …”
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Genotypic Spectrum in a Cohort of Sri Lankan Patients With Homocystinuria by Hewa Warawitage Dilanthi, Kandana Liyanage Subhashinie Jayasena, Nambage Dona Priyani Dhammika, Neluwa Liyanage Ruwan Indika, Matara Mahavidanage Nishani De Silva, Imalke Kankananarachchi, Pushpa Malkanthi Gardiye Punchihewa, Dharma Irugalbandara, Sabine Schroeder, Kosala Karunaratne, Eresha Jasinge

“…The majority of the patients were identified clinically at a later stage of the disease due to lack of a screening programme in the country. …”
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Global and Local Infall in the ASHES Sample (GLASHES). I. Pilot Study in G337.541 by Kaho Morii, Patricio Sanhueza, Timea Csengeri, Fumitaka Nakamura, Sylvain Bontemps, Guido Garay, Qizhou Zhang

“…To understand the gas dynamics at the core scale in the very early evolutionary stages before being severely affected by feedback, we have conducted Atacama Large Millimeter/submillimeter Array (ALMA) observations toward a 70 μ m dark massive clump, G337.541-00.082 as part of the Global and Local infall in the ASHES sample (GLASHES) program. …”
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Quality education for all in an ideas-informed society: exploring idea-engagement amongst friendship networks and how education can prevent idea “echo-chambers” by Chris Brown, Jana Gross Ophoff, Graham Handscomb

“…Its successful actualisation is dependent on high-quality educational opportunity at all stages of the life course. Social networks represent our connections to one another. …”
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Pathogenicity of tick-derived lymphocytic choriomeningitis virus in BALB/c mice by Ziyan Liu, Xiaojie Liang, Liang Li, Ning Liu, Zedong Wang, Feng Wei

“…Interferon gamma (IFN-γ) level was significantly elevated during the early stage of infection and returned to baseline levels within 10 days. …”
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Exploration of Muscle Fatigue Effects in Bioinspired Robot Learning from sEMG Signals by Ning Wang, Yang Xu, Hongbin Ma, Xiaofeng Liu

“…According to the identified muscle fatigue factor, a weight has been assigned to each of the demonstration trials in training stage, which is therefore termed as weighted GMMs (W-GMMs) algorithm. …”
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FORMATION AND EVOLUTION OF POLITICAL ELITES: A COMPARATIVE ANALYSIS OF HISTORICAL AND CONTEMPORARY APPROACHES by Роман КОЗАЧЕНКО

“…The main results of the research include the identification of key stages in the development of political elites, as well as new approaches to studying them in the context of technological and social changes. …”
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Prevalence of Hypercalcaemia in a Renal Transplant Population: A Single Centre Study by Tony Amin, P. Toby Coates, Jeffrey Barbara, Paul Hakendorf, Nazmul Karim

“…Results. 679 renal transplant recipients with a functioning graft were studied and 101 were hypercalcaemic between March 2011 and June 2011 (15%). 60% of the hypercalcaemic patients were male and 40% were female, with chronic glomerulonephritis (39%) being the commonest cause of their end stage kidney disease (ESKD). Prevalence was similar in those that had haemodialysis and peritoneal dialysis pretransplantation. …”
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City Through the Eyes Of Students' Youth: Assessment and Regional Practices (A Case Study of Nizhny Novgorod) by O. R. Chepyuk, O. Yu. Angelova, S. D. Makarova, N. G. Bryandinskaya, O. V. Petrova

“…Russian universities at the present stage play a significant role in shaping the students professional preferences and migration expectations, thereby contributing to socio-economic development and influencing the process of human capital management at the regional level. …”
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BRM Immunotherapy of Orthotopically Implanted Murine Bladder Tumours: Treatment Response by Monitoring MRI by Salam A Kadhim, Joseph L Chin, Bertha M Garcia, Peeyush K Lala, Chris J Norley, Barbara A McLean, Stephen J Karlik

“…Response to intravesical instillations with multiple doses ofBRMs was assessed against early stage MBT-2 bladder tumours (confirmed by MRI) 14 days after transurethral tumour implantation. …”
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The History of the Bargut Confrontation in Northeastern China (early 20th century): Ethno-Political and Religious Aspects (based on archival materials) by Bair Ts. Gomboev, Eduard V. Batunaev

