Caffeic acid and chlorogenic acid mediate the ADPN-AMPK-PPARα pathway to improve fatty liver and production performance in laying hens by Wenjie Tian, Gerard Bryan Gonzales, Hao Wang, Youyou Yang, Chaohua Tang, Qingyu Zhao, Junmin Zhang, Huiyan Zhang, Yuchang Qin

“…These findings provide a foundation for CA and CGA as therapeutic agents for fatty liver disease and related metabolic diseases in hens, and also offer insights into the targeted modification of CGA (including the isomer of CGA) into CA, thereby providing novel strategies for the efficient utilization of CGA. …”
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Integrated Multi-Omics Reveals DAM-Mediated Phytohormone Regulatory Networks Driving Bud Dormancy in ‘Mixue’ Pears by Ke-Liang Lyu, Shao-Min Zeng, Xin-Zhong Huang, Cui-Cui Jiang

“…In this study, we integrated targeted phytohormone metabolomics, full-length transcriptomics, and proteomics to explore the regulatory mechanisms of dormancy in ‘Mixue’, a pear cultivar with an extremely low chilling requirement. …”
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Salidroside can protect against ferroptosis in cardiomyocytes and may be related to the regulation of GGT1 by Tianhang Feng, Jing Shi, Jinghua Zhao, Qin Zhao, Tao Wang, Sha Wan, Chen Fan, Sijia Wang, Chunyou Lai, Yutong Yao

“…Mechanistically, SAL suppresses ferroptosis through dual regulation of GGT1: (1) enhancing glutathione synthesis via GGT1 inhibition and (2) potentiating GPX4-mediated antioxidant defense.DiscussionThese findings establish GGT1 as a pivotal therapeutic target for SAL’s cardioprotection, providing a mechanistic basis for its clinical application in ferroptosis-associated cardiovascular diseases.…”
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Dynamic epigenomic landscape and gene regulatory networks during embryonic development in Pacific white shrimp (Litopenaeus vannamei) as revealed by histone modification profiling... by Jiale Shi, Zhangru Qi, Miaomiao Yin, Qifan Zeng, Jingjie Hu, Zhenmin Bao, Zhi Ye

“…Integration with transcriptomic data uncovered a strong temporal correlation between chromatin states and gene expression, particularly during zygotic genome activation (ZGA). …”
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Multi-Omics and Functional Insights into Triterpenoid Biosynthesis Pathways in <i>Neopicrorhiza scrophulariiflora</i> (Pennell) D.Y.Hong by Pinhan Zhou, Juan Wang, Chaohui Li, Lesong Li, Luyuan Duan, Weihao Wang, Xirui Liu, Khadija Tehseen Arshad, Yanli Liang, Yan Zhao

“…These findings reveal key genes in triterpenoid biosynthesis, providing a theoretical foundation for the future production of key triterpenoids in <i>N. scrophulariiflora</i> through synthetic biology approaches.…”
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Cepharanthine hydrochloride inhibits prostate cancer progression by modulating gut microbiota and metabolites by Hui Li, Xing Luo, Peng He, Peng He, Zongming Dong, Yongming Jia, Bishao Sun, Ji Zheng, Jingzhen Zhu

“…After treatment, the tumor sizes of the mice were measured, and feces, blood, and tumor tissues from both groups were collected for 16S rDNA, metabolomics, and transcriptomics sequencing analysis.ResultsResults showed CH treatment significantly suppressed prostate cancer growth in mice without antibiotic cocktail pretreatment, but not in antibiotic-pretreated mice. 16S rRNA sequencing revealed distinct gut microbiota alterations in CH-Ctrl versus Ctrl/CH-ABX groups, with increased g_Blautia, g_Lactobacillus, g_Butyricicoccus and decreased g_Akkermansia abundances. …”
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Multi-omics insights into Chinese herbal medicine additives for mutton flavor enhancement: epigenetic and microbial mechanisms by Kai Quan, Huibin Shi, Haoyuan Han, Kun Liu, Qiufang Cui, Huihua Wang, Meilin Jin, Wei Sun, Caihong Wei, Yibao Jiang, Jun Li

