Neddylation status determines the therapeutic sensitivity of tyrosine kinase inhibitors in chronic myeloid leukemia by Congyi Zhang, Yikai Yao, Qiuting Qian, Xiongyu Han, Yunkun Lu, Xinyi Jiang, Hongqiang Cheng, Xue Zhang, Ying Chi, Yuehai Ke, Peng Xiao

“…RNA sequencing data revealed that neddylation inhibitor reversed the transcriptomic changes induced by TKI. Co-immunoprecipitation (co-IP) assay identified ABL1 kinase domain as a novel substrate for neddylation. …”
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Immunotherapy with IL12 and PD1/CTLA4 inhibition is effective in advanced ovarian cancer and associates with reversal of myeloid cell-induced immunosuppression by Paul G. Pavicic, Patricia A. Rayman, Shadi Swaidani, Amit Rupani, Vladimir Makarov, Charles S. Tannenbaum, Robert P. Edwards, Anda M. Vlad, C. Marcela Diaz-Montero, Haider Mahdi

“…We also identified marked differences in treated mice that were in remission compared to those whose tumors progressed, further confirming a pivotal role for the modulation of myeloid cell function to allow for response to immunotherapy. These findings provide the scientific basis for the combination of IL12 and ICI to improve clinical response in OC.…”
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Excessive apoptosis, glycolysis, and abnormal levels of gluconeogenase in rheumatoid arthritis involves in the dysregulation of glucose metabolism: an animal model study by Hui Pi, Qiang Fu, Juan Liu, Haotong Zhou, Youlian Wang

“…Notably, we discovered novel differentially expressed enzymes implicated in the glycolysis pathway, such as hexokinase and fructose-bisphosphate aldolase, within the CIA rat model, which may serve as new markers for the diagnosis of RA or provide new perspectives to treat RA or RA-related glucose metabolism disorder.…”
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Multi‐omics profiling reveals key factors involved in Ewing sarcoma metastasis by Mariona Chicón‐Bosch, Sara Sánchez‐Serra, Marta Rosàs‐Lapeña, Nicolás Costa‐Fraga, Judit Besalú‐Velázquez, Janet Illa‐Bernadí, Silvia Mateo‐Lozano, Florencia Cidre‐Aranaz, Thomas G.P. Grünewald, Ángel Díaz‐Lagares, Roser Lopez‐Alemany, Òscar M. Tirado

“…Further studies will provide insight into EWS metastasis mechanisms and ultimately improve survival rates for EWS patients.…”
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High paracrine activity of hADSCs cartilage microtissues inhibits extracellular matrix degradation and promotes cartilage regeneration by Wei Liu, Hongyu Jiang, Jiajie Chen, Yue Tian, Ying He, Ying Jiao, Yanjun Guan, Zhibo Jia, Yanbin Wu, Cheng Huang, Yiben Ouyang, Wenjing Xu, Jianhong Qi, Jiang Peng, Aiyuan Wang

“…However, the extracellular matrix (ECM) of native cartilage can provide structural support and is an ideal source of microcarriers. …”
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Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells by Magda R Hamczyk, Ricardo Villa‐Bellosta, Víctor Quesada, Pilar Gonzalo, Sandra Vidak, Rosa M Nevado, María J Andrés‐Manzano, Tom Misteli, Carlos López‐Otín, Vicente Andrés

“…Moreover, these findings may help to understand other vascular diseases associated with VSMC death, and provide insight into aging‐dependent vascular damage related to accumulation of unprocessed toxic forms of lamin A.…”
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Long‐Term High‐Fat Diet Affected Bone Marrow Microenvironment During Aging at Single‐Cell Resolution by Yidan Pang, Siyuan Zhu, Peng Ding, Senyao Zhang, Yi Zhang, Fang Ye, Changqing Zhang, Junjie Gao, Jimin Yin

