Multi-omics and experimental validation studies reveal key biomarkers of cellular senescence in diabetic retinopathy by Jinju Li, Hao Yang, Yixuan Lin, Zhaohui Fang

“…Thus, investigating these genes may provide new therapeutic targets for DR treatment by targeting cellular senescence.…”
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Epidermal growth factor receptor signaling governs the host inflammatory response to invasive aspergillosis by Hong Liu, Jianfeng Lin, Quynh T. Phan, Vincent M. Bruno, Scott G. Filler

“…Here, we analyzed transcriptomic data from the lungs of mice with invasive aspergillosis and found evidence that Aspergillus fumigatus infection activates multiple genes that are predicted to function in the EGFR signaling pathway. …”
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TRPV1 alleviates APOE4-dependent microglial antigen presentation and T cell infiltration in Alzheimer's disease by Jia Lu, Kexin Wu, Xudong Sha, Jiayuan Lin, Hongzhuan Chen, Zhihua Yu

“…Conclusions The findings provide new perspectives for the treatment of APOE4-dependent neurodegeneration including AD.…”
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Multiple-omics analysis of aggrephagy-related cellular patterns and development of an aggrephagy-related signature for hepatocellular carcinoma by Jiafen Xie, Xiaoming Wang

“…Conclusion These findings provide a molecular framework for targeting aggrephagy pathways in HCC treatment strategies.…”
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Research progress of genome-wide association study by Duan Zhongqu, Zhu Jun

“…First, the increased advances in “omics” technology (transcriptomics, proteomics and metabolomics) will provide an opportunity to study the association of phenotypic variations with mRNA, protein or metabolite, which position the omics loci linked to the interested traits. …”
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Chromophobe renal cell carcinoma – a rare kidney cancer with limited therapy options: a narrative review by Milad Pashai Fakhri, Jürgen Serth, Jan Hinrich Bräsen, Philipp Ivanyi, Markus Antonius Kuczyk, Hossein Tezval

“…This review aims to present recent therapeutic advances and provide innovative approaches for future clinical treatment decisions.…”
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Molecular and immune landscape of melanoma: a risk stratification model for precision oncology by Miao Sun, Junliang Wu

“…Conclusion This study provides a robust immune-related prognostic model for melanoma. …”
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Deciphering the role of miR-71 in Echinococcus multilocularis early development in vitro. by Matías Gastón Pérez, Markus Spiliotis, Natalia Rego, Natalia Macchiaroli, Laura Kamenetzky, Nancy Holroyd, Marcela Alejandra Cucher, Klaus Brehm, Mara Cecilia Rosenzvit

“…These findings indicate an important function of miR-71 in Echinococcus development and provide, for the first time, methodology to functionally study miRNAs in a tapeworm.…”
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A Super-Assembled Synergistically Nanoplatform AP@ZIF-8Pt for Hepatocarcinoma Therapy by Luo Z, Wang D, Lin L, Zhou R, Su Y, Zhang Z, Hu J, Dai Y, Wu J, Huang X, Zhou Y, Gong L

“…Herein, a three-step intelligent biodegradable drug delivery nanoplatform was designed.Methods: First, a hollow ZIF-8 was synthesized, embedded with platinum nanoparticle to form ZIF-8Pt, and then loaded with AP, and lastly formed AP@ZIF-8Pt, which possess pH-responsive drug release and cancer-targeted ability.Results: As expected, both in vitro and in vivo experiment demonstrated that AP@ZIF-8Pt performed treatment effects in hepatocarcinoma through relieving tumor-hypoxic microenvironment, inhibiting cell proliferation and promoting cell apoptosis. Further transcriptomic analysis showed that the specific mechanism of the AP@ZIF-8Pt was thermogenesis, signaling pathways regulating pluripotency of stem cells, ribosome, prion disease and PI3K-Akt signaling pathway.Discussion: This work highlights a new strategy for liver cancer treatment and provides a reference for treating malignant tumors. …”
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Dynamical modeling of proliferative-invasive plasticity and IFNγ signaling in melanoma reveals mechanisms of PD-L1 expression heterogeneity by Seemadri Subhadarshini, Sarthak Sahoo, Shibjyoti Debnath, Jason A Somarelli, Mohit Kumar Jolly

“…Our model predictions about changes in proliferative to invasive transition and PD-L1 levels as melanoma cells evade targeted therapy and immune checkpoint inhibitors were validated in multiple RNA-seq data sets from in vitro and in vivo experiments.Conclusion Our calibrated dynamical model offers a platform to test combinatorial therapies and provide rational avenues for the treatment of metastatic melanoma. …”
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Dysregulated lipid metabolism in a retinal pigment epithelial cell model and serum of patients with age-related macular degeneration by Ana Álvarez-Barrios, Lydia Álvarez, Pilar Sáenz de Santa María, Montserrat García, Jorge R. Álvarez-Buylla, Rosario Pereiro, Héctor González-Iglesias