“…These findings connect traditional herbal knowledge with precision agriculture, providing practical strategies for environmentally friendly mutton production that meets the global demand for safe, high-quality protein.…”
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Negative Air Ions Attenuate Nicotine-Induced Vascular Endothelial Dysfunction by Suppressing AP1-Mediated FN1 and SPP1 by Sha Xiao, Tianjing Wei, Mingyang Xiao, Mingming Shan, Ziqi An, Na Li, Jing Zhou, Shuang Zhao, Xiaobo Lu

“…Western blotting was used to detect the expression levels of the α7nAChR/MAPK/AP1 pathway. Transcriptomic sequencing was performed to identify the differentially expressed genes after treatment with nicotine or NAIs. …”
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Androgen receptor promotes arachidonic acid metabolism and angiogenic microenvironment in AFP-negative hepatocellular carcinoma by Zhilong Lin, Xiaofei Liu, Houwei Wang, Shumin Li, Ziqiang Miao, Jing Yang, Yuting Zhang, Kai Lei, Yifan Wu, Youmei Kang, Ruoyin Zheng, Zonglin Xie, Yixi Wen, Xiaoxue Ren, Chunxiao Liu, Alfred Sze-Lok Cheng, Yubin Xie, Shuling Chen, Ming Kuang, Sui Peng, Zhenwei Peng, Zihao Dai

“…AFP-positive HCC (AFP+ HCC) has been intensively investigated; however, the genomic, transcriptomic and microenvironmental characteristics of AFP-negative HCC (AFP− HCC) remain to be deciphered. …”
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Histone lactylation drives liver cancer metastasis by facilitating NSF1-mediated ferroptosis resistance after microwave ablation by Jiayan Huang, Huijing Xie, Ju Li, Xiaotong Huang, Yunshi Cai, Rui Yang, Dongmei Yang, Wuyongga Bao, Yongjie Zhou, Tao Li, Qiang Lu

“…We also bridged histone lactylation with ferroptosis, providing novel therapeutic targets for HCC following microwave ablation, particularly when combined with oxaliplatin-based chemotherapy.…”
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Deciphering human endogenous retrovirus expression in colorectal cancers: exploratory analysis regarding prognostic value in liver metastasesResearch in context by Julien Viot, Romain Loyon, Nawfel Adib, Pierre Laurent-Puig, Aurélien de Reyniès, Fabrice André, Franck Monnien, Thierry André, Magali Svrcek, Anthony Turpin, Zohair Selmani, Laurent Arnould, Laura Guyard, Nicolas Gilbert, Anthony Boureux, Olivier Adotevi, Angélique Vienot, Syrine Abdeljaoued, Dewi Vernerey, Christophe Borg, Daniel Gautheret

“…Interpretation: These findings provide insights into the lmCRC transcriptome landscape by suggesting prognostic markers and potential therapeutic targets. …”
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Intercellular TIMP-1-CD63 signaling directs the evolution of immune escape and metastasis in KRAS-mutated pancreatic cancer cells by Chu-An Wang, Ya-Chin Hou, Yi-Kai Hong, Yu-Jing Tai, Chieh Shen, Pei-Chi Hou, Jhao-Lin Fu, Cheng-Lin Wu, Siao Muk Cheng, Daw-Yang Hwang, Yung-Yeh Su, Yan-Shen Shan, Shaw-Jenq Tsai

“…Conclusions Our study reveals the vicious cycle between early infiltrating macrophages and pancreatic cancer cells, providing a mechanistic insight into the dynamic regulation directing pancreatic cancer progression.…”
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Accelerating cartilage regeneration with DNA-SF hydrogel sustained release system-based cartilage organoids by Cong-Yi Shen, Qi-Rong Zhou, Xiang Wu, Xin-Yu Han, Qin Zhang, Xiao Chen, Yu-Xiao Lai, Long Bai, Ying-Ying Jing, Jian-Hua Wang, Cheng-Long Wang, Zhen Geng, Jia-Can Su

