Regulation of tumor growth by leukocyte-specific protein 1 in T cells by Riri Kwon, Bong-Ki Hong, Kang-Gu Lee, Eunbyeol Choi, Laurent Sabbagh, Chul-Soo Cho, Naeun Lee, Wan-Uk Kim

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Characterisation of the tumour microenvironment and PD-L1 granularity reveals the prognostic value of cancer-associated myofibroblasts in non-invasive bladder cancer by Carmen G. Cañizo, Félix Guerrero-Ramos, Mercedes Perez Escavy, Iris Lodewijk, Cristian Suárez-Cabrera, Lucía Morales, Sandra P. Nunes, Ester Munera-Maravilla, Carolina Rubio, Rebeca Sánchez, Marta Rodriguez-Izquierdo, Jaime Martínez de Villarreal, Francisco X. Real, Daniel Castellano, Cristina Martín-Arriscado, David Lora Pablos, Alfredo Rodríguez Antolín, Marta Dueñas, Jesús M. Paramio, Victor G. Martínez

“…Our study provides a roadmap to establish the landscape of the NMIBC TME, highlighting myoCAFs as potential prognostic markers.…”
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Year-round infectome profiling of acute febrile respiratory illness unveiled complex epidemiological dynamics postlifting of COVID-19 restrictions by Shisong Fang, Lin Zhu, Shaohui Bai, Weijian Tian, Yuanfei Pan, Shumiao Zhang, Rongjun Bi, Minqi Liang, Gengyan Luo, Xiaojing Chen, Minwu Peng, Hanlin Liu, Lu Xie, Runzi Zhang, Wudi Zhou, Shengze Zhang, Ting Xie, Haolu Zha, Chuming Luo, Xin Wang, Ying Sun, Hui Liu, Min Jiang, Weihua Wu, Xuan Zou, Yaoqing Chen, Jianhui Yuan, Ying Jiang, Nan Wu, Mang Shi, Yuelong Shu, Huanle Luo

“…Methods: Between March 2023 and February 2024, 1163 oropharyngeal swabs from AFRI patients and 338 from healthy individuals were collected in Shenzhen. Meta-transcriptomic sequencing was employed for microbial analysis. …”
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Exploring salinity adaptation in teleost fish, focusing on omics perspectives on osmoregulation and gut microbiota by Evodia Moses Mkulo, Evodia Moses Mkulo, Evodia Moses Mkulo, Lukman Iddrisu, Mpwaga Alatwinusa Yohana, Anna Zheng, Anna Zheng, Anna Zheng, Jiahao Zhong, Jiahao Zhong, Jiahao Zhong, Minxuan Jin, Minxuan Jin, Minxuan Jin, Felix Danso, Linjuan Wang, Linjuan Wang, Linjuan Wang, Huijuan Zhang, Huijuan Zhang, Huijuan Zhang, Baogui Tang, Baogui Tang, Baogui Tang, Hui Zhou, Hui Zhou, Hui Zhou, Kwaku Amoah, Kwaku Amoah, Kwaku Amoah, Jiansheng Huang, Jiansheng Huang, Jiansheng Huang, Bei Wang, Bei Wang, Bei Wang, Zhongliang Wang, Zhongliang Wang, Zhongliang Wang, Zhongliang Wang

“…They inhabit various environments and are crucial to global fisheries, making them a focus of research using advanced omics approaches. These studies provide insights into the genetic factors, environmental adaptability, disease resistance, and metabolic processes, aiding aquaculture sustainability. …”
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Wolfram syndrome 2 gene (CISD2) deficiency disrupts Ca2+-mediated insulin secretion in β-cells by Zhao-Qing Shen, Wen-Tai Chiu, Cheng-Heng Kao, Yu-Chen Chen, Li-Hsien Chen, Tsai-Wen Teng, Shao-Yu Hsiung, Tsai-Yu Tzeng, Chien-Yi Tung, Chi-Chang Juan, Ting-Fen Tsai

“…Methods: We use β-cell specific Cisd2 knockout (Cisd2KO) mice, a CRISPR-mediated Cisd2KO MIN6 β-cell line and transcriptomic analysis. Results: Four findings are pinpointed. …”
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The molecular biology of peritoneal metastatic disease by Sanne Bootsma, Maarten F Bijlsma, Louis Vermeulen

“…Given the distinct route of dissemination compared with distant organ metastases, and the unique microenvironment of the peritoneal cavity, specific tumor cell characteristics are needed for the development of PMD. In this review, we provide an overview of the known histopathological, genomic, and transcriptomic features of PMD. …”
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Taltirelin induces TH expression by regulating TRHR and RARα in medium spiny neurons by Kedong Zhu, Lanxia Meng, Jiaying Luo, Tingting Wen, Liang Dan, Zhihao Wang, Xuebing Cao, Zhaohui Zhang, Guiqin Chen

“…In this study, a variety of in vivo and in vitro methods, including transcriptomic analysis, were employed to elucidate the effects of Taltirelin on cellular composition and signaling pathways in the striatum of hemi-PD rats. …”
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Regulation of fruit quality formation in strawberry: from omics to biotechnology by Zhang-Ying Wang, An-Qing Shen, Yan-Xin Ge, Cheng-Ling Zhou, Yu-Shan Qiao, Ai-Sheng Xiong, Guang-Long Wang

