Y665F variant of mouse Stat5b protects against acute kidney injury through transcriptomic shifts in renal gene expression by Jakub Jankowski, Hye Kyung Lee, Lothar Hennighausen

“…Our data indicate new links between the JAK/STAT pathway and known kidney injury markers, contribute to the understanding of the sexual dimorphism of renal disease, and provide new potential targets for JAK inhibitor- and amino acid transport modulation-based therapies.…”
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Integrated transcriptomics and metabolomics analysis reveal the regulatory mechanisms underlying the combined effects of heat and glucose starvation on carotenoid biosynthesis in R... by Xingyu Huang, Caina Guo, Xiaolan Huang, Meixia He, Jingdie Fan, Yuan Chen, Jingwen Qiu, Qi Zhang

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Transcriptome Analysis Revealed Hub Genes Related to Tipburn Resistance in Chinese Cabbage (<i>Brassica rapa</i> L. ssp. <i>pekinensis</i>) by Yaning Bi, Wenjing Zhang, Yuxiang Yuan, Jianqi Feng, Peiyun Wang, Cong Ding, Yanyan Zhao, Lin Li, Henan Su, Baoming Tian, Fang Wei, Xiaochun Wei, Xiaowei Zhang

“…Analysis of gene expression regulation in the three modules revealed 13 hub genes related to tipburn resistance, which were involved in the cell wall, photosynthesis, transcription factors, hormones, and the stress response, indicating that these factors play an important role in the tipburn response of Chinese cabbage. These transcriptome data and analysis results provide a basis for the study of the molecular mechanism of calcium deficiency-induced tipburn in Chinese cabbage.…”
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Application of Transcriptome Analysis for the Exploration of the Mechanism of Methionine Promoting the Synthesis of Cephalosporin C in <i>Acremonium chrysogenum</i> by Employing a... by Yifan Li, Zhen Chen, Wei Hong, Tao Feng, Xiwei Tian, Ju Chu

“…By integrating medium optimization with transcriptomic analysis, we provided more reliable insights into the regulatory role of methionine in <i>A. chrysogenum</i> growth and CPC biosynthesis using a chemically defined medium, offering valuable guidance for fermentation process optimization and subsequent metabolic engineering strategies.…”
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Genomic, Transcriptomic and Suspect/Non‐Target Screening Analyses Reveal the Role of CYP450s in the Degradation of Imazalil and Delineate Its Transformation Pathway by Cladosporium... by Christina V. Papazlatani, Sotirios Vasileiadis, Eleni I. Panagopoulou, Dimitrios E. Damalas, Panagiotis A. Karas, Evdoxia Gerovasileiou, Nikolaos S. Thomaidis, Dimitrios G. Karpouzas

“…Here we describe the genetic network utilised by the fungus to degrade IMZ and its detailed transformation. Genomic and transcriptomic analysis of C. herbarum pointed to the involvement of strongly upregulated CYP450s in IMZ degradation, as further verified by cessation of its biodegradation by CYP450 inhibitors. …”
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Transcriptome and Proteome Analysis Identify Decorin as a Principal Antifibrotic Component Trapping TGF-β1 Within Adipose-Derived Stem Cell Secretome by Lin Kang, Zhujun Li, Fangyuan Li, Ziming Li, Liquan Wang, Tianhao Li, Jieyu Xiang, Songlu Tseng, Nanze Yu, Jiuzuo Huang, Xiao Long

“…This study conducted an in-depth insight into the paracrine function of ADSCs through transcriptome and proteome analysis, identifying DCN as an essential paracrine factor mediating the antifibrotic effect of ADSCs, which could provide valuable theoretical support for the use of ADSC secretions as well as DCN in the treatment of fibrotic diseases.…”
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Acute PM2.5 Exposure in Distinct NSCLC Cell Lines Reveals Strong Oxidative Stress and Therapy Resistance Signatures Through Transcriptomic Analysis by Aussara Panya, Saruda Thongyim, Pachara Sattayawat, Sahutchai Inwongwan

“…This study investigates how mutation-specific transcriptional responses influence susceptibility to PM2.5-induced oncogenic alterations, focusing on A549 and NCI-H1975 cells. This provides preliminary insight into the transcriptomic effects of acute PM2.5 exposure in NSCLC cells with distinct oncogenic mutations (A549 and NCI-H1975), serving as a guide for understanding mutation-specific responses to environmental stress. …”
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Integrated Transcriptome Analysis Reveals the Lung miRNA–mRNA Regulatory Network Associated with Avian Pathogenic <i>E. coli</i> Infection by Huan Li, Jishuang Tan, Xiaoyi Li, Susan J. Lamont, Hongyan Sun

