Mechanisms of Resistance to Trastuzumab and Novel Therapeutic Strategies in HER2-Positive Breast Cancer by Andrea L. A. Wong, Soo-Chin Lee

“…HER2-positive breast cancers have poorer prognosis and are prime candidates for molecular-targeted therapy because they are driven by the unique mechanism of HER2 oncogene addiction. While anti-HER2 agents such as trastuzumab and lapatinib are integral to the treatment of HER2-positive breast cancer, intrinsic and secondary resistance pose a significant challenge, underscoring the need to develop novel anti-HER2 therapies. …”
Get full text

Asian Perspective on Hepatitis B Virus and Hepatitis C Virus Elimination by Apichat Kaewdech, Phunchai Charatcharoenwitthaya, Teerha Piratvisuth

“…Given the overlapping epidemiology of HBV and HCV, comprehensive public health interventions tailored to the unique contexts of different Asian countries are crucial for achieving global elimination goals. …”
Get full text

The role of immersive technologies in increasing labour productivity on the example of augmented and virtual reality by N. G. Merzlikin

“…In essence, these technologies expand the boundaries of human capabilities in interaction with virtual and augmented spaces, providing unique management tools for solving tasks of varying complexity, and have significant potential in the context of better productivity. …”
Get full text

Raman Spectroscopic Analysis of H2O2-Stimulated Three-Dimensional Human Skin Models Containing Asian, Black, and Caucasian Melanocytes by Shin-ichi Morita, Sota Takanezawa, Akira Date, Shin Watanabe, Yasushi Sako

“…The changes in the Asian skin model were unique compared to those in the above two. Eumelanin and pheomelanin are probably the main compounds that differentiate dermal cells in terms of their sensitivity to hydrogen peroxide.…”
Get full text

Compiling Multicopy Single-Stranded DNA Sequences from Bacterial Genome Sequences by Wonseok Yoo, Dongbin Lim, Sangsoo Kim

“…Among 16,844 bacterial sequences possessing a retron-type RT domain, we identified 48 unique types of msDNA. Currently, the biological role of msDNA is not well understood. …”
Get full text

Triskelion—In Pursuit of Proficiency Through Immersive Gameplay by Victor Winter

“…This composition of elements makes Triskelion unique in the genre of academic educational games. …”
Get full text

Measurement of the Physical Properties during Laparoscopic Surgery Performed on Pigs by Using Forceps with Pressure Sensors by Hiroyuki Yamanaka, Kazuhide Makiyama, Kimito Osaka, Manabu Nagasaka, Masato Ogata, Takahiro Yamada, Yoshinobu Kubota

“…Objectives. Here we developed a unique training system, a patient specific virtual reality simulator, for laparoscopic renal surgery. …”
Get full text

Cerebral hypoperfusion due to rapid blood pressure control in a patient with type B aortic dissection: A case report by Yikun Zhao, Heng Li, Yuanyuan Guo

“…While current guidelines emphasize specific numerical values for blood pressure control in type B aortic dissection, the case underscores the potential need for a more individualized approach tailored to the unique characteristics of each patient.…”
Get full text

A Rare Case of Posttraumatic Bilateral BPPV Presentation by Sinisa Maslovara, Andro Kosec, Ivana Pajic Matic, Anamarija Sestak

“…The disease manifested bilaterally, which is not uncommon posttraumatically, but in this case, it manifested itself as canalithiasis of the posterior canal on both sides and cupulolithiasis of the right lateral canal, which to our knowledge is a unique and, until now, unpublished case. The aim of this review is to point out the fact that, in such a complex multicanal and bilateral clinical presentation of BPPV, it is not sufficient to perform only positioning but also additional laboratory tests. …”
Get full text

Exploring and developing diverse potentials and abilities – new perspectives by Wiesława Limont

“…Education should embrace the unique and individualized growth of gifted individuals, with the aim of facilitating their development towards higher values and a complete personality. …”
Get full text

Probabilidades de detectar rayos gamma o cósmicos por HAWC con el juego del embaldosado libre by Margarita Tetlalmatzi Montiel, Erika Elizabeth Rodríguez Torres, Rafael Villarroel Flores

“…Con la asociación realizada se tiene un modelo simple para calcular las probabilidades de que las cascadas caigan sobre HAWC y el anillo outriggers en tres casos posibles. Cada caso se estudia suponiendo la región ocupada por el observatorio como cuadrada o hexagonal. …”
Get full text

When Operating on Dead People Saves Lives: Benefits of Surgical Organ Donor Intensivists by Kristin Long, Cynthia Talley, Rebecca B. Yarrison, Andrew Bernard

“…A thorough literature review examining aggressive interventions on potential organ donors was conducted after experience with a unique case at this institution. Articles were reviewed for the types of interventions performed as well as the time frame in relation to organ donation. …”
Get full text

The teaching pathologists association of Mumbai: A legacy that lives on by Jaya Deshpande, Rachana Binayke, Bhuvaneshwari Kandalkar, Manisha Khare

“…It was left to the discretion of the head of the department. This has been a unique association with no formal office bearers and runs purely on the understanding and cooperation of the senior teachers of these institutes. …”
Get full text

Evaluation of the contemporary aesthetic education value of Chinese classical dance education thought by Wen Qi, Yunxia Ma

“…Its educational philosophy of "neutralization" and "twin" can provide a unique value perspective and practical path for modern aesthetic education. …”
Get full text

Tuning Metamaterials for Applications at DUV Wavelengths by Andrew Estroff, Bruce W. Smith

“…The unique properties of metamaterials, namely, their negative refractive index, permittivity, or permeability, have gained much recent attention. …”
Get full text

Pseudohypertension-Like Presentation: An Exceptionally Rare Presentation in an Athletic Female Patient with Morphea by Ahmed Al-Imam

“…The peculiar anatomic localization of the plaque anterior to the brachial artery leads to faulty blood pressure measurement as recorded by mercurial sphygmomanometer. Conclusion. This unique presentation of Morphea en plaque carries an important message in relation to the basic medical practice and in relation to the accurate measurement of the vital signs.…”
Get full text

Optimization of Photonic Nanocrystals for Invisibility Using Artificial Intelligence by Z. Dorrani

“…Photonic crystals, as microscopic structures with unique optical properties, are used in the design of invisibility systems. …”
Get full text

Agitated Depression Associated With Flurazepam Discontinuation by Mohamed Salih, Reem Mohamed Osman, Wala Alim, Leena Khalid, Wafa Sosal, Danya Ibrahim, Yassir Mahgoub

“…This case provides insight into this unique variant of depression and the role of GABA agonists in its pathology and management.…”
Get full text

Mitigating errors in analog quantum simulation by Hamiltonian reshaping or Hamiltonian rescaling by Rui-Cheng Guo, Yanwu Gu, Dong E. Liu

“…Quantum simulations overcome these limitations, with analog simulators offering unique advantages over digital methods, such as lower systematic errors and reduced circuit depth, making them efficient for studying complex quantum phenomena. …”
Get full text

The critical role of anthropology in attaining happiness: An Islamic perspective by Agha-Mohammadi Morteza

“…Reaching this state of spiritual fulfillment brings about a form of happiness that transcends sorrow and grief, offering a unique state of pure joy in human existence.…”
Get full text