Global, regional, and national burden of chronic obstructive pulmonary disease and its attributable risk factors from 1990 to 2021: an analysis for the Global Burden of Disease Stu... by Zhufeng Wang, Junfeng Lin, Lina Liang, Feifei Huang, Xiaoyin Yao, Kang Peng, Yi Gao, Jinping Zheng

“…The age-standardized COPD DALYs had a reversed U-shaped relationship with SDI at the regional level, with the highest burden at an SDI of about 0.45. …”
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Geothermal Fluid Variation Recorded by Banded Ca-Carbonate Veins in a Fault-Related, Fissure Ridge-Type Travertine Depositional System (Iano, southern Tuscany, Italy) by Paola Francesca Matera, Gennaro Ventruti, Martina Zucchi, Andrea Brogi, Enrico Capezzuoli, Domenico Liotta, Tsai-Luen Yu, Chuan-Chou Shen, Katharine W. Huntington, László Rinyu, Sándor Kele

“…In this time span, the geothermal fluid changed in composition, and the banded Ca-carbonate veins recorded these variations in terms of mineralogical and stable isotope composition and temperature (T) of deposition. …”
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Deep-Learning-Based Land Cover Mapping in Franciacorta Wine Growing Area by Girma Tariku, Isabella Ghiglieno, Andres Sanchez Morchio, Luca Facciano, Celine Birolleau, Anna Simonetto, Ivan Serina, Gianni Gilioli

“…The introduction of remote sensing technologies and artificial intelligence models made it possible to base land cover mapping on satellite imagery in order to monitor changes, assess ecosystem health, support conservation efforts, and reduce monitoring time. …”
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Upper Extremity Function following Transradial Percutaneous Coronary Intervention: Results of the ARCUS Trial by Eva M. Zwaan, Elena S. Cheung, Alexander J. J. IJsselmuiden, Carlo A. J. Holtzer, Ton A. R. Schreuders, Marcel J. M Kofflard, J. Henk Coert

“…Multivariate logistic regression showed that smokers were almost three times more likely to develop UED. Conclusions. This study demonstrates that UED seems to occur two times more in TR-PCI than in TF-PCI at 2 weeks of follow-up. …”
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Merck Open Global Health Library in vitro screening against Schistosoma mansoni identified two new substances with antischistosomal activities for further development by Monique Evelyn Ueberall, Martina Berchthold, Cécile Häberli, Sven Lindemann, Thomas Spangenberg, Jennifer Keiser, Christoph G. Grevelding

“…The effects of the two lead structures were investigated in more detail by confocal laser scanning microscopy and 5-ethynyl 2´-deoxyuridine (EdU) assays to assess morphological effects and stem cell effects. …”
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Probabilistic nested model selection in pharmacokinetic analysis of DCE-MRI data in animal model of cerebral tumor by Hassan Bagher-Ebadian, Stephen L. Brown, Mohammad M. Ghassemi, Prabhu C. Acharya, Indrin J. Chetty, Benjamin Movsas, James R. Ewing, Kundan Thind

“…The time-trace of change in the longitudinal-relaxivity (ΔR1) for all animals’ brain voxels was calculated. …”
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Evaluation of the efficacy of bromfenac sodium in the treatment of dry eye disease by I.A. Loskutov, E.F. Semashko, E.N. Khomyakova, E.I. Makukha, N.E. Kostina

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Integrated analysis of bioinformatics, mendelian randomization, and experimental validation reveals novel diagnostic and therapeutic targets for osteoarthritis: progesterone as a p... by Ziyu Weng, Chenzhong Wang, Bo Liu, Yi Yang, Yueqi Zhang, Chi Zhang

“…Results In this study, we identified three hub genes: interleukin 1 receptor-associated kinase 3 (IRAK3), integrin subunit beta-like 1 (ITGBL1), and Ras homolog family member U (RHOU). An Artificial Neural Network (ANN) diagnostic model constructed based on these hub genes demonstrated excellent performance in both training and validation phases. …”
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RBM47 promotes cell proliferation and immune evasion by upregulating PDIA6: a novel mechanism of pancreatic cancer progression by Yihui Ma, Enjie Liu, Huijie Fan, Chenfei Li, Pei Huang, Meiying Cui, Zhengyang Wang, Jing Zhou, Kuisheng Chen

“…Loss- and gain-of-function effects of RBM47 on cell proliferation, tumor growth, and immune evasion were determined by CCK-8, EdU incorporation, colony formation assays, the xenogeneic tumor model, and co-culture system of PC and NK-92 cells. …”
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Effect of Imeglimin, a Novel Anti-Diabetic Agent, on Insulin Secretion and Glycemic Variability in Type 2 Diabetes Treated with DPP-4 Inhibitor: A 16-Week, Open Label, Pilot Study by Itsukaichi A, Yoshikawa F, Fuchigami A, Iwata Y, Sato G, Miyagi M, Hirose T, Uchino H

