Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis by Ying Xu, Weiwei Meng, Yingqi Dai, Lin Xu, Ning Ding, Jinqing Zhang, Xuewei Zhuang

“…We utilized chromatin immunoprecipitation sequencing with H3K18la antibodies, transcriptomics of clinical BC samples, and proteomics and ATAC-seq analyses of in vivo tumors to identify the genes regulated by H3K18la and the transcription factor PPARD. qPCR and Western blot assays were used to detect expressions of molecules. …”
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Decoding per- and polyfluoroalkyl substances (PFAS) in hepatocellular carcinoma: a multi-omics and computational toxicology approach by Yanggang Hong, Deqi Wang, Zeyu Liu, Yuxin Chen, Yi Wang, Jiajun Li

“…Collectively, our findings help in advancing clinical applications by providing insights into disease mechanisms and potential therapeutic interventions.…”
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OPA1-Exon4b modulates the migration and invasion of hepatocellular carcinoma cells by ATP regulation by Haite Tang, Zhijuan Hu, Liang Yang, Zifeng Ruan, Hao Wang, Yunhao Zhou, Feixiang Bao, Xingguo Liu

“…Thus, our study demonstrated a key role of OPA1-Exon4b to regulate the migration and invasion in HCC, which could provide a new prospect for the clinical diagnosis and therapy of HCC.…”
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Elucidating the role of pyrimidine metabolism in prostate cancer and its therapeutic implications by Liang Huang, Yu Xie, Shusuan Jiang, Kan Liu, Zhihao Ming, Hong Shan

“…Moreover, key genes involved in pyrimidine de novo synthesis, such as RRM2, were identified as potential drivers of tumor progression, providing new insights into the molecular mechanisms underlying aggressive prostate cancer phenotypes. …”
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Multi-strategy ugt mining, modification and glycosyl donor synthesis facilitate the production of triterpenoid saponins by Lin Hao, Yu Liu, Guiru Dong, Jingyan Liu, Kai Qiu, Xiaopeng Li, Yanan Qiao

“…The combination of genomics, transcriptomics, and metabolomics has provided powerful tools for UGT screening, significantly improving the efficiency and accuracy of UGT identification. …”
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SOX11 and GLIS2: Novel Biomarkers for Understanding the Progression of Oral Leukoplakia by Yi Li, Zhencun Tang, Chenliang Xiao, Jun Su, Lijia He, Wenyun Zhang

“…They have the potential to serve as biomarkers and therapeutic targets for LP and OSCC, providing new insights into understanding the mechanisms of LP and developing treatment strategies.…”
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Watkins wheat landraces decode nitrogen-driven biomass trade-offs: GWAS exposes root-shoot dialectics and elite landraces for resilient agriculture by Abdul Waheed, Muhammad Shahid Iqbal, Zareen Sarfraz, Junliang Hou, Yanping Wei, Bo Song, Shifeng Cheng

“…Functional annotation and transcriptomic validation were used to elucidate gene networks, and haplotype mapping was employed to link allelic variation to geographic adaptation. …”
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Biology, genetics, and ecology of the cosmopolitan ectomycorrhizal ascomycete Cenococcum geophilum by Huayong Wang, Annegret Kohler, Francis M. Martin, Francis M. Martin

“…The nuclear genome of C. geophilum has been sequenced, providing valuable insights into the symbiont genetic traits. …”
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Memory CD4+ T cells sequentially restructure their 3D genome during stepwise activation by Alexander I. Ward, Jose I. de las Heras, Eric C. Schirmer, Ariberto Fassati

“…BackgroundCD4+ T cells are a highly differentiated cell type that maintain enough transcriptomic plasticity to cycle between activated and memory statuses. …”
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Integrating machine learning and neural networks for new diagnostic approaches to idiopathic pulmonary fibrosis and immune infiltration research. by Yali Guo, Qian Jin, Yi Kang, Wenwen Jin, Ying Liu, Qian Chen, Jian Liu, Yu Guang Wang

“…Further validation of the expression of these genes through transcriptomic sequencing data from IPF and normal group animal models. …”
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Comprehensive innate immune profiling of chikungunya virus infection in pediatric cases by Daniela Michlmayr, Theodore R Pak, Adeeb H Rahman, El‐Ad David Amir, Eun‐Young Kim, Seunghee Kim‐Schulze, Maria Suprun, Michael G Stewart, Guajira P Thomas, Angel Balmaseda, Li Wang, Jun Zhu, Mayte Suaréz‐Fariñas, Steven M Wolinsky, Andrew Kasarskis, Eva Harris

“…We present a multiscale network that summarizes all observed modulations across cellular and transcriptomic levels and their interactions with clinical outcomes, providing a uniquely global view of the biomolecular landscape of human CHIKV infection.…”
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Mechanistic insights into JSS1_004-mediated antagonism of the DndBCDE-FGH restriction system and engineering applications by Yu He, Susu Jiang, Fang Wang, Junwu Bi, Siting Li, Fuliang Yin, Shi Chen, Chao Chen, Lianrong Wang

