Therapeutic exercise protocol for the prevention of anterior cruciate ligament injuries in female soccer players with dynamic knee valgus (RCT) by Amanda Coves García, Emilio José Poveda Pagán

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Enhancing vaccine clinical trials participation among elderly: challenges and strategies by Paul Gillard, Samer Nakhle, Darin Brimhall, Ouzama Henry, Narcisa Mesaros

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A randomized controlled trial comparing immersive virtual reality games versus nitrous oxide for pain reduction in common outpatient procedures in pediatric surgery by Cordula Scherer, Ladina A. Lanz, Thoralf R. Liebs, Nadine Kaiser, Mirjam Zindel, Steffen M. Berger

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Protocol paper: randomized controlled trial of the smart online-to-offline model development for chronic diseases management through digital health in real world setting by Jae Eun Shin, Juho Choi, Heejung Lee, Suk-Won Lee, Juhwan Oh

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Effectiveness of breathing exercises on urinary symptoms, muscle activity, and strength in women with multiple sclerosis and urinary incontinence—a study protocol for a randomized controlled trial study by Atieh Nazem, Shabnam ShahAli, Mehdi Dadgoo, Holakoo Mohsenifar, Ismail Ebrahimi Takamjani, Laleh Abadi Marand

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The effect of educational intervention based on the mobile application on women’s knowledge, attitude, and practice on microplastics and health: study protocol for a randomized controlled trial by Zahra Seifi, Fatemeh Zarei, Fazlollah Ahmadi

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Non-inferiority study to compare the efficacy of relugolix with dienogest for endometriosis-associated pain and usefulness of administering relugolix prior to dienogest (READY stud... by Fuminori Taniguchi, Motoko Fukui, Yutaka Osuga, Tasuku Harada, Jo Kitawaki

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TAD-SIE: sample size estimation for clinical randomized controlled trials using a Trend-Adaptive Design with a Synthetic-Intervention-Based Estimator by Sayeri Lala, Niraj K. Jha

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Efficacy and safety of perioperative analgesia in PENG block for children undergoing hip surgery with developmental dysplasia: study protocol for a randomized, double-blinded, non-inferiority trial by Mingzhe Xu, Yi He, Zhi Li, Bin Du

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Antisecretory factor in severe traumatic brain injury (AFISTBI): protocol for an exploratory randomized placebo-controlled trial by Linus Réen, David Cederberg, Niklas Marklund, Edward Visse, Peter Siesjö

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Distribution of trial registry numbers within full-text of PubMed Central articles: implications for linking trials to publications and indexing trial publication types by Arthur M. Holt, Ang Michael Troy, Neil R. Smalheiser

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Understanding Cognition, Oxytocin, and Pain in Elders (UCOPE): protocol for a double-blinded cross-over trial in chronic knee osteoarthritis pain by Yenisel Cruz-Almeida, Soamy Montesino-Goicolea, Pedro Valdes-Hernandez, Zhiguang Huo, Roland Staud, Natalie C. Ebner

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Can a low-threshold check-up motivate older adults to schedule a dental visit? Study protocol for a randomized controlled trial by Aster De Vleeschauwer, Louise Poppe, Roos Colman, Barbara Janssens

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The impact of vitamin E supplementation on sperm analysis in varicocelectomy patients: a triple-blind randomized controlled trial by Kasra Saeedian, Saeed Davaryar, Maryam Emadzadeh, Alireza Akhavan Rezayat

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The antihypertensive efficacy of a quadruple single-pill combination in patients with resistant hypertension: study protocol for a randomized, open-label, crossover trial by Yuanyuan Yao, Xin Zhang, Runyu Ye, Shanshan Jia, Xiangyu Yang, Xiaoping Chen

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Efficacy and cost-effectiveness of an ACT and compassion-based intervention for women with breast cancer: study protocol of two randomised controlled trials {1} by Inês A. Trindade, Andreia Soares, David Skvarc, Diogo Carreiras, Joana Pereira, Óscar Lourenço, Filipa Sampaio, Bruno de Sousa, Teresa C. Martins, Paula Boaventura, Joana Marta-Simões, Mind Project Team, Helena Moreira

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Safety outcome trials in four mainline medical journals 30 years apart: a narrative review and the need for the transparency of informed consents by Sinem Nihal Esatoglu, Ayse Ozdede, Yesim Ozguler, Koray Tascilar, Hasan Yazici

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Developing generic clinical trial animated explainer videos in the UK: results of a survey and case study by Clare Calvert, Vicki S. Barber, Duncan Appelbe, Kirsty Sprange, Claire Nollett, Fiona Lugg-Widger, Samantha Tanner, Duncan B. Richards

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Statistical analysis plan for a pragmatic randomised controlled trial comparing enhanced acceptance and commitment therapy plus ( +) added to usual aftercare versus usual aftercare only, in patients living with or beyond cancer: SUrvivors' Rehabilitation Evaluation after CANcer (SURECAN) trial by Clare Robinson, Trudie Chalder, Paul McCrone, Olivier Quintin, Evdoxia Gkaintatzi, Imran Khan, Stephanie J. C. Taylor, on behalf of the SURECAN GROUP

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The PROPHECI trial: a phase II, double-blind, placebo-controlled, randomized clinical trial for the treatment of pseudoxanthoma elasticum with oral pyrophosphate by Laetitia Clotaire, Isabelle Rubera, Christophe Duranton, Jocelyn Gal, Emmanuel Chamorey, Hélène Humeau, Samir Yamani, Christine Chiaverini, Serge Willoteaux, Bernard Padovani, Laurie Mourozeau, Adam Mainguy, Stéphanie Baillif, Ludovic Martin, Georges Leftheriotis

Subjects: “…Double-blind randomized clinical trial…”
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