Genomic adaptations of Vibrio campbellii to thermal and salinity stress: insights into marine pathogen resilience in a changing ocean by Jiranan Pattano, Thitaporn Dechathai, Netnapa Chaichanit, Komwit Surachat, Korakot Wichitsa-nguan Jetwanna, Kanchana Srinitiwarawong, Pimonsri Mittraparp-arthorn

“…Conclusions This study provides a better understanding into the adaptive strategies of V. campbellii in response to thermal and osmotic stressors. …”
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USP5 Promotes Head and Neck Squamous Cell Carcinoma Progression via mTOR Signaling Pathway by Ni Xiong, Yue Wang, Junhong Jiang

“…The observed effects on cell behavior and oncogenic signaling pathways provide mechanistic insights into how USP5 for HNSCC therapy. …”
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Targeting Redox Signaling Through Exosomal MicroRNA: Insights into Tumor Microenvironment and Precision Oncology by Moon Nyeo Park, Myoungchan Kim, Soojin Lee, Sojin Kang, Chi-Hoon Ahn, Trina Ekawati Tallei, Woojin Kim, Bonglee Kim

“…Incorporating insights from spatial transcriptomics and single-cell analysis, this review provides a mechanistic foundation for the development of exosome-centered, redox-modulating therapeutics. …”
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Genome-wide identification of the H3K27ac signals reveals key thermogenic cis-regulatory elements of brown adipose tissues in Oryctolagus cuniculus by Kun Du, Qian Wu, Yu-Xuan Gan, Xin-Yue Tang, Jia-Xin Zan, Wen-Qiang Sun, Gang Luo, Xi-Wen Chen, Dai-Hua Wang

“…An integrative analysis of H3K27ac, chromatin accessibility, and transcriptomic data identified potential strongly activated enhancers (SAEs) that regulate key thermogenic genes, including UCP1, PPARGC1A, and PDK4. …”
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Lanthanum oxide nanoparticles induce AHR-mediated hepatotoxicity in zebrafish via oxidative stress and metabolic dysregulation by Jin-Xia Wang, Yiyun Liu, Yuan Ding, Bao-Fu Zhang, Yan-Ling Liao, Si-Jia Zuo, Qin-Hong Zhou, Yan Li, De-Sheng Pei

“…Exposure to La2O3 NPs triggered reactive oxygen species (ROS) overload in the liver of larvae, provoking oxidative damage and hepatocyte apoptosis. Transcriptomic analysis revealed altered expression of genes critical for liver function, including cytochrome P450 enzymes, implicating activation of the aryl hydrocarbon receptor (ahr) signaling pathway as a key mechanistic driver. …”
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Qingjin Huatan decoction attenuates lipopolysaccharide-induced acute lung injury in mice by controlling platelet-associated formation of neutrophil extracellular traps by Shunli Xiao, Yilin Wang, Lu Liu, Zhengxiao Sun, Jing Xu, Xiaojie Yin, Xin Wang, Fulong Liao, Yun You, Huamin Zhang

“…This research demonstrated the effects of QJHTD in treating ALI and provided new insights for clarifying the complex regulation of neutrophils, platelets, and NETs in ALI.…”
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Osteoclast-independent osteocyte dendrite defects in mice bearing the osteogenesis imperfecta-causing Sp7 R342C mutation by Jialiang S. Wang, Katelyn Strauss, Caroline Houghton, Numa Islam, Sung-Hee Yoon, Tatsuya Kobayashi, Daniel J. Brooks, Mary L. Bouxsein, Yingshe Zhao, Cristal S. Yee, Tamara N. Alliston, Marc N. Wein

“…Thus, this supports a model in which osteocyte dysfunction can drive OI pathogenesis and provides a valuable resource to test novel therapeutic approaches and to understand the osteocyte-specific role of SP7 in bone remodeling.…”
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A R1-type MYB CmREVEILLE2 regulates light-mediated chlorophyll biosynthesis and green color formation in chrysanthemum flowers by Jingjie Fang, Sitong Liu, Sijia Chen, Huijie Deng, Linxia Zhao, Xinwei Liang, Ziqiang Chen, Xiaoqin Zhang, Songwen Xu, Caiyun Wang, Jing Luo

“…A R1-type MYB transcription factor, CmREVEILLE2 (CmRVE2), was identified through transcriptomic analysis of flowers subjected to different light intensities (3,000 Lux for low light, LL; 6,000 Lux for moderate light, ML; and 12,000 Lux for high light, HL). …”
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Identification of the cassava NADP-ME gene family and its response and regulation in photosynthesis by Haozheng Li, Jin Xiao, Jiahui Chen, Xu Shen, Jia Luo, Fengguang Guo, Shangfei Wang, Liangye Xu, Xin Guo, Shujuan Wang, Haiyan Wang, Wenquan Wang

“…Our study lays the foundation for future functional research on the MeNADP-ME family and provides insights into the mechanisms underlying the high photosynthetic efficiency of cultivated cassava.…”
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A single cysteine residue in vimentin regulates long non-coding RNA XIST to suppress epithelial–mesenchymal transition and stemness in breast cancer by Saima Usman, William Andrew Yeudall, Muy-Teck Teh, Fatemah Ghloum, Hemanth Tummala, Ahmad Waseem

“…Altogether, our studies provide insight into how cysteine 328 in vimentin dictates mechano-transduction signals to remodel actin cytoskeleton and protect against EMT and cancer growth via modulating lncRNA XIST. …”
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Juvenile hormone and BMP signaling modulate fat body cell fate during the transition of previtellogenic development to vitellogenesis by Zhongxia Wu, Wenxiao Zhao, Mengyao Lang, Qiongjie He, Yiying Li, Yuanyuan Hu, Yan Liu, Siqian Zheng, Huanhuan Shi, Shutang Zhou

