Elucidating the Molecular Mechanisms of Physiological Fruit Abscission in <i>Actinidia arguta</i> Through Comparative Transcriptomics and Transient Genetic Transformation by Pengqiang Yuan, Yanli Wang, Yining Sun, Guoliang Liu, Hongyan Qin, Shutian Fan, Yiping Yan, Bowei Sun, Wenpeng Lu

“…This study elucidates the hormonal and transcriptional networks governing fruit abscission in <i>A. arguta</i>, providing insights for targeted breeding and cultivation strategies to mitigate yield loss.…”
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Decoding submergence tolerance in Prunus persica: Integrated transcriptomic and metabolomic acclimations of antioxidant system, cell wall dynamics, and hormonal signaling by Muhammad Ateeq, Dongmei Zhang, Jinping Xiao, Huiqin Zhang, Xingyi Shen, Jian Meng, Jinzhi Yang, Shariq Mahmood Alam, Muhammad Mohsin Kaleem, Muhammad Abbas Khan, Kaijie Zhu, Guohuai Li, Junwei Liu

“…These findings elucidate the mechanisms of peach leaf tolerance to submergence, providing insights into potential strategies for genetic improvement aimed at enhancing hypoxia resistance in fruit trees.…”
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Integrative network pharmacology, transcriptomics, and proteomics reveal the material basis and mechanism of the Shen Qing Weichang Formula against gastric cancer by Yi Wang, Xiaoyu Sun, Mingming Ren, Fangqi Ma, Ruohan Zhao, Xiaohong Zhu, Yan Xu, Nida Cao, Yuanyuan Chen, Yongfu Pan, Aiguang Zhao

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Integrated Transcriptomic and Metabolomic Analysis Identified Key Transcriptional Factors Involved in Flavonoid and Alkaloid Biosynthesis Among Different Tissues of <i>Sophora flav... by Ake Liu, Jingjing Dong, Mingyang Wang, Jin Li, Junjie Lu, Lintao Liu, Haiying Lei, Zhen Zeng, Huifang Song

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Exploring novel pyrethroid resistance mechanisms through RNA-seq in Triatoma dimidiata from Colombia by Sara Zuluaga, Geysson Javier Fernandez, Ana María Mejía-Jaramillo, Carl Lowenberger, Omar Triana-Chavez

“…This comprehensive investigation is crucial for providing insights into resistance mechanisms and generating strategies to manage these critical vector species.…”
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Spatial transcriptomic and morpho-functional information derived from single mouse FFPE slides allows in-depth fingerprinting of lung fibrosis by Erica Ferrini, Costanza Bonfini, Giovanna Marchese, Martina Buccardi, Matteo Zoboli, Primetta Faccioli, Nicola Sverzellati, Gino Villetti, Simone Ottonello, Maria Ravo, Franco F. Stellari

“…Abstract Background Transcriptome profiling by RNA sequencing (RNAseq) can provide insightful information on the molecular processes underlying disease development and progression. …”
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Transcriptomic and metabolomic analysis clarify the molecular mechanisms underlying the formation of sexual and apomictic Persian walnut (Juglans regia L.) embryos by Chunjie Bao, Chunjie Bao, Hong Chen, Hong Chen, Haoliang Zhou, Haoliang Zhou, Feng Chen, Feng Chen

“…This study integrates transcriptomic and metabolomic analyses to reveal new insights into the formation of sexual and apomictic walnut embryos, providing a valuable foundation for future research on apomictic embryo development in walnuts.MethodTo elucidate the mechanisms underlying these reproductive modes, transcriptomic and metabolomic analyses were performed on the embryos of sexual and apomictic walnut species at different developmental stages.ResultsOur findings revealed 321 differentially expressed genes (DEGs) and 19 differentially accumulated metabolites (DAMs) in apomictic vs. sexual walnut embryos. …”
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The Impact of Dissolved Biochar on Oxidative Stress and Its Effect on the Virulence of <i>Steinernema feltiae</i>: Implications for Biocontrol Efficiency by Xinrui Wang, Jie Li, Jing Li, Lan Luo, Gang Li, Weibin Ruan, Guilong Zhang

“…Overall, this study suggests that DBC may impair the biocontrol efficacy of <i>S. feltiae</i> through oxidative stress and genetic perturbations, providing new insights into its long-term ecological impacts on soil ecosystems.…”
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Copper Pyrithione Induces Hepatopancreatic Apoptosis and Metabolic Disruption in <i>Litopenaeus vannamei</i>: Integrated Transcriptomic, Metabolomic, and Histopathological Analysis by Jieyu Guo, Yang Yang, Siying Yu, Cairui Jiang, Xianbin Su, Yongfeng Zou, Hui Guo

“…A large number of differentially expressed genes (DEGs) were identified by transcriptomics analysis at 3 and 48 h, respectively. …”
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GWAS combined with transcriptomics revealed key regulatory genes for inflorescence traits and fruit set rate in Litchi (Litchi chinensis Sonn.) by Fachao Shi, Kan Huang, Yonghua Jiang, Hailun Liu, Yingjie Wen, Qian Yan

