Investigating the Prognostic Role of Telomerase-Related Cellular Senescence Gene Signatures in Breast Cancer Using Machine Learning by Qiong Li, Hongde Liu

“…Additionally, pseudo-time trajectory analysis and intercellular communication mapping provided insights into the dynamic evolution of the tumor microenvironment. …”
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Establishment and Evaluation of HepG2 Cell Insulin Resistance Model by Meng Z, Han Y, Ruan L, Xu C, Zhang M, Liu H

“…G6pase, PC, and PCK1 were elevated after glucosamine and palmitic acid stimulation, and only PCK1 was elevated after high glucose with high insulin stimulation. The transcriptomes of cells induced by the three methods differed widely.Conclusion: Treatment with 0.2 mM palmitic acid for 24 h is a simple and stable method to induce insulin resistance in HepG2 cells.Keywords: HepG2 cells, insulin resistance model, palmitic acid…”
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Multi-omics exploration of CAV1+ tumor epithelial subcelltype in oral squamous cell carcinoma and its impact on the immune microenvironment by Yan’an Shi, Yiting Shao, Bin Xia, Wenying Yang, Yan Wang, Lifu Yu, Yonghui Zhang

“…Utilizing spatial transcriptomics, we investigated the spatial distribution of these subcelltypes. …”
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A comparison of the expression patterns and diagnostic capability of the ncRNAs NEAT1 and miR-34a in non-obstructive azoospermia and severe oligospermia by Aya Salman, Abdullah F. Radwan, Olfat G. Shaker, Adel A., Ghadir A. Sayed

“…Quantitative real-time PCR and transcriptomics-based bioinformatics tools were employed to explore the co-expression networks and molecular interactions of NEAT1, miR-34a, SIRT1, and their associated hormonal and genetic pathways. …”
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LuCSD3 enhances salt stress tolerance in flax: genome-wide profiling and functional validation of the SOD gene family by Yuan Zhang, Ruinan Wang, Hengping Wang, Huiyan Wang

“…Functional characterization of LuCSD3 in transgenic Arabidopsis confirmed its role in enhancing salt tolerance through ROS homeostasis modulation. This study provides foundational insights into LuSOD-mediated stress resilience, serving as a valuable resource for molecular breeding and functional genomics in flax.…”
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Meta_B cells: a computationally identified candidate immunosuppressive driver of gastric cancer metastasis revealed by single-cell analysis and machine learning by Tianchi Lei, Yiwen Jiang, Kexin Yang, Chuqi Meng, Yue An

“…Conclusions Meta_B cells may represent a novel B cell subset computationally associated with immunosuppression and GC metastasis potentially mediated by the BTLA axis. Our integrative transcriptomic framework provides hypothesis-generating insights into metastatic TME remodeling and a clinically actionable tool for prognostic prediction. …”
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Genome-Wide Characterization of RNA Editing Sites in Primary Gastric Adenocarcinoma through RNA-seq Data Analysis by Javad Behroozi, Shirin Shahbazi, Mohammad Reza Bakhtiarizadeh, Habibollah Mahmoodzadeh

“…RNA editing could contribute to cancer either by exclusive editing of tumor suppressor/promoting genes or by introducing transcriptomic diversity to promote cancer progression. …”
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Asxl1 loss in mice leads to microcephaly by regulating neural stem cell survival by Hyeju Kim, A.-Reum Kim, Sukyoung Byun, Soo-Jong Um

“…These findings establish Asxl1 as a critical regulator of NSC survival and neurogenesis via Ezh2-mediated chromatin modification and provide insights into the mechanisms underlying microcephaly in developmental disorders.…”
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Whole-genome identification of HSF family genes in Cerasus humilis and expression analysis under high-temperature stress by Xiaopeng Mu, Jiating Zhang, Chenyi Wang, Liming Chen, Jianying Zhang, Pengfei Wang, Jiancheng Zhang, Bin Zhang, Junjie Du

“…By analyzing the tissue specific transcriptomes, it was found that most ChHSF genes had higher expression levels in leaves than in other tissues of C.humilis. …”
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Single-cell RNAseq and longitudinal proteomic analysis of a novel semi-spontaneous urothelial cancer model reveals tumor cell heterogeneity and pretumoral urine protein alterations... by Iliana K Kerzeli, Martin Lord, Milena Doroszko, Ramy Elgendy, Aikaterini Chourlia, Ivan Stepanek, Elinor Larsson, Luuk van Hooren, Sven Nelander, Per-Uno Malmstrom, Anca Dragomir, Ulrika Segersten, Sara M Mangsbo

