The Therapeutic Efficacy and Molecular Mechanisms of <i>Artemisia argyi</i> Essential Oil in Treating Feline Herpesvirus Infection via Nasal Drops by Tian Wan, Jinze Li, Jiayi Liu, Yingxin Chen, Yihao Guo, Xianjie Deng, Xingyao Li, Jiachen Bi, Chongchong Hu, Jianyu Chang, Kai Fan

“…In vitro assays revealed that AAEO has concentration-dependent cytotoxicity in feline kidney cells (F81) and provides protective effects when used as a pre-treatment. …”
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Genome-Wide Identification and Expression Analysis of the <i>CLAVATA3/ESR</i>-Related Gene Family in Tiger Nut by Maria Gancheva, Nina Kon’kova, Alla Solovyeva, Lavrentii Danilov, Konstantin Gusev, Ludmila Lutova

“…In this study, we identified 34 <i>CLE</i> genes in the genomes, proteomes, and transcriptomes of <i>C. esculentus</i> (<i>CeCLE</i>). …”
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Halymenia durvillei Extracts Exert Antiobesity Effects by Targeting hosl‐1‐Mediated Lipolysis in a Glucose‐Induced Caenorhabditis elegans Model by Kawita Chumphoochai, Sukrit Promtang, Pawanrat Chalorak, Preeyanuch Manohong, Nakorn Niamnont, Montakan Tamtin, Prasert Sobhon, Simon Tuck, Krai Meemon

“…The results suggested that these extracts provide an antiobesity effect mediated through the lipolysis genes, atgl‐1 and hosl‐1. …”
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Silk Fibroin Films with Microscopic Surface Pattern as Promising Cartilage Tissue Engineering Scaffold in Supporting MSCs Amplification and Chondrogenic Differentiation by Xin Wang, Junjun Yang, Rong Wang, Yumengfei Huang, Zu Wan, Zhi Wang, Zhenlan Fu, Cheng Chen, Guangxing Chen, Xiaoyuan Gong

“…Overall, this study preliminarily revealed the microscopic surface pattern of SF films may induce chondrogenic differentiation of hADSCs through extracellular matrix mediated Hippo/Yap pathway, and provided a new strategy for cartilage repair.…”
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Investigating potential drug targets for the treatment of glioblastoma: a Mendelian randomization study by Hongwei Zhang, Zixuan Wang, Xiaolong Qiao, Jiaxing Wu, Chuandong Cheng

“…This study combined eQTL and pQTL analyses to identify potential GBM-related genes and circulating plasma proteins for therapeutic exploration. Using transcriptomic data from The Cancer Genome Atlas (TCGA), we identified 2,528 differentially expressed genes, including GPX7 and CXCL10. eQTL-MR analysis identifies GBM-associated differentially expressed genes and constructs a protein–protein interaction (PPI) network.Integrating pQTL data from the deCODE database, pQTL-MR, and colocalization analyses validated the therapeutic potential of GPX7 and CXCL10.These findings provide new perspectives on GBM biology and suggest actionable targets for therapy. …”
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A Comprehensive Analysis of the Genomic and Expressed Repertoire of the T-Cell Receptor Beta Chain in <i>Equus caballus</i> by Rachele Antonacci, Francesco Giannico, Roberta Moschetti, Angela Pala, Anna Caputi Jambrenghi, Serafina Massari

“…This analysis provided insights into the usage of the TRBV, TRBD, and TRBJ genes and the variability of the non-germline-encoded CDR3. …”
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Macrophages and macrophage extracellular vesicles confer cancer ferroptosis resistance via PRDX6-mediated mitophagy inhibition by Naisheng Zheng, Fuli Li, Qing Huang, Xian Huang, Tomasz Maj

“…Together, our findings provide a novel mechanism of ferroptosis resistance in TME, wherein macrophages confer tumor cell resilience by bypassing GPX4 inhibition.…”
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Integrated multi-omics analysis describes immune profiles in ischemic heart failure and identifies PTN as a novel biomarker by Ting Xiong, Quhuan Li, Yifan Wang, Ying Kong, Hailin Li, Jie Liu, Yueheng Wu, Fengxia Zhang

