A comprehensive machine learning for high throughput Tuberculosis sequence analysis, functional annotation, and visualization by Md. Saddam Hossain, Md. Parvez Khandocar, Farzana Akter Riti, Md. Yeakub Ali, Prithbey Raj Dey, S M Jahurul Haque, Amira Metouekel, Atrsaw Asrat Mengistie, Mohammed Bourhia, Farid Khallouki, Khalid S. Almaary

“…Such algorithms provided prediction accuracies of 0.963, 0.739, 0.773, 0.866, and 0.866 sequentially. …”
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Cell-free DNA in the management of prostate cancer: Current status and future prospective by Wei He, Yutian Xiao, Shi Yan, Yasheng Zhu, Shancheng Ren

“…Results: cfDNA is primarily released from cells undergoing necrosis and apoptosis, allowing for non-invasive insight into the genomic, transcriptomic, and epigenomic alterations within various PCa disease states. …”
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Multi‐omics analyses reveal the interaction between colonic microbiota and host in Min and Yorkshire pigs by Xiaoyu Huang, Huihui Li, Feng Cheng, Ligang Wang, Guoqing Cao, Lixian Wang, Lijun Shi

“…Through the correlation analysis of colonic microbiota with metabolomics of colonic content or transcriptomics of colonic tissues, we provided direct and indirect relationships of microorganisms and hosts. …”
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Physiological Responses and Histopathological Changes in Narrow-Clawed Crayfish (<i>Pontastacus leptodactylus</i>) Under Acute Thermal Stress by Xia Zhu, Bin Li, Yuzhen Liu, Shujian Chen, Yangfang Ye, Ronghua Li, Weiwei Song, Changkao Mu, Chunlin Wang, Ce Shi

“…Similarly, the T25 group displayed increased MDA and CAT levels but decreased T-AOC. Comparative transcriptomic analysis demonstrated that differentially expressed genes (DEGs) in the control vs. …”
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Establishment and characterization of an inflammatory cartilaginous organoids model for organoid transplantation study by Yanchao Zhang, Qing Fang, Yue Peng, Honglin Liu, Jiancheng Tang, Ruichen Ma, Weiguo Wang

“…Subsequently, IL-1β induced inflammatory cartilaginous organoids were established and the transcriptomic sequencing was performed to investigate gene expression changes. …”
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Identification of critical transition signal (CTS) to characterize regulated stochasticity during ABA-induced growth-to-defense transition by Rasmieh Hamid, Bahman Panahi, Feba Jacob, Amir Ghaffar Shahriari

“…Conclusions By integrating a network-driven transcriptomic analysis, this study provides new insights into the molecular basis of ABA-induced transitions from growth to defense. …”
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The eusocial non-code: Unveiling the impact of noncoding RNAs on Hymenoptera eusocial evolution by Egor Lebedev, Daniil Smutin, Pavel Timkin, Danil Kotelnikov, Amir Taldaev, Nick Panushev, Leonid Adonin

“…Critical analysis is provided on the functional insights garnered from ncRNA profiles correlated with caste-specific phenotypes, specifical for phylogenetic branches and transitional sociality models, drawing from comparative genomics and transcriptomics studies. …”
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Mechanisms of Baicalin Alleviates Intestinal Inflammation: Role of M1 Macrophage Polarization and Lactobacillus amylovorus by Shunfen Zhang, Ruqing Zhong, Miao Zhou, Kai Li, Huiyuan Lv, Huixin Wang, Ye Xu, Dadan Liu, Qiugang Ma, Liang Chen, Hongfu Zhang

“…Furthermore, whole‐genome sequencing of Lactobacillus amylovorus provided insights into its functional potential and metabolic annotations. …”
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Denser Mitogenomic Sampling for Exploring the Phylogeny of Tellinoidea (Mollusca: Bivalvia) by Weikang Tang, Tao Xu, Jihang Gong, Lingfeng Kong

“…Combined with the published mitogenomes and transcriptomic data, we constructed the most comprehensive Tellinoidea phylogeny to date through maximum likelihood and Bayesian Inference analyses. …”
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Dose-response assessment of dipentyl phthalate effects on testosterone production and morphogenesis of late-gestation fetal rat testis by Maansi V. Gupta, Justin M. Conley, Christy Lambright, Logan F. Chin, Susan J. Hall, L. Earl Gray, Daniel J. Spade

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hiPSC-neurons recapitulate the subtype-specific cell intrinsic nature of susceptibility to neurodegenerative disease-relevant aggregation by Ian Weidling, Christina N. Preiss, Sarah E. Chancellor, Gyan Srivastava, Lauren Gibilisco, Gen Lin, Melanie Shackett Brennan, Janice Lee, Lindsay M. Roth, Olga Morozova, Kyong Nyon Nam, Nehal R. Patel, Qing Liu, J. K. Thomas, Peter Reinhardt, Ruven Wilkens, Dagmar E. Ehrnhoefer, Andreas Striebinger, Stefan Barghorn, Christina Xanthopoulos, Marie-Theres Weil, Sandra Biesinger, Miroslav Cik, Nandini Romanul, Kiran Yanamandra, Alessandra M. Welker, Jessica Wu, Laura Gasparini, Jan Stöhr, Xavier Langlois, Justine D. Manos

