The Effects of <i>P5CR</i> Gene Function of Endophytic Fungus <i>Alternaria oxytropis</i> OW7.8 on Swainsonine Biosynthesis by Fan Yang, Yinzhe Li, Ping Lu, Yu Wang, Feng Gao, Bo Yuan, Ling Du, Yuling Li, Kai Jiang

“…Metabolomic profiling further demonstrated altered levels of six metabolites linked to SW synthesis. These findings provide foundational insights into the molecular mechanisms and metabolic pathways underlying SW biosynthesis in fungi. …”
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Lon protease 1-mediated metabolic reprogramming promotes the progression of prostate cancer by Mengfei Yao, Xingming Zhang, Tianqi Wu, Tao Feng, Xiaojie Bian, Mierxiati Abudurexiti, Wenfeng Wang, Guohai Shi, Gong-hong Wei, Qin Zhang, Xiangyun Li, Gang Feng, Leilei Du, Jianhua Wang

“…Collectively, our results highlight that metabolic reprogramming induced by LONP1 in PCa is closely coupled with disease progression, suggesting that targeting the LONP1-mediated cascade in the mitochondrial may provide therapeutic potential for PCa disease.…”
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Polystyrene microplastics induce nephrotoxicity through DDIT4-mediated autophagy and apoptosis by Yujiao Wang, Anxiu Zhang, Ting Liang, Long Chen, Shuqi Feng, Zhuoyuan Zhao, Ziye Jing, Jieping Lv, Jun Xie, Bingrui Zhou

“…Furthermore, enhanced autophagy and apoptosis were observed in nephron progenitor cells (NPCs), as evidenced by a 3.5-fold increase in LC3-II expression and a 1.5-fold increase in cleaved caspase-3 levels. Transcriptomic analysis identified DNA damage-inducible transcript 4 (DDIT4) as a key mediator, linking PS-MP exposure to the inhibition of mTOR signaling. …”
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Kidney microbiota dysbiosis contributes to the development of hypertension by Xin-Yu Liu, Jing Li, Yamei Zhang, Luyun Fan, Yanli Xia, Yongyang Wu, Junru Chen, Xinyu Zhao, Qiannan Gao, Bing Xu, Chunlai Nie, Zhengyu Li, Aiping Tong, Wenjie Wang, Jun Cai

“…Taken together, the unique patterns of viable and dormant bacteria in the kidney provide insight into the pathogenesis of non-communicable chronic diseases and cardiometabolic diseases (e.g., hypertension), and may lead to potential novel microbiota-targeted dietary therapies.…”
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Transforming heart transplantation care with multi-omics insights by Zhengbang Zou, Jianing Han, Zhiyuan Zhu, Shanshan Zheng, Xinhe Xu, Sheng Liu

“…These approaches provide personalized risk stratification and mechanical insights into cardiac allograft rejection, primary graft dysfunction, and cardiac allograft vasculopathy. …”
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Brassica napus BnaWIP2 transcription factor promotes seed germination under salinity stress by repressing ABA biosynthesis and signaling by Shuangcheng He, Saiqi Yang, Yuanchang Min, Ankang Ge, Junjin Liu, Zijin Liu, Yuan Guo, Mingxun Chen

“…Collectively, these results enhance our understanding of the novel function of BnaWIP2 and provide valuable genetic resources for breeding salinity-tolerant rapeseed varieties.…”
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Tangeretin Suppresses Fumonisin Production by Modulating an NmrA- and HSCARG-like Protein in <i>Fusarium verticillioides</i> by Liuqing Wang, Wenlei Zhai, Dongmei Jiang, Nan Jiang, Jiaqi Yan, Haoyun Jiang, Meng Wang

“…Consequently, tangeretin significantly curtailed fungal growth and FB₁ production and provided protection against pathogenic infection on corn. …”
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Rap1 and mTOR signaling pathways drive opposing immunotoxic effects of structurally similar aryl-OPFRs, TPHP and TOCP by Bilin Zhao, Shuang Zheng, Gaoxiang Yang, Zhijun He, Jiewei Deng, Lijuan Luo, Xinyan Li, Tiangang Luan

