Single-cell transcriptomic landscape reveals complex cellular heterogeneity and dysregulated signaling pathways in nasopharyngeal carcinoma by Xiaoyan Zhang, Zuojia Guan, Zhan Xu

“…Conclusion This study employed single-cell transcriptomics to comprehensively elucidate the complexity of the NPC tumor microenvironment, providing new insights into the underlying mechanisms of disease pathogenesis and suggesting potential therapeutic targets. …”
Get full text

Transcriptomic exploration yields novel perspectives on the regulatory network underlying trichome initiation in Gossypium arboreum hypocotyl by Yuxing Xie, Luying Yang, Zewei Zhao, Mingquan Ding, Yuefen Cao, Xin Hu, Junkang Rong

“…Our study establishes a comprehensive framework for research on cotton trichomes and identifies critical genetic components governing epidermal hair development, thereby providing new insights for the molecular breeding of stress-resistant cotton varieties.…”
Get full text

Transcriptome and translatome profiling of Col-0 and grp7grp8 under ABA treatment in Arabidopsis by Jing Zhang, Yongxin Xu, Jun Xiao

Get full text

Transcriptomic and network toxicology approaches reveal potential mechanisms of DEHP induced intrahepatic cholestasis during pregnancy by Lun Zhang, Qianqian Huang, Yun Yu, Yue Jiang, Mengzhen Hou, Wenkang Tao, Cheng Zhang, Jianqing Wang

“…In conclusion, this study offers novel insights into the molecular mechanisms of DEHP-induced hepatotoxicity during pregnancy while providing a systematic framework for assessing risks associated with DEHP exposure; thus contributing to the prevention and treatment of ICP.…”
Get full text

Epithelial and immune transcriptomic characteristics and possible regulatory mechanisms in asthma exacerbation: insights from integrated studies by Ye Liu, Yue Li, Ruhao Wu, Yu Wang, Pengfei Li, Tianci Jiang, Ke Wang, Yize Liu, Zhe Cheng

Get full text

Combined transcriptomic and metabolomic analyses reveal the pharmacognostic mechanism of the metabolism of flavonoids in different parts of Polygonum capitatum by Jie Yang, Yu Zhang, Bu‐Fa Guo, Qi‐Lun Peng, Hong‐Yu Chen, Mao Ye, Wei Yi, Wei‐Jun Ding

“…In this study, combined with transcriptomic and metabonomic analysis, we identified significant DEGs related to variations in flavonoid composition among different parts of P. capitatum. …”
Get full text

Integration of transcriptome and Mendelian randomization analyses in exploring the extracellular vesicle-related biomarkers of diabetic kidney disease by Xu Yang, Rensong Yue, Liangbin Zhao, Qiyue Wang

Get full text

Research on biliary atresia and epigenetic factors from the perspective of transcriptomics: identification of key genes and experimental validation by Zhao Na, Hang Yang, Li Chen, Han Xiao, Bo Hai, Chuanxin Li, Xiaohui Xie, Qiang Bai

“…This study aimed to identify key genes associated with BA and epigenetic factors, as well as to explore potential therapeutic drugs, thereby offering new insights into the treatment of this condition.MethodsTranscriptomic datasets (training set GSE122340 and validation set GSE46960) were analyzed. …”
Get full text

Transcriptomic profiling and machine learning reveal novel RNA signatures for enhanced molecular characterization of Hashimoto’s thyroiditis by Zefeng Li, Qiuyu Xu, Fengxu Xiao, Yipeng Cui, Jue jiang, Qi Zhou, Jiangwei Yan, Yu Sun, Miao Li

“…This study demonstrates the value of transcriptome analysis in uncovering HT-associated signatures, providing insights into molecular changes and potentially guiding future research on disease mechanisms and therapeutic strategies.…”
Get full text

Transcriptomic analysis of wild Cannabis sativa: insights into tissue- and stage-specific expression and secondary metabolic regulation by Jinyuan Hu, Zishi Wang, He Xu, Zhenlong Wang, Ning Li, Rui Feng, Jianyu Yin, Fangru Liu, Baishi Wang

“…This study presents a transcriptomic analysis to elucidate tissue-specific expression and regulatory mechanisms across leaves, stems, and roots. …”
Get full text

Deciphering STAT3’s negative regulation of LHPP in ESCC progression through single-cell transcriptomics analysis by Yurao Chen, Zemao Zheng, Luoshai Wang, Ronghuai Chen, Ming He, Xiang Zhao, Liyan Jin, Juan Yao

“…Advances in single-cell transcriptomics have revolutionized cancer research by enabling a precise dissection of cellular and molecular diversity within tumors. …”
Get full text

Unveiling Salt Tolerance Mechanisms in Plants: Integrating the KANMB Machine Learning Model With Metabolomic and Transcriptomic Analysis by Shoukun Chen, Hao Zhang, Shuqiang Gao, Kunhui He, Tingxi Yu, Shang Gao, Jiankang Wang, Huihui Li

