The mechanism of egg production improvement in laying hens before and after molting revealed by transcriptome and metabolome integration by Mengqing Sun, Hailing Wang, Xinyu Zhu, Xiaohan Zhang, Yahong Min, Ming Ge, Xiaowen Jiang, Wenhui Yu

“…In conclusion, this study demonstrates that forced molting is an effective strategy for enhancing the laying rate of hens. Furthermore, it provides a valuable theoretical framework for advancing breeding practices aimed at improving egg production.…”
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Integrating network pharmacology, quantitative transcriptomic analysis, and experimental validation revealed the mechanism of cordycepin in the treatment of obesity by Yu Liao, Mingchao Wang, Fuli Qin, Taotao Liu, Jiemei Chen

“…The metabolic pathway, insulin signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, lipid and atherosclerosis pathway, and core targets including CPS1, HRAS, MAPK14, PAH, ALDOB, AKT1, GSK3B, HSP90AA1, BHMT2, EGFR, CASP3, MAT1A, APOM, APOA2, APOC3, and APOA1 are involved in regulating the therapeutic effect of Cpn.ConclusionThis study comprehensively uncovers the potential mechanism of Cpn against obesity based on network pharmacology and quantitative transcriptomics, which provides evidence for revealing the pathogenesis of obesity, suggesting that Cpn is a possible lead compound for anti-obesity treatment.…”
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Transcriptome Analysis Reveals Key Pathways and Candidate Genes for Resistance to <i>Plasmodiophora brassicae</i> in Radish by Yinbo Ma, Xinyuan Li, Feng Cui, Qian Yu, Baoyang Liu, Xinyi Guo, Liwang Liu

“…The outcomes of this study would not only facilitate clarifying the molecular mechanism underlying clubroot resistance, but also provide valuable resources for genetic improvement of clubroot resistance in radish.…”
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Network-Based Method to Investigate the Promoted Cell Apoptosis Mechanisms of Oridonin in OSCC through the RNA-Transcriptome by Guohui Wu, Yusheng Guo, Yang Liu, Xiangsheng Cai, Tanggang Deng, Tianchu Pei, Long Huang, Kai Chen, Xuan Pan

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Transcriptomics-driven exploration of genetic variation and peptide discovery in the sea anemones Anthopleura midori and Actinia equina by Han Zhang, Xinghua Pan, Chen Weigang

“…More importantly, it aims to provide a solid theoretical foundation for drug development and biodiversity conservation research. …”
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Identification and Expression Profiles of Chemosensory Genes in the Antennal Transcriptome of <i>Protaetia brevitarsis</i> (Coleoptera: Scarabaeidae) by Shi-Hang Zhao, Yang Yue, Qi Gao, Rui-Tao Yu, Zhao-Hui Yang, Nan Zhou, Guo-Liang Xu

“…We conducted antennal transcriptome sequencing of adult beetles and identified 117 chemosensory-related genes, including 66 odorant receptors (ORs), 20 ionotropic receptors, 10 gustatory receptors, 13 odorant-binding proteins (OBPs), four chemosensory proteins, and four sensory neuron membrane proteins. …”
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Transcriptomic Changes of Telencephalon and Hypothalamus in Largemouth Bass (<i>Micropterus salmoides</i>) Under Crowding Stress by Meijia Li, Leshan Yang, Ying Liu

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Histological and Transcriptomic Insights into Rugose Surface Formation in Pepper (<i>Capsicum annuum</i> L.) Fruit by Yiqi Xie, Haizhou Zhang, Chengshuang Li, Qing Cheng, Liang Sun, Huolin Shen

“…To investigate its regulatory basis, histological, textural, and transcriptomic differences, contrasting genotypes were analyzed. …”
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Transcriptome analysis of Bombyx mori larval midgut during persistent and pathogenic cytoplasmic polyhedrosis virus infection. by Anna Kolliopoulou, Filip Van Nieuwerburgh, Dimitrios J Stravopodis, Dieter Deforce, Luc Swevers, Guy Smagghe

“…Collectively, our data provide an initial assessment of the relative significance of persistent infection of silkworm larvae on the host response following pathogenic infection with CPV, while they also highlight the relative importance of RNAi as an antiviral mechanism.…”
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Transcriptome enhanced rice grain metabolic model identifies histidine level as a marker for grain chalkiness by Niaz Bahar Chowdhury, Anil Kumar Nalini Chandran, Harkamal Walia, Rajib Saha

