Development of a conjunctival contact–type drug delivery device for latanoprost using hyaluronic acid by Soomin Lee, Mi-Young Jung, Choul Yong Park

“…However, these results are based on animal testing, so further development is needed for clinical use.…”
Get full text

Evaluation of the Digital Ventilated Cage® system for circadian phenotyping by Selma Tir, Russell G. Foster, Stuart N. Peirson

“…C57BL/6J mice exhibited a 24 h period under light/dark conditions, with a free-running period of 23.5 h under constant dark, and period lengthening under constant light. Animals displayed expected phase shifting responses to jet-lag and nocturnal light pulses. …”
Get full text

Traffic-related-air-pollutant PM2.5 Caused Toxicity on Caenorhabditis elegans with Cotreatment of High-dose Glucose and Tempeh by Jian-He Lu, Ming-Hsien Tsai, Sen-Ting Huang, Jia-De Lee, Ta-Chih Hsiao, Wan Nurdiyana Wan Mansor, How-Ran Chao

“…Using Caenorhabditis elegans (C. elegans) as an in vivo animal model, we found that exposure to 12.74 mg L−1 TRAP PM2.5 and 80 mM D-glucose could induce toxicity in nematodes that affects growth, reproduction, locomotion behavior, and lifespan. …”
Get full text

Selection of an optimal method for screening the collection of narrow-leaved lupine held by the Vavilov Institute for the qualitative and quantitative composition of seed alkaloids by A. V. Kushnareva, Т. V. Shelengа, I. N. Perchuk, G. P. Egorova, L. L. Malyshev, Yu. A. Kerv, A. L. Shavarda, M. A. Vishnyakova

“…The collection of narrow-leaved lupine genetic resources held by the N.I. Vavilov Institute of Plant Genetic Resources (VIR) offers wide opportunities for such search by means of mass screening. …”
Get full text

AFP shields hepatocellular carcinoma from macrophage phagocytosis by regulating HuR-mediated CD47 translocation in cellular membrane by Yinglian Pan, Qiushi Yin, Zhaoliang Wang, Gang Wu, Kun Liu, Xiaowei Li, Jinchen Liu, Jiangzheng Zeng, Bo Lin, Wei Li, Mingyue Zhu, Mengsen Li

“…The effect of AFP on regulating the level of CD47 in cellular membrane and growth of tumor in vivo was performed by animal experiment. The association of AFP and CD47 in HCC cells was detected by single cell analysis. …”
Get full text

Developing a Framework to Support the Delivery of Effective Pain Management for Children: An Exploratory Qualitative Study by Joan Simons, Bernie Carter, Jennie Craske

“…Next steps include the development of infographic posters, an animation, and a free online course, which will incorporate the use of Bloom’s taxonomy.…”
Get full text

SEM-2/SoxC regulates multiple aspects of C. elegans postembryonic mesoderm development. by Marissa Baccas, Vanathi Ganesan, Amy Leung, Lucas R Pineiro, Alexandra N McKillop, Jun Liu

“…Detailed analyses of mutant animals harboring this point mutation uncovered new functions of SEM-2 in the M lineage. …”
Get full text

Attenuation of Myocardial Injury by HMGB1 Blockade during Ischemia/Reperfusion Is Toll-Like Receptor 2-Dependent by Jan Mersmann, Franziska Iskandar, Kathrina Latsch, Katharina Habeck, Vera Sprunck, René Zimmermann, Ralf R. Schumann, Kai Zacharowski, Alexander Koch

“…Injection of HMGB1 did, however, not increase infarct size in WT animals. In TLR2−/−-hearts, neither BoxA nor HMGB1 affected infarct size. …”
Get full text

Physical activity, Vitamin D, and all-cause/cardiovascular mortality: a prospective study in older Chinese adults by Mingrui Chen, Ling Cheng, Sisi Yang, Yan Zhang

“…Furthermore, vitamin D accounted for a greater mediating proportion in the physical activities of housework and raising domestic animals/pets. Conclusions Physical activity could reduce the risk of all-cause/cardiovascular mortality and was mediated by vitamin D in older Chinese adults.…”
Get full text

Lack of intracranial atherosclerosis in various atherosclerotic mouse models by Diewertje I Bink, Katja Ritz, Claire Mackaaij, Olga Stam, Sanny Scheffer, Mark R Mizee, Hanneke J Ploegmakers, Bert J van het Hof, Onno J de Boer, Judith C Sluimer, Guido R Y De Meyer, Louise van der Weerd, Helga E de Vries, Mat J A P Daemen

“…Since intracranial atherosclerosis is a common cause of stroke and is associated with dementia, a relevant animal model is needed to study these diseases. We examined the presence of intracranial atherosclerosis in different atherogenic mouse strains and studied differences in vessel wall characteristics in mouse and human tissue in search of possible explanations for the differing atherosclerotic susceptibility between extracranial and intracranial vessels. …”
Get full text

Optimizing Fresh-Cut Apple (Malus sylvestris (L.) Mill.) Quality Through Combination of Sodium Alginate and Calcium Chloride Coatings by Maharani Retna Duhita, Muhammad Khairul Ikhsan

“…The study was conducted at the Biochemistry and Food Laboratory of the Biology Study Program of UIN Maulana Malik Ibrahim Malang and the Animal Husbandry Laboratory of Universitas Brawijaya. …”
Get full text