“…The consistent lipidomic alterations observed in RPE cultures and AMD patient serum reinforce their potential as biomarkers for disease progression and therapeutic targets. These findings provide a robust framework for understanding AMD-associated lipid metabolism changes and their systemic impact.…”
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<i>SlMYC2</i> Mediates the JA Pathway by Responding to Chlorocholine Chloride in the Regulation of Resistance to TYLCD by Yanan Ma, Liangfang Wang, Zuozeng Cao, Hui Wang, Fu Wang, Wenying Zhu

“…These results indicated that exogenous spraying CCC affected the expression of genes such as <i>MYC2</i> and <i>JAZ2</i>, and then regulated JA pathway, increased the endogenous JA content in plants, and enhanced the disease resistance of tomato plants to TYLCD. This study provides a scientific reference for effectively preventing and controlling TYLCD in tomato production and reducing the influence of TYLCD on tomato yield and quality.…”
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Identification of signature genes and subtypes for heart failure diagnosis based on machine learning by Yanlong Zhang, Yanming Fan, Fei Cheng, Dan Chen, Hualong Zhang

“…Consequently, identifying specific genes for HF at the transcriptomic level may enhance early detection and allow for more targeted therapies for these individuals.MethodsHF datasets were acquired from the Gene Expression Omnibus (GEO) database (GSE57338), and through the application of bioinformatics and machine-learning algorithms. …”
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Genome-Wide Identification, Characterization, and Expression Analysis of Orphan Genes Within Coriander by Meidi Zhang, Mo Zhu, Hong Lang, Weiming Wang, Xiaonan Li, Mingliang Jiang

“…Identifying and characterizing <i>OGs</i> have become more feasible with the increasing availability of plant transcriptomes and genome sequences. <i>OGs</i> play important roles in response to both biotic and abiotic stresses, contributing to biological functions and lineage-specific traits. …”
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Genome-Wide Identification of the <i>Eceriferum</i> Gene Family and Analysis of Gene Expression Patterns Under Different Treatments in Pepper (<i>Capsicum annuum</i> L.) by Fan Yang, Kai Wei, Ying Zhang, Xiaoke Chang, Wenrui Yang, Qiuju Yao, Huaijuan Xiao

“…This study underscores evolutionary conservation and species-specific expansion of the pepper <i>CER</i> family, linking their expression to wax biosynthesis and stress adaptation. These insights provide a foundation for enhancing stress resilience in crops. …”
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Expression and prognostic value of SEC13 across multiple tumour types and its association with the regulation by Pulsatilla chinensis: a multi-omics and Mendelian Randomization Stu... by Huaqing Leng, Xin Luan, Ming Li

“…However, Mendelian randomization did not provide clear evidence for a direct causal link between SEC13 and any of the six cancers studied (P-IVW > 0.05). …”
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Genetic Landscape of Obesity in Children: Research Advances and Prospects by Rita Khusainova, Ildar Minniakhmetov, Olga Vasyukova, Bulat Yalaev, Ramil Salakhov, Darya Kopytina, Raisat Guseinova, Ekaterina Dobreva, Galina Melnichenko, Ivan Dedov, Natalia Mokrysheva

“…However, further advancement requires integrative multiomics analyses that encompass genomic, epigenomic, transcriptomic, proteomic, metabolomic, and microbiome data. …”
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Low-Density Lipoprotein Cholesterol as a Protective Factor in COPD and Implications for Statin Therapy: A Multi-Omics Genetic Epidemiology Study by Du T, Cao J, Dai Z, Xie X, Zhang G, Li Y, Chen B, Xu T, Feng J

“…This finding provides a new perspective on the metabolic disruptions in COPD and offers significant guidance for future therapeutic strategies.Conclusion: This research confirms the inverse correlation between LDL-C and COPD and reveals that statin drugs might influence the progression of COPD by affecting LDL-C levels. …”
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Calcium-Induced Regulation of <i>Sanghuangporus baumii</i> Growth and the Biosynthesis of Its Triterpenoids by Zengcai Liu, Ying Yu, Shiyuan Wang, Li Zou

“…Our study demonstrates the feasibility of producing triterpenoids in <i>Saccharomyces cerevisiae</i> and provides a foundation for future optimization toward achieving industrially relevant yields.…”
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Identification of key genes and immune infiltration mechanisms in limb ischemia-reperfusion injury: a bioinformatics and experimental study by Qiyun Shi, Taotao Tian, Yanfeng Li

“…Our cross-tissue bioinformatic approach, reinforced by pharmacological and histological evidence, provides a novel framework for IRI analysis when direct patient data are unavailable. …”
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