“…By employing large-scale sample analysis and multi-omics technologies, this study systematically unraveled the intrinsic relationships between litchi inflorescence traits and fruit set rate, providing a solid scientific basis and novel insights for litchi breeding practices.…”
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Integrative transcriptomic and metabolomic reveals squalene alleviating the inflammatory response and enhancing immunity of hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lance... by Xiaobo Yan, Simiao Pan, Xiangxiang Suo, Weibin Huang, Tao Li, Shuang Zhang, Yuanzhi Yang, Beiping Tan, Xiaohui Dong

“…Therefore, the present study was designed to use corn oil as the main lipid source to create a model of inflammation or low immunity and investigate the regulatory effect of squalene on the immunity of grouper, and to perform hepatic transcriptomic and metabolomic assays of grouper using omics technology, with the aim of providing basic data for the study of the mechanism of squalene. …”
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The potential mechanism of MicroRNA involvement in the regulation of muscle development in weaned piglets by tryptophan and its metabolites by Tianle He, Qingyun Chen, Huifeng Li, Jiani Mao, Ju Luo, Dengjun Ma, Zhenguo Yang

“…Conclusions This study uncovers the potential mechanisms by which miRNAs participate in the regulation of muscle development in weaned piglets mediated by Trp and its metabolites, providing a theoretical basis and practical guidance for optimizing piglet management and health improvement.…”
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Effect of GR24 on the growth and development of licorice under low phosphorus stress by Yuting Jing, Man Li, Yong Wu, Chengming Zhang, Chengshu Qiu, Hengming Zhao, Li Zhuang, Hongling Liu

“…The research aimed to ascertain the optimal concentration of GR24 for promoting licorice growth and development, thereby providing a theoretical foundation for its agricultural management. …”
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Targeting and editing the second exon of bmp6 gene results in a silver carp with reduced intramuscular bones by Shuang Niu, Xiaohui Li, Cui Feng, Zewen Zhang, Hang Sha, Xiangzhong Luo, Guiwei Zou, Hongwei Liang

“…The findings offer a reliable knockout sites on exon 2 of the bmp6 gene, providing valuable insights for the future breeding of silver carp new varieties devoid of IBs.…”
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The critical role of PDGFRa + Sca1 + fibroblasts in angiogenesis and vascular repair in the corpus cavernosum by Biao Liu, Zitaiyu Li, Zhitao Han, Yuzhuo Chen, Yanghua Xu, Jiarong Xu, Hongji Hu, Ningjing Ou, Xiaoping Zheng, Yinghao Yin, Dongyi Peng, Liangyu Zhao, Yuxin Tang

“…The depletion of these FBs in disease conditions may contribute to the exhaustion of ECs and SMCs, providing new insights into the pathogenesis of ED. …”
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Integrated ultrasensitive metabolomics and single-cell transcriptomics identify crucial regulators of sheep oocyte maturation and early embryo development in vitro by Bo Pan, JianPeng Qin, KunLin Du, LuYao Zhang, GongXue Jia, JiangFeng Ye, QiuXia Liang, QiEn Yang, GuangBin Zhou

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Metabolic engineering of crocins and picrocrocin apocarotenoids in potato group phureja by Lourdes Gómez‐Gómez, Alberto José López‐Jimenez, Cristian Martinez Fajardo, Lucía Morote, Sarah Frusciante, José Luis Rambla, Gianfranco Diretto, Ángela Rubio‐Moraga, María Mondejar‐López, Enrique Niza, Javier Argandoña, Silvia Presa, Antonio Granell, Oussama Ahrazem

“…Furthermore, we performed transcriptome analyses of tubers from Desirée and 01H15 wild type and carrying O6 construct. …”
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Transcriptome analysis of Thevetia peruviana cell suspensions treated with methyl jasmonate reveals genes involved in phenolics, flavonoids and cardiac glycosides biosynthesis by Olmedo Cuaspud, Olmedo Cuaspud, Dary Mendoza, Gigliola Navarro, Gigliola Navarro, Juan Arias, Isabel Calle, Juliana Arcila-Galvis, Juliana Arcila-Galvis, Rafael Eduardo Arango Isaza

“…This de novo assembly of T. peruviana transcriptome provides a valuable resource for future research in functional genomics and metabolic engineering of bioactive SMs. …”
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Single-cell transcriptomics of clinical grade adipose-derived regenerative cells reveals consistency between donors independent of gender and BMI by Frederik Adam Bjerre, Jakob Vennike Nielsen, Mark Burton, Pratibha Dhumale, Mads Gustaf Jørgensen, Sabrina Toft Hansen, Lars Lund, Mads Thomassen, Jens Ahm Sørensen, Ditte Caroline Andersen, Charlotte Harken Jensen

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Spatial Transcriptomics in Inflammatory Skin Diseases Using GeoMx Digital Spatial Profiling: A Practical Guide for Applications in Dermatology by Christina Cho, Nazgol-Sadat Haddadi, Michal Kidacki, Gavitt A. Woodard, Saeed Shakiba, Ümmügülsüm Yıldız-Altay, Jillian M. Richmond, Matthew D. Vesely

“…In particular, the skin immune microenvironment is arranged spatially and temporally, such that imbalances in the immune milieu are indicative of disease. Spatial transcriptomic platforms are helping to provide additional insights into aberrant inflammation in tissues that are not captured by tissue processing required for single-cell RNA sequencing. …”
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