Extending FABRIK with Obstacle Avoidance for Solving the Inverse Kinematics Problem by Songqiao Tao, Huajin Tao, Yumeng Yang

“…Inverse kinematics (IK) has been extensively applied in the areas of robotics, computer animation, ergonomics, and gaming. Typically, IK determines the joint configurations of a robot model and achieves a desired end-effector position in robotics. …”
Get full text

THE CURRENT DEVELOPMENTS OF AGRICULTURAL BIOTECHNOLOGIES MARKET by A. M. Shkolyarenko

“…In 2015, the US Department of Agriculture authorized the commercial use of GM farm animals. The development of agricultural biotechnology market is constrained by opponents of GM crops in more than 160 countries, which include Russia and the European Union, where the production of GM crops is banned due to economic, ethical, ideological and biological reasons. …”
Get full text

CYTOTOXIC EFFECT OF FREEZE DRIED BOVINE CARTILAGE POWDER AND PLATELET RICH PLASMA (PRP) TO MESENCHYMAL STEM CELL (MSCs) by Dwikora Novembri Utomo, Anthoni Yusbida

“…This research was conducted using pure experimental research design in 4 groups of animal stem cells which being added with scaffold freeze dried bovine cartilage scaffold provided with platelet rich plasma. …”
Get full text

Deciphering the Role of Adrenergic Receptors in Alzheimer’s Disease: Paving the Way for Innovative Therapies by Androulla N. Miliotou, Andria Kotsoni, Lefteris C. Zacharia

“…The scope of this review article is to comprehensively review the literature on the possible role of adrenergic receptors in neurodegenerative diseases, stemming from the use of agonists and antagonists including antihypertensive and asthma drugs acting on the adrenergic receptors, but also from animal models and in vitro models where these receptors have been studied. …”
Get full text

Successfully Climbing the “STAIRs”: Surmounting Failed Translation of Experimental Ischemic Stroke Treatments by Michael P. Kahle, Gregory J. Bix

“…Therefore, this paper will focus on considerations for several key aspects of preclinical stroke studies including the selection and execution of the animal stroke model, drug/experimental treatment administration, and outcome measures to improve experimental validity and translation potential. …”
Get full text

Viral Transgene Expression Delivered by Repeat Intraocular Adenoviral Vector Injection: in Vivo Live Imaging Study by Peter L. Gehlbach, Roy S. Chuck, Chung-Gyu Park, Choul Yong Park

“…In vivo live imaging technology was able to assess dynamically intraocular luciferase expression in a single animal population throughout the entire experiment period. …”
Get full text

Effectiveness of natural coagulants in water and wastewater treatment by S. Nimesha, C. Hewawasam, D. Jayasanka, Y. Murakami, N. Araki, N. Maharjan

“…Natural coagulants are derived from either plants, animals, or microorganisms. This study has elaborated on the nature and mechanisms, and types of natural coagulants. …”
Get full text

Alterations of the Murine Gut Microbiome with Age and Allergic Airway Disease by Marius Vital, Jack R. Harkema, Mike Rizzo, James Tiedje, Christina Brandenberger

“…After challenge, the animals were sacrificed, blood serum was collected for cytokine analysis, and the lungs were processed for histopathology. …”
Get full text

Significance of Persistent Inflammation in Respiratory Disorders Induced by Nanoparticles by Yasuo Morimoto, Hiroto Izumi, Etsushi Kuroda

“…Pulmonary inflammation, especially persistent inflammation, has been found to play a key role in respiratory disorders induced by nanoparticles in animal models. In inhalation studies and instillation studies of nanomaterials, persistent inflammation is composed of neutrophils and alveolar macrophages, and its pathogenesis is related to chemokines such as the cytokine-induced neutrophil chemoattractant (CINC) family and macrophage inflammatory protein-1α and oxidant stress-related genes such as heme oxygenase-1 (HO-1). …”
Get full text

The Anti-Inflammatory Role of Vitamin E in Prevention of Osteoporosis by A. S. Nazrun, M. Norazlina, M. Norliza, S. Ima Nirwana

“…Anticytokine therapy using cytokine antagonists such as IL-receptor antagonist and TNF-binding protein was able to suppress the activity of the respective cytokines and prevent bone loss. Several animal studies have shown that vitamin E in the forms of palm-derived tocotrienol and α-tocopherol may prevent osteoporosis in rat models by suppressing IL-1 and IL-6. …”
Get full text

Dehydration-Induced Anorexia Reduces Astrocyte Density in the Rat Corpus Callosum by Daniel Reyes-Haro, Francisco Emmanuel Labrada-Moncada, Ricardo Miledi, Ataúlfo Martínez-Torres

“…Anorexia nervosa is an eating disorder associated with severe weight loss as a consequence of voluntary food intake avoidance. Animal models such as dehydration-induced anorexia (DIA) mimic core features of the disorder, including voluntary reduction in food intake, which compromises the supply of energy to the brain. …”
Get full text