“…Given the substantial size of our transcriptomic dataset, we used diverse machine learning techniques to identify key mRNAs. …”
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Dynamic Coordination of Alternative Splicing and Subgenome Expression Bias Underlies Rusty Root Symptom Response in <i>Panax ginseng</i> by Jing Zhao, Juzuo Li, Xiujuan Lei, Peng Di, Hongwei Xun, Zhibin Zhang, Jian Zhang, Xiangru Meng, Yingping Wang

“…Ginseng rusty root symptoms (GRSs) compromise the yield and quality of <i>Panax ginseng</i>. While transcriptomic analyses have demonstrated extensive remodeling of stress signaling networks, the post-transcriptional defense circuitry remains obscure. …”
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BCMA: An integrative and versatile database for multi-scale and multi-omics molecular atlas of breast cancer by Wenbo Guo, Zikang Yin, Qinglin Mei, Lianshuo Li, Yonghui Gong, Xinqi Li, Wei Zhang, Wenjie Lei, Bingqiang Liu, Lin Hou, Mei Yang, Jin Gu

“…Here, we present BCMA (Breast Cancer Molecular Atlas, http://lifeome.net/database/bcma/), a multi-scale, multi-omics BC database that encompasses 6 bulk multi-omics datasets and 9 single-cell transcriptomics datasets, collectively covering 5424 cases and 236,363 cells. …”
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Disulfidptosis in tumor progression by Senlin Wan, Changming Liang, Chengwei Wu, Song Wang, Jiawei Wang, Lishuai Xu, Xu Zhang, Yinfen Hou, Yabin Xia, Li Xu, Xiaoxu Huang

“…By integrating multiomics data and single-cell transcriptomics, we comprehensively decipher the heterogeneous expression patterns of disulfidptosis-related genes (DRGs) and their dynamic interplay with immune microenvironment remodeling. …”
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Mycobacterial PstP impairs host RNA alternative splicing by dephosphorylation of spliceosome RBMX at S189 by Tianxian Liu, Jun‐Yu Xu, Lei Zhao, Yameng Fan, Shuyu Xie, Ke Ma, Ying Zhou, Minjia Tan, Bang‐Ce Ye

“…Here, we employed a multi‐omics strategy, including proteomics, phosphoproteomics, transcriptomics and interactomics, to investigate the impact of Mtb infection on host cellular processes. …”
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NSD2 and miRNAs as Key Regulators of Melanoma Response to Romidepsin and Interferon‐α2b Treatment by Alessandro De Santis, Lucrezia De Santis, Francesca Rossi, Silvia Gasparini, Valerio Licursi, Vito Antonio Amico, Imerio Capone, Alessandra Fragale, Stefania D'atri, Lucia Gabriele, Carlo Presutti

“…Methods RNA‐seq and TCGA transcriptomic data were re‐analyzed to identify miRNAs and NSD2 expressions. …”
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Exploring research trends in cancer immunotherapy via single-cell technologies: a scientometric perspective by Zhongxun Li, Zhongxun Li, Qi Han, Qi Han, Zimu Huang, Sen Zhang, Huina Guo, Huina Guo, Hongliang Liu, Hongliang Liu, Hongliang Liu, Xiaoya Guan, Xiaoya Guan, Hairong Li, Chunming Zhang, Chunming Zhang, Chunming Zhang

“…Research trends such as spatial transcriptomics, standardized processes, and T cell function are becoming increasingly popular.ConclusionIn tumor immunotherapy, single-cell sequencing is profoundly changing the research paradigm. …”
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Gene Expression Dynamics of Sugar Metabolism and Accumulation During Fruit Ripening in <i>Camellia drupifera</i> by Xue Sun, Muhammad Zeeshan Ul Haq, Ya Liu, Dongmei Yang, Huageng Yang, Yougen Wu

