Differential Gene and Protein Expressions Responsible for Vasomotor Signaling Provide Mechanistic Bases for the Opposite Flow-Induced Responses of Pre- and Post-Circle of Willis Ar... by Zoltan Nemeth, Krisztian Eros, Gyongyi Munkacsy, Akos Koller

“…Increases in flow elicit dilations in the basilar artery (BA) supplied by the posterior cerebral circulation (PCC), and ensuring efficient blood supply to the circle of Willis in which blood flow and pressure can distribute and equalize, and thus provide the appropriate supply for the daughter branches to reach certain brain areas. …”
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Utilizing machine learning and bioinformatics analysis to identify drought stress responsive genes in wheat (Triticum aestivum L.) by Jiabei He, Jiabei He, Baoyue Cui, Baoyue Cui, Pingzeng Liu, Pingzeng Liu, Xianyong Meng, Xianyong Meng, Jun Yan, Jun Yan

“…This study aims to uncover transcriptomic changes in wheat leaves under drought stress using machine learning and bioinformatics approaches, thereby providing new research perspectives and solutions for understanding the mechanisms of abiotic stress responses in wheat and identifying drought-tolerant genes. …”
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Decoding the transcriptome from bulk RNA of infection-naïve versus imprinted patients with SARS-CoV-2 Omicron B.1.1.529 by Sissy Therese Sonnleitner, Samira Walder, Eva Hinterbichler, Ludwig Knabl, Roswitha Poernbacher, Gernot Walder

“…ABSTRACT Total RNA-seq allows for the comprehensive detection of differentially expressed genes (DEGs), providing insight into immune responses during infection. …”
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Establishment of a chemoresistant laryngeal cancer cell model to study chemoresistance and chemosensitization responses via transcriptomic analysis and a tumor‐on‐a‐chip platform... by Christian R. Moya‐Garcia, Meghana Munipalle, Alain Pacis, Nader Sadeghi, Maryam Tabrizian, Nicole Y. K. Li‐Jessen

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Transcriptomic Analysis Reveals Candidate Hub Genes and Putative Pathways in <i>Arabidopsis thaliana</i> Roots Responding to <i>Verticillium longisporum</i> Infection by Qiwei Zheng, Yangpujia Zhou, Sui Ni

“…We report <i>V. longisporum</i>-responsive components in <i>Arabidopsis</i>, providing insights for disease resistance studies in Brassicaceae crops.…”
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Integrative Mendelian randomization and multi-omics analysis identifies anti-allergic drug targets associated with cardiovascular disease risk by Huilin Lian, Dai Li, Youjie Zeng, Yi Meng, Ruifang Chen, Ren Guo

“…This study explores links between anti-allergic drugs and CVD risk, providing valuable insights for clinical pharmacotherapy. …”
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Parent‐Specific Transgenerational Immune Priming Enhances Offspring Defense—Unless Heat Stress Negates It All by Ralf F. Schneider, Arseny Dubin, Silke‐Mareike Marten, Olivia Roth

“…Transcriptomic phenotypes elicited by maternal and paternal TGIP had limited overlap and were not additive. …”
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Mutual suppression between mutations in the Dictyostelium Greenbeard pathway restores wild-type development by Mariko Katoh-Kurasawa, Lena Trnovec, Peter Lehmann, Blaž Zupan, Gad Shaulsky

“…Using RNA-sequencing analyses, we compared the transcriptomes of the wild type to those of several mutant strains and found that the single-gene mutations attenuated transcriptome progression over developmental time, whereas the double-gene mutation strain rapgapB – tgrB1 – and the activated tgrB1 mutation exhibited near wild-type transcriptomes. …”
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Integrated multi-omics analysis identifies lipid metabolism biomarkers in ONFH and reveals therapeutic potential of retinoic acid by Chuan Wang, Chaode Cen, Huachuan Su, Yuhui Peng, Tao Wang, Jian Li, Fei Zhang, Wuxun Peng

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Integrated omics reveal the mechanisms underlying softening and aroma changes in pear during postharvest storage and the role of melatonin by Jiayu Xu, Ying Zhang, Hongliang Huo, Dan Qi, Xingguang Dong, Luming Tian, Chao Liu, Yufen Cao

“…The mechanism underlying these effects was elucidated, providing theoretical basis for study of pear fruit softening and preservation technology.…”
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Transcriptome Analysis of Potato (<i>Solanum tuberosum</i> L.) Seedlings with Varying Resistance Levels Reveals Diverse Molecular Pathways in Early Blight Resistance by Jiangtao Li, Jie Li, Hongfei Shen, Rehemutula Gulimila, Yinghong Jiang, Hui Sun, Yan Wu, Binde Xing, Ruwei Yang, Yi Liu

“…These findings highlight critical molecular pathways and candidate genes involved in early blight resistance, providing a foundation for further functional studies and breeding strategies to enhance potato resilience.…”
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Early transcriptional and cellular abnormalities in choroid plexus of a mouse model of Alzheimer’s disease by Zhong-Jiang Yan, Maosen Ye, Jiexi Li, Deng-Feng Zhang, Yong-Gang Yao

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Metabolite differences and molecular mechanism between dehiscent and indehiscent capsule of mature sesame by Yinping Zhang, Ruirui Chen, Yujun Liu, Shuwen Xu, Shuguang Gao, Haiyang Zhang, Hongmei Miao, Lingling Qin, Xiangyu Zhou, Kiran Thakur, Cheng Li, Juan Li, Pengcheng Wei, Zhao-Jun Wei

