Pyrrocidines A and B demonstrate synergistic inhibition of Fusarium verticillioides growth by Lily W. Lofton, Lily W. Lofton, Quentin D. Read, Hailey L. Hamilton, Anthony E. Glenn, Jaci A. Hawkins, Trevor R. Mitchell, Scott E. Gold

“…This protective endophyte produces secondary metabolites of interest, pyrrocidines A and B, which inhibit the growth of F. verticillioides and specifically block fumonisin biosynthesis. Previous transcriptomic analyses found FvZBD1 (FVEG_00314), a gene adjacent to the fumonisin biosynthetic gene cluster, to be induced over 4,000-fold in response to pyrrocidine challenge. …”
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Multi-omics approaches to deciphering complex pathological mechanisms of migraine: a systematic review by Jiaojiao Liu, Qiaosheng Ren, Boxuan Du, Xian Liu, Yuqiu An, Peichi Zhang, Lexi Li, Zhenhong Liu, Zhenhong Liu, Kegang Cao, Kegang Cao

“…The rapid progress in multi-omics technologies has provided new tools to uncover the intricate pathological mechanisms underlying migraine. …”
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Multi-omics mechanical analysis of gut microbiota, carboxylic acids, and cardiac gene expression interaction triggering diabetic cardiomyopathy by Meixin Shi, Bingbing Zhao, Wenjie Cai, Hui Yuan, Xiao Liang, Zhitao Li, Xinyu Liu, Ye Jin, Xi Liu, Can Wei

“…In this study, metagenomics, metabolomics, and transcriptomics were chosen to sequence the changes in gut microbiota, serum metabolite levels, and differentially expressed genes (DEGs) in leptin receptor-deficient db/db mice and analyze the correlation between serum metabolites and gut microbiota or DEGs. …”
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Potential physiological mechanisms behind variation in rainbow trout (Oncorhynchus mykiss) to biosynthesize EPA and DHA when reared on plant oil replacement feeds by Ken Overturf, Jason Abernathy, Dietmar Kültz, Jacob Bledsoe, Shawn Narum, Thomas Welker

“…Lipids provide essential fatty acids necessary for proper fish growth and maintenance of crucial functions. …”
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Diabetes exacerbates SARS-CoV-2 replication through ineffective pulmonary interferon responses, delayed cell-mediated immunity, and disruption of leptin signaling by Côme J. Thieulent, Côme J. Thieulent, Udeni B. R. Balasuriya, Udeni B. R. Balasuriya, Anna Tseng, Nicholas A. Crossland, Nicholas A. Crossland, Nicholas A. Crossland, Jacqueline M. Stephens, Wellesley Dittmar, Wellesley Dittmar, Jaroslaw Staszkiewicz, Juergen A. Richt, Mariano Carossino, Mariano Carossino

“…These data shed light on the alteration of the innate immune pathway in the lung using in-depth transcriptomic analysis and on adaptive immune responses to SARS-CoV-2 under T2DM conditions. …”
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Identification and expression analysis of NUDIX gene family in Rosa chinensis ‘Old Blush’ by FANG Huiyi, LIANG Yuwei, LI Xinyuan, Sun Fuhui, BI Bo, ZHANG Liangsheng

“…The chromosome localization results indicated that NUDIX genes of Rosa chinensis ‘Old Blush’ underwent multiple tandem duplication event, most of which went through purifying selection. Transcriptomic data analysis revealed that RcNUDIX1a/1b/1d/1e were specifically expressed in petals. …”
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Simple Sequence Repeats (SSRs) and Telomeric Analysis in Somatic Organs of Reproductive and Non-Reproductive Castes of Termite <i>Reticulitermes chinensis</i> by Haroon, Zahid Khan, Wasim Javaid, Lian-Xi Xing

“…Moreover, the variation and organization of SSRs in <i>R. chinensis</i> provide a rich genetic resource for genome mapping, evolutionary research, and population genetics. …”
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Molecular analysis of precursor lesions in familial pancreatic cancer. by Tatjana Crnogorac-Jurcevic, Claude Chelala, Sayka Barry, Tomohiko Harada, Vipul Bhakta, Sam Lattimore, Stipo Jurcevic, Mary Bronner, Nicholas R Lemoine, Teresa A Brentnall

“…We demonstrate the need for accumulation of transcriptomic changes during the progression of PanIN to PDAC, both in the epithelium and in the surrounding stroma. …”
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Abscisic acid pathway involved in the regulation of watermelon fruit ripening and quality trait evolution. by Yanping Wang, Shaogui Guo, Shouwei Tian, Jie Zhang, Yi Ren, Honghe Sun, Guoyi Gong, Haiying Zhang, Yong Xu

“…Our results not only demonstrate for the first time that ABA is involved in the regulation of watermelon fruit ripening, but also provide insights into the evolutionary mechanisms of this phenomenon.…”
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Disease association study of Autoimmune and autoinflammatory diseases by integrating multi-modal data and hierarchical ontologies by Axian Liu, Yutong Su, Jinwei Zhu, Yuan-Yuan Li