“…Conclusions The findings provide novel insights into the regulation of fat body cell fate during the transition of previtellogenic growth to vitellogenic Vg synthesis for reproductive requirements.…”
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Single cell sequencing and spatial multiomics of diabetic kidney segmentation insights zonation-specific therapeutic metabolic pathways by Shi Qiu, Zhibo Wang, Sifan Guo, Dandan Xie, Ying Cai, Xian Wang, Chunsheng Lin, Songqi Tang, Yiqiang Xie, Aihua Zhang

“…A deeper understanding of the organizational spatial environment and metabolic pathways of diabetic kidney damage will provide new insights to develop new therapies. By integrating high-resolution spatial multi-omics and single-cell transcriptomics, we mapped region-specific metabolic dysregulation in diabetic kidneys, identifying glutathione metabolism, pentose phosphate, and glycolytic pathways as zonally disrupted in cortical and medullary regions. …”
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Spatiotemporal analysis of lung immune dynamics in lethal Coccidioides posadasii infection by Oscar A. Davalos, Aimy Sebastian, Nicole F. Leon, Margarita V. Rangel, Nadia Miranda, Deepa K. Murugesh, Ashlee M. Phillips, Katrina K. Hoyer, Nicholas R. Hum, Gabriela G. Loots, Dina R. Weilhammer

“…Using single-cell RNA sequencing and spatial transcriptomics, we characterized lung responses during Coccidioides infection. …”
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Auxin signaling related to H+-ATPase synthesis and antioxidant enzyme activities regulates fluoranthene uptake by ryegrass roots by Yuanzhou Xu, Yunyun Li, Xinyue Zhang, Zhuoliang Xiao, Jiaguo Jiao, Huijuan Zhang, Huixin Li, Feng Hu, Li Xu

“…Elucidating the molecular mechanisms underlying Flu uptake in ryegrass may provide a theoretical foundation for developing strategies to regulate Flu accumulation in plants.…”
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Threonine modulates the STAT3-SCD1 pathway to reduce fatty acid metabolism in duck hepatocytes by Zhong Zhuang, Lei Wu, Wenqian Jia, Yongpeng Li, Yijia Lu, Minghong Xu, Hao Bai, Yulin Bi, Zhixiu Wang, Shihao Chen, Guobin Chang, Yong Jiang

“…The overexpression of STAT3 also inhibited TG accumulation under conditions in response to Thr deficiency (P < 0.01). Transcriptomic analyses indicated that the overexpression of STAT3 inhibits the activity of triglyceride metabolism and unsaturated fatty acid biosynthesis (P < 0.01). …”
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A novel Arthrobotrys species: Taxonomic characterization, nematicidal activity, and multi-omics insights into nematode predation by Mengting Gao, Zhaoqi Yan, Zexin Liu, Yunxia Jiang, Tengteng Liu, Xingjun Miao, Meixue Dai, Tanay Bose, Runlei Chang

“…The integrated in vitro nematicidal activity, physiological adaptability, and multi-omics data suggest A. byssisimilis warrants further evaluation as a potential biocontrol agent against PWN, while its unique genomic features provide new molecular targets for investigating fungal-nematode interactions.…”
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Long-read sequencing uncovers key regulatory genes involved in the differentiation of preadipocytes of Chinese red steppe cattle by Wenwen Fang, Shaoying Yang, Xuanyu Li, Asadollahpour Nanaei, Yu Liu, Yang Cao, Cheng Xiao, Xin Li, Haiguo Jin, Yumin Zhao, Yang Cao

“…Here, we utilized ONT full-length transcript sequencing from 9 bovine preadipocytes during 3 periods to find 2502 novel genes and 3253 novel transcriptomes, further improving the quality of reference genome annotation. …”
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Pyrotinib targeted EGFR/GRP78 mediated cell apoptosis in high EGFR gene copy number gastric cancer by Lingbo Bao, Xudong Wang, Xiuyong Liao, Dong Li, ChunXue Li, Nan Dai, Xiaoyan Dai, Jing Yang, Nana Hu, Xueling Tong, Zhenjie He, Yuancheng Zhao, Zheng Liu, Yue Hu, Jinlu Shan, Dong Wang, Mengxia Li, Qian Chen

“…Conclusion This translational study suggests that pyrotinib combined with oxaliplatin may serve as a promising strategy for patients with EGFR-high copy number gastric cancer and highlighted the discovery of this previously unknown EGFR/ GRP78 signaling axis, which provides the molecular basis and the rationale to target EGFR.…”
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Systematic identification and expression profiling of calmodulin-binding transcription activator genes reveal insights into their functional diversity against pathogens in sugarcan... by Talha Javed, Wenzhi Wang, Juan Li, Tingting Sun, Linbo Shen, San-Ji Gao, Shuzhen Zhang

“…Overall, our results provide valuable candidate gene resources for the development of disease-resistant sugarcane cultivars in the face of current climate change scenarios.…”
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Inhibiting the RNA helicase DDX3X in Burkitt lymphoma induces oxydative stress and impedes tumor progression in xenografts by Hugues Beauchemin, Zeinab Dalloul, Eva-Maria Piskor, Eva-Maria Piskor, Virginie Calderon, Andrew Chatr-aryamontri, Thierry Bertomeu, Tarik Möröy, Tarik Möröy, Tarik Möröy

“…We therefore tested the inhibition of the glutathione pathway with buthionine sulfoximine and showed that it reduced the CC50 of RK-33 in BL cells lines.ConclusionOur findings not only support DDX3X as a therapeutic target in BL but also provide evidence for a combinatorial treatment strategy to improve the efficacy of current treatments.…”
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