“…This study sought to address the knowledge gap by integrating transcriptomic and metabolomic analyses to elucidate the intricate mechanisms. …”
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Identification of palmitoylated biomarkers in non-alcoholic fatty liver disease via integrated bioinformatics analysis and machine learning by Zheng Liu, Xiaohong Wang, Mingzhu Xiu, Rui Luo, Xiaomin Shi, Yizhou Wang, Yusong Ye, Ruiyu Wang, Sha Liu, Muhan Lv, Xiaowei Tang

“…This study unveils novel palmitoylation-related biomarkers and provides insights into NAFLD pathogenesis, offering diagnostic and therapeutic avenues.…”
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Circulating immune cells exhibit distinct traits linked to metastatic burden in breast cancer by S. Mangiola, R. Brown, C. Zhan, J. Berthelet, S. Guleria, C. Liyanage, S. Ostrouska, J. Wilcox, M. Merdas, P. Fuge-Larsen, C. Bell, J. Schröder, L. A. Mielke, J. M. Mariadason, S. Chang-Hao Tsao, Y. Chen, V. K. Yadav, S. Vodala, R. L. Anderson, D. Merino, A. Behren, B. Yeo, A. T. Papenfuss, B. Pal

“…Methods In this study, we characterised the systemic immune landscape associated with varying levels of metastatic burden by analysing the single-cell transcriptomes of PBMCs from breast cancer patients and healthy controls. …”
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Auts2 enhances neurogenesis and promotes expansion of the cerebral cortex by Cédric Boucherie, Maisa Alkailani, Yves Jossin, Nuria Ruiz-Reig, Asma Mahdi, Arwa Aldaalis, Mohamed Aittaleb, Fadel Tissir

“…Conclusion: The study provides evidence that AUTS2 is expressed in germinal zones and plays a key role in fate decision of neural progenitor cells with impact on corticogenesis. …”
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Revealing the role of U2AF1 in splicing regulation and chimeric RNA dynamics by Sangeen Khan, Yue Tang, Yangyang Guo, Jing Feng, Hui Wu, Zhenguo Song, Chengjuan Zhang, Fujun Qin

“…Employing knockdown and overexpression strategies in leukemia and esophageal cancer cell lines, we conducted paired-end RNA sequencing following U2AF1 knockdown to assess transcriptomic alterations and their influence on alternative splicing patterns. …”
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Improving the therapeutic profile of MSCs: Cytokine priming reduces donor-dependent heterogeneity and enhances their immunomodulatory capacity by Jaris Valencia, Jaris Valencia, Jaris Valencia, Rosa M. Yáñez, Rosa M. Yáñez, Rosa M. Yáñez, Sandra Muntión, Sandra Muntión, Sandra Muntión, María Fernández-García, María Fernández-García, María Fernández-García, Jorge Diego Martín-Rufino, Jorge Diego Martín-Rufino, Agustín G. Zapata, Agustín G. Zapata, Agustín G. Zapata, Juan A. Bueren, Juan A. Bueren, Juan A. Bueren, Ángeles Vicente, Ángeles Vicente, Ángeles Vicente, Fermín Sánchez-Guijo, Fermín Sánchez-Guijo, Fermín Sánchez-Guijo

“…Several priming approaches have provided non-conclusive results, and the duration of priming effects on MSC properties or their response to a second inflammatory stimulus have not been fully addressed.MethodsWe have investigated the impact of triple cytokine priming in MSCs on their characterization and viability, their transcriptomic profile, the functionality of innate and acquired immune cells, as well as the maintenance of the response to priming over time, their subsequent responsiveness to a second inflammatory stimulus.ResultsPriming MSCs with proinflammatory cytokines (CK-MSCs) do not modify the differentiation capacity of MSCs, nor their immunophenotype and viability. …”
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Pre-immunotherapy alters stereotactic ablative radiotherapy-induced systemic T cell responses in early-stage NSCLC by Chao Liu, Yanjuan Chen, Xiaohui Li, Zhijie Bai, Meilin Jiang, Dongsheng Sheng, Wenxue Zou, Rui Huang, Qingyu Huang, Fuhao Wang, Jingyang Zhu, Huiru Sun, Bing Liu, Zongcheng Li, Bing Sun

