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801
Integrated transcriptomic and metabolomic analyses identify key factors in the vitellogenesis of juvenile Sichuan bream (Sinibrama taeniatus)
Published 2023-10-01“…In the liver, energy metabolism was promoted by activating glucolipid metabolic pathways to provide sufficient ATP, but at the same time, the ovary tends to retain nutrients rather than decompose them to produce energy. …”
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802
Comparative transcriptome analysis of cucumber fruit tissues reveals novel regulatory genes in ascorbic acid biosynthesis
Published 2024-10-01“…These six genes are considered the key candidate genes for further research. This study provides insight for further study on the regulation of AsA biosynthesis in cucumber fruit and provide potential candidate genes for future genetic improvement of cucumber germplasm with enhanced AsA accumulation.…”
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803
A versatile workflow to integrate RNA-seq genomic and transcriptomic data into mechanistic models of signaling pathways.
Published 2021-02-01“…Moreover, this is the first workflow that provides a framework for the integration of transcriptomic and genomic data based on a mechanistic model of signaling pathway activities that allows a detailed biological interpretation of the results, including a comprehensive functional profiling of cell activity. …”
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804
Identification of hub genes regulating seed germination viability in soybean via comparative transcriptome analysis and WGCNA
Published 2025-07-01“…Conclusions Through screening of soybean genotypes with contrasting seed germination viability from natural populations and comparative transcriptome analysis, we elucidated the antioxidant capacity and expression profile changes during seed deterioration, which will provide worthy genotype resources and targets for efficient improvement of soybean seed vigor.…”
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805
Cross-tissue gene expression interactions from bulk, single cell and spatial transcriptomics with crossWGCNA
Published 2025-07-01“…CrossWGCNA can be applied to bulk, single cell and spatial transcriptomics data. We validate it both in silico and experimentally, and we provide a fully documented R package allowing users to employ it. …”
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806
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807
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808
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809
Transcriptomic analysis of the 12 major human breast cell types reveals mechanisms of cell and tissue function.
Published 2024-11-01“…Unfortunately, the complexity of tissues often hinders our ability to distinguish between neighboring cell types and, in turn, scrutinize their transcriptomes and generate reliable and tractable cell models for studying their inherently different biologies. …”
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810
De Novo Assembly, Characterization and Comparative Transcriptome Analysis of the Mature Gonads in <i>Megalobrama terminalis</i>
Published 2025-07-01“…This paper presents the first comparative transcriptome analysis of the gonads of female and male <i>M. terminalis</i>. …”
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811
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812
Comparative transcriptome analysis revealed gene expression differences in fruits between two Actinidia chinensis cultivars
Published 2024-12-01“…However, the fruit transcriptome differences at the ripening stage between JD and HY are poorly understood. …”
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813
A Complex Network of Obesity-Risk Genes Revealed by Systematic Bioinformatics and Single-Cell Transcriptomic Analyses
Published 2025-01-01“…Moreover, our in-depth analysis of single-cell transcriptomic datasets from the human hypothalamus, pancreatic islets, adipose tissue, and liver has shed light on the distinct expression profiles of these obesity-linked genes across various tissue and cell types. …”
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814
Transcriptomic analysis reveals molecular mechanism by which Chinese olive fruit prolongs lifespan of Caenorhabditis elegans
Published 2025-05-01“…The positive results provide a theoretical basis and valuable reference for developing Chinese olive into functional food to delay aging and treat aging-related diseases.…”
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815
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816
Cryogenic mouse tissue homogenization as an alternative to fresh-frozen biopsy use for genomics, transcriptomics, proteomics and metabolomics
Published 2025-06-01“…Here, we compare individual omics layer readouts from fresh-frozen adjacent tissue pieces and homogenized powder in mouse brain, kidney, and liver. Genomics, transcriptomics, proteomics, and metabolomics analyses showed comparable RNA integrity, DNA methylation, and coverage of transcripts, proteins, and metabolites across both methods. …”
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817
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818
Integrated physiological and transcriptomic data revealed the cold-resistant mechanisms in reproductive organs of the ‘Jinguang’ pear cultivar
Published 2025-02-01“…Further weighted gene co-expression network analysis uncovered the core transcription factors that may be potentially involved in the pear cold resistance, including MYB20, WRKY53, and WRKY30. Our findings provide valuable insights and candidate gene resources for further exploration of the molecular mechanisms underlying cold resistance in pear trees.…”
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819
Anatomy and transcriptomics of the common jingle shell (Bivalvia, Anomiidae) support a sensory function for bivalve tentacles
Published 2024-12-01“…In addition to applying microscopy techniques, we performed transcriptome sequencing of dissected tentacles using phylogenetically-informed annotation to identify candidate receptors. …”
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820
