Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery by Arda Halu, Sarvesh Chelvanambi, Julius L. Decano, Joan T. Matamalas, Mary Whelan, Takaharu Asano, Namitra Kalicharran, Sasha A. Singh, Joseph Loscalzo, Masanori Aikawa

“…Results Cell type-specific gene-drug perturbation networks built using QUIZ-C are topologically distinct, reflecting the biological uniqueness of the cell lines in CMap, and are enriched in known drug targets. …”
Get full text

Liver transcriptome analysis reveals PSC-attributed gene set associated with fibrosis progression by Alena Laschtowitz, Eric L. Lindberg, Anna-Maria Liebhoff, Laura Anne Liebig, Christian Casar, Silja Steinmann, Adrien Guillot, Jun Xu, Dorothee Schwinge, Michael Trauner, Ansgar Wilhelm Lohse, Stefan Bonn, Norbert Hübner, Christoph Schramm

“…Herein, we identify a PSC-specific gene set of biliary fibrosis progression attributing to a uniquely complex milieu of different cell types, including innate and adaptive immune cells while neutrophils and macrophages showed an earlier involvement in fibrosis initiation in PSC in contrast to PBC and metabolic dysfunction-associated steatotic liver disease. …”
Get full text

Multispecies pasture diet and cow breed affect the functional lipid profile of milk across lactation in a spring-calving dairy system by Renata Kostovska, Gaetan Drouin, Joaquín J. Salas, Mónica Venegas-Calerón, Brendan Horan, John T. Tobin, Tom F. O'Callaghan, Sean A. Hogan, Alan L. Kelly, Laura G. Gómez-Mascaraque

“…In addition to the 2 pasture diets, the study uniquely examined the combined effects of breed, namely Holstein Friesian (HF) or Jersey Holstein Friesian (JFX), and lactation stage in Ireland, spanning from March to November. …”
Get full text

Synthetic CB1 Cannabinoids Promote Tunneling Nanotube Communication, Cellular Migration, and Epithelial–Mesenchymal Transition in Pancreatic PANC-1 and Colorectal SW-620 Cancer Cel... by David A. Bunsick, Leili Baghaie, Yunfan Li, Abdulrahman M. Yaish, Emilyn B. Aucoin, Elizabeth Skapinker, Rashelle Aldbai, Myron R. Szewczuk

“…By initiating their communications for invasion, cancer cells can reprogram their cellular activities to initiate their proliferation and migration and uniquely counteract metabolic stress during their progression. …”
Get full text

Continuous theta-burst stimulation demonstrates language-network-specific causal effects on syntactic processing by Chenyang Gao, Junjie Wu, Yao Cheng, Yuming Ke, Xingfang Qu, Mingchuan Yang, Gesa Hartwigsen, Luyao Chen

“…These results shed light on the uniqueness and the specific causal role of the language network for the human language faculty, further supporting the causally separable view of the functional dissociation between the language network and the domain-general/multiple-demand network.…”
Get full text

TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles by Dorival Mendes Rodrigues-Junior, Chrysoula Tsirigoti, Konstantina Psatha, Dimitris Kletsas, Michalis Aivaliotis, Carl-Henrik Heldin, Aristidis Moustakas

“…., matrix metalloproteinases, including MMP9) were either uniquely enriched on EVs or strongly enhanced after TGF-β stimulation. …”
Get full text

Modelo de aprendizaje para la selección de un proyecto diseño-construcción (llave en mano) en el sector público A learning model for design-build project selection in the public se... by Alfonso Bastias, Keith R Molenaar

“…El método primario de ejecución de proyectos en el sector público en los Estados Unidos (U.S.), tradicionalmente ha sido la ejecución diseño-licitación-construcción. …”
Get full text

SARS-CoV-2 infections in pediatric and young adult recipients of chimeric antigen receptor T-cell therapy: an international registry report by Hongyan Liu, Colleen Callahan, Shannon L Maude, Kevin Owen McNerney, Rebecca M Richards, Paibel Aguayo-Hiraldo, Friso G Calkoen, Julie-An Talano, Amy Moskop, Adriana Balduzzi, Jennifer Krajewski, Hema Dave, Anant Vatsayan, Yimei Li, Kara Lynn Davis

“…Patients undergoing chimeric antigen receptor (CAR) T-cell therapy for relapsed/refractory B-cell malignancies are uniquely immunosuppressed due to CAR T-mediated B-cell aplasia (BCA). …”
Get full text

Autoinducer-2 enhances the defense of Vibrio furnissii against oxidative stress and DNA damage by modulation of c-di-GMP signaling via a two-component system by Heng Zhang, Wenjin Zhao, Wenguang Yang, Huimin Zhang, Xinyu Qian, Kai Sun, Qiao Yang, Xihui Shen, Lei Zhang

“…It is worth noting that the periplasmic protein LuxP is the uniquely identified receptor for AI-2 in Vibrio spp. …”
Get full text

Broad-line Region Characterization in Dozens of Active Galactic Nuclei Using Small-aperture Telescopes by Catalina Sobrino Figaredo, Doron Chelouche, Martin Haas, Michael Ramolla, Shai Kaspi, Swayamtrupta Panda, Martin W. Ochmann, Shay Zucker, Rolf Chini, Malte A. Probst, Wolfram Kollatschny, Miguel Murphy