“…Using KANMB, 226 metabolic biomarkers significantly linked to salt stress responses, grounded in metabolomic and transcriptomic profiles are identified. These biomarkers correlate with metabolic pathways associated with salt tolerance, providing insight into the underlying biochemical mechanisms. …”
Get full text

Transcriptomic analysis of Andrias davidianus meat and experimental validation for exploring its bioactive components as functional foods by Changge Guan, Zhenglin Tan, Shucheng Li, Yi Wang, Naoyuki Yamamoto, Chong Zhang, Songjun Wang, Junjie Chen, Xin-Hui Xing

“…This study suggested that transcriptomic analysis can be used as a reference to guide polypeptide mining in CGS meat, thereby providing a powerful mining strategy for the bioresources with unknown genomic and proteomic sequences.…”
Get full text

Unraveling dynamic transcriptomic changes in sheep's lactating mammary gland following Escherichia coli lipopolysaccharide exposure by R. Pelayo, B. Gutiérrez-Gil, H. Marina, P.A.S. Fonseca, M. Alonso-García, J.J. Arranz, A. Suárez-Vega

“…In summary, this study reveals how the sheep mammary gland transcriptome responds dynamically to an LPS inoculation, providing a comprehensive understanding of how gene expression patterns evolve over time and shedding light on the molecular mechanisms driving the initial defensive response of the mammary gland against potential inflammatory challenges.…”
Get full text

Transcriptomic Insights and Quantification of Free Amino Acids in <i>Auricularia heimuer</i> Cultivated on Corncob Substrate by Xu Sun, Fangjie Yao, Fanchao Lai, Ming Fang, Lixin Lu, Xiaoxu Ma, Wei Wang, Jingjing Meng, Kaisheng Shao

“…In this study, agricultural waste-derived corncob was used as the treatment group (T1), with sawdust serving as the control (CK), to systematically investigate the variation in free amino acid (FAA) content and transcriptomic expression profiles in fruiting bodies of <i>A. heimuer</i> under the two substrate conditions. …”
Get full text

Joint Genomic and Transcriptomic Analysis Reveals Candidate Genes Associated with Plumage Color Traits in Matahu Ducks by Pengwei Ren, Liu Yang, Muhammad Zahoor Khan, Yadi Jing, Meixia Zhang, Chao Qi, Xin Zhang, Xiang Liu, Zhansheng Liu, Shuer Zhang, Mingxia Zhu

“…This study aims to identify the genetic mechanisms underlying the emergence of white-feathered individuals in the Matahu duck population through combined genome and transcriptome analysis, providing insights for selective breeding and the development of new white-feathered lines. …”
Get full text

Single-cell analysis reveals transcriptomic features and therapeutic targets in primary pulmonary lymphoepithelioma-like carcinoma by Binghua Tan, Ke Xu, Yingcheng Lyu, Yicheng Liang, Ruihao Liang, Kai Lei, Jialu Liang, Jing Huang, Kefeng Wang, Duoguang Wu, Wenjian Wang, Xueting Hu, Kexi Wang, Minghui Wang, Huayue Lin

“…In this study, we perform single-nucleus transcriptome analysis on PPLELC samples to reveal the molecular tumor heterogeneity and characterize the functional states of immune cells within the tumor microenvironment. …”
Get full text

Varied cellular abnormalities in thin vs. normal endometrium in recurrent implantation failure by single-cell transcriptomics by Xiaoying Fu, Xiaoyan Guo, Han Xu, Yini Li, Bihui Jin, Xirong Zhang, Chongyi Shu, Yuhang Fan, Yiqi Yu, Yuqing Tian, Jiao Tian, Jing Shu

“…Single-cell RNA sequencing (scRNA-seq) was utilized to capture comprehensive transcriptomic profiles at the single-cell level, providing insights into gene expression patterns within specific cell types. …”
Get full text

Role of sphingolipid metabolism signaling in a novel mouse model of renal osteodystrophy based on transcriptomic approach by Yujia Wang, Yan Di, Yongqi Li, Jing Lu, Bofan Ji, Yuxia Zhang, Zhiqing Chen, Sijie Chen, Bicheng Liu, Rining Tang, Yuanyuan Ji

“…RNA-seq analysis revealed that the sphingolipid metabolism pathway is likely a key player in ROD pathogenesis, thereby providing new avenues for therapeutic intervention.…”
Get full text

Transcriptome analysis of insecticide resistance mechanisms in field populations of the bean flower thrips, Megalurothrips usitatus (Bagnall) by Hongyi Cao, Jiangjiang Yuan, Yanran Wan, Yingxi Tang, Xiaobin Zheng, Jing Wang, Kanghua Qian, Jiuming Feng, Sirui Chen, Youjun Zhang, Qingjun Wu

Get full text