The Synergistic Effects of Celastrol in combination with Tamoxifen on Apoptosis and Autophagy in MCF-7 Cells by Lijun Wang, Luqun Tang, Chengyun Yao, Chunyan Liu, Yongqian Shu

“…Breast cancer is one of the most common cancers among females and is associated with high mortality and morbidity rates. Several studies have demonstrated that combination treatments with natural products and tamoxifen can improve the sensitivity and cytotoxicity of oestrogen-positive breast cancer cells in response to tamoxifen. …”
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P2Y2 Receptor Induces L. amazonensis Infection Control in a Mechanism Dependent on Caspase-1 Activation and IL-1β Secretion by Maria Luiza Thorstenberg, Monique Daiane Andrade Martins, Vanessa Figliuolo, Claudia Lucia Martins Silva, Luiz Eduardo Baggio Savio, Robson Coutinho-Silva

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Modern concept of bacterial complications at liver cirrhosis by M. S. Zharkova, M. V. Mayevskaya, V. T. Ivashkin

“…Proinflammatory response related to bacterial complication stimulates progression of liver failure, encephalopathy, disorders in blood coagulation system, thus triggering gastro-intestinal bleeding.Conclusion. Bacterial infections is the important cause of morbidity and mortality in patients with LC that is caused, first of all, by immune-compromised state. …”
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The Opportunistic Pathogen Listeria monocytogenes: Pathogenicity and Interaction with the Mucosal Immune System by Markus Schuppler, Martin J. Loessner

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Innovations in hypoxic training by Raphael Faiss, Martin Faulhaber

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The mRNA-1647 vaccine: A promising step toward the prevention of cytomegalovirus infection (CMV) by Adewunmi Akingbola, Abiodun Adegbesan, Olajumoke Adewole, Kolade Adegoke, Akpevwe Emmanuella Benson, Paul Ayomide Jombo, Sandra Uchechukwu Eboson, Victor Oluwasola, Ademola Aiyenuro

“…This vaccine could significantly reduce CMV-related morbidity and mortality, particularly in newborns and immunocompromised individuals, addressing a critical unmet medical need.…”
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The Role of Inflammation in the Pathogenesis of Preeclampsia by Michał Michalczyk, Aleksander Celewicz, Marta Celewicz, Paula Woźniakowska-Gondek, Rafał Rzepka

“…Preeclampsia (PE) affects 5-8% of pregnant women, and it is the major cause of perinatal morbidity and mortality. It is defined as arterial hypertension in women after 20 weeks of gestation which cooccurs with proteinuria (300 mg/d) or as arterial hypertension which is accompanied by one of the following: renal failure, liver dysfunction, hematological or neurological abnormalities, intrauterine growth restriction, or uteroplacental insufficiency. …”
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Active Surveillance for Localized Prostate Cancer – Current Practices and Recommendations by Jennifer N. Wu, Marc A. Dall'Era

“…Active surveillance for prostate cancer allows one to limit prostate cancer treatment with concomitant risks of treatment-related morbidity to the men who will benefit the most from aggressive therapies. …”
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Segregação socioambiental: estudo de caso no bairro colôniaventura/Tefé-AM a partir de uma perspectiva geográfica by Antonio Jucivan Martins Bruce, Eubia Andréa Rodrigues

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Noninvasive Techniques for Management of Erythema Multiforme by Fabiana Martins, Debora Pallos, Jodkandlys Candeia, Rodrigo Zerbinati, Paulo Henrique Braz-Silva, Luana Campos

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Discovery of giant unit-cell super-structure in the infinite-layer nickelate PrNiO2+x by Jens Oppliger, Julia Küspert, Ann-Christin Dippel, Martin v. Zimmermann, Olof Gutowski, Xiaolin Ren, Xingjiang Zhou, Zhihai Zhu, Ruggero Frison, Qisi Wang, Leonardo Martinelli, Izabela Biało, Johan Chang

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<i>Сlostridium difficile</i> Infection in a COVID-19 Patient by A. A. Timofeeva, Yu. O. Shulpekova, V. M. Nechaev, M. R. Skhirtladze

