Crizotinib: A Novel Strategy to Reverse Immunosuppression in Melanoma by Targeting Lactate Transport by Zhe Zhou, Xu Zhang, Susi Zhu, Waner Liu, Yeye Guo, Siyu Xiong, Cong Peng, Xiang Chen

“…Taken together, these findings provide new insights into targeting metabolic‐immune crosstalk and highlight the value of disrupting CD147–MCT1 interactions to improve immunotherapeutic responses in patients with melanoma.…”
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iPSC-derived NK cells engineered with CD226 effectively control acute myeloid leukemia by Runze Cai, Binyan Lu, Xiangyu Zhao, Shixin Zhou, Yang Li

“…In this study, we engineered iPSC-NK cells with CD226 to assess the ability of killing AML cells. iPSC-NK cells engineered with CD226 have a typical NK cell phenotype and demonstrate improved anti-AML activity and multiple cytokines releasing at low effector-to-target ratios. Transcriptomic analysis revealed upregulation of immune effector function pathways associated with cytotoxicity and immune activation in CD226-overexpression iPSC-NK cells. …”
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Pathological and Molecular Characterization of Grass Carp Co-Infected with Two <i>Aeromonas</i> Species by Wenyao Lv, Zhijie Zhou, Lingli Xie, Xinyue Wang, Yifei Zhou, Lang Gui, Xiaoyan Xu, Yubang Shen, Jiale Li, Junqiang Qiu

“…Histopathological evaluation revealed severe hepatic lesions characterized by cellular necrosis, cytoplasmic vacuolization, and hemorrhagic manifestations. Comparative transcriptomic analysis of hepatic tissues between co-infected and control specimens identified 868 and 411 differentially expressed genes (DEGs) at 1 and 5 dpi, respectively. …”
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Haplotype-resolved genome reveals haplotypic variation and the biosynthesis of medicinal ingredients in Areca catechu L. by Chao Wang, Lei Tan, Zhonghui Zhang, Xianggui Li, Linghao Xia, Peng Cao, Haiyang Tong, Xumin Ou, Shixuan Li, Jianing Zhang, Chun Li, Jun Yang, Wen-Biao Jiao, Shouchuang Wang

“…Furthermore, A. catechu shared two whole genome duplications with other palm plants and its genome size had increased due to the insertion of transposons within the last 2.5 million years. By integrating transcriptomics and metabolomics, two tandem genes (AcGNMT1 and AcGNMT2) were negatively associated with guvacine and trigonelline in gene-metabolite interaction network. …”
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Integrated multi-omics analysis unravels the floral scent characteristics and regulation in “Hutou” multi-petal jasmine by Jingping Fang, Linwei Zhou, Qinchang Chen, Jinbin Wang, Ying Zhuang, Shaoqing Lin, Hansong Yan, Kai Zhao, Jisen Zhang, Robert J. Henry

“…Our integrated dataset of genomics, transcriptomics, and metabolomics present here provides a theoretical basis for the practical utilization of fragrance and genetic improvement in horticultural applications of “Hutou” jasmine.…”
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Role of carbohydrate-active enzymes in brown planthopper virulence and adaptability by Fang Liu, Fang Liu, Jing Xiao, Xin-Feng Wang, Ya-Xuan Wang, Hou-Hong Yang, Yu-Biao Cai, Feng-Xiang Lai, Qiang Fu, Pin-Jun Wan

“…MethodsThis study aims to address this gap by analyzing CAZymes in 182 insect genomes, followed by a detailed genomic and transcriptomic analysis of BPH.ResultsWe identified 644 CAZymes in BPH, including enzymes related to plant cell wall degradation. …”
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PLIN2 Promotes Lipid Accumulation in Ascites‐Associated Macrophages and Ovarian Cancer Progression by HIF1α/SPP1 Signaling by Hui Luo, Xiaolu She, Yubo Zhang, Bingfan Xie, Shibo Zhang, Qianqian Li, Yangyang Zhou, Shuang Guo, Shushan Zhang, Yanhui Jiang, Yingying Dong, Jianzhong He, Lijie Wang, Qianqian Zhang, Yuan Zhuang, Panxia Deng, Feng Wang, Jihong Liu, Xin Chen, Huilong Nie, Huanhuan He