“…Single‐cell transcriptomics of bone marrow cells highlighted LHA‐driven perturbations in immune cell populations with distinct metabolic adaptations to LHA. …”
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Nanoparticle‐Mediated CXCL12–CXCR4 Inhibition Reprograms Macrophages and Suppresses Gastric Carcinoma by Qianqian Cao, Xiaolei Cheng, Rongbin Lv, Dianshui Sun, Jihua Wang, Runjia Fu, Rumei Gong, Yueying Xiao, Qin Liu, Xiaomei Li

“…Multi‐omics approaches, including transcriptomics, proteomics, and metabolomics, identify key genes and pathways affected by treatment. …”
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Metabolomics profiling of apples of different cultivars and growth locations by Kang Chen, Raghunath Pariyani, Yajing Li, Jindong Li, Xiongwu Qiao, Shu Qin, Baoru Yang

“…Future research using transcriptomic and proteomic approaches could reveal the impact of gene-environment interaction on biochemical pathways involved in the primary and secondary metabolism of apples.…”
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Altered Methylation Profile of Lymphocytes Is Concordant with Perturbation of Lipids Metabolism and Inflammatory Response in Obesity by Mette J. Jacobsen, Caroline M. Junker Mentzel, Ann Sofie Olesen, Thierry Huby, Claus B. Jørgensen, Romain Barrès, Merete Fredholm, David Simar

“…The dramatic changes in the transcriptomic and epigenetic signature of circulating lymphocytes reinforce the concept that epigenetic processes participate in the increased immune cell activation and impaired metabolic functions in obesity.…”
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Virome specific to tick genus with distinct ecogeographical distribution by Di Tian, Run-Ze Ye, Yu-Yu Li, Ning Wang, Wan-Ying Gao, Bai-Hui Wang, Zhe-Tao Lin, Wen-Jie Zhu, Qiu-Shi Wang, Ya-Ting Liu, Hua Wei, Yi-Fei Wang, Yi Sun, Xiao-Yu Shi, Na Jia, Jia-Fu Jiang, Xiao-Ming Cui, Tick Genome and Microbiome Consortium (TIGMIC), Wu-Chun Cao, Zhi-Hong Liu

“…Results We conducted the meta‑transcriptomic sequencing of 155 pools of ticks encompassing 7 species of 3 genera collected from diverse geographical fauna of Ningxia Province, China. …”
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Protogenin facilitates trunk-to-tail HOX code transition via modulating GDF11/SMAD2 signaling in mammalian embryos by Yu-Sheng Hung, Wei-Mi Lin, Yu-Chiuan Wang, Wei-Chih Kuo, Yu-Yang Chen, Ming-Ji Fann, Jenn-Yah Yu, Yu-Hui Wong

“…Prtg knockout (Prtg − / − ) mice manifest anterior homeotic transformations in their vertebral columns and significant alterations in homeobox (Hox) gene expression. Transcriptomic profiling of Prtg − / − mouse embryos highlights Prtg-regulated genes involved in axial development, particularly within the transforming growth factor beta (TGFβ) signaling pathway. …”
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Monocyte eukaryotic initiation factor 2 signaling differentiates 17-hydroxy-docosahexaenoic acid levels and pain by Peter R.W. Gowler, Asta Arendt-Tranholm, James Turnbull, Rakesh R. Jha, David Onion, Tony Kelly, Afroditi Kouraki, Paul Millns, Sameer Gohir, Susan Franks, David A. Barrett, Ana M. Valdes, Victoria Chapman

“…Summary: Our goal was to probe the potential transcriptomic basis for the relationship between plasma levels of the specialized pro-resolving precursor, 17-hydroxy-docosahexaenoic acid (17-HDHA) and chronic pain. …”
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Disentangling the Switching Behavior in Functional Connectivity Dynamics in Autism Spectrum Disorder: Insights from Developmental Cohort Analysis and Molecular‐Cellular Association... by Wei Li, Xia Qiu, Jin Chen, Kexuan Chen, Meiling Chen, Yinyan Wang, Wenjie Sun, Jing Su, Yongchang Chen, Xiaobao Liu, Congying Chu, Jiaojian Wang

