Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways by Sofie Rennen, Victor Bosteels, Clint De Nolf, Sandra Maréchal, Jessica Vetters, Karo Van Lil, Greta Webb, Janne Swinnen, Evelien Van De Velde, Farzaneh Fayazpour, Ria Roelandt, Niels Vandamme, Kevin Verstaen, Stefaan C. De Smedt, Karine Breckpot, Stijn Vanhee, Philippe Gevaert, Eric Hoste, Bruno G. De Geest, Rein Verbeke, Ine Lentacker, Sophie Janssens

“…This reveals that LNPs are not decoded as “dangerous” by DCs, and that the cargo is essential to provide adjuvant activity, which is highly relevant for the targeted design of LNP-based therapies.…”
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Interpretable Multimodal Fusion Model for Bridged Histology and Genomics Survival Prediction in Pan‐Cancer by Feng Gao, Junxiang Ding, Baowen Gai, Du Cai, Chuling Hu, Feng‐Ao Wang, Ruikun He, Junwei Liu, Yixue Li, Xiao‐Jian Wu

“…This not only aids in reducing the healthcare burden on cancer patients but also provides improved assistance for clinical practitioners in precise diagnosis and treatment.…”
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Insights into latent tuberculosis biomarkers from differential gene expression analysis in CD8 memory cells using secondary data Insilico approach by Atmadi Atmadi, Tiara Rahayu, Indah Kusuma Wardani, Reihana Marsha Cahyani Elsadi, Azizah Eka Milasari, M. Ridwan Amarullah Witadi

“…In the quest for effective diagnostic tools and precise treatment strategies, differential gene expression (DEG)-based biomarkers offer a promising avenue. These biomarkers provide specific insights into disease states and treatment responses by deciphering gene alterations within body cells. …”
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Identification of genes involved in verazine biosynthesis in Veratrum grandiflorum and their heterologous production in Saccharomyces cerevisiae by Kaiyun Hong, Xiangyu Liu, Changqing Wang, Yanjiao Xu, Guisheng Xiang, Shengchao Yang, Jianli Yang, Guanghui Zhang, Simei He

“…In this study, we sequenced the transcriptomes of Veratrum grandiflorum roots treated with methyl jasmonate, genes involved in verazine biosynthesis VgCYP90B27, VgCYP94N1, VgCYP90G1, and VgGABAT, were characterized. …”
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In-depth inference of transcriptional regulatory networks reveals NPM1 as a therapeutic ribosomal regulator in MYC-amplified medulloblastoma by Tong Chen, Huiyao Chen, Mingyang Xia, Yunfei Liao, Hao Li, Xinran Dong, Yifeng Lin, Wenhao Zhou

“…Together, our findings highlight NPM1 as a promising therapeutic target and provide new insights into the regulatory mechanisms in MB.…”
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scCompass: An Integrated Multi‐Species scRNA‐seq Database for AI‐Ready by Pengfei Wang, Wenhao Liu, Jiajia Wang, Yana Liu, Pengjiang Li, Ping Xu, Wentao Cui, Ran Zhang, Qingqing Long, Zhilong Hu, Chen Fang, Jingxi Dong, Chunyang Zhang, Yan Chen, Chengrui Wang, Guole Liu, Hanyu Xie, Yiyang Zhang, Meng Xiao, Shubai Chen, Haiping Jiang, The X‐Compass Consortium, Yiqiang Chen, Ge Yang, Shihua Zhang, Zhen Meng, Xuezhi Wang, Guihai Feng, Xin Li, Yuanchun Zhou

“…Here scCompass is proposed, which provides a comprehensive resource designed to build large‐scale, multi‐species, and model‐friendly single‐cell data collection. …”
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Proteogenomic verifies targets underlying erythromycin alleviate neutrophil extracellular traps-induced inflammation by Nan Ma, Xiao Na Liang, Quan Fang Chen, Mei Hua Li, Guang Sheng Pei, Xiao Fei Yi, Li Yan Guo, Fu Gang Chen, Zhi Yi He

“…The aim of our study is investigate the molecular mechanisms of EM's anti-inflammatory effects in NETs-induced inflammation. Methods Transcriptomics and proteomics data were obtained from U937 cells treated with NETs and EM. …”
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Emilia sonchifolia (L.) DC. inhibits the growth of Methicillin-Resistant Staphylococcus epidermidis by modulating its physiology through multiple mechanisms by Lili An, Wei Peng, Yuqi Yang, Gongzhen Chen, Qian Tonghan Luo, Meng Ni, Xuebing Wang, Yufeng Fu, Yonghui Zhou, Xin Liu

“…Additionally, proteomic and transcriptomic analyses revealed considerable down-regulation of purine metabolism, that were associated with oxidative stress and cell wall synthesis. …”
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Molecular characterization and expression analysis of hypoxia inducible factor-1α during hypoxic stress in speckled blue grouper (Epinephelus cyanopodus) by Along Gao, Qiaoyi Chen, Yukun Huang, Zhiya Yu, Wenjie He, Jinhui Wu, Jinxiong Huang, Tiangaung Cai, Hu Shu