“…Here, a single‐cell transcriptomic landscape of CD45+ immune cells across multiple anatomical sites is depicted, including primary tumors, metastatic lesions, and ascites, from patients diagnosed with high‐grade serous ovarian carcinoma (HGSOC). …”
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FGFR antagonists restore defective mandibular bone repair in a mouse model of osteochondrodysplasia by Anne Morice, Amélie de La Seiglière, Alexia Kany, Roman H. Khonsari, Morad Bensidhoum, Maria-Emilia Puig-Lombardi, Laurence Legeai Mallet

“…The latter model presented pseudarthrosis and impaired chondrocyte differentiation. Spatial transcriptomic analyses of the Hch callus revealed abnormally low expression of Col11, Col1a, Dmp1 genes in mature chondrocytes. …”
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Treg cell plasticity as a driver of inflammation in spondyloarthritis and psoriasis by Ingrid Itzayanna Ortega-Mejia, Ingrid Itzayanna Ortega-Mejia, Nayeli Romero-López, Nayeli Romero-López, Julio César Casasola-Vargas, Rubén Burgos-Vargas, María Lilia Domínguez-López, José Pablo Romero-López

“…Genetic factors, including HLA-B27, may further predispose Tregs to instability. Single-cell transcriptomic analyses have provided evidence of shared TCR repertoires between Tregs and effector T cells, reinforcing the concept of lineage plasticity. …”
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Nanoliposome-sericin hydrogel microneedle patches effectively alleviate inflammation and scavenge ROS for the treatment of CKD-aP by Lichang Liu, Longbao Feng, Yuanyuan Zhang, Junjie Xu, Le Liu, Lichun Wang, Weihong Hong, Yuyan Jin, Jiahao Zeng, Peihua He, Xusheng Liu

“…In vivo transcriptomic analysis revealed significant modulation of immune-related genes and reduction of oxidative stress markers, confirming its immune-regulatory and anti-inflammatory effects. …”
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Characterization of human living myocardial slices culture-induced adaptations: a translational perspective by Jort S.A. van der Geest, Ernest Diez Benavente, Willem B. van Ham, Pieter A. Doevendans, Linda W. van Laake, Teun P. de Boer, Vasco Sampaio-Pinto, Joost P.G. Sluijter

“…Interestingly, LMS exhibited increased expression of genes associated with early cardiac development after the culture period.LMS provide a powerful translational model for cardiovascular research, enabling the evaluation of novel therapies and fundamental studies. …”
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Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication by Xiaojie Zhao, Yan Li, Siwei Zhang, Ari Sudwarts, Hanwen Zhang, Alena Kozlova, Matthew J. Moulton, Lindsey D. Goodman, Zhiping P. Pang, Alan R. Sanders, Hugo J. Bellen, Gopal Thinakaran, Jubao Duan

“…CRISPR-Cas9 editing generated isogenic pairs, which were then differentiated into glutamatergic neurons (iGlut). Transcriptomic analysis and functional studies of iGlut co-cultured with mouse astrocytes assessed neuronal excitability and lipid droplet formation. …”
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Manipulation of Surface Potential Distribution Enhances Osteogenesis by Promoting Pro‐Angiogenic Macrophage Polarization via Activation of the PI3K‐Akt Signaling Pathway by Qun Cui, Xiaona Zheng, Yunyang Bai, Yaru Guo, Shuo Liu, Yanhui Lu, Lulu Liu, Jia Song, Yang Liu, Boon Chin Heng, Fuping You, Mingming Xu, Xuliang Deng, Xuehui Zhang

“…This study elucidates the cascade of biological processes by which heterogeneous electrical signals at the micro‐ and nanoscale modulate macrophage functions to promote vascularization and bone regeneration. Hence, this study provides new insights into how the micro‐ and nanoscale distribution characteristics of electrical signals facilitate bone regeneration.…”
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UBC9 overexpression promotes proliferation and metastasis in gastric cancer via ATF2 by QingShui Wang, ShengZhao Li, YiNing Xu, Yuluo Chen, Chao Xu, QiuYan He, Yan Ye, YiMin Huang, Yue Wu, KeJia Guo, YaJuan Wei, Yide Huang, Yan Liu, Qing Lin, Shanshan Wang, Feng Li, Minghan Huang, FangQin Xue, Yao Lin

