Model systems of human immunodef iciency virus (HIV-1) for in vitro eff icacy assessment of candidate vaccines and drugs against HIV-1 by N. B. Rudometova, D. N. Shcherbakov, A. P. Rudometov, A. A. Ilyichev, L. I. Karpenko

“…The classical method of virology, which makes it possible to evaluate the neutralizing activity of the sera of animals immunized with experimental vaccines and the eff icacy of chemotherapy agents is the method of neutralization using viral isolates and infectious molecular clones, i. e. infectious viral particles obtained via cell transfection with a plasmid vector including the full-length HIV-1 genome coding structural, regulatory, and accessory proteins of the virus required for the cultivation of replication-competent viral particles in cell culture. …”
Get full text

Evolution of SARS-CoV-2 in white-tailed deer in Pennsylvania 2021-2024. by Andrew D Marques, Matthew Hogenauer, Natalie Bauer, Michelle Gibison, Beatrice DeMarco, Scott Sherrill-Mix, Carter Merenstein, Ronald G Collman, Roderick B Gagne, Frederic D Bushman

“…SARS-CoV-2 continues to transmit and evolve in humans and animals. White-tailed deer (Odocoileus virginianus) have been previously identified as a zoonotic reservoir for SARS-CoV-2 with high rates of infection and probable spillback into humans. …”
Get full text

Abatement by Alhagi maurorum of lead-induced nephrotoxicity in rats: emphasis on Nrf2/HO-1 by Mardi M. Algandaby

“…Acute oral toxicity studies indicated that the extract is safe for animals. Rats were allocated into five groups and treated for 28 days as follows: control, AM (200 mg/kg, orally), Pb (15 mg/kg, orally), Pb + AM (100 mg/kg), and Pb + AM (200 mg/kg). …”
Get full text

Enucleated bone marrow-derived mesenchymal stromal cells regulate immune microenvironment and promote testosterone production through efferocytosis by Lu Sun, Jiayu Huang, Xuezi Wang, Peng Huang, Baolin Dong, Zehang Liang, Jiahong Wu, Jiancheng Wang

“…Extracellular vesicles (EVs) were isolated by ultracentrifugation and characterized. For the animal studies, enucleated BMSCs were labelled with Mitotracker and injected into ethane dimethanesulfone (EDS)-treated rats. …”
Get full text

CRISPR/Cas9, a universal tool for genomic engineering by A. V. Smirnov, A. M. Yunusova, V. A. Lukyanchikova, N. R. Battulin

“…The CRISPR/Cas9 system was initially described as an element of archeal and bacterial immunity, but gained much attention recently for its outstanding ability to be programmed to target any genomic loci through a short 20-nucleotide sgRNA region. …”
Get full text

Screening of <em>FecLL</em> prolific allele of the <em>B4GALNT2</em> gene in Algerian sheep populations by Assia Hadjazi, Fatima Zahra Belharfi, Fatima Zohra Mahammi, Stéphane Fabre, Semir Bechir Suheil Gaouar, Nacera Tabet-Aoul

“…Methods: A total of 338 animals from 12 breeds were genotyped using the PCR-RFLP technique. …”
Get full text

Isoxazole-based molecules restore NK cell immune surveillance in hepatocarcinogenesis by targeting TM4SF5 and SLAMF7 linkage by Ji Eon Kim, Hyun Su Kim, Wonsik Kim, Eun Hae Lee, Soyeon Kim, Taewoo Kim, Eun-Ae Shin, Kyung-hee Pyo, Haesong Lee, Seo Hee Jin, Jae-Ho Lee, Soo-Min Byeon, Dong Joo Kim, Jinwook Jeong, Jeongwon Lee, Minjae Ohn, Hyojung Lee, Su Jong Yu, Dongyun Shin, Semi Kim, Jun Yeob Yoo, Seung-Chul Lee, Young-Ger Suh, Jung Weon Lee

“…TSI treatments in cell lines and animal models of HCC blocked this binding, intracellular trafficking, and downregulation, resulting in higher levels of stimulatory NK cell ligands. …”
Get full text

Humoral and Cellular Immune Regulation in Albino Rat Exposed to Glyphosate and Aluminum Phosphide by Ujuamala Ezeani, Onyemaechi Afonne, Michael Ezeani

“…This phenomenon aligns with the animals' increasing exposure to the chemicals, showing no significant difference in the changes due to dosage across both sexes. …”
Get full text

IMMUNOMODULATORY ACTIVITY OF THE LACTOBACILLUS DELBRUECKII SUBSP. BULGARICUS LB 86 ENZYME LYSATE by L. Lаzarenko, L. Orіabinska, T. Bohdan

“…In vitro and in vivo experiments, using an experimental model of intact BALB/c mice, investigated the effect of enzyme lysate on the functional activity of animal peritoneal exudate macrophages and the production of immunoregulatory cytokines, using conventional research methods. …”
Get full text

Proximate, Mineral Contents and Physicochemical Properties of <i>Chrysophyllum Albidum</i> (African Star Apple) Kernel Flour and Oil by S.S. Audu, C.I. Beetseh, D.U. Edward-Ekpu, A.A. Ewuga

“…This suggests that the flour can be a used as an alternative to cereals in compounding animal feed. The results from the Mineral Analysis showed the kernel has 0.01 mg/g of copper, 0.01 mg/g of Iron, 37.50 mg/g of phosphorus, 57.37 mg/g of calcium and 0.44 mg/g magnesium. …”
Get full text

