Molecular characterization of ovarian mesonephric-like adenocarcinoma: Insights from single-cell RNA sequencing and mitochondrial metabolism by Gwan Hee Han, Ye-Ah Kim, Hyunjin Park, Hee Yun, Jae-Hoon Kim, Man S. Kim, Hanbyoul Cho

“…Conclusions: This study provides the first scRNA-seq-based molecular characterization of ovarian MLA, differentiating it from HGSOC. …”
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The Use of Diagnostic Tumor Markers in Detecting Tobacco‐ and Betel Quid‐Induced Oral Squamous Cell Carcinoma: A Scoping Review of Empirical Evidence by Yovanthi Anurangi Jayasinghe, Kalpani Senevirathna, Afeez Abolarinwa Salami, Kehinde Kazeem Kanmodi, Ruwan Duminda Jayasinghe

“…Conclusion This scoping review provides insights into the current global research landscape on the use of biomarkers in the diagnosis of tobacco‐ and betel quid‐induced OSCC; it also provides potential avenues for improving early detection and management of this prevalent oral malignancy.…”
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Precision prognostication in neuroblastomas via clinically validated E2F activity signatures by Donghan Cai, Donghan Cai, Huihuang Xu, Huihuang Xu, Shiwei He, Di Xu, Di Xu, Lizhi Li, Lizhi Li

“…The identified signature enhances patient stratification and provides insights into NB tumor biology, the immune landscape, and potential treatment strategies.…”
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Subcutaneous checkpoint inhibition is equivalent to systemic delivery when combined with nelitolimod delivered via pressure-enabled drug delivery for depletion of intrahepatic myel... by Diwakar Davar, Yujia Liu, Jason Laporte, Prajna Guha, Steven C Katz, Chandra C Ghosh, Lauren Cournoyer, Alizee Ballarin, Ilan B Layman, Molly Morrissey, Kayla Fraser, Shriya Perati, Bryan F Cox, Evgeny Yakirevich, Diana O Treaba, Timothy D Murtha

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Transcriptional Differences in Peanut (Arachis hypogaea L.) Seeds at the Freshly Harvested, After-ripening and Newly Germinated Seed Stages: Insights into the Regulatory Networks o... by Pingli Xu, Guiying Tang, Weipei Cui, Guangxia Chen, Chang-Le Ma, Jieqiong Zhu, Pengxiang Li, Lei Shan, Zhanji Liu, Shubo Wan

“…In this study, seeds of the variety Luhua No.14, which undergoes nondeep dormancy, were selected, and their transcriptional changes at three different developmental stages, the freshly harvested seed (FS), the after-ripening seed (DS) and the newly germinated seed (GS) stages, were investigated by comparative transcriptomic analysis. The results showed that genes with increased transcription in the DS vs FS comparison were overrepresented for oxidative phosphorylation, the glycolysis pathway and the tricarboxylic acid (TCA) cycle, suggesting that after a period of dry storage, the intermediates stored in the dry seeds were rapidly mobilized by glycolysis, the TCA cycle, the glyoxylate cycle, etc.; the electron transport chain accompanied by respiration was reactivated to provide ATP for the mobilization of other reserves and for seed germination. …”
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Effects of leucine supplementation and serum withdrawal on branched-chain amino acid pathway gene and protein expression in mouse adipocytes. by Abderrazak Kitsy, Skyla Carney, Juan C Vivar, Megan S Knight, Mildred A Pointer, Judith K Gwathmey, Sujoy Ghosh

“…These results demonstrate that the expression of genes related to BCAA metabolism are regulated during adipocyte differentiation and influenced by nutrient levels. These results provide additional insights on how BCAA metabolism is associated with adipose tissue function and extends our understanding of the transcriptomic response of this pathway to variations in nutrient availability.…”
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Macrophages and fibroblasts in cardiac fibrosis: interactions and transformation by Daehun Kim, Jea-Hyun Baek

“…Recent single-cell transcriptomics and lineage-tracing studies have provided deeper insights into the molecular regulation of MMT and its contribution to myocardial remodeling. …”
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The thymic microenvironment gradually modulates the phenotype of thymus‐homing peripheral conventional dendritic cells by Susanne Herppich, Michael Beckstette, Jochen Huehn

“…Results Already after two days of culture, the transcriptomic profile of sp‑DCs was modulated and had acquired certain key signatures of t‑DCs. …”
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Machine Learning Inference of Gene Regulatory Networks in Developing <i>Mimulus</i> Seeds by Albert Tucci, Miguel A. Flores-Vergara, Robert G. Franks

“…In our case, GRN inference also provided the opportunity to uncover active regulatory relationships and generate a reference set of putative gene regulations. …”
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Fungal bioremediation in environmental pollution and recent strategies by Linthoingambi Ningombam, Techi Mana, Srimay Pradhan, Gemin Apum, Yengkhom Disco Singh

