A murine model lacking Lyst recapitulates Chediak-Higashi syndrome with an earlier-onset neurodegenerative phenotype by Sunny Greene, Mackenzie L. Talbert, F. Graeme Frost, Patricia M. Zerfas, Danielle Springer, Audrey Noguchi, Marie Morimoto, Dawn Maynard, Lisa Garrett, Gene Elliot, Maria Traver, David Yarnell, Petcharat Leoyklang, John D. Burke, Elena-Raluca Nicoli, William A. Gahl, Wendy J. Introne, May Christine V. Malicdan

“…The ΔLYST-B6 mouse provides a valuable tool for studying the underlying mechanisms of CHS-associated neurodegeneration and for developing potential therapeutic strategies.…”
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Overexpression of the ferroptosis-related gene, NFS1, corresponds to gastric cancer growth and tumor immune infiltration by Mao Zhiyun, Shi Zhongmei, Cui Ming, Ma Xiaohong, Wang Yan, Zhang Xiaojie, Jing Rongrong, Wang Jingchun

“…NFS1 is a potential diagnostic and prognostic biomarker linked to ferroptosis and the TME, and provides a novel target for cancer treatment and immunotherapy.…”
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Comparison of differences in transcriptional and genetic profiles between intra-central nervous system and extra-central nervous system large B-cell lymphoma by Shu Wang, Hong Chen, Bo Dai, Kang Zheng, Jiajun Zheng, Yuqi Zhu, Yan Yuan, Tianling Ding, Qian Wang, Liqian Xie, Rui Feng, Fengping Zhu, Jianbin Xiang, Weiqun Ding, Hong Ding, Yuan Li, Xiaodong Gu, Kunpeng Wu, Yifan Yuan, Jianping Song, Dongxiao Zhuang, Haoshu Zhong, Hanfeng Wu, Ying Mao, Tong Chen

“…In summary, our study provides comprehensive insights into the transcriptomic and genetic characteristics of PCNS-DLBCL in contrast to ecDLBCL and will help dissect the oncogenic mechanism of this disease.…”
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Exploring the Skin Benefits of Extremophilic Postbiotics from <i>Exiguobacterium artemiae</i>: A New Frontier in Thermal Protection by Haeun Lee, Dayeon Roo, Dong-Geol Lee, Seunghyun Kang, Jinwoo Min, Heecheol Kang, Young Mok Heo, Kyung Eun Lee

“…This study assessed <i>E. artemiae</i>-derived SUPER-T and its exosome form, Thermasome, in heat-stressed human skin fibroblasts. Transcriptomic profiling revealed that heat stress upregulated heat-related thermal receptors and downregulated key extracellular matrix (ECM)-related genes. …”
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Single-nucleus neuronal transcriptional profiling of male C. elegans uncovers regulators of sex-specific and sex-shared behaviors by Katherine S. Morillo, Jonathan St. Ange, Yifei Weng, Rachel Kaletsky, Coleen T. Murphy

“…We further demonstrate that the ubiquitously expressed MAPK phosphatase vhp-1 regulates both sex-specific and sex-shared behaviors. Our data provide a rich resource for discovering sex-specific transcriptomic differences and the molecular basis of sex-specific behaviors.…”
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Androgen receptor profiling predicts prostate cancer outcome by Suzan Stelloo, Ekaterina Nevedomskaya, Henk G van der Poel, Jeroen de Jong, Geert JLH van Leenders, Guido Jenster, Lodewyk FA Wessels, Andries M Bergman, Wilbert Zwart

“…Further refinement of the signature provided us with a concise list of nine genes that hallmark prostate cancer outcome in multiple independent validation series. …”
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Evaluation of Metabolic Characteristics Induced by Deoxynivalenol in 3D4/21 Cells by Yu Han, Bo Yu, Wenao Weng, Liangyu Shi, Jing Zhang

“…Integration with transcriptomic data confirmed that these pathways play key roles in DON-induced immunotoxicity. …”
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Corona or hydrochloric acid modulates embryonic diapause in silkworms by activating different signaling pathways by Yuli Zhang, Guizheng Zhang, Mangui Jiang, Pingyang Wang, Xia Wang, Qiuying Cui, Quan Sun

“…In addition, HCl treatment appeared to activate the heat shock protein and hormone-regulated pathways. Our study results provide a basis for further analysis of the molecular mechanisms underlying diapause termination in silkworm eggs.…”
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A double-edged sword role of IFN-γ-producing iNKT cells in sepsis: Persistent suppression of Treg cell formation in an Nr4a1-dependent manner by Yingyu Qin, Yilin Qian, Shengqiu Liu, Rong Chen

“…Our data uncover the dual function of iNKT cells in sepsis progression and provide a potential treatment target for this adverse long-term outcome induced by sepsis.…”
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Glycolysis downregulation is a hallmark of HIV‐1 latency and sensitizes infected cells to oxidative stress by Iart Luca Shytaj, Francesco Andrea Procopio, Mohammad Tarek, Irene Carlon‐Andres, Hsin‐Yao Tang, Aaron R Goldman, MohamedHusen Munshi, Virender Kumar Pal, Mattia Forcato, Sheetal Sreeram, Konstantin Leskov, Fengchun Ye, Bojana Lucic, Nicolly Cruz, Lishomwa C Ndhlovu, Silvio Bicciato, Sergi Padilla‐Parra, Ricardo Sobhie Diaz, Amit Singh, Marina Lusic, Jonathan Karn, David Alvarez‐Carbonell, Andrea Savarino