Get full text

Prediction of pathological complete response after neoadjuvant chemotherapy for HER2-negative breast cancer patients with routine immunohistochemical markers by Lothar Häberle, Ramona Erber, Paul Gass, Alexander Hein, Melitta Niklos, Bernhard Volz, Carolin C. Hack, Rüdiger Schulz-Wendtland, Hanna Huebner, Chloë Goossens, Matthias Christgen, Thilo Dörk, Tjoung-Won Park-Simon, Andreas Schneeweiss, Michael Untch, Valentina Nekljudova, Sibylle Loibl, Arndt Hartmann, Matthias W. Beckmann, Peter A. Fasching

Get full text

Idénymunka és idénymunkások a gyümölcstermesztésben. Hazai munkaerőpiaci folyamatok és közelképek európai összevetésben by Katalin Kovács, Eszter Hamza, Katalin Rácz, Nigel John Swain, Monika Mária Váradi

“…Magyarországon a szezonális foglalkoztatást a rendszerváltást követő években munkaerőtöbblet jellemezte, részint az ágazatból kikerült és munkanélkülivé vált embereknek, részint a már ekkor a határon túlról, elsősorban Erdélyből érkező szezonális munkások növekvő számának köszönhetően. Az uniós munkaerőpiac megnyílása és a 2008-as gazdasági válság átalakította a szezonális mezőgazdasági munkások összetételét: a jellemzően magyar ajkú és nemzetiségű, magasabban kvalifikált erdélyiek Európa más országai felé vették az irányt, helyükre szegénységben élő, képzetlen romák érkeztek a határon túlról. …”
Get full text

The role of teachers and administrators in supporting the adaptation of students with special needs in mainstream high schools by Amir Mahmood, Xiao Huang, Nadia Rehman

“…Originality/value – This study uniquely explores the combined effects of administrative and teacher support on the adaptation of high school students with special needs in mainstream education, highlighting the synergistic relationship between these support systems. …”
Get full text

Educide amid conflict: the struggle of the Palestinian education system by Dalal Iriqat, Rula Alousi, Tahani Z. Aldahdouh, Alaa AlDahdouh, Iman Dankar, Dima Alburai, Mohamed Buheji, Abdo Hassoun

“…By framing the deliberate dismantling of Gaza’s education sector within a genocidal context, the paper offers a novel perspective on the intersection of conflict, education and cultural preservation. It contributes uniquely to academic and policy discourse by combining documented evidence with a call for international accountability, emphasizing the critical role of education as both a human right and a foundation for resilient societies in conflict zones.…”
Get full text

Détection de différents rétrovirus chez des primates non-humains infectés par STLV-1 ou SFV et pathologie viro-induite by Jocelyn Turpin, Sandrine Alais, Ambroise Marçais, Olivier Hermine, Réjane Rua, Antoine Gessain, Romain Lacoste, Renaud Mahieux

“…Il est communément établi que l'ADN proviral de SFV peut être détecté par PCR dans les cellules du sang circulant et dans la salive, tandis que celui de STLV-1 est généralement recherché uniquement dans les cellules mononucléées du sang périphérique. …”
Get full text

El Ekhtiyar ou la mise en martyr des policiers égyptiens. La construction d’un « grand récit » sur petit écran ? by Sixtine Deroure

“…La police, qui est montrée comme étant irréprochable et toujours respectueuse des lois, est uniquement mise en scène dans la « lutte contre le terrorisme » menée aux côtés de l’armée. …”
Get full text

O delírio segundo Freud e Jung: aportes recíprocos e distinções by Carlos Augusto Pereira Viana

“…A partir de então, muitos foram os encontros, os estudos, a profícua correspondência ocorrido entre ambos, culminando inclusive com a viagem histórica que Jung acompanharia Freud aos Estados Unidos da América, onde este anunciou que viera trazer à peste à comunidade acadêmica americana, termo pelo que designou à sua descoberta. …”
Get full text

Presenting a model to explain unfavorable risk and favorable risk according to psychological variables in predicting market fluctuations in the Iranian capital market. by Hasan Rezaeikangi, Mahdi Mohammad Bagheri, Hojat Babaei, Ali Raeispour Rajabali

“…At the system level, there is a significant difference in uniqueness and overlap between linear and non-linear risk spillover networks. …”
Get full text

The Secondary Component of the Extremely Low Mass Ratio Massive Binary HD 165246 Revealed by GHOST by C. N. Rodriguez, T. Ansin, G. A. Ferrero, O. G. Benvenuto, R. Gamen, N. I. Morrell, J. I. Arias, R. E. Higa, C. Putkuri, C. Johnston, K. Chiboucas, E. Deibert, C. R. Hayes, J.-E. Heo, M. Jeong, V. Kalari, E. Martioli, V. M. Placco, K. A. Venn, S. Xu, R. Diaz, M. Gomez-Jimenez, R. Ruiz-Carmona, C. Simpson, A. W. McConnachie, J. Pazder, G. Burley, T. A. M. Berg, J. G. Robertson, K. Labrie, J. Thomas-Osip

Get full text

Pressure Methods for Primary Hemorrhage Control: A Randomized Crossover Trial

“…Resumen Antecedentes: la importancia del control de la hemorragia en las lesiones traumáticas se destacó en la campaña federal de 2015 Stop the Bleed (Detén el Sangrado) en los Estados Unidos y posteriormente en el desarrollo de los cursos modulares de control de hemorragia ofrecidos por organizaciones como la Cruz Roja Americana (https://www.dhs.gov/stopthebleed). …”
Get full text