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Integrated Transcriptomic and Functional Analyses Reveal the Role of the Plant–Pathogen Interaction Pathway in <i>Fusarium solani</i> Infection of <i>Zingiber officinale</i> by Lingling Zhang, Qie Jia, Lei Liu, Yiqing Liu

“…To explore the molecular mechanisms underlying <i>F. solani</i> infection and disease progression, we performed a comparative transcriptome analysis of ginger rhizomes during storage, comparing inoculated and non-inoculated samples. …”
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Differential expression of RHD and RHCE in immune cell populations of acute myeloid leukaemia: insights from TCGA and GTEx transcriptomic analysis using GEPIA platforms by A. Aslam, S. Kabrah

“…Conclusions: The differential expression of RHD and RHCE in immune cells suggests their potential roles in modulating the immune microenvironment in AML. These findings provide a foundation for future research into the functional implications of RHD and RHCE in leukaemia progression and immune regulation. …”
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Development of an Agrobacterium tumefaciens-mediated transformation system for somatic embryos and transcriptome analysis of LcMYB1’s inhibitory effect on somatic embryogenesis in... by Yaqi Qin, Bo Zhang, Xueliang Luo, Shiqian Wang, Jiaxin Fu, Zhike Zhang, Yonghua Qin, Jietang Zhao, Guibing Hu

“…The development of this transformation system provides valuable support for functional genomics research in litchi.…”
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Time-resolved dual transcriptome profiling of interactions between tea plants (Camellia sinensis (L.) O. Kuntze) and its anthracnose pathogen Colletotrichum gloeosporioides by Jing-Jing Ye, Han-Qing Gao, Yun-Long Shi, Xin-Yi Lin, Yue-Rong Liang, Jian-Liang Lu, Jian-Hui Ye, Xin-Qiang Zheng

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Predicting Clinical Response to Monoclonal TNF Inhibitors in Rheumatoid Arthritis: A Transcriptomic Approach Based on Transmembrane TNF Reverse Signaling and Nrf2 Activation by Katy Diallo, Yannick Degboé, Michel Baron, Anaïs Bellin-Robert, Jean-Frédéric Boyer, Adeline Ruyssen-Witrand, Arnaud Constantin, Benjamin Rauwel, Alain Cantagrel, Jean-Luc Davignon

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Integrated network toxicology and bioinformatics reveal PFAS-driven prognostic biomarkers and molecular mechanisms in breast cancer: insights from transcriptome analysis and molecu... by Yingqiang Fu, Yiyang Liu, Ziqi Sui

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Identification of programmed cell death-related genes and construction of a prognostic model in oral squamous cell carcinoma using single-cell and transcriptome analysis by Yongheng Li, Yang Yu, Shaonan Hu, Simin Li

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Integrated metabolomics and transcriptomics analysis reveals the potential mechanism by which Methyl jasmonate enhances the pungent flavor of soilless-cultivated Chinese chives (Al... by Cheng Wang, Jing Zhang, Jing Li, Qiang Chai, Jianming Xie

“…Methodology This study integrated metabolomic and transcriptomic analyses to elucidate how MeJA modulates the biosynthesis of flavor substance precursors in soilless-cultivated Chinese chives. …”
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Integrated Transcriptomic and Metabolomic Analyses Reveal the Positive Effects of 5-Aminolevulinic Acid (ALA) on Shading Stress in Peanut (<i>Arachis hypogaea</i> L.) by Qi Wu, Liyu Yang, Haiyan Liang, Miao Liu, Dianxu Chen, Pu Shen

“…Our results extend the application of ALA in agricultural production and will provide a reference for crop cultivation, especially for peanut/maize intercropping systems.…”
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Transcriptome Analysis Revealed the Molecular Mechanism of Acetic Acid Increasing <i>Monascus</i> Pigment Production in <i>Monascus ruber</i> CICC41233 by Yan Wang, Weiwei Wu, Xiaoshu Wu, Weiyu Li, Jingjing Cui, Chuannan Long

“…This study clarified the metabolic mechanism of acetic acid promoting the growth of <i>M. ruber</i> and the synthesis of MPs, which provided some theoretical guidance for the large-scale production of MPs in the industry in future.…”
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Discovery of Hub Genes Involved in Seed Development and Lipid Biosynthesis in Sea Buckthorn (<i>Hippophae rhamnoides</i> L.) Using UID Transcriptome Sequencing by Siyang Zhao, Chengjiang Ruan, Alexey A. Dmitriev, Hyun Uk Kim

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Identification of reference genes via real-time quantitative PCR for investigation of the transcriptomic basis of the squalene biosynthesis in different tissues on olives under dro... by Haiyang Chi, Shasha Bai, Chenxiao Chen, Yuying Bao, Xiaoxin Qu, Shitao Sun, Jiangpeng Pan, Xiushi Yang, Chunsheng Hou, Yanchun Deng

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