Integrated transcriptome profiling and in vitro analysis reveals MLN4924’s role in inducing ferroptosis in acute myeloid leukemia by Jinli Jian, Yuancheng Guo, Xiao Tang, Long Zhao, Bei Liu

“…This study aimed to investigate the role of MLN4924 in modulating ferroptosis and its molecular targets in AML.Methods: Transcriptome sequencing and bioinformatics analyses were performed to identify MLN4924 potential targets in ferroptosis. …”
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Integrative transcriptomic and metabolomic analyses reveal the role of melatonin in promoting secondary hair follicle development in cashmere goats by Xiaogao Diao, Jiaxin Qin, Chenxi Dong, Liwen He, Wei Zhang

“…Conclusions In summary, by integrating transcriptomics and metabolomics, this study provides novel insights into the role of melatonin in promoting SHF development. …”
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Transcriptome Analysis of <i>Culex pipiens quinquefasciatus</i> Larvae Exposed to a Semi-Lethal Dose of Vermistatin by Junhui Chen, Zhiyong Xu, Feiying Yang, Jian Yang, Wendong Kuang, Jianghuai Li, Yaqi Wang, Liang Jin

“…Here, we conducted a transcriptomic analysis of <i>Cx. p. quinquefasciatus</i> larvae treated with a median lethal concentration of 28.13 mg/L vermistatin. …”
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Lipidomic and transcriptomic profiling reveal alterations in the coexistence of gestational diabetes mellitus and preeclampsia impacting maternal and neonatal outcomes by Chenxiao Zhang, Yanli Huang, Xixian Mai, Lu Liu, Yan Li, Fei Zheng, Judan Cao, Chen Zou, Changshan Wang, Jinjun Ran, Hui Zhang, Xiaonan Wang

“…Despite the limitation of a modest sample size, the study provides evidence that subclinical alterations in maternal peripheral blood lipidomic and transcriptomic profiles, along with aberrations in cord blood gas (CBG) parameters, may exert adverse effects on both maternal and neonatal health. …”
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Comparative transcriptome analysis on candidate genes involved in lipid biosynthesis of developing kernels for three walnut cultivars in Xinjiang by Wenqiang Wang, Hao Wen, Qiang Jin, Wenjun Yu, Gen Li, Minyu Wu, Hongjin Bai, Lirong Shen, Cuiyun Wu

“…These findings will provide a comprehensive understanding and valuable information on the genetic engineering and molecular breeding in walnut.…”
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Nitrogen Deprivation Drives Red Motile Cell Formation in <i>Haematococcus pluvialis</i>: Physiological and Transcriptomic Insights by Hailiang Xing, Na Zhou, Kai Liu, Xiaotian Yan, Wanxia Li, Xue Sun, Liuquan Zhang, Fengjie Liu, Nianjun Xu, Chaoyang Hu

“…<b>Methods:</b> In this study, the physiological and transcriptomic responses of <i>H. pluvialis</i> to ND were investigated at various time points under high light conditions. …”
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Transcriptome dataset to investigate the effect of deep seawater on the gene expression and functional compounds of leaves of Ligularia stenocephalaNCBI. by Dewi Komang Anggita, Bimpe Suliyat Azeez, Se-Jin Oh, Jong-Kuk Na

“…Due to the lack of the reference genome for read mapping, the three transcriptome data from this study were merged to generate a reference transcriptome. …”
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Unveiling tolerance mechanisms in pepper to combined low-temperature and low-light stress: a physiological and transcriptomic approach by Jie Zhang, Hamza Sohail, Xuewen Xu, Yongtai Zhang, Yongji Zhang, Yibo Chen

“…In this study, we conducted physiological and transcriptomic analyses on two pepper genotypes: Y2, a LL-sensitive genotype, and Y425, a LL-tolerant genotype. …”
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Whole-Transcriptome Sequencing and Differential Expression Analysis of the Epididymis in Junggar Bactrian Camels Before and After Sexual Maturity by Jiahao Liu, Xinkui Yao, Jun Meng, Jianwen Wang, Yaqi Zeng, Linling Li, Wanlu Ren

“…In this study, we conducted whole-transcriptome sequencing of epididymal tissues from Junggar Bactrian camels before and after sexual maturity. …”
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Color-dependent defense mechanisms of Quinoa (Chenopodium quinoa Willd.) against Spodoptera exigua: metabolomic and transcriptomic insights by Junna Liu, Hanxue Li, Hongxin Wang, Ping Zhang, Qianchao Wang, Li Li, Heng Xie, Shunhe Cheng, Peng Qin

“…We aimed to evaluate the defense mechanisms of differently colored quinoa (red, white, yellow, and black) against S. exigua using metabolomics and transcriptome analyses. Metabolomic analysis was used to identify insect-resistant metabolites in four differently colored quinoa cultivars, whereas transcriptome analysis was used to explore related pathways and gene associations. …”
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A cross-tissue transcriptome-wide association study identifies new susceptibility genes for benign prostatic hyperplasia by Li Wang, Si-yu Chen, Jian-wei Yang, Kang-yu Wang, Kun-peng Li, Shun Wan, Xiao-ran Li, Li Yang

