L-Citrulline in Neonates: From Bench to Bed Side by Dwayne Mascarenhas, Atefeh Mohammadi, Randa Higazy, Julijana Ivanovska, Estelle Gauda, Bonny Jasani

“…Detoxification of endogenously produced superoxide radicals is inadequate in preterm infants due to immature antioxidants that leads to the production of peroxynitrite, a reactive oxygen-free radical that is cytotoxic and causes damage to organelles and cellular membranes, further disrupting the coupling of endothelial NO synthase enzyme and the generation of high levels of reactive nitrogen and oxygen species. Animal studies in lipopolysaccharide-induced models of chorioamnionitis and hyperoxia- and inflammation-induced BPD-PH in rodent lung models revealed that L-CIT supplementation significantly mitigated structural changes in the pulmonary vasculature, preserved alveolar growth, and increased vascular endothelial growth factor gene expression, highlighting the anti-inflammatory and antioxidant effects of L-CIT supplementation. …”
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Optimization of In Vivo Studies by Combining Planar Dynamic and Tomographic Imaging: Workflow Evaluation on a Superparamagnetic Nanoparticles System by Maritina Rouchota, Alessio Adamiano, Michele Iafisco, Eirini Fragogeorgi, Irineos Pilatis, Gilles Doumont, Sébastien Boutry, Daniele Catalucci, Argyro Zacharioudaki, George C. Kagadis

“…Studies can be optimized following this workflow, as it is possible to quickly assess more parameters in a small number of animals (injection route, dosage, and fasting conditions). …”
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Methods Used in Urban Search and Rescue in Disasters and Evaluation of Current Approaches by Gürkan Yılmaz, Sevda Demiröz Yıldırım

“…Urban search and rescue works are important for finding people and animals trapped under the collapsed structure after the collapse of buildings as a result of earthquakes, terrorist attacks and landslides. …”
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Monitoring of immune activation using biochemical changes in a porcine model of cardiac arrest by Anton Amann, Bernhard Widner, Josef Rieder, Herwig Antretter, Georg Hoffmann, Viktoria Mayr, Hans-Ulrich Strohmenger, Dietmar Fuchs

“…In animal models, immune activation is often difficult to assess because of the limited availability of specific assays to detect cytokine activities. …”
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Some haematological values in the healthy hamdani (hareki-harki) sheep by Mursayettin Eksen, Z. Tevfik Ağaoğlu, Ercan Keskin

“…In this study, 40 adult Hamdani (Hareki-Harki) sheep aged, 2-4 years old, male and female, were used. The animals divided into two equal groups as male and female, were used. …”
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Effects of biophilic virtual reality on cognitive function of patients undergoing laparoscopic surgery: study protocol for a sham randomised controlled trial by Bin Gao, Yanling Zhou, Jianhua Wang, Binbin Zhu, Qiuyan Weng, Wenjun Luo, Xiuchao He, Lufei Jin, Qinwen Wang, Ahmad Khaled Ahmad Harb

“…Due to the lack of an effective postoperative follow-up system, the incidence of POCD in China is not clear, and although many drugs have been proposed to improve POCD in the animal study, their clinical applications are limited, while VR provides an innovative method to provide non-pharmacological management.Methods and design This is a single-centre, randomised, double-blind, sham-controlled clinical trial. …”
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Periconceptional Undernutrition in Sheep Affects Adult Phenotype Only in Males by Anne L. Jaquiery, Mark H. Oliver, Maggie Honeyfield-Ross, Jane E. Harding, Frank H. Bloomfield

“…At the age of 3-4 years, body composition was assessed by dual-emission X-ray absorptiometry followed by postmortem examination. Compared with N animals, male, but not female, offspring of all UN groups had greater % fat mass (all UN versus N: 9±1 versus 2±1%, P<0.001) and perirenal fat (544±36 versus 222±44 g, P=0.002), and proportionately smaller hearts (4.5±0.1 versus 5.2±0.2 g·kg−1), lungs (9.1±0.2 versus 10.6±0.5 g·kg−1), and adrenals (0.06±0.002 versus 0.08±0.003 g·kg−1). …”
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Production of probiotic kefir from different plant-based milks by Berra Ceylan, Nilgün Öncül

“…This study has provided alternative plant-based fermented beverages for individuals who do not consume or cannot consume animal-derived products.…”
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The Anti-Cytokine Storm Activity of Quercetin Zinc and Vitamin C Complex by Hayder B. Sahib, Omer Abid Kathum, Rafal Shakeeb Alanee, Rehab A. M Jawad, Ahmed Majeed Al-Shammari

“…Then, levels of interleukin 1 and interleukin 6 were measured in the serum, and lung and kidney tissues were investigated for any changes that may have happened. Thirty mice were used to investigate the acute toxicity; mice were distributed into six groups: one control group and five treated groups; then several serial dilutions from the complex have been prepared for different concentrations from 5 g/kg to 0.312 g/kg. …”
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Polydatin retards the progression of osteoarthritis by maintaining bone metabolicbalance and inhibiting macrophage polarization by Qi Sun, Xin-Yu Nan, Hui Wang, Shuo Pan, Gang Ji, Ya-Feng Guo, Ya-Heng Zhao, Gao-Cen Li, Shao-Shi Guo, Lu-Feng Lin, Yu-Jie Jin, Xue Li Zhang, Chang-Cheng Liu, Guo-Bin Liu