“…Using comparative metabolome and transcriptome analysis, this work investigated the molecular regulation and enrichment pathways in two sesame types of indehiscent capsule WanZhi28 (ND) and dehiscent capsule WanZhi2 (WZ2). …”
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Evaluation of Drought Tolerance and Trehalose Response in <i>Auricularia heimuer</i> by Jian Sun, Fangjie Yao, Lixin Lu, Youmin Zhang, Ming Fang, Xiaoxu Ma, Kaisheng Shao, Xu Sun

“…This study discovered, for the first time, that the synthesis pathway of trehalose is involved in the response of edible fungi to drought stress, thus providing a reference for the genetic improvement of <i>A. heimuer</i> and the selection of drought-tolerant strains, laying a theoretical foundation for the resistance breeding of other edible fungi.…”
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Overexpression of the Kiwifruit Transcription Factor <i>AaMYB44</i> Decreases the Cold Tolerance in <i>Arabidopsis thaliana</i> by Yihang Li, Miaomiao Lin, Qina Zhang, Peng Zhang, Zhenzhen Zhang, Yukuo Li, Leiming Sun, Sumei Li, Congcong Li, Dixin Chen, Xiujuan Qi

“…Overall, <i>AaMYB44</i> might play a negative regulatory role in response to cold stress, providing new insight into the mechanism of cold tolerance.…”
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Signaling pathways mediating the induction of preharvest fruit drop in litchi by Jun Wang, Jun Wang, Jun Wang, Wuqiang Ma, Wuqiang Ma, Fei Wang, Fei Wang, Zidi He, Zidi He, Xiangyang Ye, Xiangyang Ye, Jiahui Deng, Jiahui Deng, Minglei Zhao, Minglei Zhao, Jianguo Li, Jianguo Li

“…Based on these comprehensive findings, we propose a model for preharvest fruit drop triggered by a series of molecular events in litchi, providing valuable insights into the complex mechanisms governing this phenomenon.…”
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Interferon and B-cell Signatures Inform Precision Medicine in Lupus Nephritis by Ioannis Parodis, Julius Lindblom, Daniel Toro-Domínguez, Lorenzo Beretta, Maria O. Borghi, Jessica Castillo, Elena Carnero-Montoro, Yvonne Enman, Chandra Mohan, Marta E. Alarcón-Riquelme, Guillermo Barturen, Dionysis Nikolopoulos, Lorenzo Beretta, Barbara Vigone, Jacques-Olivier Pers, Alain Saraux, Valérie Devauchelle-Pensec, Divi Cornec, Sandrine Jousse-Joulin, Bernard Lauwerys, Julie Ducreux, Anne-Lise Maudoux, Carlos Vasconcelos, Ana Tavares, Esmeralda Neves, Raquel Faria, Mariana Brandão, Ana Campar, António Marinho, Fátima Farinha, Isabel Almeida, Miguel Angel Gonzalez-Gay Mantecón, Ricardo Blanco Alonso, Alfonso Corrales Martínez, Ricard Cervera, Ignasi Rodríguez-Pintó, Gerard Espinosa, Rik Lories, Ellen De Langhe, Nicolas Hunzelmann, Doreen Belz, Torsten Witte, Niklas Baerlecken, Georg Stummvoll, Michael Zauner, Michaela Lehner, Eduardo Collantes, Rafaela Ortega-Castro, Ma Angeles Aguirre-Zamorano, Alejandro Escudero-Contreras, Ma Carmen Castro-Villegas, Norberto Ortego, María Concepción Fernández Roldán, Enrique Raya, Inmaculada Jiménez Moleón, Enrique de Ramon, Isabel Díaz Quintero, Pier Luigi Meroni, Maria Gerosa, Tommaso Schioppo, Carolina Artusi, Carlo Chizzolini, Aleksandra Zuber, Donatienne Wynar, Laszló Kovács, Attila Balog, Magdolna Deák, Márta Bocskai, Sonja Dulic, Gabriella Kádár, Falk Hiepe, Velia Gerl, Silvia Thiel, Manuel Rodriguez Maresca, Antonio López-Berrio, Rocío Aguilar-Quesada, Héctor Navarro-Linares

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Identification of genes in response to cucurbit aphid-borne yellows virus infection in melon by YANG Siyu, GONG Zihui, HU Zhongyuan, ZHANG Mingfang, YANG Jinghua

“…Identification of CABYV-responsive genes can provide target genes for breeding of melon resistant to the viral disease. …”
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Insights to microsporidia Nosema bombycis congenital infection and host immune responses in the embryo and larva stages of silkworms by Tangxin Li, Yue Song, Quan Sun, Qiong Yang, Yunlin Tang, Zigang Shen, Zhangshuai He, Yabin Dou, Junzheng Zhang, Sheng Li, Tian Li, Xianzhi Meng, Zeyang Zhou, Jie Chen, Guoqing Pan

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Modelling the liver’s regenerative capacity across different clinical conditions by Anh Thu Nguyen-Lefebvre, Soumita Ghosh, Cristina Baciu, Bima J. Hasjim, Sara Naimimohasses, Graziano Oldani, Elisa Pasini, Michael Brudno, Nazia Selzner, Jeffrey Wrana, Mamatha Bhat

“…The deep learning model integrating clinical and transcriptomic data predicted regenerative outcomes with 87.9% accuracy. …”
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