“…Abstract Background Stereotactic ablative radiotherapy (SABR) is thought to activate T cell responses in patients with cancer, leading to its combination with immunotherapy and chemotherapy for treatment of non-small-cell lung cancer (NSCLC). Here, we aimed to provide a high-resolution transcriptomic profiling of the systemic T cell response following SABR, with or without preceding immunotherapy/chemotherapy. …”
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The developmental toxicity of bisphenol F exposure on the zebrafish larvae by Biyu Wu, Zirui Cheng, Xiang Li, Minxing Liang, Xue Wang, Duan Pi, Jiayi Liu, Huiling Li, Jun Zhao, Junjie Wang, Fang Liang, Xuegeng Wang

“…To explore the underlying mechanisms, transcriptomic analysis was performed to identify differentially expressed genes (DEGs). …”
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The Spodoptera frugiperda L-aminoacylase degrades fatty acid-amino acid conjugates and promotes larvae growth on Zea mays by Bin Li, Mei Luo, Xiaofeng Liu, Wangpeng Shi, Jinfeng Qi, Shaoqun Zhou, Guirong Wang

“…Finally, comparative transcriptomic analyses of maize leaves showed more pronounced inducible defense responses when attacked by the SfruACY knocked-out larvae than the wildtype intruders. …”
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Reprogramming Hairy Root Cultures: A Synthetic Biology Framework for Precision Metabolite Biosynthesis by Chang Liu, Naveed Ahmad, Ye Tao, Hamad Hussain, Yue Chang, Abdul Wakeel Umar, Xiuming Liu

“…Hairy root cultures induced by <i>Agrobacterium rhizogenes</i> (<i>Rhizobium rhizogenes</i>) provide a sustainable approach to meet the growing demand for economically valuable plant-derived compounds in the face of depleting natural resources. …”
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Polymorphisms in immunosuppression-related genes are associated with AML by Mingying Li, Mingying Li, Jingjing Ye, Jingjing Ye, Mengyuan Chang, Mengyuan Chang, Lei Feng, Lei Feng, Tingting Liu, Tingting Liu, Di Zhang, Di Zhang, Yuyan Wu, Yuyan Wu, Yuechan Ma, Yuechan Ma, Guangqiang Meng, Guangqiang Meng, Chunyan Ji, Chunyan Ji, Tao Sun, Tao Sun

“…Multi-omics analyses, such as single-cell transcriptomics, have revealed many potential new targets to improve AML prognosis from an immunological perspective.MethodsDNA from 307 AML patients and 316 healthy individuals were extracted. …”
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Multi-omics profiling of Nanhaia speciosa and Nanhaia fordii: insights into lectin dynamics, nodulation, and triterpenoid saponin biosynthesis by Zhiying Li, Jiabin Wang, Junfang Zhang, Yunliu Fu, Yonglin Jing, Bilan Huang, Huazhou Wu, Chunyang Meng, Li Xu

“…Results To analyze the differences and underlying basis between N. speciosa and N. fordii, we conducted a comprehensive comparison of their genomic, transcriptomic, and metabolomic data. Using PacBio HiFi and Hi-C data, we achieved high-quality haploid genomes for both N. speciosa and N. fordii. …”
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KIF2C Deletion Causes Meiotic Abnormalities and Nonobstructive Azoospermia in Mice by Hiroaki Kitakaze, Haruhiko Miyata, Yuki Oyama, Chen Pan, Yuma Kujime, Go Tsujimura, Takahiro Imanaka, Sohei Kuribayashi, Norichika Ueda, Kentaro Takezawa, Shinichiro Fukuhara, Norio Nonomura, Masahito Ikawa

“…However, its role in spermatogenesis remains unclear. Recent transcriptomic analyses suggest a potential link between KIF2C and male infertility. …”
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