Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy by Eugenia Hovsepian, Federico Penas, Gerardo A. Mirkin, Nora B. Goren

“…Chagas disease, which is caused by Trypanosoma cruzi (T. cruzi), remains a substantial public health concern and an important cause of morbidity and mortality in Latin America. T. cruzi infection causes an intense inflammatory response in diverse tissues by triggering local expression of inflammatory mediators, which results in the upregulation of the levels of cytokines and chemokines, and important cardiac alterations in the host, being one of the most characteristic damages of Chagas disease. …”
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A Brief Observational History of the Black-Hole Spacetimes by Wolfgang Kundt

“…In this year (2015), black holes (BHs) celebrate their 100th birthday, if their birth is taken to be triggered by a handwritten letter from Martin Schwarzschild to Albert Einstein, in connection with his newly found spherically symmetric vacuum solution.…”
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The Immune Response and Its Therapeutic Modulation in Bronchiectasis by Massoud Daheshia, James D. Prahl, Jacob J. Carmichael, John S. Parrish, Gilbert Seda

“…Bronchiectasis (BC) is a chronic pulmonary disease with tremendous morbidity and significant mortality. As pathogen infection has been advocated as a triggering insult in the development of BC, a central role for the immune response in this process seems obvious. …”
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Overview of Community-Acquired Pneumonia and the Role of Inflammatory Mechanisms in the Immunopathogenesis of Severe Pneumococcal Disease by Helen C. Steel, Riana Cockeran, Ronald Anderson, Charles Feldman

“…Community-acquired pneumonia (CAP) remains a leading cause of morbidity and mortality among the infectious diseases. …”
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The mRNA-1647 vaccine: A promising step toward the prevention of cytomegalovirus infection (CMV) by Adewunmi Akingbola, Abiodun Adegbesan, Olajumoke Adewole, Kolade Adegoke, Akpevwe Emmanuella Benson, Paul Ayomide Jombo, Sandra Uchechukwu Eboson, Victor Oluwasola, Ademola Aiyenuro

“…This vaccine could significantly reduce CMV-related morbidity and mortality, particularly in newborns and immunocompromised individuals, addressing a critical unmet medical need.…”
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The Role of Inflammation in the Pathogenesis of Preeclampsia by Michał Michalczyk, Aleksander Celewicz, Marta Celewicz, Paula Woźniakowska-Gondek, Rafał Rzepka

“…Preeclampsia (PE) affects 5-8% of pregnant women, and it is the major cause of perinatal morbidity and mortality. It is defined as arterial hypertension in women after 20 weeks of gestation which cooccurs with proteinuria (300 mg/d) or as arterial hypertension which is accompanied by one of the following: renal failure, liver dysfunction, hematological or neurological abnormalities, intrauterine growth restriction, or uteroplacental insufficiency. …”
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The Synergistic Effects of Celastrol in combination with Tamoxifen on Apoptosis and Autophagy in MCF-7 Cells by Lijun Wang, Luqun Tang, Chengyun Yao, Chunyan Liu, Yongqian Shu

“…Breast cancer is one of the most common cancers among females and is associated with high mortality and morbidity rates. Several studies have demonstrated that combination treatments with natural products and tamoxifen can improve the sensitivity and cytotoxicity of oestrogen-positive breast cancer cells in response to tamoxifen. …”
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PSYCHOPATHIC PERSONALITY DISORDER IN LARSSON’S “THE GIRL WITH THE DRAGON TATTOO” by Christy Tisnawijaya, Puji Astuti

“…These experiences are the seeds of crimes that Martin commits as an adult. By using descriptive analysis, this paper explores how Martin, who was once a victim of child abuse, turns into the abuser. …”
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Secondary Hemophagocytic Syndrome Associated with Richter’s Transformation in Chronic Lymphocytic Leukemia by Nura El-Haj, Wilson I. Gonsalves, Vinay Gupta, Jacob P. Smeltzer, Sameer A. Parikh, Preet P. Singh, Naseema Gangat