“…Our research identified the INO80B gene, whose predicted expression is associated with BPH risk and hence provided a new insight into the genetic basis of this disease. …”
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Metabolomics and transcriptomics analyses reveal the complex molecular mechanisms by which the hypothalamus regulates sexual development in female goats by Qing Li, Tianle Chao, Yanyan Wang, Peipei He, Lu Zhang, Jianmin Wang

“…In this study, we conducted metabolomic and transcriptomic analyses on the hypothalamic tissues of female Jining grey goats at different stages of sexual development (1 day old (neonatal, D1, n = 5), 2 months old (prepuberty, M2, n = 5), 4 months old (sexual maturity, M4, n = 5), and 6 months old (breeding period, M6, n = 5)). …”
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Understanding Mantle Edge Pigmentation Through Comprehensive Transcriptomic Profiling of the Chilean Oyster (<i>Ostrea chilensis</i>) by Camila Godoy-Diaz, Katalina Llanos-Azócar, Gonzalo J. Ruiz-Tagle, Jorge E. Toro, Pablo A. Oyarzún, Juan A. Valdés

“…A total of 935,620,583 paired-end reads were de novo assembled, 50,908 transcripts produced, and a reference transcriptome created with 37.92% GC content and an N50 of 1929 bp. …”
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Machine learning-assisted multi-dimensional transcriptomic analysis of cytoskeleton-related molecules and their relationship with prognosis in hepatocellular carcinoma by Yuxuan Li, Mingbo Cao, Xiaorui Su, Gaoyuan Yang, Yupeng Ren, Zhiwei He, Zheng Shi, Ziyi Hu, Guirong Liang, Qi Zhang, Zhicheng Yao, Meihai Deng

“…The five-gene model provides a reliable tool for risk stratification, and the irinotecan-sorafenib combination shows promise as a therapeutic strategy.…”
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Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states by Revathi Balasubramanian, Krishnakumar Kizhatil, Taibo Li, Nicholas Tolman, Aakriti Bhandari, Graham Clark, Violet Bupp-Chickering, Ruth A Kelly, Sally Zhou, John Peregrin, Marina Simón, Christa Montgomery, W Daniel Stamer, Jiang Qian, Simon WM John

“…It has distinct inner and outer walls, each composed of Schlemm’s canal endothelial cells (SECs) with different morphologies and functions. Recent transcriptomic studies of the anterior segment added important knowledge, but were limited in power by SEC numbers or did not focus on SC. …”
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Neutrophil extracellular traps drive osteoporosis via NCF2-dependent signaling: integrated transcriptomics with mechanistic validation by Xiangyun Guo, Liang Wang, Shuangliu Chen, Chuanrui Sun, Jinran Qin, Qingqing Liu, Yiwen Gan, Yan Li, Zikai Jin, Xu Wei, Yili Zhang

“…Understanding these mechanisms is essential for targeted therapies.Methods We established a rat OP model via bilateral ovariectomy. Transcriptomic sequencing (RNA-seq) identified differentially expressed genes (DEGs), and summary data-based Mendelian randomization (SMR) analysis validated their causal associations with OP. …”
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The Effects of Acute Temperature Changes on Transcriptomic Responses in the Liver of Leopard Coral Groupers (<i>Plectropomus leopardus</i>) by Yilan Guo, Chaofan Jin, Cun Wei, Kangning Zhong, Yurui Gao, Peiyu Li, Zhe Qu, Zhenmin Bao, Bo Wang, Jingjie Hu

“…Taken together, this study provides a systematic analysis of the effects of acute cold exposure and temperature recovery stress on the liver of the leopard coral grouper, laying the groundwork for further research on the temperature stress responses in teleost species.…”
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Transcriptomic analysis of muscle and adipose tissues identifies myokines and adipokines contributing to lipid deposition in Taoyuan Black pigs by Liu Guo, Junfei Xu, Wenyue Zhou, Sisi Chen, Hanjing Shi, Mengmeng Han, Weijun Pang, Yulong Yin, Fengna Li

“…The “window phase” of lipid deposition in TB pigs was defined from 120 to 180 d of age according to carcass traits, intramuscular fat (IMF), and adipocyte area. Comparative transcriptome of the longissimus dorsi (LD) muscle and subcutaneous adipose revealed upregulated energy and lipid metabolism pathways in TB pigs at 180 d compared to 120 d (P < 0.05). …”
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Deciphering the molecular signatures of tropical Areca catechu L. under cold stress: an integrated physiological and transcriptomic analysis by Han Li, Linbi Zhang, Xinyu Wen, Changlei Ji, Hui Chen, Meng Tian, Fusun Yang, Jun He, Jun He

“…However, A. catechu is a tropical plant that is particularly susceptible to low temperatures.MethodsThis study integrates physiological profiling with transcriptomic sequencing to systematically investigate the cold-response mechanisms of A. catechu.ResultsMultivariate variance analysis revealed that peroxidase (POD) activity and chlorophyll content are significant biomarkers strongly correlated with cold tolerance. …”
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Integrated analysis of single-cell and bulk transcriptomics reveals cellular subtypes and molecular features associated with osteosarcoma prognosis by Feng Liu, Tingting Zhang, Yongqiang Yang, Kailun Wang, Jinlan Wei, Ji-Hua Shi, Dong Zhang, Xia Sheng, Yi Zhang, Jing Zhou, Faming Zhao

“…Conclusion In summary, our work provides novel insights into the molecular biology of OS, and offers valuable resource for OS biomarker discovery and treatment strategy development.…”
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