“…The absence of a consistent transcriptional response following aggregate seeding further indicated that intrinsic neuronal subtype-specific properties could drive susceptibility. The present data provides evidence that hiPSC-neurons exhibit features of selective neuronal vulnerability which manifest in a cell autonomous manner, suggesting that mining intrinsic (or basal) transcriptomic signatures of more vulnerable compared to more resilient hiPSC-neurons could uncover the molecular underpinnings of differential susceptibility to protein aggregation found in a variety of neurodegenerative diseases.…”
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KAT2B regulates estradiol synthesis via H3K27ac/PPARα in granulosa cells of PCOS patients by Ao Wang, Xiao-Fei Zhang, Cong-Jian Luo, Yu-Dong Liu, Pei-Ru Chen, An-Lan Wang, Jun Zhang, Song-Yu Huang, Xin-Yi Huang, Shi-Ling Chen, Xing-Yu Zhou

“…Untargeted metabolomics analysis provided additional insights into systemic circulatory changes in the two rat models. …”
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The Antibiotic-Resistant Protein MfpA Modulates Host Cell Apoptosis and Promotes Mycobacterial Survival by Targeting Mitochondria and Regulating the NF-κB Signaling Pathway by Weishan Zhang, Zheng Jiang, Kaixia Mi

“…MfpA was found to localize to mitochondria, increasing ROS production and disrupting mitochondrial membrane potential. Transcriptomic analysis revealed that MfpA modulated the NF-κB signaling pathway, regulating the expression of <i>gadd45β</i>. …”
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Nucleosome organization of mouse embryos during pre-implantation development by Jitao Zeng, Xiaojuan Tu, Siming Qu, Xichan Chen, Ying Wang, Xiaona Liu, Enchuan Kang, Yi Tian, Qianming Xiang, Binbin Lai, Weiwu Gao, Bing Ni, Wei He

“…Our study systematically delineates nucleosome reorganization principles during mammalian embryogenesis and provides a high-resolution resource for understanding chromatin remodeling in early development.…”
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Depressive patient‐derived GABA interneurons reveal abnormal neural activity associated with HTR2C by Kaiqin Lu, Yuan Hong, Mengdan Tao, Luping Shen, Zhilong Zheng, Kaiheng Fang, Fang Yuan, Min Xu, Chun Wang, Dongya Zhu, Xing Guo, Yan Liu

“…Furthermore, targeting 5‐HT2C receptor, using a small molecule agonist or genetic approach, restored neuronal activity deficits in sMDD GINs. Our findings provide a human cellular model for studying the molecular mechanisms and drug discoveries for sMDD.…”
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Recent Advances in Omics, Computational Models, and Advanced Screening Methods for Drug Safety and Efficacy by Ahrum Son, Jongham Park, Woojin Kim, Yoonki Yoon, Sangwoon Lee, Jaeho Ji, Hyunsoo Kim

“…Additionally, technologies such as physiologically based pharmacokinetic (PBPK) modeling and micro-physiological systems (MPS) provide more precise preclinical-to-clinical translation, thereby improving drug safety assessments. …”
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Alternative splicing of squid is associated with sex-ratio allocation in the wasp Copidosomopsis nacoleiae by Huili Ouyang, Xuesheng Li, Dongyu Chen, Xia-Lin Zheng, Wen Lu, Xiaoyun Wang

“…Conclusions Overall, the study provides important insights into the reproductive biology of C. nacoleiae and sheds light on the molecular mechanisms underlying sex differentiation in this species.…”
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A review of emerging technologies, nutritional practices, and management strategies to improve intramuscular fat composition in beef cattle by Belete Kuraz Abebe, Jianfang Wang, Juntao Guo, Hongbao Wang, Anning Li, Linsen Zan

“…Consequently, the aim of this paper was to provide insight and synthesis into the emerging technologies, nutritional practices and management strategies to improve IMF composition in beef cattle. …”
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Exercise training remodels inter-organ endocrine networks by Cheehoon Ahn, Andrea L. Hevener, Laurie J. Goodyear, Sue C. Bodine, Karyn A. Esser, Marcus M. Seldin, Lauren M. Sparks

“…Conclusion: Our systems genetics framework provides an unprecedented atlas of inter-organ communication significantly remodeled by endurance exercise, serving as a valuable resource for novel exerkine discovery.…”
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Acid-exposed and hypoxic cancer cells do not overlap but are interdependent for unsaturated fatty acid resources by Katarzyna Głowacka, Sébastien Ibanez, Ophélie Renoult, Perrine Vermonden, Maria Virginia Giolito, Kübra Özkan, Charline Degavre, Léo Aubert, Céline Guilbaud, Florine Laloux-Morris, Elena Richiardone, Jérôme Ambroise, Caroline Bouzin, Davide Brusa, Jonas Dehairs, Johan Swinnen, Cyril Corbet, Yvan Larondelle, Olivier Feron

“…This bystander effect provides unbiased evidence for a lack of full overlap between hypoxic and acidic tumor compartments, highlighting a rationale for targeting desaturase activity in cancer.…”
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