Prolonged exposure to insulin might cause epigenetic alteration leading to insulin resistance by Shehnaz Bano, Shyam More, Dattatray S. Mongad, Abdul Khalique, Dhiraj P. Dhotre, Manoj K. Bhat, Vasudevan Seshadri

“…The observed insulin resistance is likely due to epigenetic alterations, as it can be maintained for several generations even when insulin is not provided, and epigenetic modifiers can reverse it. …”
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In Silico Network Toxicology, Molecular Docking, and Multi‐Level Bioinformatics Reveal Methyl Eugenol‐Induced Hepatocellular Carcinoma Mechanisms in Humans by Fuat Karakuş, Zübeyde Tanrıverdi, Burak Kuzu

“…Methods This study aims to investigate the potential molecular mechanisms and underlying ME‐induced hepatocellular carcinoma (HCC) in humans using network toxicology, molecular docking, and integrative bioinformatics approaches, including transcriptomic and survival analyses of human HCC datasets. …”
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Antifungal and antibiofilm activities of flavonoids against Candida albicans: Focus on 3,2′-dihydroxyflavone as a potential therapeutic agent by Jin-Hyung Lee, Yong-Guy Kim, Inji Park, Jintae Lee

“…Current results indicate that hydroxylated flavone derivatives can enhance anti-fungal and antibiofilm activities and provide a source of potential anti-fungal agents against drug-resistant C. albicans.…”
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An insulin-like peptide specific for a cockroach male reproductive gland. by Viviana Pagone, David Pujal, José Luis Maestro

“…A comparison of the transcriptomes of control and BgILP8-depleted glands revealed only small differences. …”
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Characterization of TLR9 responsiveness in cell subsets derived from in vitro pDC differentiation of hematopoietic stem and progenitor cells by Sabina Sánchez Hernández, Tobias Wang Bjerg, Ian Helstrup Nielsen, Anders Laustsen, Hai Q Tang, Lars Henning Pedersen, Lars Henning Pedersen, Lars Henning Pedersen, Eynav Klechevsky, Martin R. Jakobsen, Rasmus O. Bak

“…Here, we characterize different cell subsets from in vitro pDC differentiation and identify a distinct population, which is the major producer of IFNα in response to TLR9 stimulation and display a transcriptomic profile similar to what is seen for pDCs circulating in the blood. …”
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Genome-wide identification, evolutionary expansion and expression divergence of the AP2/ERF gene family in loquat (Eriobotrya japonica) by Yumeng Liu, Linqi Cai, Xiurun Fan, Huiling Zhang, Minghui Chen, Yue Lin, Junwei Chen, Kai Xu, Boping Wu

“…The syntenic analysis of AP2/ERF genes between Arabidopsis, pomegranate, peach, and loquat provided valuable clues for the potential evolution of AP2/ERF family in loquat. …”
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Establishment and application of highly efficient regeneration, genetic transformation and genome editing system for cucurbitacins biosynthesis in Hemsleya chinensis by Juan Wang, Chao-Hui Li, Chun-Fan Xiang, Pin-Han Zhou, Le-Song Li, Xia Li, Sheng-Chao Yang, Guang-Hui Zhang, Yan Zhao

“…By combining high-efficiency tissue culture, transformation, and genome editing systems, we provide a powerful platform that supports functional research on molecular mechanisms of secondary metabolism.…”
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A novel telomere-associated genes signature for the prediction of prognosis and treatment responsiveness of hepatocellular carcinoma by Kuo Kang, Hui Nie, Weilu Kuang, Xuanxuan Li, Yangying Zhou

“…The single-cell and spatial transcriptomics were utilized to analyze the expression and distribution of 18 TRGs in HCC. …”
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Curcumin-Induced Molecular Mechanisms in U-87 MG Glioblastoma Cells: Insights from Global Gene Expression Profiling by Nicole Tendayi Mashozhera, Chinreddy Subramanyam Reddy, Yevin Nenuka Ranasinghe, Purushothaman Natarajan, Umesh K. Reddy, Gerald Hankins

“…Several pro-apoptotic and anti-BCL, cell-cycle-regulated genes were modulated following curcumin treatment, emphasizing its potential role in curcumin-mediated anti-tumor effects. This study provides insight into the molecular mechanisms underlying curcumin’s action against glioblastoma.…”
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Increased distribution of carbon metabolic flux during de novo cytidine biosynthesis via attenuation of the acetic acid metabolism pathway in Escherichia coli by Tong Ye, Wei Ding, Zhengxu An, Haojie Zhang, Xiaobo Wei, Junnan Xu, Huiyan Liu, Haitian Fang