“…The results of qRT-PCR were consistent with the transcriptomic techniques, and the expression of EcHIF-1α was significant after hypoxia. …”
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From Molecules to Amoeboid Movement: A New Way for Understanding the Morphology Through Actin-Binding Proteins by Ekaterina Volkova, Igor Pozdnyakov, Mikhail Petukhov, Valeriia Polezhaeva

“…One of the actin-binding proteins is the Arp2/3 complex that provides a connection between actin filaments at an angle of 70°. …”
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Advances in tumor subclone formation and mechanisms of growth and invasion by Yuhong Zhang, Weidong Wang

“…Major methodologies for studying tumor subclones include single-cell sequencing, liquid biopsy, and spatial transcriptomics, which provide insights into clonal architecture and dynamic evolution. …”
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Intrinsic Muscle Stem Cell Dysfunction Contributes to Impaired Regeneration in the mdx Mouse by Marie E. Esper, Caroline E. Brun, Alexander Y. T. Lin, Peter Feige, Marie J. Catenacci, Marie‐Claude Sincennes, Morten Ritso, Michael A. Rudnicki

“…Conclusions Our study provides evidence that dystrophin deficiency in MuSCs and myofibres together contributes to progression of DMD. …”
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Calcium overload via PVT1 reprograms neutrophil fate and constrains gastric cancer progression by Dong Wang, Yunlong Li, Xiaoyu Peng, Lulu Zhang, Ying Zhang, Xue Guan, Xiao Liang, Songbin Fu, Jingcui Yu

“…Mechanistically, multi-omics integration of transcriptomics and 4D-label-free quantitative proteomics identified PVT1-associated pathways driving GC progression. …”
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Regulation of HSC development and function by Lin28b by Grant Cox, Michihiro Kobayashi, Brian D. Rudd, Momoko Yoshimoto

“…Hematopoietic stem cells (HSCs) provide all kinds of blood cells for life while maintaining self-renewal ability. …”
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Reciprocal regulation of MMP-28 and EGFR is required for sustaining proliferative signaling in PDAC by Zhengtao Hong, Xing Huang, Linghao Xia, Tingbo Liang, Xueli Bai

“…In return, EGFR upregulated MMP-28 through AP-1-mediated transcription, forming a positive feedback loop that provided sustaining proliferation signaling for PDAC. …”
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Single-cell and bulk RNA analysis identifies EMT-associated CAF signatures and prognostic model in lung adenocarcinoma by He An, Ping An

“…The model effectively predicts patient survival risk and provides new insights for risk stratification and personalized treatment. …”
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Multi-omics analysis reveals CMTR1 upregulation in cancer and roles in ribosomal protein gene expression and tumor growth by Ion John Campeanu, Yuanyuan Jiang, Hilda Afisllari, Sijana Dzinic, Lisa Polin, Zeng-Quan Yang

“…The study highlights CMTR1’s potential as a therapeutic target in certain cancer types and provides a foundation for developing novel cancer treatments targeting mRNA cap methylation.…”
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Characterization of the Vibrio anguillarum VaRyhB regulon and role in pathogenesis by Yingjie Li, Xinran Yu, Peng Li, Xin Li, Lushan Wang

“…It is also essential for the activation of siderophore synthesis, chemotaxis and motility, and anaerobic denitrification. Our work provides the first evidence of the VaRyhB regulon and its role in the pathogenesis of V. anguillarum.…”
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CD300f epitopes are specific targets for acute myeloid leukemia with monocytic differentiation by Edward Abadir, Robin E. Gasiorowski, Kaitao Lai, Fiona Kupresanin, Adelina Romano, Pablo A. Silveira, Tsun‐Ho Lo, Phillip D. Fromm, Marina L. Kennerson, Harry J. Iland, P. Joy Ho, P. Mark Hogarth, Kenneth Bradstock, Derek N.J. Hart, Georgina J. Clark

“…While one CD300f monoclonal antibody (mAb) reportedly did not bind healthy hematopoietic stem cells, transcriptomic analysis found that CD300f transcripts are expressed by healthy HSPC. …”
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Drp1–associated genes implicated in sepsis survival by Marissa D. Pokharel, Marissa D. Pokharel, Anlin Feng, Anlin Feng, Ying Liang, Ying Liang, Wenli Ma, Wenli Ma, Saurabh Aggarwal, Hoshang Unwalla, Stephen M. Black, Stephen M. Black, Stephen M. Black, Ting Wang, Ting Wang, Ting Wang

“…Such biomarkers would be invaluable in clinical settings, aiding healthcare providers in the early identification of high-risk patients and improving treatment strategies. …”
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