“…The research methodology is based on comparative historical, historical-genetic, historical-dynamic, retrospective methods, and interviewing methods, which made it possible to most fully analyze the main stages and patterns of the history of the Bargut confrontation in Manchuria in the context of historical events in China, taking into account ethno political and religious aspects. …”
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Response of some wheat cultivars to plot orientation and foliar boron levels by Lana Dhahir Mohammed, Sami Mohammad Amin Mohammed Amin

“…This investigation was conducted to understand the response of three newly introduced bread wheat cultivars to Erbil area (V1: FLORKWA, V2: BAJ and V3: FRANKOLIN) to three boron levels sprayed at elongation stage 0, 1 and 1.5 ppm concentration and oriented (South-North and East-West) row directions to study the vegetative and reproductive growth characters of wheat. …”
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Efficient continuous SF6/N2 separation using low-cost and robust metal-organic frameworks composites by Jinjian Li, Yuting Chen, Tian Ke, Yuanyuan Jin, Rongrong Fan, Guihong Xu, Liu Yang, Zhiguo Zhang, Zongbi Bao, Qilong Ren, Qiwei Yang

“…Herein, with insights into in-pore chemistry and industrial process design, we report a systematic investigation that constructed two low-cost composites pellets (Al(fum)@2%HPC and Al(fum)@5%Kaolin) coupled with an innovative two-stage Vacuum Temperature Swing Adsorption (VTSA) process for the ultra-efficient recovery of low-concentration SF6 from N2. …”
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IMPLEMENTASI SISTEM PENGOLAHAN DATA SKY QUALITY METER BERBASIS VISUAL BASIC UNTUK ANALISIS PERUBAHAN TINGKAT KECERAHAN LANGIT by Mustofa Ahyar, Yudhiakto Pramudya, Okimustava Okimustava

“…Software development used the waterfall model with five stages of modeling, namely: analysis, design, implementation, testing, and maintenance. …”
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Artificially intelligent nursing homes: a scoping review of palliative care interventions by Isabel Ronan, Sabin Tabirca, Sabin Tabirca, David Murphy, Nicola Cornally, Mohamad M. Saab, Patrice Crowley

“…A further 61 articles were excluded during the full-text screening stage. We included 19 articles in our analysis. Studies either focus on intelligent physical systems or decision support systems. …”
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Engineering properties and life cycle assessment of a rapidly clayey soil stabilizer utilizing alkali-activated GFRP waste powder and slag by Zhenying Xie, Dan Yu, Jun Wang

“…Furthermore, an increase in GFRP powder replacement improved permeability coefficient in the early stages, with minimal impact observed after 28 days. …”
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Dynamics and diversity of vaginal microbiota in bacterial vaginosis among Thai patients treated with metronidazole by Auttawit Sirichoat, Pranom Buppasiri, Kiatichai Faksri, Viraphong Lulitanond

“…There was higher diversity and abundance in the VMB from pre-MTZ samples, while post-MTZ and follow-up samples displayed lower diversity. In the follow-up stage, the VMB was divided into two subgroups: the larger cured subgroup, which shifted towards a Lactobacillus-dominated composition resembling healthy controls, and the small treatment-failure subgroup, which exhibited a Gardnerella-dominated profile similar to pre-MTZ. …”
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A transgenic cell line with inducible transcription for studying (CGG)n repeat expansion mechanisms by I. V. Grishchenko, A. A. Tulupov, Y. M. Rymareva, E. D. Petrovskiy, A. A. Savelov, A. M. Korostyshevskaya, Y. V. Maksimova, A. R. Shorina, E. M. Shitik, D. V. Yudkin

“…It is proposed that these DNA secondary structures can block various stages of DNA metabolism processes, such as replication, repair and recombination and it is considered as the source of repeat instability. …”
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Design of Interface ASIC with Power-Saving Switches for Capacitive Accelerometers by Juncheng Cai, Yongbin Cai, Xiangyu Li, Shanshan Wang, Xiaowei Zhang, Xinpeng Di, Pengjun Wang

“…Additionally, a class-AB output stage is employed to enhance the dynamic range of the circuit. …”
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Nakłady na innowacje ekologiczne w krajach Unii Europejskiej w latach 2010‒2018 by Jolanta Pakulska

“…W obliczu narastających problemów środowiskowych stale rośnie rola przedsięwzięć minimalizujących negatywny wpływ działalności gospodarczej na środowisko. …”
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