Cerebrovascular damage caused by the gut microbe/host co-metabolite p-cresol sulfate is prevented by blockade of the EGF receptor by Sita N. Shah, Tobias B-A. Knausenberger, Matthew G. Pontifex, Emily Connell, Gwénaëlle Le Gall, Tom A.J. Hardy, David W. Randall, Kieran McCafferty, Muhammad M. Yaqoob, Egle Solito, Michael Müller, Andrew V. Stachulski, Robert C. Glen, David Vauzour, Lesley Hoyles, Simon McArthur

“…Our results define a pathway linking the co-metabolite pCS with BBB damage and suggest that targeting the EGFR may mitigate against cerebrovascular damage in CKD. This work further provides mechanistic evidence indicating the role of gut microbe-derived metabolites in human disease.…”
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Efficacy, safety, and biomarker analysis of first-line immune checkpoint inhibitors with chemotherapy versus chemotherapy for advanced gastric cancer: a multicenter, retrospective... by Xue Zhang, Xin Dai, Aina Liu, Meili Sun, Lei Cong, Jing Liang, Zimin Liu, Zhen Li, Jinling Zhang, Jing Lv, Fangli Cao, Linli Qu, Haiyan Liu, Lu Yue, Yi Zhai, Fujun Yang, Jiahui Chu, Shuang Wang, Qian Xu, Jianyuan Zhou, Shulun Nie, Miao Huang, Ruitao Xu, Qiushi Wang, Xinyu Song, Di Zhang, Zhaodi Nan, Song Li, Lian Liu

“…Conclusions Adding ICIs to first-line treatment significantly prolongs survival in overall patients and in those with PD-L1 CPS 1–4 or unknown. This study also provides valuable insights into prognostic markers and resistance mechanisms, potentially guiding immunotherapy strategies.…”
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Establishing 3D organoid models from patient-derived conditionally reprogrammed cells to bridge preclinical and clinical insights in pancreatic cancer by Jin Su Kim, Chan Hee Park, Eunyoung Kim, Hee Seung Lee, Jinyoung Lee, Jeehoon Kim, Eun Hee Kam, Sanghee Nam, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Sangwoo Kim, Galam Leem, Seungmin Bang

“…Conclusion Matrigel-based 3D organoid culture models provide a robust platform for pre-clinical drug evaluation, overcoming the limitations of 2D models. …”
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Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10 by Bernard A Fox, Cristina Bergamaschi, George N Pavlakis, Antonio Valentin, Jenifer Bear, Barbara K Felber, Shawn M Jensen, Hrishikesh Pandit, Bethany A Nagy, Dimitris Stellas, Maggie Cam

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Molecular mechanisms and therapeutic targets of acute exacerbations of chronic obstructive pulmonary disease with Pseudomonas aeruginosa infection by Zhiwei Lin, Shuang Liu, Ke Zhang, Tianyu Feng, Yewei Luo, Yu Liu, Baoqing Sun, Luqian Zhou

“…Conclusions This study provides a comprehensive understanding of the molecular mechanisms underlying AECOPD with P. aeruginosa infection, highlighting the pivotal roles of oxidative stress and NET formation in disease progression. …”
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<i>ZmNLR</i><i>-7</i>-Mediated Synergistic Regulation of ROS, Hormonal Signaling, and Defense Gene Networks Drives Maize Immunity to Southern Corn Leaf Blight by Bo Su, Xiaolan Yang, Rui Zhang, Shijie Dong, Ying Liu, Hubiao Jiang, Guichun Wu, Ting Ding

“…This study established a new paradigm for the study of NLR protein-mediated plant immune mechanisms and provided target genes for molecular breeding of disease resistance in maize. …”
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Exploring PDE5A upregulation in bipolar disorder: insights from single-nucleus RNA sequencing of human basal ganglia by Zhixin Bai, Peilong Li, Xu Gao, Gaoyu Zu, Andrew Jiang, Keting Wu, Naguib Mechawar, Gustavo Turecki, Klaus Lehnert, Russell G. Snell, Jin Zhou, Jia Hu, Bingbing Yan, Liang Chen, Wensheng Li, You Chen, Shuai Liu, Ying Zhu, Linya You

“…This study provides a single-nucleus transcriptomic profile of human control and bipolar disorder (BD) basal ganglia. …”
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Targeting glycolysis in esophageal squamous cell carcinoma: single-cell and multi-omics insights for risk stratification and personalized therapy by Yan Wang, Yan Wang, Yunjie Shi, Yunjie Shi, Xiao Hu, Xiao Hu, Chenfang Wang, Chenfang Wang

“…This study employs single-cell transcriptomics and multi-omics approaches to unravel glycolysis-mediated mechanisms in ESCC, with a focus on risk stratification and therapeutic opportunities.MethodsData from TCGA and GEO databases were integrated with single-cell RNA sequencing, bulk RNA sequencing, as well as clinical datasets to investigate glycolysis-associated cell subtypes and their clinical implications in ESCC. …”
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Identification of crucial LncRNAs associated with testicular development and LOC108635509 as a potential regulator in black goat spermatogenesis by Zhiqiang Wang, Yunjia Qi, Nan Xiao, Liu She, Yunchuang Zhang, Junzhi Lu, Qinyang Jiang, Chan Luo

“…Overall, this study provides new insight into the regulatory mechanisms that support spermatogenesis and testicular development in black goats.…”
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Effects of different fiber levels of energy feeds on rumen fermentation and the microbial community structure of grazing sheep by Xiaoyun Zhang, Xulei Liu, Kaili Xie, Yueting Pan, Fuyao Liu, Fujiang Hou