“…Prompt initiation of treatment is warranted in either scenario in order to decrease mortality. Most cases are triggered by infectious agents, malignancy, or drugs. …”
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Old and Recent Advances in Life Cycle, Pathogenesis, Diagnosis, Prevention, and Treatment of Malaria Including Perspectives in Ethiopia by Dejen Nureye, Solomon Assefa

“…Half of the world’s population is at risk for malaria infection. Globally, the morbidity and mortality rates of malaria have become decreased even though few reports in Ethiopia showed high prevalence of malaria. …”
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A Rare Case of ARDS Caused by Bupropion Inhalation and Treated with Noninvasive Ventilation by Yousif Al-Saiegh, Jenna Spears, Pieter S. De Klerk, Joshua Hitchings, Christopher Lee, Tamara Mahr

“…Acute respiratory distress syndrome, characterized by the Berlin criteria, is associated with a high mortality rate. Its treatment includes addressing the underlying etiology, general supportive measures, and achievement of effective oxygenation. …”
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Systemic Lupus Erythematosus (SLE): A review on the prevalence, clinical manifestation, and disease assessment by Malarvili Selvaraja, Maha Abdullah, Anim Md Shah, Masita Arip, Syafinaz Amin Nordin

“…Hence, this review aims to discuss the prevalence, mortality, clinical manifestation and disease assessment of SLE. …”
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Inferior Frontal Gyrus Activation Underlies the Perception of Emotions, While Precuneus Activation Underlies the Feeling of Emotions during Music Listening by Ken-ichi Tabei

“…While music triggers many physiological and psychological reactions, the underlying neural basis of perceived and experienced emotions during music listening remains poorly understood. …”
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Brain Symmetry Index in Healthy and Stroke Patients for Assessment and Prognosis by Andrei Agius Anastasi, Owen Falzon, Kenneth Camilleri, Malcolm Vella, Richard Muscat

“…EEG was subsequently recorded first with subjects at rest and then during hand grasping motions, triggered by visual cues. Brain symmetry index (BSI) was used to identify the differences in EEG-quantified interhemispheric cortical power asymmetry observable in healthy versus cortical and subcortical stroke patients. …”
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Conservative Treatment of Spontaneous Rectus Sheath Hematomas: Single Center Experience and Literature Review by Banu Karapolat, Halil Afsin Tasdelen, Hatice Ayca Ata Korkmaz

“…Considering the presence of SRSH particularly in older female patients who use anticoagulant drugs and have newly developed an abdominal pain and a palpable mass after coughing spells is the key to make an early and correct diagnosis and to prevent possible morbidity and mortality with an appropriate treatment method.…”
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Local endoreduplication of the host is a conserved process during Phytomyxea–host interaction by Michaela Hittorf, Andrea Garvetto, Marianne Magauer, Martin Kirchmair, Willibald Salvenmoser, Pedro Murúa, Sigrid Neuhauser

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Long term adult visual plasticity after the developmental critical period in genetically determined peripheral visual loss by Otília C. d’Almeida, Joana M. Sampaio, Sónia Ferreira, Eduardo D. Silva, Miguel Castelo-Branco

“…We found evidence for reorganization based on pRF size metrics and explained variance of reorganized visual field maps. In sum, visual cortical plasticity triggered by peripheral visual loss occurs beyond the critical period of visual maturation.…”
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Chloroquine inhibits artificial oocyte activation induced by ethanol or Sr2+ but not by sperm in mice by Tadashi YAMAZAKI, Md Wasim BARI, Satoshi KISHIGAMI

“…In in vitro fertilization, although the fertilization rate was decreased in the CQ-treated group, in which CQ treatment was continuously applied during insemination, pronuclear formation and cortical granule release were observed. The decrease in the fertilization rate was likely attributable to reduced sperm motility and decreased penetration of the zona pellucida. …”
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Preeclampsia, Natural History, Genes, and miRNAs Associated with the Syndrome by Laura Parada-Niño, Luisa Fernanda Castillo-León, Adrien Morel

“…This disease is associated with an important risk of maternal and fetal mortality. PE is described as a placental pathology because, after delivery, most women recover normal arterial pressure. …”
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Sickle Cell Anemia, the First Molecular Disease: Overview of Molecular Etiology, Pathophysiology, and Therapeutic Approaches by Martin H. Steinberg

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