“…The viewpoints in this article may provide new ideas for breeders and scientists aimed to regulate and improve strawberry quality in the future.…”
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Quantitative proteomic analysis revealed the protein expression characteristics of primary follicle subtypes in zebrafish by Guangjing Zhang, Jing Huang, Liangyue Peng, Jinhui Liu, Wenbin Liu, Wen Fu

“…These results provide reference to the molecular mechanisms underlying follicular development in fish.…”
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The role of the glutathione pathway in tracheal regeneration with aortic allografts through antioxidant-driven tissue integration by Shixiong Wei, Yao Zhi, Zhou Chen, Yiyuan Zhang, Kexing Duan, Mingqian Li, Guoyue Lv

“…These findings provide mechanistic insights into oxidative stress-mediated tissue remodeling and suggest that targeting redox signaling could optimize bioengineered tracheal grafts for clinical translation.…”
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NDUFAB1 as a Novel Regulator of NEFA-Induced Metabolic Dysfunction in Bovine Adipocytes by Jing Zhou, Tao Tang, Wenqiang Sun, Xianbo Jia, Jie Wang, Hengwei Yu, Songjia Lai

“…Through integrated transcriptomic and functional analyses, we identified NDUFAB1 as a central metabolic regulator that counteracts NEFA-induced adipocyte dysfunction. …”
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Protocol for in vitro generation of innate lymphoid cells from human embryonic tissues by Chen Liu, Qingfeng Fu, Guoju You, Tao Cheng, Yu Lan, Bing Liu

“…We describe steps for identifying lymphoid progenitors in human embryonic tissues, then culturing mature ILCs in vitro, and identifying characteristics and functions of different cultured ILC subsets using cellular indexing of transcriptomes and epitopes (CITE)-sequencing and flow cytometry analysis. …”
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The glutamate receptor gene GLR3.3: A bridge of calcium-mediated root development in poplar by Yi An, Ya Geng, Yu Liu, Xiao Han, Lichao Huang, Wei Zeng, Jin Zhang, Mengzhu Lu

“…This study not only provides novel insight into how the Ca2+ channels mediated root growth and development in trees, but also provides a directive breeding of new poplar species for biofuel and bioenergy production.…”
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Exploring therapeutic paradigm focusing on genes, proteins, and pathways to combat leprosy and tuberculosis: A network medicine and drug repurposing approach by Mohd Imran, Ahmed S. Alshrari, Mariah N. Hafiz, Mohammed M. Jawad, Abida Khan, Fadiyah Jadid Alanazi, Syed Mohammed Basheeruddin Asdaq

“…Methods: Transcriptomic datasets were analyzed to identify dysregulated genes and pathways. …”
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Research progress in molecular omics of neovascular age-related macular degeneration by ZHUANG Xuenan, GUI Mi, WEN Feng

“…Genomics, transcriptomics, proteomics, metabolomics, and multi-omics integration analyses have not only helped to deeply explore disease-related key molecules, pathways, and networks but also provided new perspectives for discovering novel biomarkers and potential therapeutic targets. …”
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Divergent B-cell and cytotoxic TNK cell activation signatures in HLA-B27-associated ankylosing spondylitis and acute anterior uveitis by Eisa Mahyari, Sean Davin, Kimberly Ogle, Emma Fale-Olsen, Carley Shaut, Tammy M. Martin, Jasvinder S. Ahuja, Eric Suhler, Atul Deodhar, James T. Rosenbaum, James T. Rosenbaum, Tejpal Gill, Tejpal Gill

“…Using cellular indexing of transcriptomes and epitopes (CITE-Seq) in a well-characterized cohort of 25 subjects—including AS (HLA-B27pos), AS+AAU (HLA-B27pos), AAU (HLA-B27pos), HCs (HLA-B27pos), and HCs (HLA-B27neg); N = 5/group—we identified transcriptomic differences at the single-cell level, along with differentially expressed cell surface markers. …”
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An autoencoder learning method for predicting breast cancer subtypes. by Zahra Rostami, Kavitha Mukund, Maryam Masnadi-Shirazi, Shankar Subramaniam

“…However, the large dimensionality of this transcriptomic data and the heterogeneity between the molecular profiles of breast cancers poses a barrier to identifying minimal markers and mechanistic consequences. …”
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Comprehensive Analysis of TCR and BCR Repertoires: Insights into Methodologies, Challenges, and Applications by Kayoung Seo, Jung Kyoon Choi

“…Recent advancements in RNA sequencing have expanded its application beyond transcriptomics to include the analysis of immune repertoires, enabling the exploration of TCR and BCR sequences across various physiological and pathological contexts. …”
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SCSMRD: A database for single-cell skeletal muscle regeneration by Xi-kang FENG, Chun-di XIE, Yong-yao LI, Zi-shuai WANG, Li-jing BAI

“…Single-cell RNA-sequencing (scRNA-seq) provides the opportunity to deconvolute heterogeneous tissue into individual cells based on their transcriptomic profiles. …”
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Identification of candidate transcripts associated with marennine biosynthesis in Haslea ostrearia: investigating enzymes and metabolic pathways involved by Feriel KHIAR, Noujoud GABED, Nadir B. DERGAL, Sid A.C. LAMARA, Sidi-Mohammed E.-A. ABI-AYAD

“…Functional annotation and enrichment analysis provided insights into these transcripts’ role in marennine production. …”
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