“…Our findings advance the understanding of phage-host interactions and provide a framework for optimizing phage therapeutics to circumvent bacterial defense barriers.IMPORTANCEOur recent investigation elucidated the molecular mechanism by which bacteriophage JSS1 counteracted the bacterial DndBCDE-FGH anti-phage defense system. …”
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Identification, Evolution and Expression Analyses of the Hox Family in Procambarus clarkii by Xiaoyu WEI, Qian HU, Zemao GU, Yanhe LI

“…In this study, the bioinformatics methods were used to identify the Hox gene family based on the genome and transcriptome data of Procambarus clarkii to comprehensively understand the distribution, evolution, and function of the Hox gene family in the genome of P. clarkii. …”
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Cardiomyocyte Foxp1‐Specific Deletion Promotes Post‐injury Heart Regeneration via Targeting Usp20‐HIF1ɑ‐Hand1 Signaling Pathway by Yanfang Wang, Xiaoyu Wang, Ji Fang, Xiaoli Chen, Teng Xu, Tao Zhuang, Sheng Peng, Wenzhen Bao, Wenrun Wu, Yushi Lu, Haikun Wang, Brian Tomlinson, Paul Chan, Shougang Zhuang, Qi Zhang, Lin Zhang, Zhongmin Liu, Jingjiang Pi, Yuzhen Zhang, Jie Liu

“…Analysis of the Single‐cell transcriptome database reveals reduced Foxp1 expression in the cardiomyocyte population with high regenerative capacity. …”
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Neural representation of cytokines by vagal sensory neurons by Tomás S. Huerta, Adrian C. Chen, Saher Chaudhry, Aisling Tynan, Timothy Morgan, Kicheon Park, Richard Adamovich-Zeitlin, Bilal Haider, Jian Hua Li, Mitali Nagpal, Stavros Zanos, Valentin A. Pavlov, Michael Brines, Theodoros P. Zanos, Sangeeta S. Chavan, Kevin J. Tracey, Eric H. Chang

“…Thus, nodose ganglia neurons perform real-time encoding of cytokines at the first neural station in a body-brain axis, providing a new framework for studying the dynamic nature of neuroimmune communication.…”
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Adipocyte/Tumor cell crosstalk via IGF-1/TXNIP axis promotes malignancy and endocrine resistance in breast cancer by Amanda Caruso, Felice Maria Accattatis, Cinzia Giordano, Luca Gelsomino, Piercarlo Del Console, Maria Francesca Fiorita, Balazs Gyorffy, Laura Bianchi, Alfonso Carleo, Rossana De Salvo, Bruno M Simões, Robert B Clarke, Lorenzo Memeo, Cristina Colarossi, Eleonora Aiello, Francesco Conforti, Suzanne A W Fuqua, Matilde Todaro, Giorgio Stassi, Catia Morelli, Diego Sisci, Daniela Bonofiglio, Stefania Catalano, Sebastiano Andò, Ines Barone

“…Methods We used co-culture systems followed by validation through an ‘ex vivo’ model of human mammary obese (Ob) adipocytes and obese endocrine-resistant metastatic Patient-Derived Organoids (PDOs). Transcriptomics with MixOmics-MINT and MetaCore Functional Tools along with lentiviral and pharmacological approaches provide insights into mechanisms. …”
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Circulating T cell atlas in Moyamoya disease: insights into immunopathogenesis of cerebrovascular disorders by Chenglong Liu, Junsheng Li, Siqi Mou, Yuheng Pang, Liujia Chan, Qiheng He, Wei Liu, Zhikang Zhao, Bojian Zhang, Zhiyao Zheng, Wei Sun, Xiangjun Shi, Qian Zhang, Rong Wang, Yan Zhang, Wenjing Wang, Dong Zhang, Peicong Ge

“…Conclusions This study highlights the critical involvement of immune activation and mitochondrial dysfunction in the pathophysiology of MMD, providing novel insights into disease mechanisms and identifying immunometabolic pathways as potential targets for therapeutic intervention.…”
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Exploring human pancreatic organoid modelling through single-cell RNA sequencing analysis by Alessandro Cherubini, Francesco Rusconi, Roberta Piras, Kaja Nicole Wächtershäuser, Marta Dossena, Mario Barilani, Cecilia Mei, Lotta Hof, Valeria Sordi, Francesco Pampaloni, Vincenza Dolo, Lorenzo Piemonti, Lorenza Lazzari

“…Together our results offer an in-depth description of human pancreatic organoids providing a strong foundation for future in vitro diagnostic and translational studies of pancreatic health and disease.…”
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USP5 inhibition via bone marrow-targeted engineered exosomes for myeloproliferative neoplasms therapy by Wenjun Wang, Yufeng Jiang, Donglei Zhang, Xian Zhang, Qian Liang, Jun Shi, Yuan Zhou, Fuling Zhou

“…This approach combines USP5 inhibition with BM-targeted nanotechnology, providing a proof-of-concept for personalized MPN therapy with improved efficacy and reduced off-target effects.…”
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Molecular subtyping and precision therapy for esophageal cancer by Guangkun Pei, Zhuoran Liang, Bianli Gu, Linlin Shi, Ze‐Xian Liu, Shegan Gao

“…We emphasize how multiple omics, such as genomics, transcriptomics and proteomics, enhance our understanding of the molecular characteristics of EC. …”
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