Downregulation of the Yes-Associated Protein Is Associated with Extracellular Matrix Disorders in Ascending Aortic Aneurysms by Haiyang Li, Wenjian Jiang, Weihong Ren, Dong Guo, Jialong Guo, Xiaolong Wang, Yuyong Liu, Feng Lan, Jie Du, Hongjia Zhang

“…Previous studies indicate that extracellular matrix (ECM) disorders lead to the apoptosis of Vascular Smooth Muscle Cells (VSMCs), which impairs the aortic wall by reducing the generation of elastic fibers, and ultimately result in ascending aortic aneurysm. …”
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Endothelial cells under disturbed flow release extracellular vesicles to promote inflammatory polarization of macrophages and accelerate atherosclerosis by Zhe Hou, Li Deng, Fei Fang, Ting Zhao, Yaojia Zhang, Gang Li, Michael Z. Miao, Yongcang Zhang, Hongchi Yu, Xiaoheng Liu

“…However, the phenotypic switching of vascular smooth muscle cells was not affected by exposure to these EVs. …”
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Modulation of Biomaterial‐Associated Fibrosis by Means of Combined Physicochemical Material Properties by Lisa E. Tromp, Torben A.B. van derBoon, Roderick H.J. deHilster, Ruud Bank, Patrick van Rijn

“…This research provides a powerful tool for cell‐material studies and represents a critical step toward enhancing implant properties and reducing complications, ultimately improving patient outcomes.…”
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Atractylenolide-I prevents abdominal aortic aneurysm formation through inhibiting inflammation by Shuxiao Chen, Xiaotian Liu, Xincheng Zhou, Weixiao Lin, Minting Liu, Haoran Ma, Keli Zhong, Qiming Ma, Chengjian Qin, Chengjian Qin

“…Moreover, ATL-I restrained loss of smooth muscle cells and elastic fiber degradation by suppressing MMP-2 and MMP-9 expression. …”
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Single-nucleus RNA sequencing reveals distinct pathophysiological trophoblast signatures in spontaneous preterm birth subtypes by Cherilyn Uhm, Jianlei Gu, Weina Ju, Stephanie Pizzella, Hande Oktay, Joyce Yao-Chun Peng, Sararose Guariglia, Yong Liu, Hongyu Zhao, Yong Wang, Ramkumar Menon, Nanbert Zhong

“…In contrast, sPTL was marked by increased smooth muscle contraction, vascular remodeling, and altered signaling dynamics involving fibroblasts, including TGF-β and WNT pathways. …”
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Cellular Contractility Profiles of Human Diabetic Corneal Stromal Cells by Thi N. Lam, Sarah E. Nicholas, Alexander Choi, Jian-Xing Ma, Dimitrios Karamichos

“…These findings, and future studies, may contribute to better understanding of the pathobiology of diabetic keratopathy and ultimately the development of new therapeutic approaches.…”
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Metabolics-Based Study on the Therapeutic Mechanism Behind the Effect of Shenhuang Plaster Applied to the Shenque Acupoint on Gastrointestinal Motility in POI Mice by Yanan Shi, Chenglei Wu, Ting Liu, Rongyun Wang, Bin Ding, Qiuhua Sun

“…Results: We found that SHP could reduce the mRNA expression of inflammatory mediators in the smooth muscle tissue of the small intestine, regulate the structure and function of the intestinal microbiota, and modulate serum phenylalanine, carnitine, and glutamic acid levels. …”
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Anti-Scar Effects of Micropatterned Hydrogel after Glaucoma Drainage Device Implantation by Yiling Han, Qiangwang Geng, Aimeng Dong, Menglu Jiang, Jingyi Ma, Wulian Song, Pan Fan, Yuanyuan Li, Jiawen Gao, Fenghua Zhang, Jinsong Leng, Huiping Yuan

“…Pattern topography suppressed F-actin expression and mitigated actin-dependent nuclear migration of myocardin-related transcription factor A (MRTF-A) during the proliferative phase after GDD implantation. Ultimately, the expression of α-smooth muscle actin (α-SMA), a key fibrosis-related gene product, was suppressed. …”
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Genomic insights into pigeon breeding: GWAS for economic traits and the development of a high-throughput liquid phase array chip by Bo Zhang, Jianyuan Ma, Li Shen, Yipu Li, Shuxian Xie, Haoxuan Li, Jing Li, Xianyao Li, Zheng Wang

“…GWAS identified several candidate genes, including PPARGC1A and ADGRA3, linked to muscle development and metabolic regulation. To enhance breeding efficiency, this study developed a Liquid Phase Chip (LPC), designed to use high-throughput technology for identifying genetic markers related to carcass traits. …”
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Brodifacoum causes coagulopathy, hemorrhages, and mortality in rainbow trout (Oncorhynchus mykiss) at environmentally relevant hepatic residue concentrations by Hannah Schmieg, Hermann Ferling, Karina Annika Bucher, Stefanie Jacob, Julia Regnery, Hannah Schrader, Julia Schwaiger, Anton Friesen