“…The profiling of the model was performed by histology grading, single cell transcriptomic and proteomic analysis, while the derivation of a tumorigenic cell line was validated and used to assess in vivo anti-tumor effects in response to immunotherapy. …”
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Genome-wide Analysis of CONSTANS-like (CqCOL) Transcription Factors in Quinoa (Chenopodium quinoa): Structural Diversity, Phylogeny, and Stress-Responsive Expression by Huyen Thi Thanh Tran, Gioi Huy Dong, Ha Duc Chu, Phi Bang Cao

“…This study enhances our understanding of the CqCOL transcription factor family. It provides a foundation for future functional studies and breeding strategies aimed at improving stress tolerance and optimizing flowering time in quinoa. …”
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Multi-modal comparison of molecular programs driving nurse cell death and clearance in Drosophila melanogaster oogenesis. by Shruthi Bandyadka, Diane P V Lebo, Albert A Mondragon, Sandy B Serizier, Julian Kwan, Jeanne S Peterson, Alexandra Y Chasse, Victoria K Jenkins, Anoush Calikyan, Anthony J Ortega, Joshua D Campbell, Andrew Emili, Kimberly McCall

“…Beyond molecular differences in cell death, our investigation may also provide insights into how key systemic trade-offs are made between survival and reproduction when faced with physiological stress.…”
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Tumor-associated myeloid cells support murine T-ALL in the central nervous system via integrin signaling by Ryan S. Humphrey, Seohee Nam, Dennis C. Wylie, Lauren I. R. Ehrlich

“…Given the clinical importance of T-ALL relapse in the CNS, we tested whether myeloid cells provide a supportive niche for chemotherapy resistance. …”
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Molecular mechanisms of ageing in cancer development and therapeutic response: Translational implications for precision oncology by Laiba Husain

“…Conclusion The molecular mechanisms underlying ageing‐cancer relationships provide critical insights for advancing precision oncology approaches. …”
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Genome-wide identification and characterization of the bZIP family in the Mangrove Plant Kandelia obovata and its role in response to stress by Yuchong Yi, Yuting Qiu, Hongyao Hu, Dandan Qin, Hechen Huang, Taiping Chen, Wenqi Zha, Yingjia Shen

“…The expression patterns of KobZIP genes across different tissues and under various abiotic stress conditions were analyzed using transcriptomic data and experimental validation. Conclusion This study provides a comprehensive characterization and functional analysis of the bZIP gene family in K. obovata, offering new insights into their roles in plant development and environmental adaptation. …”
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Exploring the additive antibacterial potential of Cinnamomum cassia volatile oil and imipenem against Acinetobacter baumannii: a multi-omics investigation by Youyuan Lu, Youyuan Lu, Wanlin Xu, Jiahui Xue, Mingxia Xie, Haotian Liu, Ruilin Wang, Gang Li, Hanqing Wang, Hanqing Wang

“…Volatile oils, which function as natural antibacterial agents, may provide an effective means of inhibiting A. baumannii. …”
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Ovarian remodeling and aging-related chronic inflammation and fibrosis in the mammalian ovary by Yuanyuan Zhu, Heming Sun, Ting Gao, Shengdi Hou, Yuebo Li, Ying Xu, Qingxia Zhang, Dingqing Feng

“…Therefore, this report provides critical insights into aging-related cellular and molecular changes in the ovary.…”
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PRMT1-mediated methylation of UBE2m promoting calcium oxalate crystal-induced kidney injury by inhibiting fatty acid metabolism by Tianhui Yuan, Zehua Ye, Shuqin Mei, Miao Zhang, Ming Wu, Fangyou Lin, Weimin Yu, Wei Li, Xiangjun Zhou, Fan Cheng

“…Increased PPARγ degradation inhibited downstream fatty acid metabolism, leading to renal lipid accumulation, disrupted energy metabolism, and impaired kidney function. These findings provide a novel potential therapeutic target for CaOx kidney stones.…”
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Third-generation human mitochondria-focused cDNA microarray and its bioinformatic tools for analysis of gene expression by Xueyan Bai, Jun Wu, Qiuyang Zhang, Salvatore Alesci, Irini Manoli, Marc R. Blackman, George P. Chrousos, Allan L. Goldstein, Owen M. Rennert, Yan A. Su

“…Thus, hMitChip3 and its bioinformatics software provide an integrated tool for profiling mitochondria-focused gene expression.…”
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Deapioplatycodin D inhibits glioblastoma cell proliferation by inducing BNIP3L-mediated incomplete mitophagy by Yu Sun, Guangze Zhu, Renshuang Zhao, Yaru Li, Hongyang Li, Yunyun Liu, Ningyi Jin, Xiao Li, Yiquan Li, Tiemei Liu

“…In this study, in vitro and in vivo experiments established that DPD inhibited GBM cell growth by inducing BNIP3L-mediated incomplete mitophagy, which provides an experimental basis for studying new treatments of GBM. …”
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