“…A 57-yo female patient was admitted in May 2020 with the complaints of 39 °C fever, general weakness, polymyalgia, diarrhoea to 3–4 times a day (mushy stool, no morbid inclusions). Initial diarrhoea was non-severe and likely triggered by the coronavirus infection. …”
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The online destination image as portrayed by the user-generated content on social media and its impact on tourists' engagement by Manuela Guerreiro, Patrícia Pinto, Célia M.Q. Ramos, Nelson Matos, Homayoun Golestaneh, Bernardete Sequeira, Luís Nobre Pereira, Dora Agapito, Rafaela Martins, Magda Wijkesjö

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High-resolution Observations of an X-1.0 White-light Flare with Moving Flare Ribbons by Xu Yang, Meiqi Wang, Andrew Cao, Kaifan Ji, Vasyl Yurchyshyn, Jiong Qiu, Sijie Yu, Jinhua Shen, Wenda Cao

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Brain connectivity for constructing new face representations in typical adults versus a prosopagnosic patient by Ela I. Olivares, Jorge F. Bosch-Bayard, Ana S. Urraca, Alba Jiménez-Bascuñán, Rolando J. Biscay, Jaime Iglesias

“…Initial presentation of external features (E before I), when compared to internal ones, triggered connections encompassing extensively the right-hemisphere face processing pathway [from posterior visual cortices for initial structural analysis, towards both intermediate (occipitotemporal) and high-level (prefrontal) relay stations], in which face-identity is thought to emerge progressively. …”
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Effects of contralaterally controlled neuromuscular electrical stimulation on the connectivity pattern of poststroke patients with hemiplegia by ZHU Lan, SUI Youxin, WANG Qinglei, XU Sheng, SHEN Ying, GUO Chuan

“…The differences in overall FC strength and mean FC strength based on ROI level between the two groups were analyzed.ResultsCompared with the NMES group，the overall connectivity strength of brain regions was higher in the CCNMES group，and CCNMES could enhance the functional connectivity between the affected M1 and the healthy M1 in patients with upper limb hemiparesis in stroke，as well as enhance the functional connectivity between the affected PFC and the healthy M1 and S1，respectively，and the difference was significant （<italic>P</italic>&lt;0. 05）.ConclusionCCNMES triggers sensorimotor stimulation of the affected upper limb by active movement of the healthy upper limb and induces cortical functional reorganisation in stroke patients with hemiplegia.…”
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Old and Recent Advances in Life Cycle, Pathogenesis, Diagnosis, Prevention, and Treatment of Malaria Including Perspectives in Ethiopia by Dejen Nureye, Solomon Assefa

“…Half of the world’s population is at risk for malaria infection. Globally, the morbidity and mortality rates of malaria have become decreased even though few reports in Ethiopia showed high prevalence of malaria. …”
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Few Associations Found between Mold and Other Allergen Concentrations in the Home versus Skin Sensitivity from Children with Asthma after Hurricane Katrina in the Head-Off Environm... by L. F. Grimsley, J. Wildfire, M. Lichtveld, S. Kennedy, J. M. El-Dahr, P. C. Chulada, R. Cohn, H. Mitchell, E. Thornton, M. Mvula, Y. Sterling, W. Martin, K. Stephens, L. White

“…We evaluated allergen concentrations, skin test sensitivities, and asthma morbidity for 182 children, aged 4–12 years, with moderate to severe asthma, enrolled 18 months after Katrina, from the city of New Orleans and the surrounding parishes that were impacted by the storm, into the Head-off Environmental Asthma in Louisiana (HEAL) observational study. …”
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Novel brain SPECT imaging unravels abnormal cerebral perfusion in patients with postural orthostatic tachycardia syndrome and cognitive dysfunction by Marie-Claire Seeley, Howard O’Brien, Gemma Wilson, Clair Coat, Tess Smith, Kevin Hickson, Reynold Casse, Amanda J. Page, Celine Gallagher, Dennis H. Lau

“…Abnormal CBF was seen in 61% but did not differ by POTS triggers. The regions with the lowest mean z-scores were the lateral prefrontal and sensorimotor cortices. …”
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Plasma membrane and nuclear phosphatidylinositol 4,5-bisphosphate signalling in cancer by Agnieszka Chytła, Stephanie Rattay, Baki Akgül, Martin Sztacho

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