“…Sampling of trout every 15 days over the 60 days period allowed monitoring of brodifacoum concentrations in serum, liver, and muscle tissue, as well as occurring effects over the course of the experiment. …”
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Transcriptomic analysis of Rhipicephalus microplus hemocytes from female ticks infected with Babesia bovis or Babesia bigemina by Rubikah Vimonish, Janaina Capelli-Peixoto, Wendell Johnson, Lowell Kappmeyer, Perot Saelao, Naomi Taus, Chungwon Chung, Massaro Ueti

“…The findings of this study will enhance our understanding on how Babesia parasites survive in the hostile environment of ticks and perpetuate their transmission cycle, ultimately contributing to the spread of bovine babesiosis. …”
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The mechanisms and control strategies for quality deterioration in surimi gel during freeze-thawing cycles by Qiaoli Zhao, Bin Zheng, Yongqin Gao, Enlin Li, Xinyue Huo, Xue’er Li, Mi Zhang, Saiyi Zhong

“…However, repeated freezing and thawing during storage, processing, or consumption can cause ice crystal growth and recrystallization, leading to mechanical damage to muscle cells and tissue. Additionally, it can induce protein denaturation and oxidation, ultimately resulting in a decline in the quality of surimi gel. …”
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Case report: Successful treatment of hyperbaric oxygen for radiation-induced hemorrhagic cystitis in a 95-year-old patient with bladder cancer by Li Lin, Li Lin, Man He, Yanyan Zeng, Xiaoxiao Ni, Yequn Guo, Xiaojuan Xie, Lingling Sun, Huai Huang

“…BackgroundSevere radiation-induced hemorrhagic cystitis (RHC) may ultimately require radical cystectomy. High-quality clinical evidence exists regarding the impact of hyperbaric oxygen therapy (HBOT) on RHC. …”
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Disputable issues of the surgical strabismus correction in patients with Graves’ ophthalmopathy by D.S. Atarshchikov, E.Yu. Korchemkina

“…Korchemkina² </p> <p> ¹Central Clinical Hospital and Polyclinic of the Department for Presidential Affairs, Moscow, Russian Federation </p> <p> ²Academy of Postgraduate Education of the Federal Scientific and Clinical Center of the Federal Medical Biological Agency of Russian Federation, Moscow, Russian Federation </p> <p> Graves’ ophthalmopathy (GO) is an autoimmune disease characterized by lymphocytic infiltration, fibroblast activation and the accumulation of collagen and glycosaminoglycans in the orbital tissues and extraocular muscles. Ultimately, the inflammatory changes cause restrictive strabismus in 17–51% of patients with GO. …”
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Physical Exercise as a Diagnostic, Rehabilitation, and Preventive Tool: Influence on Neuroplasticity and Motor Recovery after Stroke by Caroline Pin-Barre, Jérôme Laurin

“…Physical exercise is considered as a major candidate for ultimately promoting neural plasticity and could be used for different purposes in human and animal experiments. …”
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Cervical Spondylotic Myelopathy Secondary to Dropped Head Syndrome: Report of a Case and Review of the Literature by Abolfazl Rahimizadeh, Housain F. Soufiani, Saghayegh Rahimizadeh

“…The dropped head syndrome (DHS) is a disabling condition caused by severe weakness of the neck extensor muscles causing progressive reducible kyphosis of the cervical spine and the inability to hold the head up. …”
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Metastatic Basal Cell Carcinoma: A Biological Continuum of Basal Cell Carcinoma? by Karaninder S. Mehta, Vikram K. Mahajan, Pushpinder S. Chauhan, Anju Lath Sharma, Vikas Sharma, C. Abhinav, Gayatri Khatri, Neel Prabha, Saurabh Sharma, Muninder Negi

“…The recurrence was diagnosed as infiltrative BCC and found metastasizing to skin, soft tissue and muscles, and pretracheal and axillary lymph nodes. …”
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Impact of Psychosocial Factors on Quality of Life: A Case Study of End Stage Renal Disease by Iqra Nazar, Dr. Fatima Kamran, Dr. Rafia Rafique, Dr. Ghulam Ishaq

“…This case study is describing how psychosocial factors have greater impact on client with ESRD, which ultimately influencing her overall quality of life (QoL). …”
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Analysis of Upper Facial Weakness in Central Facial Palsy Following Acute Ischemic Stroke by Monton Wongwandee, Kantham Hongdusit

“…Enhanced awareness may improve diagnostic accuracy, inform treatment decisions, and ultimately lead to better patient outcomes.…”
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Deployment of next-generation sequencing approach for variant detection in myocardial infarction: A concise investigation by Desaraju Suresh Bhargav, Nadeem Siddiqui, Bhadra Murthy V, Vijaya Tartte, Vanaja V

“…Background: A fatal health issue termed Myocardial Infarction (MI) is characterized by an acute loss of oxygen and blood supply to the heart muscles, ultimately leading to necrosis. This can turn life threatening if left untreated and undiagnosed at early stages. …”
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