“…Conclusions This study employs DSRGT to construct COs, providing an innovative strategy for the regeneration of cartilage defects.…”
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An insight into the draft genome of the Oriental rat flea, Xenopsylla cheopis, together with its Wolbachia endosymbiont by Stephen Lu, David M. Bland, Eric Dahlstrom, Neelam Redekar, Melina G. Guizzo, Kent Barbian, B. Joseph Hinnebusch, José M. C. Ribeiro

“…Abstract Background The Oriental rat flea, Xenopsylla cheopis, is a main vector of plague caused by the bacterium Yersinia pestis. Transcriptomic analysis of this insect and the interaction between Yersinia and the flea digestive tract have been the subject of several studies. …”
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Large-scale genomic deletion in spl39 activates immune responses and confers resistance to rice bacterial blight by Cheng Fang, Wei Ma, Xiaotong Zhu, Xiaotong Zhu, Lingling Peng, Lingling Peng, Liangzhi Tao, Zhiqiang Zhao, Fengbin Wang, Yafeng Ye, Bojun Ma, Yuejin Wu, Jie Yuan, Binmei Liu, Xifeng Chen, Weimin Cheng

“…These findings highlight the role of large genomic deletions in reprogramming plant metabolism and immunity, providing new insights into the mechanisms underlying lesion mimic phenotypes and disease resistance in rice.…”
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Novel insights into the circadian modulation of lipid metabolism in chicken livers revealed by RNA sequencing and weighted gene co-expression network analysis by Panlin Wang, Fang Li, Yanyan Sun, Yunlei Li, Xiuyu Xie, Xue Du, Lu Liu, Yongshu Wu, Dan Song, Hui Xiong, Jilan Chen, Xiangchen Li

“…However, such rhythmic variations were not observed under complete darkness incubation conditions. Using transcriptome sequencing technology, we identified 157 genes significantly upregulated at night and 313 genes significantly upregulated during the 12-h light/12-h dark cycle. …”
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Chronic arsenic exposure-provoked biotoxicity involved in liver-microbiota-gut axis disruption in chickens based on multi-omics technologies by Jiayi Li, Changming Guo, Yan Liu, Biqi Han, Zhanjun Lv, Huijie Jiang, Siyu Li, Zhigang Zhang

“…Multi-omics is a revolutionary technique to data analysis providing an integrated view of bioinformation for comprehensively and systematically understanding the elaborate mechanism of diseases. …”
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Pan-cancer analysis identifies tRNA modification enzyme CTU2 as a novel tumor biomarker and its role in immune microenvironment by Jiaojiao Wang, Chang Gao, Junyi Zhang, Huahong Luo, Siqi Dai, Jianwei Wang, Jianwei Wang

“…Single-cell and spatial transcriptomic analyses were performed to identify CTU2’s cell-type labels and distribution. …”
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An mRNA expression atlas for the duck with public RNA-seq datasets by Qiuyu Tao, Anqi Huang, Jingjing Qi, Zhao Yang, Shihao Guo, Yinjuan Lu, Xinxin He, Xu Han, Shuaixue Jiang, Mengru Xu, Yuan Bai, Tao Zhang, Shenqiang Hu, Liang Li, Lili Bai, HeHe Liu

“…A thorough understanding of the functional genomic and transcriptomic sequences is crucial for improving production efficiency. …”
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Dissecting the genetic basis of response to salmonid alphavirus in Atlantic salmon by Domniki Manousi, Dorota Monika Jaskula, Fabian Grammes, Tim Martin Knutsen, Shahmir Naseer, Samuel AM Martin, Thomas Moen, Marie Saitou, Sigbjørn Lien

“…Conclusions This study provides a detailed investigation of the genetic architecture underlying PD resistance in farmed Atlantic salmon. …”
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