“…Of note, blocking NADPH downstream effectors, thioredoxin and glutathione, favors HIV‐1 reactivation from latency in lymphoid and myeloid cellular models. This provides a “shock and kill effect” decreasing proviral DNA in cells from people living with HIV/AIDS. …”
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Resolving spatial subclonal genomic heterogeneity of loss of heterozygosity and extrachromosomal DNA in gliomas by Michelle G. Webb, Frances Chow, Carmel G. McCullough, Bohan Zhang, John J. Y. Lee, Rania Bassiouni, Norman E. Garrett, Kyle Hurth, John D. Carpten, Gabriel Zada, David W. Craig

“…Abstract Mapping the spatial organization of DNA-level somatic copy number changes in tumors can provide insight to understanding higher-level molecular and cellular processes that drive pathogenesis. …”
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Autophagic-active nanosystem for senile bone regeneration by in-situ mitochondrial biogenesis and intercellular transfer by Meihua Zhang, Xiaoqing Sun, Ming Lu, Xingyou Wang, Shuyao Liu, Xiaoqin Hu, Jing He, Bin Luo, Yao Wu

“…In conclusion, the autophagy-activating CNS, by effectively rejuvenating S-BMDMs and promoting mitochondrial biogenesis and transfer, provides an innovative therapeutic strategy for SOP-associated bone regeneration.…”
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Tumor budding and poorly differentiated clusters as a biological continuum in colorectal cancer invasion and prognosis by Tariq Sami Haddad, John-Melle Bokhorst, Luuk van den Dobbelsteen, Sonay K. Öztürk, Elias Baumann, Shannon van Vliet, Kiek Verrijp, Nigel B Jamieson, Colin Wood, Martin D. Berger, Richard Kirsch, Marco Aben, Natasja Rutgers, Hideki Ueno, Francesco Ciompi, Femke Simmer, Jeroen van der Laak, Alessandro Lugli, Inti Zlobec, Iris Nagtegaal

“…Using a combination of spatial transcriptomic and immunohistochemical (IHC) techniques, we demonstrated a biological continuum from larger to smaller tumor clusters, with TB possessing greater invasive potential than PDCs. …”
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Rheumatic heart valve disease: navigating the challenges of an overlooked autoimmune disorder by Adrien Lupieri, Prabhash K. Jha, Victor Nizet, Walderez O. Dutra, Maria Carmo P. Nunes, Robert A. Levine, Elena Aikawa, Elena Aikawa

“…Additionally, perspectives of discoveries in biomarkers and the development of genetic, transcriptomic, and provide a solid foundation for further advancements in the field.…”
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Biomass-based carbon dot-modified cerium oxide nanoparticles (BCDs@CeO2) efficiently promote Myriophyllum aquaticum to remove NH4+-N and TP in eutrophic water by Xingling Nie, Jun Ma, Ming Chen, B. Larry Li

“…In summary, this study provides an effective strategy to enhance eutrophication phytoremediation.…”
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LncRNA HSCHARME is altered in human cardiomyopathies and promotes stem cell-derived cardiomyogenesis via splicing regulation by Giulia Buonaiuto, Fabio Desideri, Adriano Setti, Alessandro Palma, Angelo D’Angelo, Giulio Storari, Tiziana Santini, Pietro Laneve, Daniela Trisciuoglio, Monica Ballarino

“…Here, we exploit the synteny between the mouse and human genomes to identify the human lncRNA HSCHARME and combine single-cell transcriptomics, CAGE-seq data, RNA-FISH imaging and CRISPR/Cas9 genome editing to document its role in cardiomyogenesis. …”
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Differentiation‐related epigenomic changes define clinically distinct keratinocyte cancer subclasses by Llorenç Solé‐Boldo, Günter Raddatz, Julian Gutekunst, Oliver Gilliam, Felix Bormann, Michelle S Liberio, Daniel Hasche, Wiebke Antonopoulos, Jan‐Philipp Mallm, Anke S Lonsdorf, Manuel Rodríguez‐Paredes, Frank Lyko

“…Here, we combined single‐cell multi‐omics, transcriptomics, and methylomics to investigate the epigenomic dynamics during epidermal differentiation. …”
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Continuous map of early hematopoietic stem cell differentiation across human lifetime by Hana Komic, Tessa Schmachtel, Catia Simoes, Marius Külp, Weijia Yu, Adrien Jolly, Malin S. Nilsson, Carmen Gonzalez, Felipe Prosper, Halvard Bonig, Bruno Paiva, Fredrik B. Thorén, Michael A. Rieger

“…We employed single cell proteo-transcriptomic sequencing to FACS-enriched bone marrow hematopoietic stem and progenitor cells (HSPCs) from 15 healthy donors. …”
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Induced collagen type‐I secretion by hepatocytes of the melanoma liver metastasis is associated with a reduction in tumour‐infiltrating lymphocytes by Shodai Mizuno, Matias A. Bustos, Yoshinori Hayashi, Kodai Abe, Satoru Furuhashi, Yalda Naeini, Xiaowei Xu, Anton J Bilchik, Dave S. B. Hoon

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Potential Resistance Mechanisms Exhibited by Cystic Fibrosis Patients Against SARS-CoV-2 by Yasmin K. Elsharabassi, Nuha T. Swaidan, Mohamed M. Emara

“…Analyzing the genomics and transcriptomics profiles of CF patients could provide insights into potential resistance mechanisms. …”
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