“…However, the potential molecular mechanisms of PD in osteoarthritis have not been clearly elucidated.MethodsAnterior cruciate ligament transection (ACLT) surgery was performed to establish an osteoarthritis animal model. Female mice at the age of 12 weeks were intraperitoneally injected with different concentrations of PD (20 and 40 mg/kg). …”
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Yiqi Fumai Lyophilized injection protects cardiac contractility in a rat model of heart failure with reduced ejection fraction by modulating SERCA2 by Yongwei Nie, Lu Chen, Yanxin Zhang, Yuqing Yao, Zizhuo Xue, Na Guo, Meixiu Wan, Zhi Li, Chunhua Liu, Dekun Li, Aichun Ju

“…Background: Yiqi Fumai Lyophilized Injection (YQFM) is a plant-derived preparation that shows protective effects against cardiac dysfunction in both human and animal models. In heart failure (HF), proteins involved in Ca2+ regulation, such as sarcoplasmic/endoplasmic reticulum Ca2+ transporting protein 2 (SERCA2) and cardiac ryanodine receptor 2 (RyR2), are dysfunctional. …”
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From bench to bedside: Developing CRISPR/Cas-based therapy for ocular diseases by Qing Zhao, Linxin Wei, Youxin Chen

“…This system has contributed to the development of representative disease models, including animal models, organoids, and cell lines, thereby facilitating investigations into the pathogenesis of disease-related genes. …”
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Inhibition of Endothelial–Mesenchymal Transition Mediated by Activin Receptor Type IIA Attenuates Valvular Injury Induced by Group A Streptococcus in Lewis Rats by Zirong Lu, Yuan Li, Chuanghong Lu, Zhongyuan Meng, Ling Bai, Feng Huang, Zhiyu Zeng

“…The EndMT cell model was established via human umbilical vein endothelial cells (HUVECs), and the RHD animal model was established via female Lewis rats. …”
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UHRF1 promotes epithelial-mesenchymal transition mediating renal fibrosis by activating the TGF-β/SMAD signaling pathway by Lijie Yang, Penghui Si, Tuoheti Kuerban, Linfa Guo, Shanzhi Zhan, Yisha Zuhaer, Yingtong Zuo, Peixiang Lu, Xiaojie Bai, Tongzu Liu

“…By establishing a TGF-β1-stimulated HK2 cell model and animal models of renal fibrosis induced by UUO and folic acid, we confirmed that UHRF1 was highly expressed in both in vitro and in vivo models of renal fibrosis. …”
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Simultaneous determination of 11 kinds of siloxanes in drinking water and source water using solid-phase microextraction combined with gas chromatography-mass spectrometry by Sijie Liu, Jie Ma, Su Jiang

“…It has been reported that methylsiloxane has toxic effects on the nervous, immune and reproductive systems of aquatic animals, and is carcinogenic and mutagenic. Therefore, in order to protect human health, it is urgent to establish a method for the determination of siloxane content in drinking water and source water.MethodsHerein, this paper proposes a precise, fast, and selective method using solid-phase microextraction combined with gas chromatography-mass spectrometry (GC-MS/MS) method for the simultaneous detection of 11 kinds of siloxanes in drinking water and source water. …”
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Pre-Season Precipitation and Temperature Have a Larger Influence on Vegetation Productivity than That of the Growing Season in the Agro-Pastoral Ecotone in Northern China by Yuanyuan Zhang, Qingtao Wang, Xueyuan Zhang, Zecheng Guo, Xiaonan Guo, Changhui Ma, Baocheng Wei, Lei He

“…These findings not only emphasize the critical role of both historical and contemporary climate conditions in shaping vegetation growth but also provide valuable insights into how to adjust agricultural and animal husbandry management strategies to improve regional climate adaptation based on climate information from previous seasons in fragile regions.…”
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Immunomodulatory Potential of Piperine in Rats by Alireza Ghavami, Seyyed Meysam Abtahi Froushani, Aliasghar tehrani

“…In a separate set of experiments, the effects of piperine gavage on T helper lymphocyte responses in vivo and ex vivo and their subsets were performed in animals challenged with ovalbumin (OVA). Results: Oral administration of piperine for one month reduced the adhesion of neutrophils (p=0.04). …”
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Out-of-phase relationship of Holocene moisture variations between the northeastern and southeastern Tibetan plateau and its societal impacts by Duo Wu, Minmin Ma, Yongxiu Lu, Shilong Guo, Tao Wang, Xuyi Ma, Guanghui Dong

“…In the present study, well-dated sedimentary records with unambiguous indicators of humidity variations from the NETP and YNP were integrated, along with radiocarbon dates from human and animal bones and the remains of crop plants from archaeological sites in this region. …”
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Understanding Cognition, Oxytocin, and Pain in Elders (UCOPE): protocol for a double-blinded cross-over trial in chronic knee osteoarthritis pain by Yenisel Cruz-Almeida, Soamy Montesino-Goicolea, Pedro Valdes-Hernandez, Zhiguang Huo, Roland Staud, Natalie C. Ebner

“…A promising treatment is the neuropeptide oxytocin (OT), which has been shown to play a role in endogenous analgesia with human and animal studies demonstrating anti-nociceptive effects. …”
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Stem Cells and Platelet-Rich Plasma Enhance the Healing Process of Tendinitis in Mice by Rosangela Alquieri Fedato, Júlio César Francisco, Gabriel Sliva, Lúcia de Noronha, Márcia Olandoski, Jose Rocha Faria Neto, Priscila Elias Ferreira, Rossana Baggio Simeoni, Eltyeb Abdelwahid, Katherine Athayde Teixeira de Carvalho, Luiz César Guarita-Souza

“…Cell therapy has been studied in several animal models, and encouraging results have been observed with respect to tissue regeneration. …”
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