“…HOMA-IR and glucagon kinetics did not change with the addition of imeglimin.Conclusion: The addition of imeglimin to DPP-4i significantly improved glycemic control and glycemic variability, based on increased glucose-induced insulin secretion, indicating its potential as a therapeutic option for patients with T2D.Keywords: imeglimin, DPP-4 inhibitor, time in range, glycemic variability, continuous glucose monitoring, meal tolerance test…”
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Le camp légionnaire romain de Mayence/Mogontiacum (Allemagne) : nouveaux résultats sur l’enceinte et la chronologie by Daniel Burger-Völlmecke

“…It runs along the slope of the Linsenberg and is thus as much as 70 m further north than had been presumed, meaning that the fortress was larger than previously thought, roughly 37 ha, rather than some 35-36 ha. …”
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Smaller-incision new-generation implantable miniature telescope in late-stage age-related macular degeneration: 6 month outcomes by Mario Damiano Toro, Alfonso Savastano, Faustino Vidal Aroca, Paola Sasso, Giuseppe Francione, Gaetano Fioretto, Marina Montemagni, Claudio Xompero, Nicola Claudio D'Onofrio, Ciro Costagliola, Stanislao Rizzo

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A methotrexate labelled dual metal oxide nanocomposite for long-lasting anti-cancer theranostics by Joyce L.Y. Tang, Shehzahdi S. Moonshi, Yuao Wu, Gary Cowin, Karla X. Vazquez- Prada, Huong D.N. Tran, Andrew C. Bulmer, Hang Thu Ta

“…The nanocomposite demonstrated both pro-oxidative and antioxidative properties, significantly increasing reactive oxygen species (ROS) production in U87MG cells (1.4-fold change), which triggered apoptosis in these cancer cells. …”
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Midostaurin shapes macroclonal and microclonal evolution of FLT3-mutated acute myeloid leukemia by Romane Joudinaud, Augustin Boudry, Laurène Fenwarth, Sandrine Geffroy, Mikaël Salson, Hervé Dombret, Céline Berthon, Arnaud Pigneux, Delphine Lebon, Pierre Peterlin, Simon Bouzy, Pascale Flandrin-Gresta, Emmanuelle Tavernier, Martin Carre, Sylvie Tondeur, Lamya Haddaoui, Raphael Itzykson, Sarah Bertoli, Audrey Bidet, Eric Delabesse, Mathilde Hunault, Christian Récher, Claude Preudhomme, Nicolas Duployez, Pierre-Yves Dumas

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Extracellular acyl-CoA-binding protein as an independent biomarker of COVID-19 disease severity by Stephane Isnard, Stephane Isnard, Tsoarello Mabanga, Tsoarello Mabanga, Léna Royston, Léna Royston, Léna Royston, Carolina A. Berini, Carolina A. Berini, Simeng Bu, Simeng Bu, Orthy Aiyana, Orthy Aiyana, Hansen Feng, Hansen Feng, Bertrand Lebouché, Bertrand Lebouché, Bertrand Lebouché, Bertrand Lebouché, Cecilia T. Costiniuk, Cecilia T. Costiniuk, Joseph Cox, Joseph Cox, Guido Kroemer, Guido Kroemer, Guido Kroemer, Madeleine Durand, Jean-Pierre Routy, Jean-Pierre Routy, Jean-Pierre Routy, the Biobanque Québécoise de la COVID-19 (BQC-19)

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Laser Applications in Metal Orthodontic Bracket Debonding: A Systematic Review by Patryk Woś, Sylwia Kiryk, Tomasz Dyl, Jan Kiryk, Tomasz Horodniczy, Magdalena Szablińska, Magdalena Aleksandra Dubowik, Wojciech Dobrzyński, Marcin Mikulewicz, Jacek Matys, Maciej Dobrzyński

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Enhancing safety in CT-guided lung biopsies: correlation of MinIP imaging with pneumothorax risk prediction by Michael P. Brönnimann, Leonie Manser, Bernhard Gebauer, Timo A. Auer, Dirk Schnapauff, Federico Collettini, Alexander Pöllinger, Alois Komarek, Miltiadis E. Krokidis, Johannes T. Heverhagen

“…Our method detects high-risk lung changes linked to pneumothorax without additional software. …”
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Anatomical and functional efficacy of radial scleral buckling and combined laser and surgical intervention for local macula-on retinal detachment by M.R. Taevere, L.A. Kryl, A.V. Doga, D.O. Shkvorchenko

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Explaining the effective variables in measuring intellectual capital and providing the optimal model by hatef mollazadeh jebdreghi, mahdi zeinali, ali akbar nonahal, ahmad mohamadi

“…The results of structural equation modeling showed that the effect coefficients of all sub-factors and variables (the four dimensions of the intellectual capital evaluation model, including human, structural, relational, and innovation capital) are significant and higher than 5.00, and also their significance levels are higher than 96.1. …”
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Pharmacodynamic characteristics and influencing factors of tapentadol for chronic pain relief under dose titration by Liang Xin, Haoxiang Zhu, Haoxiang Zhu, Suping Niu, Xie Han, Hongxian Pang, Jiangfan Li, Ye Hu, Xuhong Wang, Lujin Li, Lujin Li, Yi Fang

“…A time-effect relationship model of the percent change in Numerical Rating Scale (NRS) scores post-tapentadol intervention from baseline was constructed, along with a covariate model to identify factors significantly impacting the analgesic effects of tapentadol. …”
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