Contamination of Japanese Retail Foods With Enterotoxigenic Clostridium Perfringens Spores by Takahiro Ohnishi, Maiko Watanabe, Yusuke Yodotani, Emiri Nishizato, Seiya Araki, Satomi Sasaki, Yukiko Hara-Kudo, Yuka Kojima, Naoaki Misawa, Nobuhiko Okabe

“…The contamination of Japanese retail foods and the intestinal contents of animals with the spores of enterotoxigenic Clostridium perfringens were investigated by analyzing clostridial toxin genes (cpa and cpe) using a culture method and PCR. …”
Get full text

PROFIL KOMPETENSI SISWA SMP DI JAWA TIMUR DALAM MENYELESAIKAN TES BERFIKIR TINGKAT TINGGI PEMBELAJARAN SAINS by Hasan Subekti

“…Familiarize learners to communicate, think critically and creatively and to consider moral values of Pancasila is one Permendikbud 81 A mandate in 2013. The need for students to be exposed to high level thinking tests in Learning Science is to hone the skills of students at the high school level. The purpose of this study was to describe the level of student mastery and achievement test indicator junior high school students in East Java in resolving high level thinking tests of learning science. This study was conducted at 20, 23, and 28 November 2012 in three districts, there are: Blitar, Mojokerto, and Pamekasan. The population of this study were junior high school students in East Java with a sample of students SMP 3 Nglegok Blitar (15 peoples), SMP 2 Dlanggu Mojokerto (15 peoples) and SMP 7 Pamekasan (15 peoples) by using purposive sampling technique. Data sources such as student scores on the analysis of high-level thinking skills test developed by USAID Priority Team. Techniques of data collection conducted by researchers through the provision of test instruments to students, then corrected degree of truth answers based on predefined criteria. Analysis of data in quantitative descriptive data then qualitatived. The conclusions of this study are: competence Junior high school students in East Java in resolving high level thinking tests category learning science enough (enough with a mean value of C- with a score of 43.8) and achievement test results categorized good indicators, namely: (a) observation of characteristic Distinctive animals (75.6), and analyze the properties of liquid water (75.6).…”
Get full text

Plasticizers May Activate Human Hepatic Peroxisome Proliferator-Activated Receptor α Less Than That of a Mouse but May Activate Constitutive Androstane Receptor in Liver by Yuki Ito, Toshiki Nakamura, Yukie Yanagiba, Doni Hikmat Ramdhan, Nozomi Yamagishi, Hisao Naito, Michihiro Kamijima, Frank J. Gonzalez, Tamie Nakajima

“…However, species differences in the receptor functions between rodents and human make it difficult to precisely extrapolate their toxicity from animal studies to human. In this paper, we compared the species differences in the activation of mouse and human hepatic PPARα by these plasticizers using wild-type (mPPARα) and humanized PPARα (hPPARα) mice. …”
Get full text

Within-host bayesian joint modeling of longitudinal and time-to-event data of Leishmania infection. by Felix M Pabon-Rodriguez, Grant D Brown, Breanna M Scorza, Christine A Petersen

“…The cohort was chosen to start with healthy infected animals, and this is the majority of the data. The model also characterizes the relationship features of the longitudinal outcomes and time-to-death due to progressive Leishmania infection. …”
Get full text

Statin Induced Changes in Rat Pancreatic Tissue: A Histological and Biochemical Perspective by Abdullah Qamar, Hammad Gul Khan, Muhammad Marghoob Khan, Muhammad Rizwan Bashir Kiani, Hina Kundi, Fareeha Mushtaq

“…These novel findings provide unique insights into simvastatin's effects on pancreatic morphology using a robust animal model. …”
Get full text

A Novel Paramagnetic Substrate for Detecting Myeloperoxidase Activity in Vivo by Mohammed S. Shazeeb, Yang Xie, Suresh Gupta, Alexei A. Bogdanov

“…Specifically, gadolinium chelates of bis-5-hydroxytryptamide-DTPA (bis-5HT-DTPA(Gd)) have been used to image localized inflammation in animal models by detecting neutrophil-derived myeloperoxidase (MPO) activity at the inflammation site. …”
Get full text

Lactoferrin: a secret weapon in the war against pathogenic bacteria by Lucero Ruiz-Mazón, Gerardo Ramírez-Rico, Mireya de la Garza

“…Because of its effectiveness, accessibility, low cost, and nontoxicity, Lf could be a promising alternative for preventing or treating infections in animals and humans.…”
Get full text

The effect of space flight on genes expression in brain by A. S. Tsybko, T. V. Ilchibaeva, N. K. Popova

“…In search of underlying mechanisms, many experimental tools have been developed, ranging from microgravity modeling on Earth to space flight investigations, part of which is to study the expression of genes and proteins. Unlike bone and muscle tissue, molecular changes in nerve cells during spaceflight are practically unexplored. …”
Get full text

Interferon gamma‐mediated prevention of tumor progression in a mouse model of multiple myeloma by Zoltán Kellermayer, Sabrin Tahri, Madelon M. E. deJong, Natalie Papazian, Cathelijne Fokkema, Elodie C. G. Stoetman, Remco Hoogenboezem, Gregory vanBeek, Mathijs A. Sanders, Louis Boon, Chelsea Den Hollander, Annemiek Broijl, Pieter Sonneveld, Tom Cupedo

“…Transfer of 5TGM1 cells in C57Bl/6 mice led to stable disease with low tumor burden in a subset of animals. Stable disease was associated with sustained activation and expansion of NK cells, ILC1, and CD8+ T cells, a response that was lost upon disease progression. …”
Get full text