Aerosol Filtration Testing of Fabrics for Development of Reusable Face Masks by Adrian Stan, Sandro Steiner, Shoaib Majeed, Sandra Schorderet Weber, Samik Gosh, Tanja Živković Semren, Philippe Alexandre Guy, Stefan Lebrun, Jérôme Steinhauser, Yanik Tardy, Andreas Hogg, Sophie Chiquet, Jean-Luc Perret, Arkadiusz Kuczaj, Manuel Peitsch, Julia Hoeng

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Identification of ALEKSIN as a novel multi-IRF inhibitor of IRF- and STAT-mediated transcription in vascular inflammation and atherosclerosis by Aleksandra Antonczyk, Katarzyna Kluzek, Natalia Herbich, Mahdi Eskandarian Boroujeni, Bart Krist, Dorota Wronka, Anna Karlik, Lukasz Przybyl, Adam Plewinski, Joanna Wesoly, Hans A. R. Bluyssen

“…The key factors contributing to the onset and progression of atherosclerosis include the pro-inflammatory cytokines interferon (IFN)α and IFNγ and the pattern recognition receptor (PRR) Toll-like receptor 4 (TLR4). Together, they trigger the activation of IFN regulatory factors (IRFs) and signal transducer and activator of transcription (STAT)s. …”
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Tumor mutation burden for predicting immune checkpoint blockade response: the more, the better by Ming Zheng

“…Thus, to better implement TMB as a robust biomarker of ICB response, an optimal and generalizable TMB cut-off within and across cancer types must be addressed as soon as possible.Methods Using Morris’s and Kurzrock’s cohorts (n=1662 and 102), we exhaustively tested all possible TMB cut-offs for predicting ICB treatment outcomes in 10 cancer types. …”
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Perspectives on Adipose Tissue, Chagas Disease and Implications for the Metabolic Syndrome by Fnu Nagajyothi, Mahalia S. Desruisseaux, Linda A. Jelicks, Fabiana S. Machado, Streamson Chua, Philipp E. Scherer, Herbert B. Tanowitz

“…While T. cruzi infection causes hypoglycemia which correlates with mortality, hyperglycemia is associated with increased parasitemia and mortality. …”
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A cell-based model to study mechanisms of endothelial-dependent thrombin generation in response to inflammation and its modulation by hydroxychloroquine by Deepa J. Arachchillage, Golzar Mobayen, Mike Laffan, Anna M. Randi, Josefin Ahnström, Charis Pericleous

“…Results: Endothelial stimulation with TNF-α or IL-1β caused ECs to trigger TG without the addition of exogenous TF, with higher TG observed after 6 hours of stimulation than 24 hours. …”
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Understanding the Difficulties in Diagnosing Neonatal Sepsis: Assessing the Role of Sepsis Biomarkers by Lungu Nicoleta, Jura Ana-Maria-Cristina, Popescu Daniela-Eugenia, Horhat Florin George, Manea Aniko Maria, Boia Marioara

“…Neonatal sepsis is a serious condition with high rates of morbidity and mortality, caused by the rapid growth of microorganisms that trigger a systemic reaction. …”
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Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis by Jeanneth Elizabeth Jami Carrera, John Sebastián Carvajal Gavilanes, Karen Gabriela Sulca Espín, Dennis Alexander Montenegro Montenegro

“…Stevens-Johnson syndrome and toxic epidermal necrolysis are severe mucocutaneous rare diseases with high morbid mortality characterized by generalized epidermal necrosis and skin detachment; They are distinguished from each other due to the extent of skin that is affected. …”
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Mechanisms underlying CSD initiation implicated by genetic mouse models of migraine by Daniela Pietrobon, K.C. Brennan

“…Abstract A key unanswered question in migraine neurobiology concerns the mechanisms that make the brain of migraineurs susceptible to cortical spreading depression (CSD, a spreading depolarization that underlies migraine aura and may trigger the migraine pain mechanisms). …”
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Modulation of Toll-Like Receptor Activity by Leukocyte Ig-Like Receptors and Their Effects during Bacterial Infection by Louise E. Pilsbury, Rachel L. Allen, Martin Vordermeier

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The Case of the Disappearing Spindle Burst by Alexandre Tiriac, Mark S. Blumberg

“…Sleep spindles are brief cortical oscillations at 10–15 Hz that occur predominantly during non-REM (quiet) sleep in adult mammals and are thought to contribute to learning and memory. …”
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‘Avoidance Preening’, Displacement Behavior and Co-Dependency in Professional Team Sport: When Wants Become More Important Than Needs by Blake D. McLean, Donnie S. Strack, David T. Martin

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Kawasaki Disease: A Clinician’s Update by Nathan Jamieson, Davinder Singh-Grewal

“…Treatment with intravenous immunoglobulin within ten days of fever onset improves clinical outcomes and reduces the incidence of coronary artery dilation to less than 5%. Given its severe morbidity and potential mortality, Kawasaki disease should be considered as a potential diagnosis in cases of prolonged paediatric fever.…”
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Atrial Fibrillation and Long QT Syndrome Presenting in a 12-Year-Old Girl by Jonathan W. Knoche, Kate M. Orland, Craig T. January, Kathleen R. Maginot

“…Due to the potential for increased morbidity and mortality, young patients who present with AF and a family history suggestive of inherited arrhythmias should trigger further investigation for LQTS and subsequent familial genetic counseling.…”
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Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal by Diego E. Hernandez, Andrei Ciuparu, Pedro Garcia da Silva, Cristina M. Velasquez, Benjamin Rebouillat, Michael D. Gross, Martin B. Davis, Honggoo Chae, Raul C. Muresan, Dinu F. Albeanu

“…Both odor and, surprisingly, the sound cues trigger responses in the cortical bulbar feedback axons which precede the behavioral report. …”
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Mitral Stenosis Berat pada Penyakit Jantung Rematik by Cokorda Istri Padmi Suwari, Widyawati Desak Gede

“…Rheumatic Heart Disease (RHD) has high morbidity and mortality. Cardiac valve disorders after rheumatic fever are the leading cause of heart failure in children and young adults. …”
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Adhesion of Neisseria meningitidis to dermal vessels leads to local vascular damage and purpura in a humanized mouse model. by Keira Melican, Paula Michea Veloso, Tiffany Martin, Patrick Bruneval, Guillaume Duménil

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Primary Headache Attributed to External Compression or Traction to the Head: A Narrative Review by Ole Hensel, Torsten Kraya

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Dendritic Cells and Their Multiple Roles during Malaria Infection by Kelly N. S. Amorim, Daniele C. G. Chagas, Fernando B. Sulczewski, Silvia B. Boscardin

“…Despite many efforts to control this infection, malaria is still responsible for high rates of morbidity and mortality. Different groups have shown that DCs act during Plasmodium infection, and data suggest that the phenotypically distinct DCs subsets are key factors in the regulation of immunity during infection. …”
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Association of Acute Kidney Injury with Bronchopulmonary Dysplasia in Preterm Infants by Saime Hacer OZDEMIR, Husnu Fahri OVALI

“…Objective: Bronchopulmonary dysplasia (BPD) is among the most common complications of prematurity and is associated with high morbidity and mortality rates. Acute kidney injury (AKI) is also commonly observed in premature infants and significantly increases morbidity and mortality. …”
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TNF Tolerance in Monocytes and Macrophages: Characteristics and Molecular Mechanisms by René Huber, Rolf Bikker, Bastian Welz, Martin Christmann, Korbinian Brand

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