“…Additionally, changes in RFSI at different developmental stages of ASD correlated with transcriptomic profiles and neurotransmitter density maps. …”
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FAP-CAR-T cells reduce dystrophic muscle fibrosis, improving adeno-associated virus gene transfer efficacy by Maxime Ferrand, Céline J. Rocca, Guillaume Corre, Valentina Buffa, Sophie Frin, Francine Garnache-Ottou, Elodie Bôle-Richard, Sonia Albini, Isabelle Richard, Anne Galy

“…Reducing fibrosis with FAP-CAR-T cells enhanced adeno-associated virus (AAV) microdystrophin gene transfer in the model by increasing vector copies, demonstrating that fibrosis is a restriction factor for AAV gene delivery in skeletal muscle. These results provide novel insights into therapeutic strategies for DMD or other fibrotic diseases.…”
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Dynamic multi-omics and mechanistic modeling approach uncovers novel mechanisms of kidney fibrosis progression by Nadine Tuechler, Mira Lea Burtscher, Martin Garrido-Rodriguez, Muzamil Majid Khan, Dénes Türei, Christian Tischer, Sarah Kaspar, Jennifer Jasmin Schwarz, Frank Stein, Mandy Rettel, Rafael Kramann, Mikhail M Savitski, Julio Saez-Rodriguez, Rainer Pepperkok

“…This work advances our understanding of the pathogenesis of kidney fibrosis and provides a resource to be further leveraged by the community.…”
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Bacterial volatile organic compounds supplemented with light‐emitting diode lighting enhance antioxidant capacity and delay senescence in broccoli by Taishan Huang, Junyan Shi, Xiaozhen Yue, Shuzhi Yuan, Xiangbin Xu, Jinhua Zuo, Qing Wang

“…Overall, the LED‐BVOCs treatment improved the antioxidant capacity and reduced ethylene production in stored broccoli, thus delaying senescence. Our study provides new insights on the ability of using BVOCs as biopreservatives to improve the antioxidant capacity and delay senescence of broccoli during storage.…”
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Decoding Acute Myeloid Leukemia: A Clinician’s Guide to Functional Profiling by Prasad Iyer, Shaista Shabbir Jasdanwala, Yuhan Wang, Karanpreet Bhatia, Shruti Bhatt

“…GEP, particularly RNA sequencing, evaluates the transcriptomic landscape and identifies gene expression alterations specific to AML subtypes. …”
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Multi-omics integrated analysis reveals the molecular mechanism of tail fat deposition differences in sheep with different tail types by Wannian Wang, Zhixv Pang, Siying Zhang, Pengkun Yang, Yangyang Pan, Liying Qiao, Kaijie Yang, Jianhua Liu, Ruizhen Wang, Wenzhong Liu

“…Conclusions Our results provide insights into the molecular mechanisms of tail fat deposition in sheep with different tail types, and provide a deeper explanation for the development and functional regulation of adipocytes.…”
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Developmental immune network of airway lymphocytes and innate immune cells in patients with stable COPD by Lanlan Liu, Mei Zhou, Shengwen Sun, Long Chen, Dehu Li, Dehu Li, Jiaxi Lv, Rui Cheng, Rui Cheng, Jianchu Zhang, Jianghua Wu, Jianghua Wu, Xianzhi Xiong

“…However, the molecular alterations and precise origins of immune cells in COPD airways remain poorly understood.MethodsHere, CD45+ immune cells in bronchoalveolar lavage fluid and peripheral blood mononuclear cells were collected from four COPD patients and four healthy smokers to provide a comprehensive single-cell transcriptomic atlas of immune cells in COPD airways.ResultsNotably, CD8+ T cells exhibited increased exhaustion, reduced cytotoxicity, and decreased TCR diversity in COPD airways. …”
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