Study on the Function and Mechanism of miR-585-3p Inhibiting the Progression of Ovarian Cancer Cells by Targeting FSCN1 to Block the MAPK Signaling Pathway by Yiming Jia, Jingru Li, Jinfeng Wang, Tianjiao Luo, Xiaoqian Jing, Hongmin Zhao

“…Western blot analysis showed that miR-585-3p targeted FSCN1 to inhibit protein phosphorylation of ERK. In vivo animal experiments also confirmed that miR-585-3p targets FSCN1 to inhibit tumor growth and block the MAPK signaling pathway. …”
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Exploring Advances in Natural Plant Molecules for Allergic Rhinitis Immunomodulation in Vivo and in Vitro by Li B, Dong B, Xie L, Li Y

“…In contrast, widely available natural plant molecules offer multiple targeting pathways that uniquely modify the typical pathophysiology of AR through immunomodulatory processes. …”
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Collagen deposition in lung parenchyma driven by depletion of interstitial Lyve-1+ macrophages prevents cigarette smoke-induced emphysema and loss of airway function by Yinebeb Mezgebu Dagnachew, Yinebeb Mezgebu Dagnachew, Yinebeb Mezgebu Dagnachew, Hwee Ying Lim, Hwee Ying Lim, Liao Wupeng, Liao Wupeng, Sheau Yng Lim, Sheau Yng Lim, Sheng Jie Natalie Lim, Sheng Jie Natalie Lim, Chung Hwee Thiam, Chung Hwee Thiam, Shu Wen Tan, Shu Wen Tan, Joan Lau Joo Eng, Joan Lau Joo Eng, Dan Mei, Syaza Hazwany Mohammad Azhar, Wei Siong Ong, Qi Hui Caris Tan, Wai-Shiu Fred Wong, Wai-Shiu Fred Wong, Wai-Shiu Fred Wong, Veronique Angeli, Veronique Angeli

“…Next, we investigated the effect of the collagen remodeling on the pathophysiology of COPD and airway function in mice lacking Lyve-1+ macrophages exposed chronically to cigarette smoke (CS), a well-established animal model of COPD. We found that deposition of collagen prior CS exposure protected these mice against destruction of alveoli (emphysema), and bronchi thickening and prevented loss of airway function.DiscussionThus, we uncover that interstitial Lyve-1+ macrophages regulate the composition, amount, and architecture of collagen network in the lungs at steady state and that such collagen remodeling functionally impacts the development of COPD. …”
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Avian Infectious Bronchitis Virus: Molecular Detection in Southwestern Ethiopia Chickens by Bezina Arega Emeru, Haregawi Tesfaye Desta

“…No statistical association was observed between any of the animal risk factors and the detection of the virus (P=0.57, 0.586, and 1). …”
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Early Electrophysiological Disintegration of Hippocampal Neural Networks in a Novel Locus Coeruleus Tau-Seeding Mouse Model of Alzheimer’s Disease by A. Ahnaou, C. Walsh, N. V. Manyakov, S. A. Youssef, W. H. Drinkenburg

“…Strikingly, hippocampal CA1 coherence and Eglob measures were impaired in K18-treated animals. Estimation of instantaneous EEG amplitudes revealed deficiency in the propagation directionality of gamma oscillations in the CA1 circuit. …”
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Uncertainty analysis in river quality management considering failure probability: controllable and uncontrollable input pollutants by Mohsen Dehghani Darmian, Britta Schmalz

“…Sustainable protection tools, including dilution flow and detention time, are considered to manage uncontrollable pollutants within a specific time (Tc) and river length constraints (Lc), safeguarding river water quality for both human and animal populations. Dilution flow is practical for specific base velocities but ineffective at high base flow rates. …”
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Fecal shedding level of Haemonchus contortus is associated with gastrointestinal bacterial microbial composition in naturally infected sheep by Jeferson Vidart Ramos, Verônica Rocha Merched, Laura Dias da Silva Ribeiro, Guilherme Neves Lima Rattmann, Renan Eugênio Araújo Piraine, Fabio Pereira Leivas Leite

“…Stool samples were collected monthly for egg counts (EPG), and 16S rRNA gene sequencing was performed on five animals from each group. The average EPG was 2,635 ± 105 for HC, 845 ± 129 for IC, and 110 ± 70 for LC, with a significant difference (p = 0.0001). …”
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ULK1 methylation promotes TGF‐β1‐induced endometrial fibrosis via the FOXP1/DNMT1 axis by Yuhua Zeng, Qing Feng

“…This study will investigate the function and mechanism of forkhead box P1 (FOXP1)/DNA methyltransferase 1 (DNMT1)/unc‐51‐like autophagy activating kinase 1 (ULK1) in IUA. …”
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Use of a microvascular anastomotic coupler device for kidney transplantation in rats by Henrik Lauer, Jana Ritter, Patrick Nachtnebel, Kathrin Simmendinger, Emily Lerchbaumer, Vladyslav Kavaka, Dominik Steiner, Jonas Kolbenschlag, Adrien Daigeler, Johannes C. Heinzel

“…In the research setting, rat models are widely utilized to refine surgical techniques and enhance graft viability. …”
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Cytogenetic impact of gamma radiation and its effects on growth, yield and drought tolerance of maize (Zea mays L.) by Walaa M. Al-Sayed, Hanaa H. El-Shazly, Awatif I. El-Nahas, Ahmed A. A. Omran