“…At the same time, it provides a theoretical basis for the genetic improvement and effective utilization of other oil crops, supporting their broader agricultural and industrial applications.…”
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The energy-health-environment nexus: assessing the transboundary impacts of coal-fired power plants by Raja Dhar, Sayantan Sarkar, Chen Luo, Megha Anand, Shyamasree Dasgupta, Ujjwal Neogi, Apostolos Bossios, Rausan Zamir, Mohammad Shoeb, Joyanto Routh

“…To address this gap, a comprehensive, multicenter, interdisciplinary study on a transboundary scale (India and Bangladesh) has been launched, which includes modeling power plant emissions, seasonal collection of particulate matter and its chemical analysis, socioeconomic surveys of the case (downwind) and control (upwind) populations, lung health assessments, and transcriptomic analyses of blood samples. The outcomes will provide quantitative estimates of power plant impacts on air quality, lung health, and blood markers associated with pulmonary complications. …”
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Early-life exposure to polypropylene nanoplastics induces neurodevelopmental toxicity in mice and human iPSC-derived cerebral organoids by Fangfang Huang, Haizhen You, Xiaogang Tang, Yuantao Su, Huijuan Peng, Huizhen Li, Zhiyun Wei, Jing Hua

“…Furthermore, human brain organoids exposed to PP-NPs exhibited reduced growth and neuronal differentiation, with significant downregulation of key neuronal markers such as TUJ1, MAP2, and PAX6. Transcriptomic analysis identified alterations in gene expression, particularly in neuroactive ligand-receptor interaction pathway. …”
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Integrating Radiogenomics and Machine Learning in Musculoskeletal Oncology Care by Rahul Kumar, Kyle Sporn, Akshay Khanna, Phani Paladugu, Chirag Gowda, Alex Ngo, Ram Jagadeesan, Nasif Zaman, Alireza Tavakkoli

“…We examine integrating quantitative imaging features from MRI, CT, and PET with genomic and transcriptomic data to enable non-invasive tumor profiling. …”
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GPATCH11 variants cause mis-splicing and early-onset retinal dystrophy with neurological impairment by Andrea Zanetti, Gwendal Dujardin, Lucas Fares-Taie, Jeanne Amiel, Jérôme E. Roger, Isabelle Audo, Matthieu P. Robert, Pierre David, Vincent Jung, Nicolas Goudin, Ida Chiara Guerrera, Stéphanie Moriceau, Danielle Amana, Nurit Assia Batzir, Anat Bachar-Zipori, Lina Basel Salmon, Nathalie Boddaert, Sylvain Briault, Ange-Line Bruel, Christine Costet-Fighiera, Luisa Coutinho Santos, Cyril Gitiaux, Karolina Kaminska, Paul Kuentz, Naama Orenstein, Nicole Philip-Sarles, Morgane Plutino, Mathieu Quinodoz, Cristina Santos, Sabine Sigaudy, Mariana Soeiro e Sá, Efrat Sofrin, Ana Berta Sousa, Rui Sousa-Luis, Christel Thauvin-Robinet, Erwin L. van Dijk, Khaoula Zaafrane-Khachnaoui, Dinah Zur, Josseline Kaplan, Carlo Rivolta, Jean-Michel Rozet, Isabelle Perrault

“…Proteomic analysis of mouse retina confirms the roles GPATCH11 plays in RNA processing, splicing, and transcription regulation, while also suggesting additional functions in synaptic plasticity and nuclear stress response. Our research provides insights into the diverse roles of GPATCH11 and identifies that the mutations affecting this protein are responsible for a recently characterized described syndrome.…”
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Transcriptional engineering for value enhancement of oilseed crops: a forward perspective by Charli Kaushal, Mahak Sachdev, Mansi Parekh, Harini Gowrishankar, Mukesh Jain, Subramanian Sankaranarayanan, Bhuvan Pathak

“…Plant-derived oils provide 20%–35% of dietary calories and are a primary source of essential omega-6 (linoleic) and omega-3 (α-linolenic) fatty acids. …”
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