“…However, further understand the mechanism of the effect of fiber level on the rumen of sheep, it is necessary to conduct in-depth analysis using research methods such as transcriptomics, proteomics and metabolomics.…”
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Integrative analysis and experimental validation identify the role of CD44 and Nucleolin in regulating gliogenesis following spinal cord injury by Ming Shi, Yazhou Sun, Lu Ding, Xinyue Li, Qi Xu, Fuxin Wei, Tianshun Gao, David Y. B. Deng

“…Targeting the CD44 and NCL receptors may provide promising therapeutic strategies to modulate inflammation and promote tissue repair after SCI.…”
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Deciphering the heterogeneity of epithelial cells in pancreatic ductal adenocarcinoma: implications for metastasis and immune evasion by Jie Liu, Hui Li, Xiuyun Lin, Jiani Xiong, Guangfeng Wu, Lingyan Ding, Bin Lin

“…Through single-cell transcriptomic and CNV analyses, we identified epithelial subpopulations with varying malignant potentials and distinct interactions with the tumor microenvironment. …”
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Integrative genomic and bioinformatic prioritization of drug repurposing candidates for prostate cancer by Lalu Muhammad Irham, Wirawan Adikusuma, Arief Rahman Afief, Sabiah Khairi, Rockie Chong, Syarifatul Mufidah, Rahmat Dani Satria, Eko Mugiyanto, Darmawi Darmawi, Danang Prasetyaning Amukti, Brilliant Citra Wirsahada, Petrina Theda Philothra, Indra Jaya

“…Conclusions Integrating genomics, bioinformatics, and molecular docking provides an effective strategy for identifying and prioritizing drug repurposing candidates in prostate cancer. …”
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Integrative analysis of m6A-SNPs and single-cell RNA sequencing reveals key drivers of endocrine combined with CDK4/6 inhibitor therapy resistance in ER+ breast cancer by Ruijie Ming, Ruijie Ming, Han Zhang, Huan Wu, Fangbiao Zhan, Fangbiao Zhan, Xiaoping Huang, Xiaoping Huang, Huawen Liu, Huawen Liu

“…The dynamic regulation of FILIP1L and TOM1L1 along the developmental trajectory of tumor cells from sensitivity to resistance provides insights into the molecular complexity of therapy resistance. …”
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Analysis of the Expression Profile in COVID-19 Patients in the Russian Population Considering Disease Severity, Mortality, and Cytokine Storm by Valentin Shimansky, Oleg Popov, Alexander Kel, Igor Goryanin, Tatiana Klochkova, Svetlana Apalko, Natalya Sushentseva, Anna Anisenkova, Sergey Mosenko, Sergey Shcherbak

“…<b>Methods</b>: We conducted a transcriptomic analysis of patients admitted to the Infectious Disease Department of City Hospital No. 40, confirmed with SARS-CoV-2 via PCR. …”
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Characterization of immune microenvironment associated with medulloblastoma metastasis based on explainable machine learning by Fengmao Zhao, Xiangjun Liu, Jingang Gui, Hailang Sun, Nan Zhang, Yun Peng, Ming Ge, Wei Wang

“…Interpretation This study identifies metastasis as the key prognostic factor in MB and reveals the pivotal roles of CD8+ T cells, CTLs, and TGF‐β1 within the TME in promoting metastasis and poor outcomes. These findings provide a foundation for developing future therapeutic strategies targeting the TME to improve MB patient outcomes.…”
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Chaperonin containing TCP1 subunit 5 as a novel pan-cancer prognostic biomarker for tumor stemness and immunotherapy response: insights from multi-omics data, integrated machine le... by Jiajun Li, Nuo Xu, Leyin Hu, Jiayue Xu, Yifan Huang, Deqi Wang, Feng Chen, Yi Wang, Jiani Jiang, Yanggang Hong, Huajun Ye

“…The machine learning-derived CCT5.Sig model provides a robust tool for patient stratification and may inform personalized immunotherapy strategies. …”
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Identification and prognostic analysis of propionate metabolism-related genes in head and neck squamous cell carcinoma by Shitong Zhou, Shitong Zhou, Yu Jiang, Panhui Xiong, Zhongwan Li, Lifeng Jia, Wei Yuan, Xiufu Liao, Xiang An, Jie Hu, Rui Luo, Hailan Mo, Hongyan Fang, Yucheng Yang

“…The proposed four-gene signature provides a novel tool for prognosis prediction and offers new insights for risk stratification and individualized therapy. …”
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New insights into the evolution analysis of trihelix gene family in eggplant (Solanum melongena L.) and expression analysis under abiotic stress by Yanhong Lan, Fangyi Gong, Chun Li, Feng Xia, Yifan Li, Xiaojun Liu, Duchen Liu, Genyun Liang, Chao Fang, Peng Cai

“…Expression analysis on the basis of transcriptomic profiles revealed that SmGT18, SmGT29, SmGT6, and SmGT28 are highly expressed in roots, leaves, flowers, and fruits, respectively. …”
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Feed status and skin injury modulate immunopathology, global gene expression, and survival in channel catfish during virulent Aeromonas hydrophila infection by Yesutor K. Soku, Miles D. Lange, Jason W. Abernathy, Nithin M. Sankappa, Nithin M. Sankappa, Craig A. Shoemaker, Karl Hayden, Linnea K. Andersen, Ida Phillips, Ida Phillips, Toufic Nashar, Temesgen Samuel, Abdelrahman Mohamed

“…Histopathological analyses revealed more severe intestinal and gastric lesions in fed groups, characterized by epithelial necrosis, hemorrhage, and edema. Transcriptomic analysis among the groups identified significant differentially expressed genes associated with inflammation, apoptosis, and metabolic stress, with notable upregulation of interleukin 1-beta (il-1β), and complement C3 (c3). …”
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