CHH demethylation in the ZmGST2 promoter enhances maize drought tolerance by regulating ROS scavenging and root growth by Xiaocui Yan, Mengjie Zhang, Yuan Zhong, Tinashe Zenda, Songtao Liu, Anyi Dong, Mengyu Kou, Jialong Liu, Nan Wang, Huijun Duan

“…Overall, this study provides both a new candidate gene and a novel approach for molecular breeding aimed at enhancing maize drought resistance.…”
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BNSTGABA neurons regulate autophagy to alleviate depression with gastric dysfunction symptoms by Yi Yuan, Jiangang Xu, Shanlan Zhu, Hongkun Ma, Hao Wang, Xiyang Wang, Guoming Shen

“…Thus, our study describes a neural mechanism that regulates autophagy in gastric cells via BNSTGABA neurons, thereby alleviating gastric dysfunction in depression, and provides a theoretical basis for electroacupuncture in the treatment of mood disorders with comorbid somatic symptoms.…”
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The unfolded protein response influences therapy outcome and disease progression in chronic lymphocytic leukaemia by Umair Tahir Khan, Kim Clarke, Gina Eagle, Melanie Oates, Peter Hillmen, Sandrine Jayne, Martin J. S. Dyer, Alex Phipps, Francesco Falciani, Rosalind E. Jenkins, Andrew R Pettitt

“…Abstract Since genomics, epigenomics and transcriptomics have provided only a partial explanation of chronic lymphocytic leukaemia (CLL) heterogeneity, and since concordance between mRNA and protein expression is incomplete, we related the CLL proteome to clinical outcome. …”
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Deciphering alternative splicing patterns during cell fate transition of fast chemical reprogramming by Yunkun Lu, Kainan Lin, Yeling Ruan, Junjie Li, Huizhen Zhang, Tianyuan Pan, Qianqian Wang, Lianyu Lin, Sijie Feng

“…Conclusions This research provided a comprehensive characterization of AS during FCR, highlighting the pivotal roles of AS in regulating cell fate transitions. …”
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Enhancer transcription profiling reveals an enhancer RNA-driven ferroptosis and new therapeutic opportunities in prostate cancer by Sheng Ma, Zixian Wang, Zezhong Xiong, Yue Ge, Meng-Yao Xu, Junbiao Zhang, Yuzheng Peng, Qin Zhang, Jiaxue Sun, Zirui Xi, Hao Peng, Wenjie Xu, Yanan Wang, Le Li, Chunyu Zhang, Zheng Chao, Baojun Wang, Xu Gao, Xu Zhang, Gong-Hong Wei, Zhihua Wang

“…In this study, we performed integrated chromatin accessibility and transcriptomic analyses using ATAC-seq and RNA-seq on twenty pairs of prostate cancer and matched benign tissues. …”
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Impact of Salinity Stress on Antioxidant Enzyme Activity, Histopathology, and Gene Expression in the Hepatopancreas of the Oriental River Prawn, <i>Macrobrachium nipponense</i> by Shubo Jin, Zhenghao Ye, Hongtuo Fu, Yiwei Xiong, Hui Qiao, Wenyi Zhang, Sufei Jiang

“…Quantitative real-time PCR validation confirmed the reliability of RNA-seq data. This study provides molecular insights into the salinity adaptation mechanisms in <i>M. nipponense</i>, offering potential applications for improving cultivation practices in brackish water environments.…”
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Epigenomic and 3D genomic mapping reveals developmental dynamics and subgenomic asymmetry of transcriptional regulatory architecture in allotetraploid cotton by Xianhui Huang, Yuejin Wang, Sainan Zhang, Liuling Pei, Jiaqi You, Yuexuan Long, Jianying Li, Xianlong Zhang, Longfu Zhu, Maojun Wang

“…In summary, this study provides abundant resources and depicts the regulatory architecture of the genome, which thereby facilitates the understanding of biological processes and guides cotton breeding.…”
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ApoE2 affects insulin signaling in the hippocampus and spatial cognition of aged mice in a sex-dependent manner by Yu Wang, Hanchen Liu, Yijuan Ye, Wenting Fang, Anlan Lin, Xiaoman Dai, Qinyong Ye, Xiaochun Chen, Jing Zhang

“…The research findings not only provide new insights into the impact of ApoE2 on cognition but also offer a new strategy for cognitive improvement through inositol supplementation in older women.…”
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Functional analysis of the xyloglucan endotransglycosylase/hydrolase gene MdXTH2 in apple fruit firmness formation by Li Liu, Yifeng Feng, Ziqi Han, Yaxiao Song, Jianhua Guo, Jing Yu, Zidun Wang, Hui Wang, Hua Gao, Yazhou Yang, Yuanji Wang, Zhengyang Zhao

“…Here, we identified the gene MdXTH2 by integrating metabolomic and transcriptomic data, and analyzed its function and molecular mechanism in the formation of apple fruit firmness. …”
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Proton motive force generated by microbial rhodopsin promotes extracellular electron transfer by Wenqi Ding, Tong Lin, Yun Yang, Wen-Wei Li, Shaoan Cheng, Hao Song

“…The results suggested that strain cR-1 effectively expels protons to generate additional PMF and provide extra ATP supply to the cells, which facilitated lactate uptake and utilization, thus enhancing electrons generation in cells. …”
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Spatially Resolved Multiomics: Data Analysis from Monoomics to Multiomics by Changxiang Huan, Jinze Li, Yingxue Li, Shasha Zhao, Qi Yang, Zhiqi Zhang, Chuanyu Li, Shuli Li, Zhen Guo, Jia Yao, Wei Zhang, Lianqun Zhou