“…Abstract Maize is the third most important grain crop worldwide after wheat and rice; it is a vital global crop, serving as a key source of food, animal feed, and industrial products, making it essential for food security and economic stability in many countries. …”
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EFFECT OF REPLACING SOYBEAN MEAL WITH LARVAE MEAL OF BLACK SOLDIER FLY HERMETIA ILLUCENS IN GROWTH PERFORMANCE AND SOME BIOCHEMICAL BLOOD PARAMETERS OF COMMON CARP CYPRINUS CARPIO... by Ahmed I. Albayati, R. S. Attee, M. S. Al-Khshali

“… This study was conducted at the College of Agriculture/ Diyala University/ Department of Animal production to determine the effect of replacing soybean meal with black soldier fly Hermetia illucens larvae meal on the growth performance and some biochemical blood parameters of common carp Cyprinus carpio L. …”
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Analysis of serum levels and DNA methylation of fibroblast growth factor 21 using peripheral blood-derived genomes in patients with obesity by Hiroyuki Shinozaki, Shiori Kawai, Mami Gamo-Kawasaki, Ayano Takei, Kyoko Tsujikado, Kazunori Fukuda, Mototaka Yamauchi, Kenji Hara, Takafumi Tsuchiya, Kohzo Takebayashi, Koshi Hashimoto

“…Furthermore, we found that the DNA methylation state of Fgf21 was involved in obesity in adult animals. In the present study, we analyzed the DNA methylation state of the FGF21 gene (FGF21) in obese patients using genomic DNA extracted from human monocytes and macrophages and investigated the pathophysiological significance of the FGF21 expression response to pemafibrate (PM), a PPARα ligand. …”
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Usp7 contributes to the tail regeneration of planarians via Islet/Wnt1 axis by Ang Liang, Jinglong Liu, Zhiyuan Zhang, Jing Xiao, Dezeng Liu, Zimei Dong, Guangwen Chen

“…Planarians, as ideal model animals for studying regeneration, stem cell proliferation, and apoptosis, have the strong regenerative abilities. …”
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Microglia-secreted TNF-α affects differentiation efficiency and viability of pluripotent stem cell-derived human dopaminergic precursors. by Shirley D Wenker, María Isabel Farias, Victoria Gradaschi, Corina Garcia, Juan Beauquis, María Celeste Leal, Carina Ferrari, Xianmin Zeng, Fernando J Pitossi

“…Even though successful transplantation of dopamine-producing cells into the striatum exhibits favourable effects in animal models and clinical trials; transplanted cell survival is low. …”
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Characterization of Novel Nonobese Type 2 Diabetes Rat Model with Enlarged Kidneys by Ayaka Domon, Kentaro Katayama, Yuki Tochigi, Hiroetsu Suzuki

“…A variety of animal models of diabetes mellitus (DM) are required to study the genetics and pathophysiology of DM. …”
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Snack products from whole-grain red sorghum flour with paprika and cocoa powders by Janić-Hajnal Elizabet, Banjac Vojislav, Filipčev Bojana, Radić Bojana, Kos Jovana, Šimurina Olivera, Cvetković Biljana

“…Given its many health benefits, including its ability to suppress the formation of cancer cells and reduce obesity, heart disease, and diabetes, sorghum is used for both human and animal consumption. It can be used for baking, extrusion, and different cereal-based products such as bread, cookies, pasta, expanded snacks, and breakfast cereals. …”
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Endogenous Estrogen Influences Predator Odor-Induced Impairment of Cognitive and Social Behaviors in Aromatase Gene Deficiency Mice by Yaner Gao, Lei Ma, Feng Gao, Zuoli Sun, Zhengrong Zhang, Yuhong Li, Rena Li

“…In addition, the changes in brain regional neurotransmitters and their associations with TMT-induced changes in behaviors were further investigated in these animals. Our results showed TMT induced immediate fear response in both Ar+/- and WT mice regardless of sexes. …”
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ZNF169 promotes thyroid cancer progression via upregulating FBXW10 by Wen Luo, Qiyu Xiao, Ying Fu

“…Recovery assay in cells and animals were also performed to demonstrate the mechanism. …”
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Effects of Celery Seed Extracts on Some Haematological and Biochemical Parameters in Albino Rats Treated with Gentamicin by Tavga Ismael Mustafa, Zhakaw Khudir Abdullah, Nazar Mohammed Shareef Mahmood, Shorish Mustafa Abdullah Gorony, Kurdo Bapir Chato, Ranjbar Muksy Mohammed Shareef

“…Thirty-two male rats were weighing 300-400 gm carried out for the present research, they controlled environmentally. Animals were divided equally and randomly into four groups each of which contained eight rats. …”
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The Effect of Plastic Waste Attachment on Branching Coral to Zooxanthellae Abundance in the Kelapa Dua Island Waters, Seribu Islands by Fadel Muhammad, Neviaty Putri Zamani, Meutia Samira Ismet, Muhammad Irlan Assidiq Kusuma Ramadhan

“…These results indicated that the attachment of plastic waste to branching coral colonies could be a stressor on coral animals in reducing light intensity, which caused a reduction of zooxanthellae abundance as coral endosymbiont.…”
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