Identifying key signs of motor neurone disease in primary care: a nested case–control study using the QResearch database by Aleksandar Radunović, Carol Coupland, Julia Hippisley-Cox, Christopher J McDermott, Tom A Ranger, Judith Burchardt, Xue W Mei

“…Objective To confirm the symptoms and signs for motor neuron disease (MND) in the Red Flag tool; to quantify the extent to which the key symptoms and signs are associated with MND; and to identify additional factors which may be helpful within the primary care setting in recognition of possible MND and triggering timely referral to neurology specialists.Design A nested case–control study.Setting 1292 UK general practices contributing to the QResearch primary care database, linked to hospital and mortality data.Participants Baseline cohort included 16.8 million individuals aged 18 years and over without a diagnosis of MND at study entry and with more than 3 years of digitalised information available. …”
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Characterisation of <i>Staphylococcus aureus</i> Strains and Their Prophages That Carry Horse-Specific Leukocidin Genes <i>lukP/Q</i> by Stefan Monecke, Sindy Burgold-Voigt, Andrea T. Feßler, Martina Krapf, Igor Loncaric, Elisabeth M. Liebler-Tenorio, Sascha D. Braun, Celia Diezel, Elke Müller, Martin Reinicke, Annett Reissig, Adriana Cabal Rosel, Werner Ruppitsch, Helmut Hotzel, Dennis Hanke, Christiane Cuny, Wolfgang Witte, Stefan Schwarz, Ralf Ehricht

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Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy by James Dooley, Bart Neyns, Elizabeth Allen, Frank Tacke, Louis Boon, Damya Laoui, Julia Katharina Schwarze, Helena Van Damme, Bruno Dombrecht, Máté Kiss, Heleen Roose, Eva Van Overmeire, Daliya Kancheva, Liesbet Martens, Aleksandar Murgaski, Pauline Madeleine Rachel Bardet, Gillian Blancke, Maude Jans, Evangelia Bolli, Maria Solange Martins, Yvon Elkrim, Kiavash Movahedi, Niels Vandamme, Sebahat Ocak, Isabelle Scheyltjens, Lars Vereecke, Frank Aboubakar Nana, Pascal Merchiers, Jo Agnes Van Ginderachter

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COVID-19 on patients with immune-mediated rheumatic disease: a comparative study of disease activity, fatigue, and psychological distress over six months by Claudia Marques, Marcelo M. Pinheiro, Jennifer Lopes, Sandra Lúcia Euzébio Ribeiro, Mary Vânia Marinho de Castro, Lilian David de Azevedo Valadares, Aline Ranzolin, Nicole Pamplona Bueno de Andrade, Rafaela Cavalheiro do Espírito Santo, Nafice Costa Araújo, Cintya Martins Vieira, Valéria Valim, Flavia Patricia Sena Teixeira Santos, Laurindo Ferreira da Rocha, Adriana Maria Kakehasi, Ana Paula Monteiro Gomides Reis, Edgard Torres dos Reis-Neto, Gecilmara Salviato Pileggi, Gilda Aparecida Ferreira, Licia Maria Henrique da Mota, Odirlei Monticielo, Ricardo Machado Xavier

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Editorial by Lindsay B. Flynn

“…The first, a global financial crisis, was triggered by the 2008 US housing market crash. The second now asks them to shelter in homes they struggle to afford. …”
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Iconic Celebration of Charms and Friendship in Poetry: Fálétí’s “Adébímpé Ọ̀jẹ́dòkun” by Michael Oladejo Afoláyan

“…Even the most callous, capable of “eating the head of the tortoise, and drinking cold-heartedly with the empty shell of the diminutive snail” would hear the tragic narrative and snivel. …”
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Le réseau hydraulique à Pompéi (Italie) de l’époque des Samnites à Auguste (fin ive-fin ier s. av. J.-C.) by Federico Giletti

“…While it is true that the decision to install chambered cisterns to regulate the slope of the hillside may have served to enlarge the building spaces, it is equally plausible that their purpose was also to provide the city wall defences with water reserves to supply the militia in case of siege or fire, in accordance with a common practice in ancient urban design.The military value of some of these cisterns, however, lost its significance after the establishment of the colony, as did walled fortifications. For this reason, the growing tendency to build sumptuous dwellings, with an enviable viewpoint overlooking the Sarno plain below, led to buildings being extended above and beyond the defensive walls, even reusing structural parts that were no longer considered necessary.In the same way, many of the cisterns behind them lost their function, being converted into rooms in the house or used as stairways or corridors.The large basins seem to have retained their function until the advent of the aqueduct system, introduced in Pompeii in the Augustan age. …”
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