The BLUP method in evaluation of breeding values of Russian spring wheat lines using micro- and macroelements in seeds by N. A. Potapova, A. S. Zlobin, I. N. Leonova, E. A. Salina, Y. A. Tsepilov

“…Genomic selection is a technology that allows for the determination of the genetic value of varieties of agricultural plants and animal breeds, based on information about genotypes and phenotypes. …”
Get full text

Statistical analyzes and anomalies of precipitation in cold period in order to understand the effect of climate change on different regions of Iran (1951-2010) by elham yarahmadi, mostafa karampoor, hooshang ghaemi, mohammad moradi, behrouz nasiri

“…Investigating of rainfall behavior in the spatial-temporal dimension and determining the tolerance thresholds of different geographical areas with respect to vegetation, animal life and human activities, is essential for any decision in the environment. …”
Get full text

Safety and efficacy of omaveloxolone v/s placebo for the treatment of Friedreich's ataxia in patients aged more than 16 years: a systematic review by Ankita Umrao, Monika Pahuja, Nabendu Sekhar Chatterjee

“…Nrf2 is a regulator of FXN, which is a modulator of oxidative stress in animals and humans. Omaveloxolone (Omav) is an Nrf2 activator and has been reported to have antioxidative potential in various disease conditions. …”
Get full text

Rectal application of a highly osmolar personal lubricant in a macaque model induces acute cytotoxicity but does not increase risk of SHIV infection. by Sundaram A Vishwanathan, Monica R Morris, Richard J Wolitski, Wei Luo, Charles E Rose, Dianna M Blau, Theodros Tsegaye, Sherif R Zaki, David A Garber, Leecresia T Jenkins, Tara C Henning, Dorothy L Patton, R Michael Hendry, Janet M McNicholl, Ellen N Kersh

“…However, the estimated AID50 (50% animal infectious dose) was not different in lubricant- and control buffer-treated macaques (p = 0.4467; logistic regression models).…”
Get full text

Species Composition, Genetic Structure, and Pathogen Prevalence in Tick Populations in Guangxi, China by Na Jiang, Haoqiang Tian, Chunfu Li, Rui Ma, Mengyun Liu, Shurong Wang, Qingan Zhou, Xiankai Wei, Juanmei Mo, Zimei Chen, Zhaoan Sheng, Lei Duan, Lu He, Peng Song, Jiahui Sun, Jian Li, Wei Hu, Xinyu Feng

“…Ticks are important vectors for many pathogens affecting humans and animals. This study was aimed at investigating the species composition, genetic diversity, and potential transmission risks of tick-borne pathogens in the Guangxi Zhuang Autonomous Region, China. …”
Get full text

Hypotheses and evidence related to intense sweeteners and effects on appetite and body weight changes: A scoping review of reviews. by Annhild Mosdøl, Gunn Elisabeth Vist, Camilla Svendsen, Hubert Dirven, Inger Therese Laugsand Lillegaard, Gro Haarklou Mathisen, Trine Husøy

“…Systematic reviews of animal studies are lacking in this topic area. The systematic evidence only partly explore forwarded hypotheses found in the literature. …”
Get full text

Immunoinformatics design of a novel multiepitope vaccine candidate against non-typhoidal salmonellosis caused by Salmonella Kentucky using outer membrane proteins A, C, and F. by Elayoni E Igomu, Paul H Mamman, Jibril Adamu, Maryam Muhammad, Abubarkar O Woziri, Manasa Y Sugun, John A Benshak, Kingsley C Anyika, Rhoda Sam-Gyang, David O Ehizibolo

“…Kentucky) is rising, particularly due to the dissemination of antimicrobial resistance genes in human and animal populations. This serovar, widespread in Africa, has emerged as a notable cause of non-typhoidal gastroenteritis in humans. …”
Get full text

The effect of thioredoxin and prochymosin coexpression on the refolding of recombinant alpaca chymosin by S. V. Belenkaya, D. N. Shcherbakov, A. I. Chapoval, T. I. Esina, V. V. Elchaninov

“…Another source of chymosin, which does not require the killing of animals, is based on recombinant DNA technology. Recombinant alpaca chymosin has a number of valuable technological properties that make it attractive for use in cheese-making as an alternative to recombinant bovine chymosin. …”
Get full text

Gut colonization of Bacteroides plebeius suppresses colitis-associated colon cancer development by Hung-Lin Chen, Po-Yuan Hu, Chang-Shan Chen, Wei-Han Lin, Daniel K. Hsu, Fu-Tong Liu, Tzu-Ching Meng

“…We found that mice orally administered with B. plebeius and fed a diet containing 1% seaweed developed a unique gut microbial composition. By linear discriminant analysis effect size analysis, we found that B. plebeius colonization increased the abundance of Blautia coccoides and reduced the abundance of Akkermansia sp. and Dubosiella sp. …”
Get full text

The role of sensitization to aeroallergens and its determination in children with asthma in Ukraine by O.V. Mozyrska, Ya.V. Socolova

“…The most important inhalant allergens for patients with bronchial asthma are pollens (trees, grasses, and weeds), house dust mites, molds, and animal dander. Identifying causative allergens allows for monitoring allergy triggers and determining which asthma patients will be candidates for allergen-specific immunotherapy (ASIT). …”
Get full text