“…Through integrated transcriptomic and proteomic analyses, we identified ATF2 (Activating Transcription Factor 2) as a crucial downstream effector of UBC9-mediated oncogenic signaling. …”
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The genomic architecture of circulating cytokine levels points to drug targets for immune-related diseases by Marek J. Konieczny, Murad Omarov, Lanyue Zhang, Rainer Malik, Tom G. Richardson, Sebastian-Edgar Baumeister, Jürgen Bernhagen, Martin Dichgans, Marios K. Georgakis

“…Integration with transcriptomic data point to key regulatory mechanisms, such as the buffering function of the Atypical Chemokine Receptor 1 (ACKR1) acting as scavenger for multiple chemokines and the role of tumor necrosis factor receptor-associated factor 1 (TRAFD1) in modulating the cytokine storm triggered by TNF signaling. …”
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Molecular characterisation of influenza B virus from the 2017/18 season in primary models of the human lung reveals improved adaptation to the lower respiratory tract by Duygu Merve Çalışkan, Sriram Kumar, Saskia Hinse, Klaus Schughart, Rainer Wiewrodt, Stefan Fischer, Vera Krueger, Karsten Wiebe, Peter Barth, Alexander Mellmann, Stephan Ludwig, Linda Brunotte

“…Comparative replication kinetics in different cell lines provided further evidence for improved replication fitness, tolerance towards higher temperatures, and the development of immune evasion mechanisms by the 2018 IBV isolates. …”
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AMPK Signaling Axis-Mediated Regulation of Lipid Metabolism: Ameliorative Effects of Sodium Octanoate on Intestinal Dysfunction in Hu Sheep by Huimin Zhang, Shuo Yan, Zimeng Ma, Ruilin Du, Xihe Li, Siqin Bao, Yongli Song

“…Comprehensive assessment of Cd-induced intestinal injury using hematoxylin and eosin (H&E) staining, immunostaining and carried out in-depth analyses combined with lipid metabolomics and transcriptomics. The results showed that Cd exposure triggered intestinal inflammation, barrier function damage and oxidative stress imbalance. …”
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Evaluation of pyroptosis-associated genes in endometrial cancer utilizing a 101-combination machine learning framework and multi-omics data by Li Juan Huang, Chen Liu, Lin Chen, Min Tang, Shi Tong Zhan, Feng Chen, An Yi Teng, Li Na Zhou, Wei Lin Sang, Ye Yang

“…Drug sensitivity analysis revealed several therapeutic agents with potential efficacy in high-risk and low-risk subgroups.ConclusionThis study highlights the clinical and immunological relevance of pyroptosis in EC and introduces a PAG-based model with strong predictive and therapeutic potential. These findings provide a foundation for developing pyroptosis-guided precision immunotherapy strategies in EC.…”
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Alleviating Overgrazing Stress and Promoting Grassland Plant Regeneration via Root Exudate-Mediated Recruitment of Beneficial Bacteria by Ting Yuan, Jiatao Zhang, Shaohong Zhang, Shuang Liang, Changhong Zhu, Weibo Ren, Jialu Liang

“…This study provides a scientific basis and support for elucidating the response mechanisms of how grassland plants cope with OG stress, optimizing grassland management, and rapidly restoring and enhancing grassland productivity.…”
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Single-cell technology for drug discovery and development by Anzhuo Zhang, Jiawei Zou, Yue Xi, Lianchong Gao, Fulan Deng, Yujun Liu, Pengfei Gao, Henry H. Y. Tong, Lianjiang Tan, Xin Zou, Xin Zou, Jie Hao

“…Single-cell omics, encompassing transcriptomics, genomics, epigenomics, proteomics, and metabolomics enable the analysis of gene expression profiles and cellular heterogeneity from the perspective of individual cells, offering a high-resolution view of their functional diversity. …”
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