“…These findings provide novel insights into the influence of the acetate metabolic pathway on cytidine biosynthesis in E. coli. …”
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Expanding our understanding of (mal)adapted stress physiology in psychiatric disorders: achieving single-cell characterisation of steroids and neuropeptides by Katrina Z. Edmond, Natalie Matosin

“…Foundational studies using histology, genetic manipulation, and bulk transcriptomic approaches, primarily in rodent models, have provided critical insights into their roles. …”
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A coagulation-related long non-coding RNA signature to predict prognosis and immune features of breast cancer by Yetao Han, Mengsi Hu, Yanzhong Wang, Shoufang Xu, Feiyu Jiang, Yingjian Wang, Zhiwei Liu

“…This CRG-lncRNA signature provides a novel tool for prognosis prediction and personalized immunotherapy in BC, illuminating crosstalk between coagulation and immune pathways.…”
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Complexity of combined abiotic stresses to crop plants by Nasir Ali Khan, Lucille Owens, Martin A Nuñez, Abdul Latif Khan

“…Integrating advanced tools like omics technologies (transcriptomics, proteomics, metabolomics), genetic engineering (CRISPR/Cas9), speed breeding, and systems biology provides insights into stress-responsive pathways and accelerates the development of resilient crops. …”
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Identification of progression related LncRNAs in colorectal cancer aggressiveness by Wei Xi, Xinxin Sun, Mingwei Wang, Xizi Wang, Kun Li, Runze Jiang, Xiaodong Jia, Wenxiao Wang

“…In this study, we identified key progression-related lncRNAs in CRC by integrating transcriptomic data from TCGA and single-cell RNA sequencing (scRNA-seq). …”
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SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection by Alexsia Richards, Andrew S. Khalil, Max Friesen, Troy W. Whitfield, Xinlei Gao, Tenzin Lungjangwa, Roger D. Kamm, Zhengpeng Wan, Lee Gehrke, David Mooney, Rudolf Jaenisch

“…Utilizing RNA sequencing, we characterize the transcriptomic changes accompanying SARS-CoV-2 infection of SMCs, PCs, and ECs. …”
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A stable NTN1 fluorescent reporter chicken reveals cell specific molecular signatures during optic fissure closure by Brian Ho Ching Chan, Holly Hardy, Teresa Requena, Amy Findlay, Jason Ioannidis, Dominique Meunier, Maria Toms, Mariya Moosajee, Anna Raper, Mike J. McGrew, Joe Rainger

“…This work provides a novel fluorescent NTN1 chicken reporter line with broad experimental utility and is the first to directly molecularly characterise pioneer cells during OFC.…”
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Viral-Track integrated single-cell RNA-sequencing reveals HBV lymphotropism and immunosuppressive microenvironment in HBV-associated hepatocellular carcinoma by Zhepeng Liu, Wajeeha Naz, Tanzeel Yousaf, Junwei Sun, Qijia Wu, Mingxiong Guo, Geng Tian, Guihong Sun

“…We combine the Viral-Track method with scRNA sequencing and profile the transcriptomes of 70,056 cells from HBV and non-HBV-HCC patients. …”
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Identification of macrophage-associated diagnostic biomarkers and molecular subtypes in gestational diabetes mellitus based on machine learning by Kai Wei, Liyun Yuan, Yongsheng Ge, Han Yu, Guoping Zhao, Guoqing Zhang, Guohua Liu

“…A diagnostic model for GDM derived from endothelial cell transcriptomes was constructed by employing a variety of machine learning ensemble algorithms, achieving an AUC of 0.887. …”
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Genome-Wide Identification, Characterization, and Expression Analysis of the NAC Transcription Factor Family in Sweet Cherry (<i>Prunus avium</i> L.) by Feng An, Xin Yin, Kaibire Jueraiti, Yuanyuan Yang, Zhuoyang Yan, Jie Li, Dongqian Shan

“…These findings provide valuable insights for future research on the functional characteristics of the <i>PaNAC</i> genes in the growth, development, and responses to abiotic stress in sweet cherry.…”
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WRKY Transcription Factors Modulate the Flavonoid Pathway of <i>Rhododendron chrysanthum</i> Pall. Under UV-B Stress by Wang Yu, Xiangru Zhou, Jinhao Meng, Hongwei Xu, Xiaofu Zhou

“…A theoretical reference for investigating plant stress physiology is provided in this work, which also offers insights into the stress responses of alpine plants under adverse conditions.…”
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