“…For this, we reconstructed the rice grain genome-scale metabolic model (GSM), iOSA3474-G and incorporated transcriptomics data from three different times of the day (dawn, dawn 7 h, and dusk) for both control and WNT conditions with iOSA3474-G. …”
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Integrated transcriptomic and metabolomic analysis of flavonoid biosynthesis in cigar tobacco leaves under variable nitrogen regimes by Kai Jia, Juanjuan Shi, Lingli Bai, Xueren Wang, Yuemin Wang, Xiangzhen Li, Wenqing Li, Chaoyuan Zheng

“…The reliability of transcriptome data was validated via qPCR.DiscussionThese results provide a scientific basis for elucidating the biosynthesis mechanisms of tobacco flavonoids and identifying key nitrogen-responsive genes. …”
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Transcriptomic Profiling of ‘Candidatus Liberibacter asiaticus’ in Different Citrus Tissues Reveals Novel Insights into Huanglongbing Pathogenesis by Amelia H. Lovelace, Chunxia Wang, Amit Levy, Wenbo Ma

“…Here, we investigate the transcriptomic landscape of Las in citrus seed coat vasculatures, enabling a complete gene expression profiling of Las genome and revealing unique transcriptomic patterns compared with previous studies using midrib tissues. …”
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Physiological Characteristic Changes and Transcriptome Analysis of Maize (Zea mays L.) Roots under Drought Stress by Chenglin Zou, Hua Tan, Kaijian Huang, Ruining Zhai, Meng Yang, Aihua Huang, Xinxing Wei, Runxiu Mo, Faqian Xiong

“…The two TFs, including bHLH 35 and bHLH 96, involved in the MAPK signal pathway and plant hormones pathway, are significantly upregulated in 5%, 10%, 15%, and 20% PEG stress groups. The present study provides greater insight into the fundamental transcriptome reprogramming of grain crops under drought.…”
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Comparative transcriptome analysis of genes related to tuberization in late and early maturing potato (Solanum tuberosum) cultivars by Qingquan Li, Yue Wang, Yunfei Gao, Qiao Wang, Zhimin Niu, Xiangri Nan, Guoquan Fan, Wanmin Sheng

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Integrated transcriptome and metabolome analyses reveal the differentially expressed metabolites and genes involved in lipid in olive fruits by Jipeng Qu, Zhou Xu, Zhengsong Peng, Zhenyong Chen, Tao Chen, Chunbang Ding

“…These DEGs were associated with the pathways of fatty acid biosynthesis, arachidonic acid metabolism, and limonene degradation. This study provides a strong theoretical and experimental foundation for further revealing the molecular mechanisms regulating lipid synthesis and metabolism in different olive cultivars.…”
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Characteristics of immune-active and immune-silent phenotypes of early-stage cervical carcinoma as revealed by transcriptome sequencing by O. V. Kurmyshkina, P. I. Kovchur, T. O. Volkova

“…Overall, the existence and detectability of different transcriptomic immune-based phenotypes of invasive CeCa at its initial stages of progression is shown, which may provide new options to broaden the knowledge and applicability of target and immune anti-cancer therapy.…”
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Leveraging autoencoder models and data augmentation to uncover transcriptomic diversity of gingival keratinocytes in single cell analysis by Pradeep Kumar Yadalam, Prabhu Manickam Natarajan, Carlos M. Ardila

“…This study employs autoencoder models and data augmentation techniques to explore the transcriptomic diversity of gingival keratinocytes at the single-cell level. …”
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Transcriptomic dynamics and cell-to-cell communication during the transition of prospermatogonia to spermatogonia revealed at single-cell resolution by Zhen He, Rong-Ge Yan, Qin-Bang Shang, Qi-En Yang

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Comparative transcriptomes of adenocarcinomas and squamous cell carcinomas reveal molecular similarities that span classical anatomic boundaries. by Eric W Lin, Tatiana A Karakasheva, Dong-Jin Lee, Ju-Seog Lee, Qi Long, Adam J Bass, Kwok K Wong, Anil K Rustgi

“…Advances in genomics in recent years have provided key insights into defining cancer subtypes "within-a-tissue"-that is, respecting traditional anatomically driven divisions of medicine. …”
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Comprehensive RNA-Seq profiling of the lung transcriptome of Bashbay sheep in response to experimental Mycoplasma ovipneumoniae infection. by Zhihui Du, Yanming Sun, Jixue Wang, Haiyan Liu, Yi Yang, Ning Zhao

“…Transcriptome profiling was performed by deep RNA sequencing, using the Illumina platform. …”
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