Classification, Mechanisms of Action, and Therapeutic Applications of Inhibitory Oligonucleotides for Toll-Like Receptors (TLR) 7 and 9 by Petar S. Lenert

“…Several short ODNs have already shown promise as pathway-specific therapeutics for animal lupus. We envision their future use in human SLE, microbial DNA-dependent sepsis, and in other autoinflammatory diseases.…”
Get full text

Impact of cholesterol in encapsulated vitamin E acetate within cocoliposomes by Hudiyanti Dwi, Hidayati Salma Nur, Siahaan Parsaoran, Ngadiwiyana Ngadiwiyana, Nur Abidin, Sari Ratna Indria, Amalia Indrian Rizka, Christa Sherllyn Meida, Patrechia Amanda Chindy, Maharani Adinda Eka

“…Vitamin E acetate (VEA) is commonly used in manufacturing pharmaceuticals, food additives, and animal feeds. However, VEA possesses disadvantages, including low water solubility, low bioavailability, and susceptibility to degradation and oxidation. …”
Get full text

Thiazolidinediones and Edema: Recent Advances in the Pathogenesis of Thiazolidinediones-Induced Renal Sodium Retention by Shoko Horita, Motonobu Nakamura, Nobuhiko Satoh, Masashi Suzuki, George Seki

“…TZDs improve insulin resistance by activating peroxisome proliferator-activated receptor gamma (PPARγ) and ameliorate diabetic and other nephropathies, at least, in experimental animals. However, TZDs have side effects, such as edema, congestive heart failure, and bone fracture, and may increase bladder cancer risk. …”
Get full text

Neuroprotection and Functional Recovery Associated with Decreased Microglial Activation Following Selective Activation of mGluR2/3 Receptors in a Rodent Model of Parkinson's Diseas... by Hugh Chan, Helen Paur, Anthony C. Vernon, Virginia Zabarsky, Krishna P. Datla, Martin J. Croucher, David T. Dexter

“…We now report that delayed post lesion treatment with 2R,4R-APDC (10 nmol), results in robust neuroprotection of the nigrostriatal system, which translated into functional recovery as measured by improved forelimb use asymmetry and reduced (+)-amphetamine-induced rotation compared to vehicle treated animals. Interestingly, these beneficial effects were associated with a decrease in microglial markers in the SNc, which may suggest an antiinflammatory action of this drug.…”
Get full text

Efficacy of Oregano Extract Ointment on Fibroblast Cells and Epidermis in Albino Rats with Excisional Wound Model by Muhammad Arfan Lesmana, Indah Amalia Amri, Ardilla Rachma Cahyanissa, Kartika Myrnandari Geoputri, Agri Kaltaria Anisa, Andreas Bandang Hardian

“…This study aimed to determine the effect of oregano extract ointment therapy on the number of fibroblast cells and the epidermal thickness in excised wounds. The experimental animals used were 20 male Wistar strain albino rats, 12 weeks old, weighing 100–150 g, divided into 5 treatment groups i.e., (C-) not excised and without ointment, (C+) excised and without ointment, and the treatment group were excised using a 5 x 5 mm biopsy punch and treated with oregano extract ointment using concentrations of (T1) 3%, (T2) 6% and (T3) 9% twice daily for 14 days in an excised wound. …”
Get full text

Ganoderma lucidum spore oil (GLSO), a novel antioxidant, extends the average life span in Drosophila melanogaster by Yi Zhang, Hongfei Cai, Zhu Tao, Cheng Yuan, Zhaojian Jiang, Juyan Liu, Hiroshi Kurihara, Wendong Xu

“…Future work should investigate the value of GLSO as a functional food for the prevention of aging in larger animal models.…”
Get full text

Muscarinic ACh Receptors Contribute to Aversive Olfactory Learning in Drosophila by Bryon Silva, Claudia Molina-Fernández, María Beatriz Ugalde, Eduardo I. Tognarelli, Cristian Angel, Jorge M. Campusano

“…This effect is not explained by an alteration in the ability of animals to respond to odorants or to execute motor programs. …”
Get full text

Divergence of gut bacteria through the selection of genomic variants implicated in the metabolism of sugars, amino acids, and purines by small extracellular vesicles in milk by Fang Zhou, Peerzada Tajamul Mumtaz, Haluk Dogan, Roland Madadjim, Juan Cui, Janos Zempleni

“…Here, we report that small extracellular vesicles (sEVs) in milk mediate the communication between bacteria and animal kingdoms, increase the divergence of bacteria in the intestine, and alter metabolite production by bacteria. …”
Get full text

Domestic Horse Bite: An Unusual Etiology of Crush Injury of the Fourth Finger—How to Manage? by Naoufal Elghoul, Youssef Jalal, Ayoub Bouya, Ali Zine, Abdeloihab Jaafar

“…Almost 2% of all emergency admissions involve an animal bite. While horses bite humans very rarely, their bites are mostly associated with fatalities. …”
Get full text