“…By leveraging genetic, transcriptomic (bulk and single-cell), and phenotypic data, we built multi-layered AIID association networks and an integrated network supported by cross-scale evidence. …”
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Identification of anoikis-related genes to develop a risk model and predict the prognosis and tumor microenvironment in rectal adenocarcinoma by Bing Zhao, Xuegui Tang

“…This study aims to establish a risk model based on anoikis-related genes (ARGs) to predict prognosis and the tumor microenvironment in READ.MethodsTranscriptomic data and clinical data downloaded from the TCGA and GEO databases were used for differential analysis and Cox regression analysis. …”
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Overcoming acquired immunotherapy resistance in non-small cell lung cancer using ginsenoside Rb1-loaded, peptide-enhanced exosome delivery systems by Xiangyuan Jin, Tanghesi Wuyun, Yu Zhang, Xiaohong Wang, Ling Zhao

“…This study highlights the potential of peptide-modified Rb1@T-exo as a targeted therapeutic platform for overcoming immunotherapy resistance in PI3K-mutated NSCLC and provides a promising direction for future anti-tumor therapies. …”
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Systems approaches to predict the functions of glycoside hydrolases during the life cycle of Aspergillus niger using developmental mutants ∆brlA and ∆flbA. by Jolanda M van Munster, Benjamin M Nitsche, Michiel Akeroyd, Lubbert Dijkhuizen, Marc J E C van der Maarel, Arthur F J Ram

“…By comparing the transcriptomes, proteomes, enzyme activities and the fungal cell wall compositions of a wild type A. niger strain and these developmental mutants during carbon starvation, a global overview of the function of carbohydrate-active enzymes is provided. …”
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Unlocking Plant Resilience: Metabolomic Insights into Abiotic Stress Tolerance in Crops by Agata Głuchowska, Bartłomiej Zieniuk, Magdalena Pawełkowicz

“…Additionally, we discuss the integration of metabolomics with transcriptomics and physiological data to support system-level insights. …”
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Differential Expression and PAH Degradation: What Burkholderia vietnamiensis G4 Can Tell Us? by Guilherme Pinto Cauduro, Ana Lusia Leal, Tiago Falcón Lopes, Marcela Marmitt, Victor Hugo Valiati

“…To unravel these processes, we used the model B. vietnamiensis strain G4 in two experimental groups: one was exposed to benzo(a)pyrene and the other one (control) was not. Six transcriptomes were generated from each group aiming to compare gene expression and infer which genes are involved in degradation pathways. …”
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Nitrate deficiency decreased photosynthesis and oxidation-reduction processes, but increased cellular transport, lignin biosynthesis and flavonoid metabolism revealed by RNA-Seq in... by Cai-Hong Shao, Cai-Fei Qiu, Yin-Fei Qian, Guang-Rong Liu

“…For the first time, DEGs involved oxygen-evolving complex, phosphorus response and lignin biosynthesis were identified in rice leaves. Our RNA-Seq data provided a global view of transcriptomic profile of principal processes implicated in the adaptation of N deficiency in O. sativa and shed light on the candidate direction in rice breeding for green and sustainable agriculture.…”
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Synergistic Antioxidant and Anti-Ferroptosis Therapy via BPNS-Encapsulated Thermoresponsive Chitosan Hydrogel for Spinal Cord Injury Regeneration by Yang Liu, Yingkai Wang, Xiangzi Wang, Wanchen Zeng, Zehong Zhang, Zhengmian Zhang, Zhongquan Qi

“…In vitro, the physical properties of the composite were characterized and the cytotoxicity and ROS scavenging abilities were assessed using PC12 cells; in vivo, behavioral tests, histopathological analysis, transcriptomics, immunohistochemistry, and Western blotting were performed to explore the therapeutic effects and mechanisms. …”
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Multi-omics reveals the mechanism of Trimethylamine N-oxide derived from gut microbiota inducing liver fatty of dairy cows by Chenlei Li, Feifei Wang, Yongxia Mao, Yanfen Ma, Yansheng Guo

“…Conclusions Our study provides new insights into the role of TMAO in the pathogenesis of bovine fatty liver disease and offers a scientific basis for developing more effective treatment strategies.…”
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Glypican-3 regulated epithelial mesenchymal transformation-related genes in osteosarcoma: based on comprehensive tumor microenvironment profiling by Jiaming Zhang, Wei Wang

“…Epithelial-mesenchymal transition (EMT) plays a key role in the onset, progression, and metastasis of OS, potentially influencing patient prognosis.MethodsWe screened EMT-related genes from multiple transcriptomic datasets of OS and performed unsupervised consensus clustering of EMT-related gene sets. …”
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Spatiotemporal profile of an optimal host response to virus infection in the primate central nervous system. by Olga A Maximova, Sarah L Anzick, Daniel E Sturdevant, Richard S Bennett, Lawrence J Faucette, Marisa St Claire, Stephen S Whitehead, Kishore Kanakabandi, Zong-Mei Sheng, Yongli Xiao, John C Kash, Jeffery K Taubenberger, Craig Martens, Jeffrey I Cohen

“…An increased understanding of these processes may provide new therapeutic opportunities to improve outcomes of viral CNS diseases in humans.…”
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