“…We summarize the potential applications of spatial monoomics technology, aiming to provide researchers and clinicians with a better understanding of how such applications have advanced. …”
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A single-nucleotide mutation of G301A in GaIAA14 confers leaf curling in Gossypium arboreum by Pengfei Miao, Pengfei Miao, Huan Zhang, Huan Zhang, Yifan Xu, Yifan Xu, Ruowen Zhang, Ruowen Zhang, Yunfei Hao, Yunfei Hao, Guoli Song, Guoli Song, Ji Liu, Ji Liu

“…These findings establish a foundation for further functional studies of this gene and provide research strategies for leaf morphology improvement.…”
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High-rate mechano-stimulation alters proliferation- and maturation-related signaling of oligodendrocyte precursor cells in a 3D hydrogel by Ryosuke Yokosawa, Rachel A. Mazur, Kelsey A. Wilson, Jacob H. Lee, Noah W. Showalter, Kyle J. Lampe, Pamela J. VandeVord

“…These dysregulations and altered molecular profiles provide valuable insights into the OPC injury response and may serve as potential therapeutic targets for treating neurodegeneration.…”
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Beta‐Lactam Antibiotics Promote Extracellular Vesicle Production of Staphylococcus aureus Through ROS‐Mediated Lipid Metabolic Reprogramming by Xiaonan Huang, Zhen Hu, Weilong Shang, Juan Chen, Qiwen Hu, Yumin Zhou, Ruolan Ding, Jing Yin, Mengyang Li, He Liu, Jianxiong Dou, Huagang Peng, Yifan Rao, Lu Liu, Yuting Wang, Li Tan, Yuhua Yang, Jianghong Wu, Chuan Xiao, Yi Yang, Xiancai Rao

“…Overall, this study provided mechanic insights into β‐lactam‐promoted EV production in S. aureus, and highlighted the potential strategies to prepare EVs for various applications.…”
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Genome-Wide Analysis of GRETCHEN HAGEN3 Genes and Characterization of IAA-Amido Synthetase Gene <i>CsGH3.1</i> in Rhizome Proliferation in <i>Cymbidium sinense</i> ‘Qijianbaimo’... by Sisi Jia, Cuiling Liu, Chushu Liao, Ruizhen Zeng, Li Xie, Qian Wei, Zhisheng Zhang

“…Seven <i>GH3</i> genes (<i>CsGH3.1</i>–<i>CsGH3.7</i>) were identified using genomic and transcriptomic data. Phylogenetic analysis revealed that CsGH3s are divided into two subfamilies, with CsGH3.1–CsGH3.4 belonging to subfamily II and CsGH3.5–CsGH3.7 to subfamily I. …”
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Targeting myeloid cells in pancreatic ductal adenocarcinoma: from primary tumors to liver metastasis by Ruining Gong, Ying Chen, Chang Li, Huan Zhang, Zimin Liu, Qian Yu

“…Advancements in single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics have provided deeper insights into the molecular intricacies and diversity of PDAC, revealing potential therapeutic targets. …”
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A noncarcinoma mouse cell line is nonsusceptible to Newcastle disease virus established by spontaneous immortalization by Hanlue Li, Zijie Zhou, Chuanyu Chang, Weiwei Shi, Yuzhen Li, Qiaolin Wei, Fanxing Meng, Jianxia Tian, Qiqi Hao, Jinming Liu, Haijin Liu, Zengqi Yang, Sa Xiao

“…This study provides a basic cell platform for exploring viral susceptibility and pathogenesis as well as host–virus interactions during NDV infection.…”
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TRIM8 inhibits porcine epidemic diarrhoea virus replication by targeting and ubiquitinately degrading the nucleocapsid protein by Zhenbin Bi, Wei Wang, Shanshen Gu, Yajing Zhou, Zhengchang Wu, Wenbin Bao, Haifei Wang

“…This suggests that TRIM8 plays a crucial role in boosting antiviral immune responses against PEDV infection. Our findings provide new insights into the functions and mechanisms of TRIM8 in regulating PEDV infection and highlight its potential as a molecular target for the prevention and control of this virus.…”
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Molecular Mechanism of Body Color Change in the Ecological Seedling Breeding Model of <i>Apostichopus japonicus</i> by Lingshu Han, Pengfei Hao, Haoran Xiao, Weiyan Li, Yichen Fan, Wanrong Tian, Ye Tian, Luo Wang, Yaqing Chang, Jun Ding

“…Red individuals showed higher body length and weight, and elevated levels of astaxanthin, lutein, canthaxanthin, and β-carotene in the body wall. Transcriptomic and metabolomic analyses identified differentially expressed genes and metabolites associated with pigmentation. …”
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A novel immunocompetent transgenic mouse model of DHF reveals Syk-mediated Th2-polarized cytokine storm as a key driver of vascular leakage by YuYa Wang, Wei Yang, YuanSong Yang, HuiHui Cheng, Rui Xiong, Xi Wu, Nan Xu, ShuNan Liu, Zhe Qu, Chen Ling, Yuan Cao, Yanwei Yang, HaoYang Zhao, WenDa Gu, Yong Wu, SuSu Liu, Yining Wang, Yu Wang, SanLong Wang, Rui Fu, WeiJin Huang, Hongning Zhou, Wei Wei, Jing An, YouChun Wang, ChangFa Fan

“…Our work not only identifies hTim4 as a functional DENV-2 receptor but also provides a mechanistically grounded platform for DHF pathogenesis studies, bridging critical gaps between preclinical models and human immunopathology.…”
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