“…By bridging molecular mechanisms with field-level implementation, this work provides new insights into the potential of fungi as efficient, adaptable, and sustainable agents for environmental remediation.…”
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Cellular Tracking and Gene Profiling of Fusarium graminearum during Maize Stalk Rot Disease Development Elucidates Its Strategies in Confronting Phosphorus Limitation in the Host A... by Yan Zhang, Juan He, Lei-Jie Jia, Ting-Lu Yuan, Dong Zhang, Yan Guo, Yufeng Wang, Wei-Hua Tang

“…Using laser microdissection and microarray analysis, we profiled changes in global gene expression during pathogen growth inside pith tissues of maize stalk from 12 h to six days after inoculation and documented transcriptomic patterns that provide further insights into the infection process. …”
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Application of Genomic Selection in Beef Cattle Disease Prevention by Ramanathan Kasimanickam, Joao Carlos Pinheiro Ferreira, John Kastelic, Vanmathy Kasimanickam

“…Advances in genomics, including identification of genetic markers linked to disease resistance, provide powerful tools for early detection, selection, and management of cattle resistant to infectious diseases. …”
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Revealing the key role of the folate synthesis regulatory gene DHNA in tobacco leaf yellowing based on BSA-seq, RNA-seq, and proteomic sequencing by Qiuhe Pan, Rongli Jia, Kai Pi, Qin Tang, Jingyao Zhang, Ying Huang, Renxiang Liu

“…Subsequently, using a combination of BSA-seq, transcriptomic sequencing (RNA-seq), and proteomic sequencing approaches, we identified the candidate gene Nitab4.5_0008674g0010 that encodes dihydroneopterin aldolase as a factor associated with tobacco leaf yellowing. …”
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Impact of developmental state, p53 status, and interferon signaling on glioblastoma cell response to radiation and temozolomide treatment. by Artem Berezovsky, Oluwademilade Nuga, Indrani Datta, Kimberly Bergman, Thais Sabedot, Katherine Gurdziel, Susan Irtenkauf, Laura Hasselbach, Yuling Meng, Claudius Mueller, Emanuel F Petricoin, Stephen Brown, Neeraja Purandare, Sidhesh Aras, Tom Mikkelsen, Laila Poisson, Houtan Noushmehr, Douglas Ruden, Ana C deCarvalho

“…Our integrative analysis of the impact of GBM cell developmental states, in the context of genomic and molecular diversity of patient-derived models, provides valuable insights for pre-clinical studies aimed at optimizing treatment strategies.…”
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Changes in phytohormone levels and gene expression of potato plants in response to potato virus Y and a nonvector insect by GE Yang, ZHONG Jian, ZHANG Yadong, HE Xiaoli, LIU Lining, Asim MUNAWAR, MAO Lijuan, ZHU Zengrong, XU Yi, ZHOU Wenwu

“…In summary, this study systematically analyzed the physiological responses of potato plant confronted by the single- and co-stressed treatments of PVY infection and herbivory stimuli, which may provide scientific basis for exploring plant-virus-nonvector insect interactions.…”
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Identification, expression profiling and potential functional roles of nuclear receptors in the social aphid Pseudoregma bambucicola by Jianjun Lu, Xiaolei Huang

“…Additionally, differential expression of NR genes was analyzed using transcriptomic data. The TLL exhibited significant differential expression in adults with distinct reproductive behaviors, suggesting its involvement in the regulation of reproductive division of labor. …”
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Refining the annotation of Rhodnius prolixus aspartic proteases A1 family genes through proteogenomics by Radouane Ouali, Sabrina Bousbata

“…This study not only provides a more accurate and comprehensive genomic framework for the A1 peptidase family but also offers new insights into the functional complexity and regulation of digestive enzymes in R. prolixus. …”
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Patient-specific data fusion defines prognostic cancer subtypes. by Yinyin Yuan, Richard S Savage, Florian Markowetz

“…Fusing different data provides a more comprehensive model of the cancer cell than that offered by any single type. …”
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A multi-omics technology to the study of lactic acid bacteria responses to environmental stress: the past, current and future trends by Yaqi Liu, Jingxian Sun, Xiaowen Liu, Mingpeng Zheng, Wen Ma, Gang Jin

“…Single-cell omics techniques, analyze the targeted regulation of microbial functions in a multi-dimensional space, provides a new perspective on understanding microbes responses environment stress.…”
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Bayesian variable selection with graphical structure learning: Applications in integrative genomics. by Suprateek Kundu, Yichen Cheng, Minsuk Shin, Ganiraju Manyam, Bani K Mallick, Veerabhadran Baladandayuthapani

“…Significant advances in biotechnology have allowed for simultaneous measurement of molecular data across multiple genomic, epigenomic and transcriptomic levels from a single tumor/patient sample. …”
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